Journal
TRENDS IN MICROBIOLOGY
Volume 16, Issue 11, Pages 528-534Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2008.08.006
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Funding
- NIH [RO1 GM079185, AI065987]
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The Mycobacterium tuberculosis PhoPR two-component system is essential for virulence in animal models of tuberculosis. Recent articles have shown that among the reasons for the attenuation of the M. tuberculosis H37Ra strain is a mutation in the phoP gene that prevents the secretion of proteins that are important for virulence. There is a need for new anti-tubercular therapies because of the emergence of multi-drug-resistant M. tuberculosis strains and also the variable efficacy of the currently used bacille Calmette-Gue3rin vaccine. Because of its major role in M. tuberculosis pathogenicity, PhoP is a potential target candidate. This review summarizes our understanding of PhoPR's role in virulence and discusses areas in which our knowledge is limited.
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