Journal
TRENDS IN MICROBIOLOGY
Volume 18, Issue 5, Pages 215-223Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2010.01.001
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA055219-14, R01 CA055219] Funding Source: Medline
- NINDS NIH HHS [R01 NS035000, R01 NS035000-13] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA055219] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS035000] Funding Source: NIH RePORTER
Ask authors/readers for more resources
In the past three years, remarkable discoveries have added three new human polyomaviruses (KI virus (KIV), WU virus (WUV) and Merkel cell virus (MCV)) to a class that previously had only two disease-causing members (BK virus (BKV) and JC virus (JCV)) identified. Two monkey polyomaviruses, simian virus (SV)40 and B-cell lymphotropic polyomavirus (LPV) are also present in humans. KIV and WUV lack the agnoprotein coding sequence and regulatory micro (mi)RNA clusters of BKV, JCV and SV40. MCV lacks the agnoprotein sequence but generates miRNAs. KIV, WUV and MCV are all widespread in humans. Although they have distinctive tissue tropisms, all these viruses are probably acquired in childhood. Of these viruses, only MCV has thus far been strongly linked to cancer. Marshalled evidence from diverse sources implicates MCV as an etiological agent of Merkel cell carcinoma. This review compares the structural features of the new and previously known polyomaviruses, with the aim of identifying approaches to molecular pathology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available