Review
Biochemistry & Molecular Biology
Galateia Liouta, Maria Adamaki, Antonis Tsintarakis, Panagiotis Zoumpourlis, Anastasia Liouta, Sofia Agelaki, Vassilis Zoumpourlis
Summary: Head and neck squamous cell carcinoma (HNSCC) is a term used to describe cancers in the head and neck region. Most cases are diagnosed at a late stage and have poor prognosis. DNA methylation has been identified as a potential biomarker for HNSCC, and this study summarizes the current knowledge on how abnormally methylated DNA profiles may contribute to the development and progression of HNSCC, with the aim of improving management and survival outcomes for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Nana Wang, Abiyasi Nanding, Xiaocan Jia, Yuping Wang, Chaojun Yang, Jingwen Fan, Ani Dong, Guowei Zheng, Jiaxin Ma, Xuezhong Shi, Yongli Yang
Summary: This study comprehensively assessed the tumor immune microenvironment (TIME) of cervical cancer (CC) and constructed an ICSs prognostic model, which provides an effective tool for predicting patient's prognosis and accurate immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luca Tonella, Valentina Pala, Renata Ponti, Marco Rubatto, Giuseppe Gallo, Luca Mastorino, Gianluca Avallone, Martina Merli, Andrea Agostini, Paolo Fava, Luca Bertero, Rebecca Senetta, Simona Osella-Abate, Simone Ribero, Maria Teresa Fierro, Pietro Quaglino
Summary: Melanoma is an aggressive skin cancer with varying survival rates for stage III patients. While target and immune therapies have improved overall survival, identifying high-risk patients for relapse and determining the best treatment choice are still crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lucile Pabst, Sebastien Lopes, Basil Bertrand, Quentin Creusot, Maria Kotovskaya, Erwan Pencreach, Michele Beau-Faller, Celine Mascaux
Summary: The therapeutic algorithm for lung cancer has been revolutionized by immune checkpoint inhibitors, but the response rate and adverse events remain a challenge. Predictive and prognostic biomarkers are needed to select patients who will respond to treatment. Currently, PD-L1 expression is the only validated biomarker, but its predictive value is imperfect. New molecular features, such as tumor mutational burden, have shown promise in predicting response to immunotherapy. This review summarizes the latest knowledge on predictive and prognostic biomarkers to advance precision immuno-oncology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chiara Rossi, Sara Fraticelli, Marianna Fanizza, Alberta Ferrari, Elisa Ferraris, Alessia Messina, Angelica Della Valle, Chiara Annunziata Pasqualina Anghelone, Angioletta Lasagna, Gianpiero Rizzo, Lorenzo Perrone, Maria Grazia Sommaruga, Giulia Meloni, Silvia Dallavalle, Elisabetta Bonzano, Marco Paulli, Giuseppe Di Giulio, Adele Sgarella, Marco Lucioni
Summary: Accurate evaluation of breast cancer on bioptic samples is crucial for guiding therapeutic decisions. This study assessed the concordance of hormone receptors and Ki-67 between biopsy and surgical specimens. The results suggest suboptimal concordance for ER-low-positive, c-erbB2/HER2, and Ki-67, indicating the need for further training in this area.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Richard S. P. Huang, James Haberberger, Lukas Harries, Eric Severson, Daniel L. Duncan, N. Lynn Ferguson, Amanda Hemmerich, Claire Edgerly, Karthikeyan Murugesan, Jinpeng Xiao, Deborah McEwan, Oliver Holmes, Matthew Hiemenz, Jeffrey Venstrom, Julia A. Elvin, James Creeden, Douglas I. Lin, Jeffrey S. Ross, Shakti H. Ramkissoon
Summary: This study found genomic differences between PD-L1(positive) and PD-L1(negative) urothelial carcinomas, providing a framework for future clinical investigation. Additionally, differences in PD-L1 positivity based on sample collection sites were observed, which could influence sample selection for PD-L1 testing in patients with urothelial carcinoma.
Review
Biochemistry & Molecular Biology
Maria A. Dominguez-Cejudo, Ana Gil-Torralvo, Monica Cejuela, Sonia Molina-Pinelo, Javier Salvador Bofill
Summary: Breast cancer prognosis and treatment outcomes depend on tumor microenvironment (TME), which plays a critical role in its development, progression, and treatment response. This review examines the different components of TME as prognostic and predictive biomarkers in breast cancer. Techniques for assessing TME, such as immunohistochemistry or gene expression profiling, and their clinical utility in therapeutic decision-making are also discussed. Lastly, therapeutic strategies targeting TME are reviewed, highlighting their potential clinical benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Navid Sobhani, Richard Chahwan, Raheleh Roudi, Rachel Morris, Stefano Volinia, Dafei Chai, Alberto D'Angelo, Daniele Generali
Summary: Non-coding RNA plays a crucial role in breast cancer and has predictive and prognostic value. It can be used as biomarkers and therapies. This class of RNA molecules includes both oncogenic and tumor suppressive molecules.
Review
Biochemistry & Molecular Biology
Francesca Sanguedolce, Magda Zanelli, Andrea Palicelli, Alessandra Bisagni, Maurizio Zizzo, Stefano Ascani, Maria Carmela Pedicillo, Angelo Cormio, Ugo Giovanni Falagario, Giuseppe Carrieri, Luigi Cormio
Summary: Bladder cancer is a heterogeneous disease with molecular, morphological, and clinical variations. HER2 is an oncogene involved in the development of bladder cancer. Assessing HER2 overexpression through immunohistochemistry can be useful in correctly identifying different types of bladder lesions, providing prognostic information, and improving BC molecular subtyping. Additionally, HER2 has potential as a therapeutic target in the development of novel target therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Min Qin, Zhihai Liang, Heping Qin, Yifang Huo, Qing Wu, Huiying Yang, Guodu Tang
Summary: Through bioinformatics analysis, CGB5, MKNK2, and PAPPA2 were identified as potential novel prognostic biomarkers for gastric cancer. The prognostic model revealed significantly lower survival rates in the high-risk group compared to the low-risk group. Immune cell component analysis demonstrated differential associations between these three genes and corresponding immune cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Maurizio Capuozzo, Francesco Ferrara, Mariachiara Santorsola, Andrea Zovi, Alessandro Ottaiano
Summary: This article reviews the role of circulating tumor cells (CTCs) in solid tumors, highlighting their importance in predicting clinical outcomes and guiding prognosis. The article also discusses the recent advancements and challenges in CTC detection methods, as well as the significance of integrating CTC-based liquid biopsies into clinical practice.
Review
Medicine, Research & Experimental
Elaheh Tarighati, Hadi Keivan, Hojjat Mahani
Summary: Breast cancer is a common cancer that affects women worldwide. With advancements in technology and new diagnostic and therapeutic methods, the mortality rate of breast cancer has decreased. Prognostic and predictive biomarkers play a crucial role in determining treatment options for breast cancer patients. Molecular markers such as ER, PR, HER2, and Mib1/Ki-67 are significant in the standard care of primary, recurrent, and metastatic breast cancer patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Oncology
Darragh O'Dowd, Jacintha O'Sullivan, Simone Marcone
Summary: Oesophageal adenocarcinoma (OAC) is a type of cancer with poor patient outcomes. Surveillance programs for its precursor lesion, Barrett's oesophagus (BO), are expensive and unpleasant. Prognostic and diagnostic biomarkers can improve surveillance and early detection, while predictive biomarkers can enhance individualized therapy.
Review
Oncology
Javier Peinado-Serrano, Amancio Carnero
Summary: Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Treatment options include surgery, chemotherapy, molecular targeted therapy, and radiation. The heterogeneity of molecular profiles contributes to variations in patients' overall survival and therapeutic responses. Identifying prognostic and predictive gene signatures can improve therapeutic decision-making and clinical outcomes for NSCLC patients.
Review
Biochemistry & Molecular Biology
Martina Amato, Renato Franco, Gaetano Facchini, Raffaele Addeo, Fortunato Ciardiello, Massimiliano Berretta, Giulia Vita, Alessandro Sgambato, Sandro Pignata, Michele Caraglia, Marina Accardo, Federica Zito Marino
Summary: Microsatellite instability (MSI) is common in cancer and predicts sensitivity to immune checkpoint inhibitors. Different MSI testing methods are used in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Isaac H. Solomon, Jason L. Hornick, Alvaro C. Laga
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2017)
Article
Food Science & Technology
Piret Raudsepp, Dagmar Adeline Brueggemann, Poul Henckel, Mogens Vyberg, Kathy Groves, Niels Oksbjerg, Margrethe Therkildsen
Review
Biochemistry & Molecular Biology
Raluca Elena Sandu, Danut Dumbrava, Roxana Surugiu, Daniela-Gabriela Glavan, Andrei Gresita, Eugen Bogdan Petcu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Engineering, Biomedical
Cedryck Vaquette, P. T. Sudheesh Kumar, Eugen Bogdan Petcu, Saso Ivanovski
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2018)
Article
Oncology
Matthew B. Yurgelun, Matthew H. Kulke, Charles S. Fuchs, Brian A. Allen, Hajime Uno, Jason L. Hornick, Chinedu I. Ukaegbu, Lauren K. Brais, Philip G. McNamara, Robert J. Mayer, Deborah Schrag, Jeffrey A. Meyerhardt, Kimmie Ng, John Kidd, Nanda Singh, Anne-Renee Hartman, Richard J. Wenstrup, Sapna Syngal
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Oncology
Jakob Hofvander, Elsa Arbajian, Karin G. Stenkula, Karin Lindkvist-Petersson, Malin Larsson, Jenny Nilsson, Linda Magnusson, Fredrik Vult von Steyern, Pehr Rissler, Jason L. Hornick, Fredrik Mertens
JOURNAL OF PATHOLOGY
(2017)
Article
Pathology
Inga-Marie Schaefer, Abbas Agaimy, Christopher D. M. Fletcher, Jason L. Hornick
Article
Pathology
Vickie Y. Jo, Nicole G. Chau, Jason L. Hornick, Jeffrey F. Krane, Lynette M. Sholl
Review
Anatomy & Morphology
Carol C. Cheung, Corrado D'Arrigo, Manfred Dietel, Glenn D. Francis, Regan Fulton, C. Blake Gilks, Jacqueline A. Hall, Jason L. Hornick, Merdol Ibrahim, Antonio Marchetti, Keith Miller, J. Han van Krieken, Soren Nielsen, Paul E. Swanson, Clive R. Taylor, Mogens Vyberg, Xiaoge Zhou, Emina E. Torlakovic
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2017)
Review
Anatomy & Morphology
Carol C. Cheung, Corrado D'Arrigo, Manfred Dietel, Glenn D. Francis, C. Blake Gilks, Jacqueline A. Hall, Jason L. Hornick, Merdol Ibrahim, Antonio Marchetti, Keith Miller, J. Han van Krieken, Soren Nielsen, Paul E. Swanson, Clive R. Taylor, Mogens Vyberg, Xiaoge Zhou, Emina E. Torlakovic
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2017)
Review
Anatomy & Morphology
Emina E. Torlakovic, Carol C. Cheung, Corrado D'Arrigo, Manfred Dietel, Glenn D. Francis, C. Blake Gilks, Jacqueline A. Hall, Jason L. Hornick, Merdol Ibrahim, Antonio Marchetti, Keith Miller, J. Han van Krieken, Soren Nielsen, Paul E. Swanson, Mogens Vyberg, Xiaoge Zhou, Clive R. Taylor
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2017)
Article
Public, Environmental & Occupational Health
Helle Lund, Mogens Vyberg, Helle Hojmark Eriksen, Anni Grove, Annette Ostergaard Jensen, Lone Sunde
CLINICAL EPIDEMIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Anne-Marie Wegeberg, Theresa Meldgaard, Amanda Baek, Asbjorn Mohr Drewes, Mogens Vyberg, Niels Jessen, Birgitte Brock, Christina Brock
Summary: Liraglutide treatment leads to weight loss without significant changes in subcutaneous adipose tissue composition, including cell size, distribution of CD163-positive cells, pericellular fibrosis, and serum levels of free fatty acids, CD163, leptin, and adiponectin. The weight loss induced by liraglutide does not correlate with changes in cell size or serum markers.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Art
Eugen Bogdan Petcu
Review
Engineering, Biomedical
Eugen B. Petcu, Rajiv Midha, Erin McColl, Aurel Popa-Wagner, Traian V. Chirila, Paul D. Dalton