Journal
TRENDS IN PARASITOLOGY
Volume 27, Issue 6, Pages 263-272Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2011.01.008
Keywords
-
Categories
Funding
- Royal Society
- British Council
- MRC [G0600818] Funding Source: UKRI
- Medical Research Council [G0600818] Funding Source: researchfish
Ask authors/readers for more resources
The laminated layer (LL) is the massive carbohydrate-rich structure that protects Echinococcus larvae, which cause cystic echinococcosis (hydatid disease) and alveolar echinococcosis. Increased understanding of the biochemistry of the LL is allowing a more informed analysis of its immunology. The LL not only protects the parasite against host attack but also shapes the overall immune response against it. Because of its dense glycosylation, it probably contains few T-cell epitopes, being important instead in T-cell independent antibody responses. Crucially, it is decoded in non-inflammatory fashion by innate immunity, surely contributing to the strong immune-regulation observed in Echinococcus infections. Defining the active LL molecular motifs and corresponding host innate receptors is a feasible and promising goal in the field of helminth-derived immune-regulatory molecules.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available