Review
Biochemistry & Molecular Biology
Tapio Hellman, Panu Uusalo, Mikko J. Jaervisalo
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, leading to higher mortality risk compared to mere infection. Acute kidney injury (AKI) and renal replacement therapy (RRT) are major concerns in sepsis patients in intensive care units. Various techniques and devices have been explored to reduce inflammatory mediators and improve patient outcomes in septic shock, but the actual benefits remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Mingjing Guan, Hao Wang, Xin Tang, Yuliang Zhao, Fang Wang, Ling Zhang, Ping Fu
Summary: This study aimed to compare the efficacy of adsorbing filter oXiris in the treatment of sepsis/septic shock-associated acute kidney injury (S-AKI). The results showed that the oXiris group had lower early mortality, faster reduction of inflammatory mediators, and played a favorably important role in the prognosis compared to the control group.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Natalja L. Stanski, Rajit K. Basu, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Neal J. Thomas, Torrey Baines, Bereketeab Haileselassie, Scott L. Weiss, Mihir R. Atreya, Andrew J. Lautz, Basilia Zingarelli, Stephen W. Standage, Jennifer Kaplan, Lakhmir S. Chawla, Stuart L. Goldstein
Summary: Prediction of severe acute kidney injury (AKI) is crucial for improving outcomes and treatment in pediatric septic shock. In this study, we evaluated the performance of the modified renal angina index (sRAI) in a separate cohort and found that it had better accuracy and specificity compared to the original RAI and serum creatinine elevation.
Article
Critical Care Medicine
Ari Moskowitz, Katherine M. Berg, Anne V. Grossestreuer, Lakshman Balaji, Xiaowen Liu, Michael N. Cocchi, Maureen Chase, Michelle Ng Gong, Jonathan Gong, Samir M. Parikh, Long Ngo, Noa Berlin, Michael W. Donnino
Summary: Thiamine supplementation does not significantly attenuate kidney injury in patients with septic shock, but it does increase ICU-free days.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Anesthesiology
N. Boyer, K. Horne, N. M. Selby, L. G. Forni
Summary: Kidney disease is common in intensive care units and can greatly impact prescribing and therapeutic management due to the kidneys' role in maintaining whole body homeostasis. This review explores the pathophysiology of acute kidney injury and chronic kidney disease in critically ill patients. It covers various aspects of renal dysfunction management, including kidney replacement therapy, acute kidney injury management, and the use of novel biomarkers for identifying and stratifying patients. Early involvement of nephrology specialists can improve outcomes and provide valuable guidance for patients with end stage kidney disease or already known to nephrology services. Ongoing research questions within this field are also discussed.
Article
Medicine, General & Internal
Tomasz Skalec, Barbara Adamik, Katarzyna Kobylinska, Waldemar Gozdzik
Summary: The study aimed to establish the optimal suPAR cut-off point for predicting KRT use in sepsis patients and to analyze survival rates based on suPAR levels, AKI diagnosis, and the requirement for KRT. The results indicate that suPAR measurements may have important implications in the diagnosis of sepsis patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Samy Hakroush, Desiree Tampe, Peter Korsten, Philipp Stroebel, Michael Zeisberg, Bjorn Tampe
Summary: Renal involvement is a common and severe complication of AAV, with histopathological subgrouping and ARRS being predictive of long-term ESRD. In critically ill AAV patients requiring intensive care treatment, certain histopathological findings can predict the severity of AKI and need for RRT, while global glomerular scarring is a strong predictor of failure to recover from RRT after remission induction therapy. Further prospective studies are needed to explore the implications of these findings for therapeutic decision making in this patient subgroup.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Filippo Mariano, Consuelo De Biase, Zsuzsanna Hollo, Ilaria Deambrosis, Annalisa Davit, Alberto Mella, Daniela Bergamo, Stefano Maffei, Francesca Rumbolo, Alberto Papaleo, Maurizio Stella, Luigi Biancone
Summary: The study found that burn patients treated with CRRT had a long-term expectation of preserved renal function, but were more predisposed to microalbuminuria, diabetes, and the presence of risk factors for intercurrent comorbidities and chronic renal disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Lou'i Al-Husinat, Alameen Alsabbah, Amer Abu Hmaid, Razan Athamneh, Majd Adwan, Mohammad N. N. Hourani, Seif Almakhadmeh, Zaid Jehad Al Modanat, Mohammed I. A. Ismail, Giustino Varrassi
Summary: Sepsis, a severe complication of infection, can lead to life-threatening inflammatory responses. Septic shock, a complication of sepsis, occurs when hemodynamic instability arises. The pathophysiology and hemodynamic mechanisms of acute kidney injury in sepsis or septic shock are not fully understood, but multiple possible mechanisms have been suggested. Norepinephrine is commonly used in septic shock management, but its effects on renal circulation and potential exacerbation of acute kidney injury are still debated. This narrative review provides updates, explanations, and evidence on sepsis and septic shock, aiming to improve clinical understanding of the adverse outcomes of norepinephrine use in sepsis-associated acute kidney injury.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Natalja L. Stanski, Hector R. Wong, Rajit K. Basu, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Michael Quasney, Bereketeab Haileselassie, Lakhmir S. Chawla, Stuart L. Goldstein
Summary: The study found that the Renal Angina Index (RAI) is a sensitive and reliable tool for predicting severe AKI in children with septic shock. According to the results, recalibrating the RAI to include platelet count and setting a higher cutoff may improve the accuracy of prediction.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Critical Care Medicine
Julie Helms, Hamid Merdji, Sebastien Loewert, Francois Severac, Alexandra Monnier, Julian Kaurin, Anais Curtiaud, Ferhat Meziani, Julien Demiselle
Summary: This study analyzed the association between the occurrence, severity, and evolution of AKI in patients with septic shock-induced DIC. The results showed that DIC is strongly associated with the risk of developing the more severe form of AKI (stage 3 of the KDIGO classification, RRT requirement), even after adjusting for other factors.
ANNALS OF INTENSIVE CARE
(2023)
Article
Critical Care Medicine
Stephane Gaudry, Francois Grolleau, Saber Barbar, Laurent Martin-Lefevre, Bertrand Pons, Eric Boulet, Alexandre Boyer, Guillaume Chevrel, Florent Montini, Julien Bohe, Julio Badie, Jean-Philippe Rigaud, Christophe Vinsonneau, Raphael Porcher, Jean-Pierre Quenot, Didier Dreyfuss
Summary: This study reassessed the impact of choosing intermittent hemodialysis (IHD) or continuous renal replacement therapy (CRRT) as the first modality for patients with severe acute kidney injury (AKI), using secondary analysis of two multicenter randomized controlled trials. The results showed that CRRT as the first modality did not appear to provide a survival advantage or better kidney recovery compared to IHD, and may even be associated with a less favorable outcome in patients with lesser severity of disease.
Article
Pediatrics
Avichai Weissbach, Eytan Kaplan, Gili Kadmon, Yulia Gendler, Elhanan Nahum, Barak Meidan, Shirley Friedman, Efraim Sadot, Itay Ayalon
Summary: This retrospective observational study aimed to investigate the prevalence, severity, nature, and significance of acute kidney injury (AKI) among children admitted to the pediatric intensive care unit (PICU) with toxic shock syndrome (TSS). The study included 41 children diagnosed with TSS from 2009-2022 and found that 59% of them had AKI, indicating a complex course of illness.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Critical Care Medicine
Rachel Jeong, Ron Wald, Sean M. Bagshaw
Summary: The optimal timing of renal-replacement therapy (RRT) initiation for acute kidney injury (AKI) patients in the intensive care unit (ICU) is controversial, with conflicting results from previous studies. Early preemptive initiation of RRT may not confer clear clinical benefits, but prolonged delays in RRT initiation could be harmful.
CURRENT OPINION IN CRITICAL CARE
(2021)
Review
Gastroenterology & Hepatology
Constantine J. J. Karvellas, Thierry Gustot, Javier Fernandez
Summary: Acute on chronic liver failure (ACLF) is the development of organ failure(s) in cirrhosis patients and has a high short-term mortality rate. Medical management of ACLF needs to consider the relationship between the underlying chronic liver disease/cirrhosis, precipitating insult, and involved organ systems. Intensive care management of ACLF focuses on promptly recognizing and treating triggering events and providing aggressive support for failing organs to ensure successful liver transplantation or recovery. The complexity of managing ACLF patients arises from their propensity to develop new organ failures and complications like infections or bleeding. A multidisciplinary team with expertise in critical care and transplant medicine is best suited for the management of critically ill ACLF patients. This review aims to identify common complications of ACLF and describe the appropriate management for critically ill patients awaiting liver transplantation, including organ support, prognostic assessment, and determining the likelihood of recovery.
LIVER INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Catherine Cornu, Anne Donche, Carine Coffre, Annelie Le Gouge, Boulkedid Rym, Isabelle Vaugier, Frederic Barbot, Alain Leizorovicz, Nadine Juge, Celine Giraud, Francois Gueyffier, Alexandra Felin, Thibault Mura, Hugues Chevassus, Christine Binquet
Summary: This study presents a French version of the certified data management standards published by ECRIN. These standards provide a clear description of data management and IT requirements for clinical studies, serving as a valuable reference for academic data management structures.
Article
Multidisciplinary Sciences
Florian Perraud, Fiona Ecarnot, Melanie Loiseau, Alexandra Laurent, Alicia Fournier, Florent Lheureux, Christine Binquet, Jean-Philippe Rigaud, Nicolas Meunier-Beillard, Jean-Pierre Quenot
Summary: This study investigated the perceptions and experiences of reinforcement healthcare workers deployed to ICUs during the COVID-19 pandemic. The findings revealed difficulties with integration, lack of training, difficulties with management, and mental distress experienced by these workers. They identified important gaps in organization and preparation, as well as a marked lack of training.
Article
Health Care Sciences & Services
Diane Friedman, Lamiae Grimaldi, Alain Cariou, Philippe Aegerter, Stephane Gaudry, Abdel Ben Salah, Haikel Oueslati, Bruno Megarbane, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Carole Schwebel, Laurent Jacob, Segloene Robin Lagandre, Pierre Kalfon, Romain Sonneville, Shidasp Siami, Aurelien Mazeraud, Tarek Sharshar
Summary: This study aims to compare a multidisciplinary follow-up with a standard follow-up for critically ill patients, and to evaluate the impact on quality of life (QoL) at 1 year. The study found that multidisciplinary follow-up may improve QoL by mitigating the postintensive care syndrome (PICS).
JMIR RESEARCH PROTOCOLS
(2022)
Review
Urology & Nephrology
Isabelle Boucley, Auguste Dargent, Pascal Andreu, Jean-Baptiste Roudaut, Francois Aptel, Marie Labruyere, Marine Jacquier, Amelie Cransac, Jean-Pierre Quenot
Summary: This systematic review examined the effectiveness of different lock solutions for non-tunneled hemodialysis catheters. The results showed that there was no significant difference between the different lock solutions in terms of event-free survival of the catheters. Citrate locks were associated with lower rates of catheter-related infections and adverse events, but the evidence was not consistently significant.
HEMODIALYSIS INTERNATIONAL
(2023)
Article
Hematology
Jean-Christophe Gris, Florence Guillotin, Taissa Pereira dos Santos, Mathias Chea, Paul Loubet, Didier Laureillard, Albert Sotto, Laurent Muller, Saber Davide Barbar, Claire Roger, Jean-Yves Lefrant, Boris Jung, Kada Klouche, Thibault Mura, Isabelle Quere, Antonia Perez-Martin
Summary: In this study, thrombin generation assays were performed on severe COVID-19 patients, and it was found that these assays could not predict the early or late survival rates of the patients, nor were they associated with thrombotic events. However, by detecting the changes in endogenous thrombin potential (ETP), it was possible to predict whether patients would need to be transferred to an intensive care unit in the future.
THROMBOSIS RESEARCH
(2023)
Review
Health Care Sciences & Services
Jean-Philippe Rigaud, Fiona Ecarnot, Jean-Pierre Quenot
Summary: In this paper, the ethical issues surrounding information provision and consent in the intensive care unit are reviewed. The obligations of physicians in treating vulnerable patients are discussed, along with the challenges of providing clear information in critical illness situations. The specificities of intensive care, including the selection of a contact person and the considerations for the family of critically ill patients, are explored. Additionally, the cases of consent to research and patients who refuse care are discussed.
Correction
Health Care Sciences & Services
Diane Friedman, Lamiae Grimaldi, Alain Cariou, Philippe Aegerter, Stephane Gaudry, Abdel Ben Salah, Haikel Oueslati, Bruno Megarbane, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Carole Schwebel, Laurent Jacob, Segloene Robin Lagandre, Pierre Kalfon, Romain Sonneville, Shidasp Siami, Aurelien Mazeraud, Tarek Sharshar
JMIR RESEARCH PROTOCOLS
(2023)
Article
Multidisciplinary Sciences
Lucas Mathey, Marine Jacquier, Nicolas Meunier-Beillard, Pascal Andreu, Jean-Baptiste Roudaut, Marie Labruyere, Jean-Philippe Rigaud, Jean-Pierre Quenot, Fiona Ecarnot
Summary: This study aimed to explore the perceptions of nursing staff in the ICU about non-beneficial stays and identify potential areas for intervention to improve the patient care pathway. The findings showed that nursing staff have similar perspectives to physicians regarding admission decisions and non-beneficial stays in the ICU. It is recommended to anticipate future ICU admissions, systematically discuss them with patients, and collaborate with healthcare professionals to align healthcare goals with patients' wishes and preferences.
Article
Medicine, General & Internal
Pascal Chavanet, Isabelle Fournel, Abderrahmane Bourredjem, Lionel Piroth, Mathieu Blot, Thibault Sixt, Christine Binquet
Summary: This study aims to evaluate the efficacy and safety of adding daptomycin to the recommended treatment for adult patients with confirmed pneumococcal meningitis. The main endpoint is disability-free survival at day 30. Secondary outcomes include overall mortality, disability at day 30 and day 90, hearing loss, and quality of life. The study protocol has been approved and the results will be published in a peer-reviewed journal.
Letter
Respiratory System
Valentin Pineau, Adrien Guilloteau, Christine Binquet, Jean-Pierre Quenot, Belaid Bouhemad, Philippe Bonniaud, Frederic Dalle, Lionel Piroth, Stephane Valot, Mathieu Blot, Michele Vourc'h, Georges Moreira
Article
Critical Care Medicine
Fernando G. Zampieri, Bruno R. da Costa, Suvi T. Vaara, Francois Lamontagne, Bram Rochwerg, Alistair D. Nichol, Shay McGuinness, Danny F. McAuley, Marlies Ostermann, Ron Wald, Sean M. Bagshaw
Summary: The reanalysis using Bayesian framework of the STARRT-AKI trial found that an accelerated strategy of kidney-replacement therapy initiation did not offer clinically important benefits compared to a standard strategy. Patients receiving the accelerated strategy may have fewer days alive and free from kidney-replacement therapy.
Article
Surgery
Sehastien Gaujoux, Guillaume L. Martin, Eric Mirallie, Nicolas Regenet, Maelle Le Bras, Francois Pattou, Bruno Carnaille, Catherine Cardot-Bauters, Lionel Groussin, Matthieu Faron, Philippe Chanson, Haythem Najah, Antoine Tabarin, Alain Sauvanet, Philippe Ruszniewski, Jean-Christophe Lifante, Thomas Walter, Nicolas Carrere, Philippe Caron, Sophie Deguelte, Brigitte Delemer, Christine Binquet, Anne Sophie Jannot, Pierre Goudet
Summary: Survival of patients with MEN1 is significantly shorter than the general population, especially for those with mutations affecting the JunD interaction domain. Almost all patients undergo at least one specific MEN1 operation during their lifetime, but there is no standardized sequence of surgery.
BRITISH JOURNAL OF SURGERY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
C. Cornu, Q. Carle, M. Poite, S. Erpeldinger, N. Meunier-Beillard, C. Binquet, T. Ginhoux, M. Saidi, A. Lamotte-Felin, A. Berard, A. Paris, M. Lamort-Bouche, F. Kieffer, M. Wallon
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
T. Ginhoux, F. Kieffer, Q. Carle, M. Poite, S. Erpeldinger, N. Meunier-Beillard, M. Saidi, A. Felin, E. Tisserand, A. Berard, A. Paris, M. Lamort-Bouche, C. Cornu, C. Binquet, M. Wallon
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Stephane Gaudry, Francois Grolleau, Saber Barbar, Laurent Martin-Lefevre, Bertrand Pons, Eric Boulet, Alexandre Boyer, Guillaume Chevrel, Florent Montini, Julien Bohe, Julio Badie, Jean-Philippe Rigaud, Christophe Vinsonneau, Raphael Porcher, Jean-Pierre Quenot, Didier Dreyfuss
Summary: This study reassessed the impact of choosing intermittent hemodialysis (IHD) or continuous renal replacement therapy (CRRT) as the first modality for patients with severe acute kidney injury (AKI), using secondary analysis of two multicenter randomized controlled trials. The results showed that CRRT as the first modality did not appear to provide a survival advantage or better kidney recovery compared to IHD, and may even be associated with a less favorable outcome in patients with lesser severity of disease.