Article
Surgery
Marilena Gregorini, Elena Ticozzelli, Massimo Abelli, Maria A. Grignano, Eleonora F. Pattonieri, Alessandro Giacomoni, Luciano De Carlis, Antonio Dell'Acqua, Rossana Caldara, Carlo Socci, Andrea Bottazzi, Carmelo Libetta, Vincenzo Sepe, Stefano Malabarba, Federica Manzoni, Catherine Klersy, Giuseppe Piccolo, Teresa Rampino
Summary: This study reports on 11 years of Italian experience comparing the outcomes of kidney transplants from DCD and EPD. Despite similar graft and patient survival rates, EPD showed better clinical outcomes and the use of ECMO in the procurement phase improved graft outcomes.
TRANSPLANT INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Dubravka Sipus, Kristina Krzelj, Zeljko Duric, Hrvoje Gasparovic, Davor Milicic, Jadranka Separovic Hanzevacki, Daniel Lovric
Summary: Heart transplant remains the gold standard therapy for end-stage heart failure, but using ECMO as a bridge to transplant may be a solution for critically ill patients. However, further research is needed to determine the superiority of direct bridging compared to bridging to durable MCS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Nam Eun Kim, Ala Woo, Song Yee Kim, Ah Young Leem, Youngmok Park, Se Hyun Kwak, Seung Hyun Yong, Kyungsoo Chung, Moo Suk Park, Young Sam Kim, Ha Eun Kim, Jin Gu Lee, Hyo Chae Paik, Su Hwan Lee
Summary: In patients awaiting lung transplantation, awake ECMO strategy leads to better post-operative outcomes than non-awake ECMO strategy, with shorter ICU stay, longer ventilator free days, higher gait ability, and improved lung function at 6 months and 1 year. Additionally, awake ECMO group has lower mortality rates at 6 months and 1 year compared to non-awake group.
RESPIRATORY RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Juan B. Ivey-Miranda, Christopher Maulion, Marta Farrero-Torres, Matthew Griffin, Edith L. Posada-Martinez, Jeffrey M. Testani, Lavanya Bellumkonda
Summary: The objective of this study was to describe and risk-stratify different profiles of patients listed for heart transplant supported by ECMO. Among the analyzed patients, those in the ECMOREMOVED and ECMOBTT groups with no risk factors showed similar survival as those who were never supported on ECMO. However, in the ECMOBTT group, posttransplantation mortality significantly increased with increasing risk factors.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Pharmacology & Pharmacy
David E. Procaccini, Jennifer Roem, Derek K. Ng, Thomas E. Rappold, Dawoon Jung, Jogarao V. S. Gobburu, Melania M. Bembea
Summary: This study aims to explore the best practices for antithrombin (AT) monitoring, dosing, and dose-response in pediatric extracorporeal membrane oxygenation (ECMO) patients. The results showed a high prevalence of AT deficiency in pediatric ECMO patients. An AT replacement protocol based on evaluating heparin resistance is associated with fewer AT administrations and similar outcomes for the patient and ECMO circuit. Further research is needed to determine optimal dosing strategies.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Jinhe Sun, Yuteng Ma, Wanting Su, He Miao, Zhaotian Guo, Qianhui Chen, Yuzhong Zhang, Xiaochun Ma, Song Chen, Renyu Ding
Summary: This systematic review compared different monitoring strategies for anticoagulation in patients supported on ECMO. The results showed that the best strategies were using Anti-Xa and aPTT methods, and combined monitoring had advantages in reducing mortality and blood transfusion. However, most studies were retrospective and had small sample sizes, indicating a need for more appropriate strategies and higher quality research.
Article
Pediatrics
John S. Kim, Cindy S. Barrett, Robert W. Hyslop, Shannon M. Buckvold, Katja M. Gist
Summary: This study examines the demographics and in-hospital mortality of children with pulmonary embolism who received Extracorporeal Membrane Oxygenation (ECMO) from 2007 to 2018. Out of the 56 patients identified, 33 (61%) survived. No significant differences were found in the demographics or ECMO details between survivors and non-survivors. However, non-survivors had a higher incidence of pulmonary bleeding compared to survivors.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Holger Thiele, Uwe Zeymer, Ibrahim Akin, Michael Behnes, Tienush Rassaf, Amir Abbas Mahabadi, Ralf Lehmann, Ingo Eitel, Tobias Graf, Tim Seidler, Andreas Schuster, Carsten Skurk, Daniel Duerschmied, Peter Clemmensen, Marcus Hennersdorf, Stephan Fichtlscherer, Ingo Voigt, Melchior Seyfarth, Stefan John, Sebastian Ewen, Axel Linke, Eike Tigges, Peter Nordbeck, Leonhard Bruch, Christian Jung, Jutta Franz, Philipp Lauten, Tomaz Goslar, Hans-Josef Feistritzer, Janine Poess, Eva Kirchhof, Taoufik Ouarrak, Steffen Schneider, Steffen Desch, Anne Freund, ECLS-SHOCK Investigators
Summary: In patients with acute myocardial infarction complicated by cardiogenic shock, early extracorporeal life support (ECLS) combined with standard medical treatment did not reduce mortality.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Jose Nunez, Andre F. Gosling, Brian O'Gara, Kevin F. Kennedy, Peter Rycus, Darryl Abrams, Daniel Brodie, Shahzad Shaefi, A. Reshad Garan, E. Wilson Grandin
Summary: This study aimed to analyze the prevalence, mortality association, and risk factors for bleeding and thrombosis events among adults supported with venovenous extracorporeal membrane oxygenation. Bleeding and thrombotic events are common during VV-ECMO and have a strong, cumulative association with in-hospital mortality. While thrombotic events are more frequent, bleeding carries a higher risk of inpatient mortality. Differential risk factors for bleeding and thrombotic complications exist, suggesting the possibility of a tailored approach to VV-ECMO management.
INTENSIVE CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Jiwon Ryoo, Jung Huh, Hee Sun Cho, Jin-Jin Kim, Seok Chan Kim, Jongmin Lee
Summary: This study focuses on the diagnosis and treatment of right ventricular (RV) failure in patients undergoing venovenous ECMO, with a case report of successful atrial septostomy as a bridge to lung transplantation in a HSCT recipient.
Article
Engineering, Biomedical
Vittorio Scaravilli, Jacopo Fumagalli, Lorenzo Rosso, Federico Polli, Mauro Panigada, Chiara Abbruzzese, Stefania Crotti, Alfredo Lissoni, Mario Nosotti, Antonio Pesenti, Alberto Zanella, Giacomo Grasselli
Summary: The use of a novel no-heparin management approach during ECMO bridging to lung transplantation (LuTX) can effectively reduce the risk of perioperative bleeding, even in high-risk patients. Prospective studies are needed to further validate the effectiveness of this strategy.
Article
Cardiac & Cardiovascular Systems
Taylor Nordan, Andre C. Critsinelis, Shant H. Mahrokhian, Navin K. Kapur, Katherine L. Thayer, Frederick Y. Chen, Gregory S. Couper, Masashi Kawabori
Summary: The new donor heart allocation system has a positive impact on patients undergoing heart transplantation with extracorporeal membrane oxygenation, leading to shorter waitlist times, reduced preoperative comorbidities, and improved 180-day survival rates compared to the old system.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Kangjoon Kim, Ah Young Leem, Song Yee Kim, Kyung Soo Chung, Moo Suk Park, Young Sam Kim, Jin Gu Lee, Hyo Chae Paik, Su Hwan Lee
Summary: This study investigated the incidence of complications related to ECMO support as a bridge to lung transplantation (BTT) and their association with patient outcomes. The results showed that complications during ECMO support were associated with unfavorable outcomes in lung transplantation.
Article
Public, Environmental & Occupational Health
Xingdong Cheng, Rongzhi Zhang, Shilin Wei, Jian Huang, Kerong Zhai, Yongnan Li, Bingren Gao
Summary: The study demonstrates that Dex can alleviate myocardial injury in a rat model of AMI supported by VA ECMO. Additionally, Dex reduces inflammation, cell apoptosis, and the infiltration of leukocytes and macrophages.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Hematology
Oliver Karam, Marianne E. Nellis
Summary: Due to underlying illness and circuit-induced coagulopathy, children on ECMO are at risk of receiving large volumes of blood components. It is uncertain if modified blood products and newer biologics have the same efficacy and safety in ECMO. Research on indications for RBC, plasma, and PLT transfusions for children on ECMO is essential as most current guidance is based on expert opinion.
