Journal
TRENDS IN PARASITOLOGY
Volume 30, Issue 10, Pages 467-469Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2014.08.005
Keywords
Toxoplasma; intracellular parasitism; nutrient uptake; macromolecule digestion; protease cathepsins
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Funding
- NIAID NIH HHS [R01 AI138714] Funding Source: Medline
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In mammalian cells, the protozoan pathogen Toxoplasma resides in a nonfusiogenic vacuole that segregates it from host cell resources. How the parasite acquires nutrients and whether it is capable of internalizing host macromolecules have been long-standing mysteries. By exploiting a mutant of Toxoplasma lacking the cathepsin protease L, Dou et al observed the accumulation of host cytosolic-derived proteins in a multivesicular post-Golgi compartment, which establishes the existence of a functional heterophagic pathway in Toxoplasma.
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