Journal
TROPICAL MEDICINE & INTERNATIONAL HEALTH
Volume 14, Issue 5, Pages 529-534Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-3156.2009.02263.x
Keywords
Trypanosoma brucei gambiense; human African trypanosomiasis; CXCL-13; BCA-1; neurological stage; meningo-encephalitis; Angola
Funding
- Conseil REgional du Limousin (France)
- UniversitE de Limoges (France)
- Ministere Francais des Affaires Etrangeres [FSP 1997 000 100]
- Centre International de Recherches MEdicales de Franceville
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To determine the role of the B-cell attracting chemokine CXCL-13, which may initiate B-cell trafficking and IgM production in diagnosing HAT meningo-encephalitis. We determined CXCL-13 levels by ELISA on paired sera and CSF of 26 patients from Angola and of 16 controls (six endemic and ten non-endemic). Results were compared to standard stage determination markers and IgM intrathecal synthesis. CXCL-13 levels in patients' sera had a median value of 386.6 pg/ml and increased levels were associated with presence of trypanosomes in the CSF but not with other stage markers. CXCL-13 levels in patients' CSF had a median value of 80.9 pg/ml and increased levels were associated with all standard stage determination markers and IgM intrathecal synthesis. CXCL-13 levels in CSF increased significantly during the course of HAT. Hence the value of CXCL-13 for diagnosis, follow-up or as a marker of disease severity should be tested in a well-defined cohort study.
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