Article
Pharmacology & Pharmacy
Michael M. Farag, Mina M. Louis, Alia A. Badawy, Demiana I. Nessem, Nevine S. Abd Elmalak
Summary: This study aimed to prepare superporous hydrogel hybrid systems of drotaverine hydrochloride (DSHH systems) to extend its residence time in the stomach and achieve sustained release. The FH8 formula showed the highest incorporation efficiency, good swelling ratio, optimal viscoelastic properties, and sustained release profile. A bioequivalence study revealed increased bioavailability and delayed Tmax compared to the marketed product. These results suggest that the DSHH systems could be a potential gastroretentive approach for drugs with short residence time.
Article
Polymer Science
Janarthanan Pushpamalar, Puviarasi Meganathan, Hui Li Tan, Nuraina Anisa Dahlan, Li-Ting Ooi, Bibi Noorheen Haleema Mooneerah Neerooa, Raahilah Zahir Essa, Kamyar Shameli, Sin-Yeang Teow
Summary: Delivering drugs to target sites with minimal off-target cytotoxicity is crucial for successful disease therapy. Polysaccharides have high biocompatibility and are extensively studied as biomaterials for drug delivery systems. By crosslinking polysaccharides with various molecules to form hydrogel DDS, the physical and chemical properties of carrier drugs can be improved, leading to enhanced functionalities in nanotechnology.
Article
Polymer Science
Ghasem Rezanejade Bardajee, Seyed Ata Boraghi, Hossein Mahmoodian, Zahir Rezanejad, Kobra Parhizkari, Hamideh Elmizadeh
Summary: Hydrogels have great potential as drug delivery materials, and this study synthesized a superporous biological macromolecule hydrogel using N,N-dimethyl aminoethyl methacrylate grafted onto salep polysaccharide. The swelling behavior of the hydrogel was tested under different conditions, and various methods were used to analyze its structure. The hydrogel was successfully used as a drug delivery system, and its release behavior was investigated.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yu-Kai Liang, Wen-Ting Cheng, Ling-Chun Chen, Ming-Thau Sheu, Hong-Liang Lin
Summary: This study developed sfGRDDS tablets based on SGL and HPMC to extend the exposure of ciprofloxacin (CIP) in the body and optimize antibiotic treatment. The results showed that the SGL-HPMC-based sfGRDDS could swell and float in the stomach, preventing gastric emptying. The CIP-loaded SGL-HPMC sfGRDDS demonstrated a specific biphasic release effect and improved pharmacokinetic characteristics compared to HPMC-based sfGRDDS. The combination of SGL and HPMC in sfGRDDS is a promising antibiotic delivery system that achieves therapeutic concentration and maintains plasma concentration for an extended period of time.
Article
Pharmacology & Pharmacy
Dingding Wang, Weibo Wang, Ping Wang, Chuang Wang, Juntao Niu, Yang Liu, Yuzhou Chen
Summary: This paper summarizes the physiological factors of colonic drug delivery, the pathological characteristics of common colonic diseases, and the latest advances in the design, preparation, and characterization of natural polysaccharide hydrogels. It is expected to provide new references for colon-targeted oral hydrogel systems using natural polysaccharides as raw materials.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ousanee Issarachot, Suputra Bunlung, Kanidta Kaewkroek, Ruedeekorn Wiwattanapatapee
Summary: Resveratrol-loaded superporous hydrogels (SPHs) based on chitosan/PVA blends were developed to increase solubility and achieve sustained drug release in the stomach. These SPHs showed good floating properties and efficient drug release for up to 12 hours. The Res_SD-loaded SPHs exhibited slightly less cytotoxic effect and similar anti-inflammatory activity compared to pure resveratrol.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Worrawee Siripruekpong, Ousanee Issarachot, Kanidta Kaewkroek, Ruedeekorn Wiwattanapatapee
Summary: Curcumin, a polyphenolic extract from turmeric, has antioxidant, anti-inflammatory, and anticancer activities, but its therapeutic usefulness is limited by low solubility and short gastric residence time. In this study, curcumin-loaded solid dispersion was prepared, significantly increasing solubility. Expandable films incorporating curcumin were then prepared, showing sustained release of the drug. These films exhibited cytotoxic and anti-inflammatory effects, indicating their potential as gastroretentive dosage forms for gastric diseases.
Article
Chemistry, Multidisciplinary
Puxin Weng, Kun Liu, Meng Yuan, Guo-Quan Huang, Kun Wu, Xiaofan Yang, Honglian Dai, Weigang Lu, Dan Li
Summary: This article reports a simple and general method to prepare ZIF-91 porous liquid (ZIF-91-PL), which has permanent porosity, good fluidity, and fine dispersion, and has potential applications in drug delivery.
Article
Biophysics
Yin Xiao, Yuhong Gu, Li Qin, Lin Chen, Xiaoliang Chen, Weiheng Cui, Fuling Li, Ni Xiang, Xiaoai He
Summary: Injectable thermosensitive hydrogel is an attractive drug delivery system that has become increasingly important in cancer therapy due to its ability to provide high local drug concentration, sustained release, minimal invasiveness, and low systemic toxicities. This review highlights its extensive application in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo-/immuno- combined therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Materials Science, Paper & Wood
Lan Guo, Yali Guan, Peng Liu, Linghuan Gao, Zhifu Wang, Shengli Huang, Liang Peng, Zhiyu Zhao
Summary: Extracellular vesicles, such as exosomes and microvesicles, have been found to play a role in regenerative medicine. However, their therapeutic potential is limited by rapid clearance after injection. Chitosan-based hydrogels have been developed as delivery platforms to address this challenge.
Review
Polymer Science
Bahareh Farasati Far, Mohammad Reza Naimi-Jamal, Maryam Safaei, Kimia Zarei, Marzieh Moradi, Hamed Yazdani Nezhad
Summary: Natural polymer-based hydrogels have shown great potential and applications in drug delivery systems. Polysaccharides can cross-link with other molecules to form hydrogels, enabling targeted drug delivery. Hydrogels, as adjustable biomedical devices, have wide applications in the field of pharmaceuticals and biomedical engineering.
Review
Biochemistry & Molecular Biology
Ping He, Lei Dai, Jiasheng Wei, Xulong Zhu, Jianhui Li, Zhirong Chen, Yonghao Ni
Summary: This article comprehensively summarizes the recent research progress on nanocellulose hydrogels as drug carriers. The study evaluates the influence of nanocellulose on hydrogel properties and drug release behaviors, and highlights the application of nanocellulose hydrogel-based drug carriers in specific routes of administration. It provides a critical review and outlook in the field, aiming to inspire future work on the practical applications of nanocellulose hydrogels in designing controlled drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Ana F. Bettencourt, Joana Costa, Isabel A. C. Ribeiro, Lidia Goncalves, Maria Teresa Arias-Moliz, Juliana R. Dias, Margarida Franco, Nuno M. Alves, Jaime Portugal, Cristina B. Neves
Summary: The high recurrence rate of common denture stomatitis after antifungal treatment is still a concern. Impregnating denture materials with antimicrobials for local delivery is a strategy to improve treatment efficacy. In this study, three hard autopolymerizing reline acrylic resins loaded with different percentages of chlorhexidine (CHX) were developed and characterized. Probase Cold loaded with 5 wt% CHX showed the most promising results in terms of antimicrobial activity and lack of serious detrimental properties.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Lorenzo Marsili, Michele Dal Bo, Federico Berti, Giuseppe Toffoli
Summary: Chitosan is a natural polysaccharide with biocompatible properties, and has been combined with thermoresponsive polymers for drug delivery applications. This combination offers potential in biomedical applications due to the biodegradability and temperature responsiveness of the polymers.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
