Journal
TRENDS IN GENETICS
Volume 24, Issue 5, Pages 216-219Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2008.02.004
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Funding
- Medical Research Council [MC_U105161047] Funding Source: researchfish
- Medical Research Council [MC_U105161047] Funding Source: Medline
- MRC [MC_U105161047] Funding Source: UKRI
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By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in Saccharomyces cerevisiae and bi-directional terminators in Escherichia coli.
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