Journal
TRENDS IN BIOTECHNOLOGY
Volume 32, Issue 11, Pages 571-577Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.09.004
Keywords
intracellular environment; biosensor; nanoparticle; sub-cellular transduction
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There is rapid growth in the use of multi-functional nanoparticles as transducers to probe the intracellular environment. New designs of nanoparticles can provide quantitative information at sub-cellular resolution on parameters such as pH, temperature and concentration of nicotinamide adenine dinucleotide (NADH) or selected metal ions. This new work builds on the existing practice of using nanoparticles and fluorescent dyes to provide enhanced microscopic images of cells, but goes beyond it by adding new functionalities and analytical capabilities. In this review, we discuss the recent literature on the development of such nanoparticles for simultaneous biosensing and imaging. We explore and examine the different measurements that will be possible, and analyze the likely accuracy and resolution that could be achieved.
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