Of Cardiovascular Illness and Diversity of Biological Response

Noise in gene expression (stochastic variation In the composition of the transcriptome in response to stimuli) may play an important role m maintaining robustness and flexibility, which ensure the stability of normal physiology and provide adaptability to environmental changes for the living system. Broad-based technologies have allowed us to study with unprecedented accuracy the molecular profiles of various states of health and cardiovascular disease. In doing so, we have observed a correlation between the degree of variation in gene expression and the state of health. Specifically, the stochastic variation in gene expression in response to environmental and physiological factors is found in healthy mice, and tends to disappear in mice with advanced disease states. Although further evidence is needed to draw a solid conclusion with respect to the significance of decreased transcriptional noise in the disease state as a whole, it is tantalizing to introduce the concept that stochasticity may be linked to the organism's adaptability to a changing environment, and the quiet states of gene expression may indicate the loss of diversity in the organism's response. (Trends Cardiovasc Med 2008; 18: 194-197) (C) 2008, Elsevier Inc.