Article
Dentistry, Oral Surgery & Medicine
Gregor Brandstetter, Sebastian Blatt, Jutta Goldschmitt, Louise Taylor, Paul Heymann, Bilal Al-Nawas, Thomas Ziebart
Summary: The study suggests that inhibition of MCT, especially MCT4, may help overcome radiation resistance in tumor cell lines. Experimental results show that MCT inhibitors have significant impacts on cell growth, migration, and cell viability after radiation therapy.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
D. G. E. Thiem, R. W. Frick, E. Goetze, M. Gielisch, B. Al-Nawas, P. W. Kaemmerer
Summary: In reconstructive surgery, flap monitoring is crucial for early identification of perfusion problems. This clinical study aimed to develop a non-invasive, objective approach for perfusion monitoring of free and pedicled flaps using hyperspectral imaging. The study found differences in parameters such as StO(2), NIR, THI, and TWI over time, with specific thresholds indicating arterial or venous perfusion issues. Results showed that pedicled flaps had decreased perfusion parameters compared to free flaps after transfer but remained similar later on.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Junho Jung, Jung Soo Park, Michel Dard, Bilal Al-Nawas, Yong-Dae Kwon
Summary: EMD-liquid combined with BCP bone substitute enhances new bone formation in a rabbit calvarial model. The EMD-liquid + BS group shows accelerated graft degradation and significantly increased new bone formation compared to the BS alone group. Further studies on graft materials are needed to optimize the regenerative potential of EMD-liquid.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Robert Noelken, Tobias Pausch, Wilfried Wagner, Bilal Al-Nawas
CLINICAL ORAL IMPLANTS RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Sebastian Blatt, Andreas Pabst, Stefanie Zimmer, Christian Walter, Bilal Al-Nawas, Maximilian Kruger
Summary: This study investigated a new rapid test for L1 antibody detection in HPV-16 associated oral squamous cell carcinoma (OSCC) and validated its diagnostic performance. The results showed that the rapid test for L1 antibodies demonstrated high sensitivity and specificity.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Biochemistry & Molecular Biology
Diana Heimes, Nadine Wiesmann, Jonas Eckrich, Juergen Brieger, Stefan Mattyasovszky, Peter Proff, Manuel Weber, James Deschner, Bilal Al-Nawas, Peer W. Kammerer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Engineering, Biomedical
Roxana Schwab, Martin Heller, Celine Pfeifer, Ronald E. Unger, Stefan Walenta, Sandra Nezi-Cahn, Bilal Al-Nawas, Annette Hasenburg, Walburgis Brenner
Summary: Tissue engineering of mucosa equivalents is crucial in the genitourinary region. The choice of scaffold is key in developing tissue engineered mucosa equivalents, with collagen scaffolds being considered the gold standard. The study found that TEOMs on the Bio-Gide (R) scaffold showed the best fibroblast differentiation and organization, making it a suitable matrix for mucosa substitutes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Blatt, Daniel G. E. Thiem, Andreas Pabst, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The combination of bone substitute materials (BSMs) with platelet-rich fibrin (PRF) showed significant positive pro-angiogenic effects, particularly with alloplastic and xenogeneic materials, leading to increased vessel formation in vivo. This demonstrates the enhanced angiogenetic potential of BSMs when combined with PRF, suggesting potential for bony regeneration in clinical applications.
Editorial Material
Dentistry, Oral Surgery & Medicine
Amely Hartmann, Michael Peetz, Bilal Al-Nawas, Marcus Seiler
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Roman Kia Rahimi-Nedjat, Andrea Tuettenberg, Keyvan Sagheb, Carmen Loquai, Benedict Rybczynski, Stephan Grabbe, Christian Walter, Bilal Al-Nawas
Summary: A retrospective study on head and neck cSCC patients identified previous skin cancer as a risk factor for recurrence, while histological factors like ulceration and tumor grading can accelerate relapse. Additionally, surrounding chronic precancerotic lesions and poor tumor grading were found to accelerate the observation of secondary cSCC.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Eik Schiegnitz, Peer W. Kaemmerer, Philipp Hellwich, Jochem Koenig, Keyvan Sagheb, Bilal Al-Nawas
Summary: Comparing narrow-diameter implants (NDI) with standard-diameter implants in combination with horizontal bone augmentation procedures (SDI+A) for horizontally deficient alveolar ridges, results showed similar clinical outcomes, survival rates, and implant success rates after over 3 years of follow-up, indicating NDI as a reasonable alternative for horizontal bone atrophy cases.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Matthias Gielisch, Maximilian Moergel, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: This study found that the uptake of boron in HNSCC cells did not significantly increase with the trans-stimulation effect of L-tyrosine, but higher BPA concentrations in trans-stimulated cells led to higher intracellular boron concentrations. The impact of trans-stimulation on HNSCC seemed less relevant, but trans-stimulated cells showed a more distinct dose-dependent cellular boron uptake with higher BPA concentrations.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Daniel G. E. Thiem, Lukas Hans, Sebastian Blatt, Paul Romer, Diana Heimes, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: This study investigated the dynamic skin perfusion after applying different combinations of local anesthetics using HSI. It was found that local anesthetics with different concentrations of epinephrine can lead to different vascular reaction patterns, resulting in varying skin perfusion trends.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Till Kaemmerer, Tony Lesmeister, Victor Palarie, Eik Schiegnitz, Andrea Schroeter, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The study compared the osseointegration of CaP surfaces and SA surfaces in an in vivo minipig mandible model, showing a higher rate of osseointegration failure in CaP implants in the early phase post-insertion, but with decreasing differences between the two groups over time.
EUROPEAN SURGICAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Daniel G. E. Thiem, Daniel Schneider, Michael Hammel, Bassam Saka, Bernhard Frerich, Bilal Al-Nawas, Peer W. Kammerer
Summary: Long-term complications after orthognathic surgery occurred more frequently than commonly described in the literature, and analyses of the quality of life show the need for more comprehensive preoperative patient education.
CLINICAL ORAL INVESTIGATIONS
(2021)