Review
Medicine, Research & Experimental
Wanying Feng, Zhihua Yang, Yangxi Liu, Rui Chen, Zhihui Song, Guiyun Pan, Yuhang Zhang, Zehui Guo, Xinya Ding, Lu Chen, Yi Wang
Summary: All species have a physiological need for sleep, which plays a crucial role in preserving and restoring physiological processes. Recent research points to the influence of gut microbiota on brain function, revealing their relationship. Dysregulation of the gut-brain axis is found to be linked to insomnia, with certain gut microbiota metabolites and disturbances worsening the condition. Traditional Chinese medicine offers unique advantages in treating insomnia, and exploring its scientific relevance to gut microbiota may lead to new concepts and improved therapeutics.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Boru Li, Meijing Xu, Yu Wang, Lijin Feng, Hang Xing, Kuo Zhang
Summary: This article summarizes the pharmacological effects, targets, and mechanisms of traditional Chinese medicine (TCM) in improving depression by regulating the gut microbiota. It provides evidence that TCMs are safe and effective in the treatment of depression and may offer a new therapeutic approach.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Immunology
Lingshu Zhang, Cong-Qiu Chu
Summary: Aside from contributing to the development of rheumatic diseases, the gut microbiota also interact with anti-rheumatic drugs, directly metabolizing many drugs and indirectly altering drug metabolism through complex interactions with the host, thereby influencing individual responses to drug therapy and adverse effects. The focus of this review is on recent advances in understanding these interactions to promote precision treatment, drug discovery, and improved therapy for rheumatic diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Tzu-Lung Lin, Chia-Chen Lu, Wei-Fan Lai, Ting-Shu Wu, Jang-Jih Lu, Young-Mao Chen, Chi-Meng Tzeng, Hong-Tao Liu, Hong Wei, Hsin-Chih Lai
Summary: TCM herbs are transformed into active metabolites by gut microbiota, significantly affecting their therapeutic activity and forming the basis for future TCM research through microbiota analyses and modern multiomics platforms.
Review
Medicine, Research & Experimental
Wuwen Feng, Juan Liu, Lihua Huang, Yuzhu Tan, Cheng Peng
Summary: Traditional Chinese medicines (TCMs) are gaining global recognition for their efficacy, but concerns about their toxicity, influenced by gut microbiota, are also rising. Research on the interaction between gut microbiota and TCMs' toxicity is essential to better understand and minimize the risks associated with TCM use.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Integrative & Complementary Medicine
Tian-Yi Cheng, Jia-Xin Li, Jing-Yi Chen, Pei-Ying Chen, Lin-Rui Ma, Gui-Lin Zhang, Pei-Yu Yan
Summary: Coronary heart disease (CHD) is a common ischaemic heart disease with a yet fully elucidated pathological mechanism. Changes in gut microbiota (GM) composition and metabolites are associated with the risk of CHD, while traditional Chinese medicine interventions can regulate GM to intervene in CHD.
Review
Immunology
Manlian Zhu, Xia Liu, Yiru Ye, Xiumei Yan, Yiwen Cheng, Longyou Zhao, Feng Chen, Zongxin Ling
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor dysfunction. Gut dysbiosis is involved in the development and progression of PD, and the gut microbiota can be considered as a potential diagnostic and therapeutic target. Gut dysbiosis influences the progression and onset of PD by increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels of alpha-synuclein fibrils, increasing oxidative stress, and decreasing neurotransmitter production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Jiachen Liang, Baodong Zheng, Yi Zhang, Hongliang Zeng
Summary: This article systematically reviews the immunoglobulin E mechanisms in food allergies, the structures of intestinal microorganisms, the microbiota mechanisms alleviating food allergies, and the mechanisms of dietary components alleviating food allergies. Imbalanced helper T cell and microbiota ratios are the cause of food allergies, and the microbiota alleviate food allergies through different mechanisms. Carbohydrates, proteins, high-fat diets, and polyphenols can all alleviate food allergies by modulating microbiota and immune cells.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Review
Cell Biology
Ting Zhang, Jin-ke Cheng, Yao-min Hu
Summary: Sarcopenia, a progressive loss of skeletal muscle mass and function with aging, has been shown to be closely related to gut microbiota. Strategies such as probiotics and fecal microbiota transplantation have shown potential in ameliorating muscle loss.
AGEING RESEARCH REVIEWS
(2022)
Review
Immunology
Hanghang Yuan, Ruirui Gui, Zhicheng Wang, Fang Fang, Hongguang Zhao
Summary: Colorectal cancer (CRC) is a common and deadly cancer that poses a major burden on human health. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites, but the specific mechanisms by which gut microbiota interact with immunotherapy and radiotherapy remain incongruent. This review discusses recent advances and the potential of targeting gut microbiota to enhance the efficacy of radioimmunotherapy in CRC, providing references and fresh ideas for the clinical application of this novel strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sylvia Garcia-Belenguer, Laura Grasa, Olga Valero, Jorge Palacio, Isabel Luno, Belen Rosado
Summary: The study found differences in gut microbiota composition between epileptic dogs and control dogs, with drug-naive epileptic dogs showing significantly reduced abundance of GABA and SCFAs-producing bacteria, as well as bacteria associated with reduced risk for brain disease. Furthermore, the administration of antiepileptic drugs for a month did not alter the gut microbiota composition. These results may contribute to understanding canine idiopathic epilepsy and offer potential for exploring probiotic intervention as a therapeutic approach.
Review
Pharmacology & Pharmacy
Chenchen Bi, Shitian Guo, Shijia Hu, Jiaqi Chen, Mengfei Ye, Zheng Liu
Summary: Depression is a common and severe mental disease that leads to decreased cognitive function, energy loss, insomnia, and even suicide. Gut microbes have been found to play an important role in the occurrence and development of depression. Modulating the microbiota-gut-brain axis can enhance the efficacy of antidepressant drugs and reduce their side effects and disease recurrence.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Gaochen Lu, Sheng Zhang, Rui Wang, Zulun Zhang, Weihong Wang, Quan Wen, Faming Zhang, Pan Li
Summary: This study used bibliometrics to analyze the scientific literature on the relationship between gut microbiota and chronic painful conditions, revealing that only 122 papers discussed how nutritional interventions can modulate this link. The findings enrich the evidence in the field of microbiota medicine and contribute to the development of clinical medicine.
Review
Immunology
Amber G. Bozward, Vincenzo Ronca, Daniel Osei-Bordom, Ye Htun Oo
Summary: The close relationship between the gastrointestinal tract and liver constitutes the gut-liver axis, playing a central role in the pathogenesis of gut-liver axis diseases. This axis is crucial for immune homeostasis, influenced by factors such as the gut microbiota, diet, genetics, and environment. Through the coordinated effort of immune cells network, the liver is able to maintain its tolerogenic state.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Yu Wang, Yusheng Li, Lin Bo, Enyuan Zhou, Yanyan Chen, Shinen Naranmandakh, Wenqing Xie, Qin Ru, Lin Chen, Zhaohua Zhu, Changhai Ding, Yuxiang Wu
Summary: The musculoskeletal system and the intestinal microbiota have a mutual influence on each other. Reasonable nutritional intervention helps to maintain the homeostasis of the intestinal microbiota, which may have a positive impact on musculoskeletal health.
Review
Cell Biology
Xiao Zheng, Xiaoying Cai, Haiping Hao
Summary: The interaction between microbial metabolites and host targets plays a crucial role in signal transmission and biological regulation. Understanding the interaction between microbial metabolites and host targets can provide new insights into host health and disease, expand the range of druggable targets, and inspire drug design and discovery.
Article
Food Science & Technology
Keisuke Hamada, Ping Wang, Yangliu Xia, Nana Yan, Shogo Takahashi, Kristopher W. Krausz, Haiping Hao, Tingting Yan, Frank J. Gonzalez
Summary: WA has therapeutic effects on alcoholic liver disease by inhibiting hepatic lipogenesis to reduce liver injury caused by alcohol.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemical Research Methods
Rongfan Tang, Pengcheng Chen, Zhe Wang, Lingling Wang, Haiping Hao, Tingjun Hou, Huiyong Sun
Summary: “Drug design targeting protein-protein interactions associated with disease development is crucial. Besides interrupting interactions, stabilizing protein-protein interactions can also be beneficial for therapy. However, characterizing the stabilization effect of stabilizers is challenging, which highlights the importance of developing reliable computational strategies.”
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Gastroenterology & Hepatology
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez
Summary: Intestinal PPAR alpha signaling modulates fatty acid uptake through regulating FABP1 expression, contributing to NASH progression. Targeting this pathway could be a potential therapeutic strategy for NASH treatment.
Article
Chemistry, Medicinal
Yun Wang, Yuanyuan Xu, Xiaowei Xu, Hong Wang, Dong Wang, Wenchao Yan, Jiaying Zhu, Haiping Hao, Guangji Wang, Lijuan Cao, Jun Zhang
Summary: This study confirmed the beneficial effects of Ginkgo biloba leave extract (GbE) in alleviating hypercholesterolemia, inflammation, and atherosclerosis. GbE treatment reshaped the intestinal microbiota, downregulated proinflammatory cytokines, and enhanced the expression of tight junction proteins. It also reversed the dysfunction of microbial metabolic phenotypes and reduced atherosclerotic plaque areas. These findings provide important insights into the pharmacological mechanism underlying the antiatherogenic efficacy of GbE.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Analytical
Xiao-Wei Xu, Ya Zhu, Jiang-Zhou Song, Gui-Qing Zou, Zhou Zhao, Qiu-Ling Zheng, Li-Juan Cao, Guang-Ji Wang, Hong Wang, Hai-Ping Hao
Summary: Investigated the expression differences of FXR in different organs and the influence of factors such as diet and circadian rhythm on FXR homeostasis. Developed a method for real-time monitoring of FXR expression in cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Chujie Ding, Yu Hong, Yuan Che, Tianyu He, Yun Wang, Shule Zhang, Jiawei Wu, Wanfeng Xu, Jingyi Hou, Haiping Hao, Lijuan Cao
Summary: Cholestasis, a common complication of hepatitis B virus infection, has been found to negatively impact T cells response and hinder viral clearance. Bile acids disrupt calcium homeostasis, impairing T cells activation and signaling. Targeting bile acid regulation may be a therapeutic strategy for host-virus defense.
Article
Biotechnology & Applied Microbiology
Hai-Ping Hao, Fei Xia, Hong-Tong Bai, Xun-you Yan, Hong-xia Cui, Xiao-ming Xie, Lei Shi
Summary: This study investigates the effect of bio-control plant Litsea cubeba branch inter-row cover on soil bacterial community, soil-enriched metabolites, and soil mineral nutrition in tea plantation. The results show that Litsea cubeba inter-row cover can modify the soil microbial structure and diversity, antagonize the plant pathogen community, and improve the soil aluminum and phosphorus status.
ANNALS OF MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiajia Shen, Huimin Guo, Shijia Liu, Wei Jin, Zhi-Wei Zhang, Yong Zhang, Keanqi Liu, Shuying Mao, Zhihao Zhou, Lin Xie, Guangji Wang, Haiping Hao, Yan Liang
Summary: This study identifies the crucial role of intestinal flora and microbiota metabolites in the occurrence and treatment of ischaemic stroke. The accumulation of branched-chain amino acids is closely associated with gut microflora dysbiosis and neuroinflammation. Lactobacillus helveticus and Lactobacillus brevis colonization exhibit neuroprotective activity and alleviate the accumulation of branched-chain amino acids.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tingting Yao, Heng Xiao, Hong Wang, Xiaowei Xu
Summary: Proteolysis-targeting chimera (PROTAC) is a promising molecule that degrades specific proteins through the ubiquitin-proteasome system. It has shown remarkable efficacy in various fields and opened up new avenues for biomedical research and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Qinghua Wang, Zhe Wang, Sheng Tian, Lingling Wang, Rongfan Tang, Yang Yu, Jingxuan Ge, Tingjun Hou, Haiping Hao, Huiyong Sun
Summary: The mechanism of transcriptional regulation in nuclear receptors involves two main conformations, active and inactive. It is challenging to determine the molecular type of a ligand bound to the receptor's ligand-binding pocket (LBP) because agonists and antagonists bind to the same position. Therefore, precise and efficient methods are needed to distinguish between agonists and antagonists targeting the LBP of nuclear receptors.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Pharmacology & Pharmacy
Shuang Cui, Huijian Hu, An Chen, Ming Cui, Xiaojie Pan, Pengfei Zhang, Guangji Wang, Hong Wang, Haiping Hao
Summary: The acetylation of FXR regulates its nucleocytoplasmic shuttling and degradation under conditions of liver injury, which limits the clinical benefits of FXR agonists. SIRT1 activators can reduce FXR acetylation and prevent its cytosolic degradation, and combining SIRT1 activators with FXR agonists shows promise in treating liver diseases.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Wenjie Lu, Lingfei Yu, Lujun Wang, Songlin Liu, Manman Li, Zijun Wu, Shengqi Chen, Rongfeng Hu, Haiping Hao
Summary: A metformin hydrochloride mucosal nanoparticles enteric-coated capsule (MH-MNPs-EC) was developed to improve the bioavailability and hypoglycemic effect duration of metformin hydrochloride for the treatment of type 2 diabetes. The capsule showed improved efficacy and prolonged residence time in the intestine compared to commercial metformin hydrochloride capsules.
Review
Chemistry, Medicinal
Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang
Summary: Nonalcoholic fatty liver disease is a common liver disease without approved pharmacotherapy. Farnesoid X receptor (FXR) is considered a promising therapeutic target, but currently developed drugs have shown limited efficacy in clinical trials. This review summarizes the development of the FXR agonist obeticholic acid and discusses its limitations in depth.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Psychology, Multidisciplinary
Haiping Hao, Xiaobao Li, Xi Shen, Hong Jiang, Haoyue Xiao, Houchao Lyu
Summary: This study examined the reciprocal relationship between future time perspective and self-control among adolescents. The results showed that future-negative and future-confusional were negatively related to self-control, while future-positive, future-perspicuity, future-perseverant, and future-planning were positively related to self-control. The study also found reciprocal relationships between future-confusional, future-planning, and self-control.
CURRENT PSYCHOLOGY
(2023)