Article
Pharmacology & Pharmacy
Feuangthit N. Sorasitthiyanukarn, Chawanphat Muangnoi, Clinton B. Gomez, Apichart Suksamrarn, Pranee Rojsitthisak, Pornchai Rojsitthisak
Summary: Hexahydrocurcumin-encapsulated chitosan nanoparticles (HHC-CS-NPs) were formulated and optimized using emulsification and gelation techniques. The optimized HHC-CS-NPs exhibited a spherical shape, narrow size distribution, and molecular dispersion of the drugs. They showed sustained release, stability under various conditions, and significantly improved biological activities compared to the HHC solution. In vitro studies demonstrated enhanced antioxidant, anti-inflammatory, and cytotoxic effects, as well as up-regulation of apoptotic protein expression. These findings suggest that the optimized HHC-CS-NPs have potential as an efficient oral treatment for breast cancer.
Article
Polymer Science
Md Ali Mujtaba, Nawaf M. Alotaibi, Sultan M. Alshehri, Mohammad Yusuf, Md Khalid Anwer, Mohammad Akhlaquer Rahman, Arshiya Parveen
Summary: This study successfully optimized and formulated APG-loaded PEGylated chitosan nanoparticles through ionic gelation techniques using the Box-Behnken design. The optimized formulation showed desirable physical properties and significant anticancer potential. The study highlighted the efficacy of the Box-Behnken design in optimizing nanoparticle formulation and recognizing the impacts of formulation variables.
Article
Biochemistry & Molecular Biology
Seyed Davoud Ashrafi, Gholam Hossein Safari, Kiomars Sharafi, Hossein Kamani, Jalil Jaafari
Summary: This study synthesized CA/MWCNTs and studied its efficiency in adsorbing 4-NP, finding that MWCNTs can increase the adsorption capacity and that the synthesized adsorbent can be reused multiple times without significant reduction in efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Chemical
Thi Yen Chau Nguyen, Lan-Huong Tran, Kristin K. Mueller, Lucie Coudert, Guy Mercier, Jean-Francois Blais
Summary: A process was developed to produce a fluorite concentrate from a rare earth element (REE) bearing carbonatite, involving flotation, magnetic separation, and hydrochloric acid leaching. After magnetic separation and HCl leaching, the fluorite content in the sample significantly increased, with a high recovery rate achieved.
MINERALS ENGINEERING
(2021)
Article
Polymer Science
Touseef Nawaz, Muhammad Iqbal, Barkat Ali Khan, Asif Nawaz, Talib Hussain, Khaled M. Hosny, Walaa A. Abualsunun, Waleed Y. Rizg
Summary: Nanoparticles loaded with acriflavine were successfully prepared and optimized using a Box-Behnken design. The optimized nanoparticles exhibited good stability and drug encapsulation efficiency, showing potential for the treatment of burn wounds.
Article
Chemistry, Multidisciplinary
Kei Futagawa, Taichi Morioka, Kazuo Furihata, Hiroyuki Watanabe, Yutaka Ito, Teppei Ikeya, Akiko Hokura, Koji Nagata, Michio Suzuki
Summary: Shellfish and crustaceans use calcium carbonate (CaCO3) as a protective shell and exoskeleton. In this study, the interaction between the low-complexity region and CaCO3 was analyzed to elucidate the microstructure formation mechanism. The results showed that the Pif 80 acidic region binds the aragonite crystal surface via Asp side chains with basic residues, providing new insights into the function of acidic and basic amino acids in biomineral formation.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Analytical
Maria Sokol, Ivan Gulyaev, Mariia Mollaeva, Sergey Kuznetsov, Vladimir Zenin, Maksim Klimenko, Nikita Yabbarov, Margarita Chirkina, Elena Nikolskaya
Summary: The combinatorial administration of vorinostat and genotoxic agents enhances their antitumoral action against tumors. To support this, a high-performance liquid chromatography method was developed for the simultaneous determination of doxorubicin and vorinostat in polymeric nanoparticles. The method was precise and accurate, and could be adopted for routine analysis of the drugs in nanoparticles.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Food Science & Technology
Yuan Ma, Ping Liu, Kunyue Ye, Yezheng He, Siqi Chen, Anqi Yuan, Fang Chen, Wanli Yang
Summary: Encapsulation of oregano essential oil in chitosan nanoparticles improves its environmental sensitivity and water solubility. The optimized OEO-CSNPs exhibited desirable physical and chemical properties and antibacterial activity.
Article
Polymer Science
Anroop B. Nair, Mallikarjun Telsang, Riyaz Ali Osmani
Summary: This study investigated Gemcitabine magnetic nanoparticles prepared using Fe3O4 and chitosan, and successfully achieved the prerequisites of the target formulation through optimization. In vitro cytotoxicity studies demonstrated the potential of these magnetic nanoparticles in treating breast cancers.
Article
Nanoscience & Nanotechnology
Ping Zhao, Yuhui Liu, Bing Liu, Heng Yang, Yingying Cao, Xinguo Zhang, Wenguang Fan, Zhenji Tian
Summary: In this study, nano-attapulgite/CaCO3 carriers were developed using various raw materials, and the optimal ratio was determined. The results demonstrated that the carrier has a high deodorization effect on sulfur compounds.
Article
Thermodynamics
S. Hatte, R. Stoddard, R. Pitchumani
Summary: This study systematically analyzes the dynamic flow fouling of calcium carbonate and calcium sulfate on smooth, superhydrophobic, and liquid-infused surfaces. The fouling characteristics are examined through microstructural analysis and quantified using fouling resistance and threshold time. The study presents closed-form analytical relationships for fouling resistance and threshold time based on the Reynolds number, fouling agent concentration, and infused liquid viscosity. The results accurately predict the fouling characteristics and provide contour maps for optimal surface designs to minimize fouling resistance.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Article
Food Science & Technology
Israel Emiezi Agarry, Zhirong Wang, Tian Cai, Jianquan Kan, Kewei Chen
Summary: Soy protein isolate (SPI) and chitosan were used as carriers to encapsulate chlorophyll. The optimized encapsulation process resulted in chlorophyll-loaded nanoparticles with acceptable properties, such as green color, high encapsulation efficiency, and good dispersibility. The study also confirmed significant interaction between chlorophyll molecules and carriers, and demonstrated the stability of chlorophyll in the nanoparticles under specific conditions.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Pharmacology & Pharmacy
Mohammed H. Elkomy, Shahira F. El Menshawe, Rasha M. Kharshoum, Amany M. Abdeltwab, Raghda R. S. Hussein, Doaa S. Hamad, Izzeddin Alsalahat, Heba M. Aboud
Summary: This study developed a novel nanovesicular paradigm called novasomes (NVS) to deliver terbutaline sulfate (TBN) directly to the lungs. The optimized TBN-NVS formulation showed sustained drug release, good lung deposition, and enhanced bioavailability compared to oral TBN solution.
Article
Biochemistry & Molecular Biology
Bryan Paul Bulatao, Nonthaneth Nalinratana, Pongsakorn Jantaratana, Opa Vajragupta, Pranee Rojsitthisak, Pornchai Rojsitthisak
Summary: Magnetic drug targeting using superparamagnetic iron oxide nanoparticles can enhance the cytotoxicity of lutein in breast cancer cells. The optimized LUT-CS/Alg-Fe3O4-NPs showed controlled size, narrow distribution, better crystallinity, and sustained-release profile. With the exposure to a permanent magnet, the optimized LUT-CS/Alg-Fe3O4-NPs demonstrated significantly enhanced cytotoxicity and potential as magnetically targeted delivery for breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Multidisciplinary
Augustine Agi, Radzuan Junin, Mohd Zaidi Jaafar, Nor Aishah Saidina Amin, Mohd Akhmal Sidek, Faruk Yakasai, Azrul Nurfaiz Mohd Faizal, Afeez Gbadamosi, Jeffrey Oseh
Summary: Mesoporous silica nanoparticles (MSNP) were used to trap reservoir fines and the adsorption capacity was optimized. The effects of concentration, time, salinity, and pH on adsorption capacity of reservoir fines were modeled using Box-Behnken design. The study determined the best mathematical models to describe the adsorption process of reservoir fines and demonstrated the strong potential of MSNP in fixing and reusing reservoir fines.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Arefeh Baygan, Mohammad Reza Afshar Mogaddam, Farzaneh Lotfipour, Mahboob Nemati
Summary: This study assessed the contamination of heavy metals in salt samples from Lake Urmia. Analysis showed that two samples had heavy metal concentrations exceeding the recommended levels. Continuous monitoring of heavy metal levels in Lake Urmia salt samples is highly recommended.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Mohammad Reza Afshar Mogaddam, Mahboob Nemati, Mir Ali Farajzadeh, Farzaneh Lotfipour, Ali Akbar Alizadeh Nabil, Ali Mohebbi, Houshang Ghorbanpour
Summary: An efficient sample preparation method has been developed for the simultaneous analysis of multiple pesticide residues in eggs. The method has low limits of detection, good linearity, and satisfactory repeatability, making it suitable for pesticide residue analysis in egg samples.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
A. Farjami, M. S. Hatami, M. R. Siahi-Shadbad, F. Lotfipour
Summary: This study investigated the antibiofilm activity of peracetic acid against Escherichia coli biofilm at different concentrations and temperatures. The results confirmed the effective concentration and optimal conditions for biofilm eradication.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fahimeh Kazeminava, Siamak Javanbakht, Mohammad Nouri, Khosro Adibkia, Khudaverdi Ganbarov, Mehdi Yousefi, Majid Ahmadi, Pourya Gholizadeh, Hossein Samadi Kafil
Summary: In this study, citric acid-based quantum dots were used as a crosslinked agent to synthesize carboxymethyl cellulose/polyvinyl alcohol nanofibers. The resulting nanofibers demonstrated good cytocompatibility and antibacterial efficacy, making them potential wound healing scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Solmaz Zakhireh, Yadollah Omidi, Younes Beygi-Khosrowshahi, Abolfazl Barzegari, Jaleh Barar, Khosro Adibkia
Summary: The incorporation of Fe(3)O(4) nanoparticles into Pistacia vera L. pollen shell (PSh) could effectively increase the anticancer effects on MG-63 bone cancer cells.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Fatemeh Mehdizadeh, Mohammad Barzegar-Jalali, Ebrahim Izadi, Karim Osouli-Bostanabad, Seraj Mohaghegh, Mohammad Sadegh Shakeri, Hossein Nazemiyeh, Yadollah Omidi, Khosro Adibkia
Summary: This study compares the effect of using Lycium ruthenicum for green synthesis and wet chemical extraction using citrate reduction to synthesize stable gold nanoparticles. The pH value was found to be influential in the synthesis process. The results indicate that Lycium ruthenicum extract can be considered a simple, facile, and green technique for synthesizing stimuli-sensitive gold nanoparticles.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Seraj Mohaghegh, Ali Tarighatnia, Yadollah Omidi, Jaleh Barar, Ayuob Aghanejad, Khosro Adibkia
Summary: The study developed magnetic nanoparticles (MNPs) as targeted drug delivery and non-invasive MRI contrast agents in ovarian cancer cells, showing synergistic therapeutic effects. The size, morphology, functional groups, and magnetic properties of the nanoparticles were characterized. The cellular uptake of the nanoparticles with MUC16 overexpression and the signal intensity changes in tumor sites were evaluated using MR images and flow cytometry. The findings suggest the potential of the nanoparticles as an image-guided co-drug delivery system for ovarian cancer.
JOURNAL OF MICROENCAPSULATION
(2022)
Review
Medicine, Research & Experimental
Ramin Eskandani, Mohammad Kazempour, Raheleh Farahzadi, Zohreh Sanaat, Morteza Eskandani, Khosro Adibkia, Somayeh Vandghanooni, Ahad Mokhtarzadeh
Summary: NF-kappa B is a critical regulator of the immune response, inflammation, cell growth, and survival, but its dysregulation is associated with inflammation-related diseases and cancers. Inhibiting the NF-kappa B pathway could be a promising target for cancer therapy. Nanocarrier systems can improve treatment effectiveness and reduce off-target toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Parsa Soleymanijadidi, Meysam Moradi, Fahimeh Hamedirad, Zahra Ghanavati, Solmaz Maleki Dizaj, Sara Salatin
Summary: The study assessed the release pattern, antimicrobial action, and flexural strength of self-cured acrylic resins with added curcumin nanoparticles. The results showed a two-step release pattern for the nanocurcumin and an increase in antimicrobial activity against Streptococcus mutans. However, the flexural strength decreased with increasing weight percentage of curcumin nanoparticles. Despite this decrease, all strength values were higher than the standard. The study suggests that using self-cured resins containing curcumin nanoparticles can be beneficial for antimicrobial purposes in orthodontic removable applications.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Armin Mahmoudi, Mohammad Ali Ghavimi, Solmaz Maleki Dizaj, Simin Sharifi, Seyyede Shabnam Sajjadi, Amir Reza Jamei Khosroshahi
Summary: This study aimed to evaluate a novel gelatin-based biodegradable sponge's abilities in controlling bleeding, pain, and dry socket after mandibular posterior teeth extraction compared to a commercial sponge. In a randomized, double-blind, split-mouth clinical trial, 26 patients underwent tooth extraction with the test group using the prepared gelatin sponge and the control group using the commercial sponge. Results showed that the test group had better bleeding control, reduced bleeding within 1 hour, 1-4 hours, and after 4 hours post-operatively, decreased pain over time, and a lower occurrence of dry socket compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Mehdizadeh, Ramin Mohammadzadeh, Hossein Nazemiyeh, Mehran Mesgari-Abbasi, Mohammad Barzegar-Jalali, Morteza Eskandani, Khosro Adibkia
Summary: The aim of this study was to prepare electrosprayed nanoparticles (EP-Eudragit RS100 NPs) containing Echinacea purpurea extract to enhance its immunomodulatory effects. The results showed that EP-Eudragit RS100 NPs significantly increased the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-13 (IL1-13), as well as the white blood cell count (WBCs).
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
Article
Medicine, General & Internal
Solmaz Maleki Dizaj, Ali Torab, Shadi Kouhkani, Simin Sharifi, Ramin Negahdari, Sepideh Bohlouli, Shirin Fattahi, Sara Salatin
Summary: This study aimed to evaluate the stability of gelatin-curcumin nanocomposite coating on healing abutments. The nanocomposite showed a relatively rapid release pattern of curcumin in the first 10 days, followed by a slow release until the 30th day. The weight changes of the coated healing abutments were statistically significant during this time. The results indicated successful coating with gelatin-curcumin nanocomposite and the consistency of the coating lasted for at least one month. Further evaluations in different aspects are necessary.
CLINICS AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Sara Salatin, Mehdi Farhoudi, Afsaneh Farjami, Solmaz Maleki Dizaj, Simin Sharifi, Shahriar Shahi
Summary: Stroke is a leading cause of morbidity and mortality worldwide, but effective treatment options are lacking. Reactive oxygen species (ROS) have been identified as a major factor in brain injury after ischemic stroke. Antioxidant therapy appears to be effective in managing oxidative stress related to inflammatory disorders like stroke, but traditional antioxidants are limited in their distribution and localization in the body. However, recent breakthroughs in the use of antioxidant nanoparticles (NPs) have shown promise in stroke treatment by efficiently delivering antioxidants to the damaged areas of the brain.
Article
Biochemistry & Molecular Biology
Mina Yekani, Robab Azargun, Simin Sharifi, Javid Sadri Nahand, Alka Hasani, Hadi Ghanbari, Zahra Sadat Seyyedi, Mohammad Yousef Memar, Solmaz Maleki Dizaj
Summary: Mesoporous silica nanoparticles (MSNPs) loaded with vancomycin and meropenem (Van/Mrp-MSNPs) demonstrated effective antimicrobial properties, favorable biocompatibility, and low cytotoxicity, making them a potential system for the treatment of infections.
Article
Medicine, General & Internal
Solmaz Maleki Dizaj, Hojjat Shokrgozar, Javad Yazdani, Mohammad Yousef Memar, Simin Sharifi, Mohammad Ali Ghavimi
Summary: This study found that Porphyromonas gingivalis is one of the main causes of infection and failure in dental implants. The research also demonstrated the strong antimicrobial effects of curcumin nanocrystals against isolated P. gingivalis. Therefore, the use of curcumin nanoparticles can help control bacterial infection around dental implants.
CLINICS AND PRACTICE
(2022)
