Article
Immunology
Riad Hajdarevic, Asgeir Lande, Ingrid Rekeland, Anne Rydland, Elin B. Strand, Daisy D. Sosa, Lisa E. Creary, Olav Mella, Torstein Egeland, Ola D. Saugstad, Oystein Fluge, Benedicte A. Lie, Marte K. Viken
Summary: The study revealed associations between ME/CFS and HLA-DQB1 gene, potentially due to a specific amino acid position in the peptide binding groove or an intergenic SNP upstream. Moreover, a putative causal locus outside the classical HLA genes was identified in the HLA class I region.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Cell Biology
Irina A. Ishina, Maria Y. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov, Alexey A. A. Belogurov Jr, Alexander G. G. Gabibov
Summary: Antigen presentation by MHC-II is crucial for immune response and self-antigen tolerance. Certain MHC-II alleles are associated with autoimmune diseases. The process of MHC-II-mediated presentation plays a significant role in understanding the mechanisms of autoimmune diseases and the protective effect of certain MHC-II alleles.
Article
Biochemical Research Methods
Max Hoek, Laura C. Demmers, Wei Wu, Albert J. R. Heck
Summary: The study analyzed in depth the N-glycosylation features of HLA class I molecules, finding that HLA-A alpha-chains have distinct glycosylation patterns compared to HLA-B, HLA-C, and HLA-F. The cellular distribution of HLA molecules varies based on their glycosylation features, with HLA-B predominantly found at the plasma membrane, and HLA-C and HLA-F mainly located in the endoplasmic reticulum and Golgi membrane. The findings highlight the importance of considering allotype-specific cellular distribution when analyzing peptide antigen presentation in immunopeptidomics.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Immunology
Taushif Khan, Mahbuba Rahman, Ikhlak Ahmed, Fatima Al Ali, Puthen Veettil Jithesh, Nico Marr
Summary: This study explored the genetic variation of HLA class II genes in a cohort of Arab adults and found a strong association between zygosity of HLA class II genes and antibody responses to common pathogens. The results suggest that HLA class II gene polymorphisms confer specific humoral immunity against common pathogens, contributing to the genetic diversity of HLA class II loci during human evolution.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hidefumi Inaba, Shuhei Morita, Daisuke Kosugi, Yuki Asai, Yosuke Kaido, Saya Ito, Tomonao Hirobata, Gen Inoue, Yuki Yamamoto, Masatoshi Jinnin, Hiroaki Kimura, Masao Ota, Yuko Okudaira, Hiroyasu Nakatani, Tomoko Kobayashi, Shintaro Iwama, Hiroshi Arima, Takaaki Matsuoka
Summary: Immune-checkpoint inhibitors are effective in various advanced cancers, but the immunological mechanism behind the serious complication of ICI-T1DM is unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Romy Mosch, Henk-Jan Guchelaar
Summary: This review discusses ADA formation of mAbs and its clinical impact, as well as proposes the use of HLA haplotypes as biomarkers to predict patients' susceptibility to ADA formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gemma Palomar, Katarzyna Dudek, Magdalena Migalska, J. W. Arntzen, G. Francesco Ficetola, Dusan Jelic, Elizabeth Jockusch, Inigo Martinez-Solano, Masatoshi Matsunami, H. Bradley Shaffer, Judit Voros, Bruce Waldman, Ben Wielstra, Wieslaw Babik
Summary: The study found a positive correlation between MHC-I diversity and the diversity of two APGs (TAP1 and TAP2) in salamanders, supporting their coevolution. However, no consistent effect was detected for the other three APGs (PSMB8, PSMB9, and TAPBP). This suggests that while coevolution occurs in salamanders, it does not limit the expansion of the MHC-I gene family.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Pharmacology & Pharmacy
Natsumi Mizuno, Yoshiki Yanagawa
Summary: In this study, it was found that tofacitinib enhanced IFN-gamma-induced MHC II expression in macrophages by transcriptional regulation through induction of CIITA, while decreasing the expression of CD86.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Qi Ai, Fanlu Li, Siyi Zou, Zehui Zhang, Yangbing Jin, Lingxi Jiang, Hao Chen, Xiaxing Deng, Chenghong Peng, Nan Mou, Chenlei Wen, Baiyong Shen, Qian Zhan
Summary: KRAS(G12V) mutation is a driving factor of solid tumors, and TCR-engineered CD4(+) T cells specific to KRAS(G12V) demonstrate significant efficacy in vitro and in vivo, targeting APCs presenting the mutation peptide.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Monika Zaborek-Lyczba, Jakub Lyczba, Paulina Mertowska, Sebastian Mertowski, Anna Hymos, Martyna Podgajna, Paulina Niedzwiedzka-Rystwej, Ewelina Grywalska
Summary: HLA-G, a non-classical MHC class I molecule, has been studied for its relevance in pathological conditions like autoimmune diseases. Current research aims to utilize HLA-G in clinical practice for diagnostics and therapeutic purposes, as it is known for its immunomodulatory role in reducing inflammation and immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ya-Yu Tsai, Chenxu Qu, Joseph D. Bonner, Rebeca Sanz-Pamplona, Sidney S. Lindsey, Marilena Melas, Kevin J. Mcdonnell, Gregory E. Idos, Christopher P. Walker, Kevin K. Tsang, Diane M. Da Silva, Ferran Moratalla-Navarro, Asaf Maoz, Hedy S. Rennert, W. Martin Kast, Joel K. Greenson, Victor Moreno, Gad Rennert, Stephen B. Gruber, Stephanie L. Schmit
Summary: The diversity at HLA loci is associated with the risk of developing colorectal cancer, and increased heterozygosity at these loci may reduce the odds of developing CRC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen
Summary: Sjogren's syndrome is characterized by lymphocytic infiltration and dysfunction of salivary and lacrimal glands. Studies have shown a significant genetic correlation between specific risk HLAs and SjS, with HLA-DRB1*0301 being particularly influential. The specific autoantigens attributed to SjS and the epitopes presented by HLA-DRB1*0301 remain elusive, requiring further research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Urology & Nephrology
Carmen Lefaucheur, Kevin Louis, Aurelie Philippe, Alexandre Loupy, P. Toby Coates
Summary: The discovery of immune response to non-HLA antigenic targets, particularly anti-AT1R antibodies, has broadened our understanding of organ transplants and human diseases. By integrating non-HLA and HLA systems, new therapeutic interventions have been identified, leading to advancements in translational research and improved patient care.
KIDNEY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Robert J. Fontana, Yi-Ju Li, Elizabeth Phillips, Naba Saeed, Huiman Barnhart, David Kleiner, Jay Hoofnagle
Summary: Allopurinol hepatotoxicity is associated with systemic hypersensitivity, short latency to onset, particularly in African Americans, and three HLA risk alleles: HLA-B*58:01, HLA-B*53:01, and HLA-A*34:02. Testing for 58:01 may help confirm a diagnosis of hepatotoxicity in allopurinol-treated patients.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Ilaria Callegari, Mika Schneider, Giuliano Berloffa, Tobias Muhlethaler, Sebastian Holdermann, Edoardo Galli, Tim Roloff, Renate Boss, Laura Infanti, Nina Khanna, Adrian Egli, Andreas Buser, Gert Zimmer, Tobias Derfuss, Nicholas S. R. Sanderson
Summary: In this study, we isolated spike-protein-specific B cells and produced recombinant antibodies of IgM, IgG, and IgA classes. Two IgM antibodies demonstrated potent virus neutralization at picomolar concentrations, but this potency was lost when switched to IgG. Decreased avidity alone cannot explain the loss of potency.