Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 21, Issue 7, Pages 428-434Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2010.02.003
Keywords
-
Categories
Funding
- NIH [RO1-AI062980]
Ask authors/readers for more resources
How the fetal 'allograft' avoids rejection during pregnancy remains a major unresolved immunological paradox. Recent work has suggested that fetomaternal tolerance is in fact maintained by a number of redundant mechanisms, but their relative importance has remained poorly defined. In this paper, I discuss an emerging controversy regarding the ability of maternal T cells to mediate fetal rejection at a time when they appear to be ignorant of fetal and placental antigens. This paradox within a paradox highlights two major research directions in the field of reproductive immunology that, when ultimately reconciled, promise to give significant insight into mechanisms of impaired fertility and compromised fetal and maternal health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available