Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 23, Issue 4, Pages 91-98Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2012.09.006
Keywords
-
Categories
Funding
- German Ministry of Education and Research [01GN0813]
- German Research Foundation within the DFG Research Unit 917 [SA 1785/5-1]
Ask authors/readers for more resources
Long QT syndromes (LQTS) are a family of inherited monogenetic disorders caused by gain or loss-of-function mutations of cardiac ion channels and are characterized by a prolonged QT interval in the ECG. The disease-specific mutations lead to prolonged action potential durations and early after-depolarizations in cardiomyocytes potentially giving rise to triggered extrabeats and life-threatening arrhythmias in patients. The generation of induced pluripotent stem cells from somatic cells of patients and their differentiation into cardiomyocytes represents a powerful method enabling the investigation of disease-specific cardiomyocytes. In this review we highlight the latest progress in the generation of long QT syndrome-specific induced pluripotent stem cells and cardiomyocytes to investigate the disease in vitro. We also point out future challenges that need to be addressed to allow drug screening using patient-specific cardiomyocytes. (C) 2012 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available