Dose reduction of antiretrovirals: a feasible and testable approach to expand HIV treatment in developing countries

Why should we still care about the stavudine dose?

(2017) Steve Innes et al.   SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE

A reduced dose of darunavir/ritonavir is effective in PI-experienced HIV-infected patients

(2012) Massimiliano Lanzafame et al.   Brazilian Journal of Infectious Diseases

Efavirenz dose reduction in HIV-infected patients

(2012) M Lanzafame et al.   HIV MEDICINE

Magnitude of Virologic Blips Is Associated With a Higher Risk for Virologic Rebound in HIV-Infected Individuals: A Recurrent Events Analysis

(2012) J. Troy Grennan et al.   JOURNAL OF INFECTIOUS DISEASES

Week 48 analysis of once-daily vs. twice-daily darunavir/ritonavir in treatment-experienced HIV-1-infected patients

(2011) Pedro Cahn et al.   AIDS

Efficacy of Lopinavir-Ritonavir Reduced Dose in HIV-Infected Patients

(2011) Emanuela Lattuada et al.   AIDS PATIENT CARE AND STDS

Neither Branded Nor Generic Lopinavir/Ritonavir Produces Adequate Lopinavir Concentrations at a Reduced Dose of 200/50 mg Twice Daily

(2011) Reshmie A. Ramautarsing et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

96 week results from the MONET trial: a randomized comparison of darunavir/ritonavir with versus without nucleoside analogues, for patients with HIV RNA

(2011) N. Clumeck et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Estimated HIV Incidence in the United States, 2006–2009

(2011) Joseph Prejean et al.   PLoS One

How much ritonavir is needed to boost protease inhibitors? Systematic review of 17 dose-ranging pharmacokinetic trials

(2009) Andrew Hill et al.   AIDS

Pharmacokinetics, Efficacy, and Safety of Darunavir/Ritonavir 800/100 mg Once-Daily in Treatment-Naïve and -Experienced Patients

(2009) Marta Boffito et al.   HIV CLINICAL TRIALS

Effect of Reducing the Dose of Stavudine on Body Composition, Bone Density, and Markers of Mitochondrial Toxicity in HIV‐Infected Subjects: A Randomized, Controlled Study

(2008) G. A. McComsey et al.   CLINICAL INFECTIOUS DISEASES

A Low Dose of Ritonavir-Boosted Atazanavir Provides Adequate Pharmacokinetic Parameters in HIV-1-Infected Thai Adults

(2008) A Avihingsanon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Improvement of atazanavir-induced hyperbilirubinaemia following TDM-guided atazanavir dose reduction

(2008) M Giola et al.   Journal of the International AIDS Society