Article
Biology
Mimmi L. E. Lundahl, Morgane Mitermite, Dylan Gerard Ryan, Sarah Case, Niamh C. Williams, Ming Yang, Roisin Lynch, Eimear Lagan, Filipa M. Lebre, Aoife L. Gorman, Bojan Stojkovic, Adrian P. Bracken, Christian Frezza, Frederick J. Sheedy, Eoin M. Scanlan, Luke A. J. O'Neill, Stephen Gordon, Ed C. Lavelle, Simon Yona
Summary: This study provides new and unexpected insights into alternative macrophage activation states in the context of mycobacterial infection. Activation with IL-4 and IL-13 induces protective innate memory against mycobacterial challenge and enhances the killing capacity of macrophages. IL-4/13 trained macrophages retain heightened oxidative phosphorylation metabolism and impede heightened pro-inflammatory cytokine responses by inhibiting oxidative phosphorylation.
Article
Immunology
Hong-Miao Li, Fei Tang, Qian Huang, Hai-Feng Pan, Tian-Ping Zhang
Summary: The study aimed to explore the association between IL-13, IL-13RA1, and IL-13RA2 gene polymorphisms and PTB susceptibility and clinical features. The results showed that certain gene polymorphisms were associated with the risk of PTB and its clinical characteristics.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Florian Sicklinger, Ingmar Soren Meyer, Xue Li, Daniel Radtke, Severin Dicks, Moritz P. Kornadt, Christina Mertens, Julia K. Meier, Kory J. Lavine, Yunhang Zhang, Tim Christian Kuhn, Tobias Terzer, Jyoti Patel, Melanie Boerries, Gabriele Schramm, Norbert Frey, Hugo A. Katus, David Voehringer, Florian Leuschner
Summary: The study show that basophils play a crucial role in promoting tissue repair after myocardial infarction by increasing levels of IL-4 and IL-13 in the heart. Depletion of basophils leads to an increase in inflammatory response, scar thinning, and deterioration of cardiac function post-MI.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Quentin D'Arcy, Mehrnaz Gharaee-Kermani, Alisa Zhilin-Roth, Jill A. Macoska
Summary: The IL-4/IL-13 signaling axis plays a crucial role in the development of lower urinary tract symptoms. IL-4 and IL-13 promote the activation of prostate fibroblasts and the secretion of extracellular matrix, leading to fibrosis. These findings have important clinical implications for the treatment of lower urinary tract symptoms.
Review
Biochemistry & Molecular Biology
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann
Summary: IL-4 and IL-13 are pleiotropic Th2 cytokines involved in immune responses and have been found to play a role in oncogenesis and tumor progression. Their effects on tumor cells are mediated through specific receptors, with IL-4R alpha/IL-13R alpha 1 being the main target in tumors. Understanding the implications of these cytokines and their receptors in pancreatic cancer helps in developing potential new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lilli Arndt, Andreas Lindhorst, Julia Neugebauer, Anne Hoffmann, Constance Hobusch, Vasileia-Ismini Alexaki, Adhideb Ghosh, Matthias Blueher, Christian Wolfrum, Markus Glass, Martin Gericke
Summary: White adipose tissue fibrosis is strongly associated with inflammation and dysfunction due to obesity. IL-13 and IL-4 have been identified as critical mediators in fibrotic diseases, but their role in WAT fibrosis is still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Milena Iwaszko, Sylwia Bialy, Katarzyna Bogunia-Kubik
Summary: IL-4 and IL-13 are key mediators of allergic inflammation and have been implicated in the development of autoimmune diseases. Recent studies suggest that they may play a significant role in downregulating inflammatory processes underlying rheumatoid arthritis pathogenesis.
Article
Hematology
Johanna Melo-Cardenas, Lavanya Bezavada, Jeremy Chase Crawford, Sandeep Gurbuxani, Anitria Cotton, Guolian Kang, Jeffrey Gossett, Christian Marinaccio, Rona Weinberg, Ronald Hoffman, Anna Rita Migliaccio, Yan Zheng, Marta Derecka, Ciro R. Rinaldi, John D. Crispino
Summary: This study analyzed MF mouse models and samples from MF patients, and found that high levels of IL-13 are associated with MF progression and fibrosis. Inhibition of the IL-13/IL-4 signaling pathway may serve as a novel therapeutic target for treating MF.
Review
Immunology
Judith E. Allen
Summary: Type 2 immunity plays a crucial role in protecting against parasites and responding to allergens, as well as maintaining tissue integrity and promoting wound repair. IL-4 and IL-13, key type 2 cytokines, are involved in suppressing the initial inflammatory response to injury and modulating extracellular matrix changes for effective repair. However, the exact contribution of IL-4R alpha signaling in wound repair is still not fully understood due to redundancy and other signaling pathways.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Review
Immunology
Zachary J. J. Bernstein, Anjali Shenoy, Amy Chen, Nicola M. M. Heller, Jamie B. B. Spangler
Summary: IL-4 and IL-13 cytokines play important roles in immune activity, especially in T helper 2 cell-mediated inflammation, immune regulation, antibody production, and fibrosis. Manipulating the IL-4/IL-13 axis through cytokine engineering, fusion protein formulation, antagonist development, cell engineering, and biosensor design can lead to the discovery of new immunotherapies targeting allergy, autoimmune diseases, and cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noemie Caillot, Fabien Colaone, Samir Hamdi, Raissa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, Francois Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurelie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Geraldine Grouard-Vogel, Laurent L. Reber
Summary: The study developed vaccines targeting IL-4 and IL-13, demonstrating promising prophylactic and therapeutic effects in mouse models of asthma. Vaccines specific for human IL-4 and IL-13 also showed efficient neutralization of these cytokines in mice, suggesting a potential long-term therapeutic strategy for allergic asthma.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Jinbiao Lu, Xiaonan Guo, Chunhua Wang, Weixin Du, Xiaobing Shen, Cheng Su, Yongge Wu, Miao Xu
Summary: This study evaluated the therapeutic effect of a novel subunit vaccine AEC/BC02 after chemotherapy in a tuberculosis (TB) relapse model, showing that the vaccine could reduce bacterial loads and induce antigen-specific cellular immune responses.
Article
Plant Sciences
Christine Joy I. Bulaon, Narach Khorattanakulchai, Kaewta Rattanapisit, Hongyan Sun, Nuttapat Pisuttinusart, Richard Strasser, Shiho Tanaka, Patrick Soon-Shiong, Waranyoo Phoolcharoen
Summary: This study demonstrates the production of anti-CTLA-4 2C8 antibody using Nicotiana benthamiana as a plant expression system and validates its efficacy in inhibiting tumor growth through animal experiments. It highlights the potential of plant platforms in cancer immunotherapy.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Long Xu, Yang Yang, Jiali Jiang, Yankai Wen, Jong-Min Jeong, Christoph Emontzpohl, Constance L. Atkins, Kangho Kim, Elizabeth A. Jacobsen, Hua Wang, Cynthia Ju
Summary: This study revealed that eosinophil-derived IL-4/IL-13 played a hepatoprotective role in acetaminophen-induced liver injury. The p38 MAPK/COX/NF-kappa B signaling cascade was shown to be critical in mediating the production of IL-4/IL-13 by eosinophils in response to IL-33.
Article
Immunology
Siqi Guo, Ronald B. Smeltz, Anthony Nanajian, Richard Heller
Summary: The study demonstrates that IL-15/IL-15R alpha complex enhances CD8 T cell expansion and has potential efficacy in inhibiting breast cancer growth and improving cytotoxicity. Further research is needed to optimize the effectiveness of IL-15cx as an immunotherapy for breast cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Hui-Min Zhao, Rui Du, Chun-Ling Li, Ping Ji, Hai-cong Li, Kang Wu, Zhidong Hu, Shui-Hua Lu, Douglas B. Lowrie, Xiao-Yong Fan
JOURNAL OF INFECTION
(2019)
Letter
Infectious Diseases
Zhidong Hu, Shui-Hua Lu, Douglas B. Lowrie, Xiao-Yong Fan
LANCET INFECTIOUS DISEASES
(2019)
Article
Immunology
C. Bethune, W. Egner, T. Garcez, A. Huissoon, S. Jolles, Y. Karim, R. Jain, S. Savic, K. Kelley, D. Grosse-Kreul, S. Grigoriadou
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2019)
Article
Immunology
Todd Dumas, N. Seth Berry, Martin Wolfsegger, Stephen Jolles, Barbara McCoy, Leman Yel
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Immunology
Nicholas Brodszki, Ashley Frazer-Abel, Anete S. Grumach, Michael Kirschfink, Jiri Litzman, Elena Perez, Mikko R. J. Seppanen, Kathleen E. Sullivan, Stephen Jolles
JOURNAL OF CLINICAL IMMUNOLOGY
(2020)
Letter
Critical Care Medicine
Wioleta M. Zelek, Jade Cole, Mark J. Ponsford, Richard A. Harrison, Ben E. Schroeder, Nicholas Webb, Stephen Jolles, Christopher Fegan, Matt Morgan, Matt P. Wise, B. Paul Morgan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Allergy
Hans-Hartmut Peter, Hans D. Ochs, Charlotte Cunningham-Rundles, Donald C. Vinh, Peter Kiessling, Bernhard Greve, Stephen Jolles
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Letter
Immunology
Mark J. Ponsford, Kimberly Evans, Emily M. Carne, Stephen Jolles
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Letter
Immunology
Rachel E. Bradley, Mark J. Ponsford, Martin J. Scurr, Andrew Godkin, Stephen Jolles
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Stephen Jolles, B. Douglas Smith, Donald C. Vinh, Rajiv Mallick, Gabriela Espinoza, Mitchell DeKoven, Victoria Divino
Summary: Real-world data are lacking to identify which patients with secondary immunodeficiency may benefit most from anti-infective interventions.
The retrospective analysis used baseline characteristics to assess risk of severe infections post-SID diagnosis in patients with hematological malignancies.
Evaluation of risk factors such as hospitalizations, infections, or antibiotic use pre-SID diagnosis could inform clinical decisions regarding prophylactic anti-infective treatment.
LEUKEMIA & LYMPHOMA
(2022)
Article
Virology
Zhidong Hu, Jian-Ping Chen, Jin-Chuan Xu, Zhen-Yan Chen, Rong Qu, Ling Zhang, Wenrong Yao, Juan Wu, Heng Yang, Douglas B. Lowrie, Yong Liu, Xiao-Yong Fan
Summary: This study investigated the adjuvant effect of AS01 in a COVID-19 vaccine. The results showed that the adjuvanted vaccine induced strong antibody responses, and two doses of the vaccine were as effective as three doses.
Article
Oncology
Juan Wu, Heng Yang, Jin-chuan Xu, Zhidong Hu, Wen-fei Gu, Zhen-yan Chen, Jing-xian Xia, Douglas B. Lowrie, Shui-Hua Lu, Xiao-Yong Fan
Summary: The study demonstrated that Rv3628 could effectively enhance DC activation and antigen presentation, leading to improved anti-tumor immune responses in cancer patients.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Psychology, Multidisciplinary
Sanjay Rao, Tarek Benzouak, Sasha Gunpat, Rachel J. Burns, Tayyeb A. Tahir, Stephen Jolles, Steve Kisely
Summary: This study systematically evaluated the prevalence of fatigue after recovery from COVID-19. The results showed that post-COVID-19 patients reported higher levels of fatigue compared to healthy controls. Over 50% of inpatients and 10% of community patients reported fatigue during the first month post-recovery. Female patients had a higher self-report of fatigue, and patients recruited through social media had the highest levels of fatigue.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Stuart J. Moat, Sharon Hillier, Sikha de Souza, Malorie Perry, Simon Cottrell, Alex Lench, Heather Payne, Stephen Jolles
Summary: SARS-CoV-2 vaccine uptake in pregnant women is low and lags behind the general population, leading to increased hospital admissions and poor maternal and fetal outcomes. Our study demonstrates the importance of analyzing newborn screening samples to monitor the serostatus of pregnant women and assess the impact of interventions.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Immunology
Lucy Jefferson, Athimalaipet Vaidyanathan Ramanan, Stephen Jolles, Jolanta Bernatoniene, Anne-Laure Mathieu, Alexandre Belot, Marion Ruth Roderick
Summary: This article reviews the current data on the pathophysiology, clinical presentation, investigation and management of PKC delta deficiency. Twenty cases have been described in the literature with significant heterogeneity.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
