Article
Cell Biology
Qiuli Liu, Xiaoyong Chen, Chang Liu, Lijie Pan, Xinmei Kang, Yanli Li, Cong Du, Shuai Dong, Andy Peng Xiang, Yan Xu, Qi Zhang
Summary: CHI3L1 is a novel immunosuppressive factor secreted by MSCs, which plays a crucial role in inhibiting T cell activation and inflammatory responses in immune-mediated liver injury. Downregulating CHI3L1 in hUC-MSCs mitigates their therapeutic effects on liver injury by affecting T cell function. Additionally, CHI3L1 exerts its immunosuppressive effects by upregulating PPAR δ to inhibit the JAK/STAT signaling pathway in T cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Chenxi Zheng, Bingdong Sui, Xiao Zhang, Jiachen Hu, Ji Chen, Jin Liu, Di Wu, Qingyuan Ye, Lei Xiang, Xinyu Qiu, Siying Liu, Zhihong Deng, Jun Zhou, Shiyu Liu, Songtao Shi, Yan Jin
Summary: The study revealed that apoptotic vesicles (apoVs) derived from MSCs can modulate liver macrophage homeostasis and counteract type 2 diabetes (T2D) by inducing macrophage reprogramming. Through efferocytosis, apoVs inhibit macrophage accumulation and promote their transformation towards an anti-inflammatory phenotype in the liver to ameliorate T2D phenotypes.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Cell Biology
Chong Huang, Lu Zhao, Yun Xiao, Zihao Tang, Li Jing, Kai Guo, Lei Tian, Chunlin Zong
Summary: This study aimed to investigate the role of macrophages and macrophage-derived exosomes in restoring irradiated bone marrow mesenchymal stem cells (BMMSCs) function. M2 macrophage-derived exosomes (M2D-exos) were found to inhibit the fibrogenic differentiation and promote the osteogenic differentiation of irradiated BMMSCs. The miRNA miR-142-3p in M2D-exos targeted transforming growth factor beta 1 (TGF-beta 1) to restore the differentiation balance of irradiated BMMSCs. These findings provide a promising and cell-free method to treat irradiation-induced bone damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Ya Yang, Yanfei Chen, Yalei Zhao, Feiyang Ji, Lingjian Zhang, Shima Tang, Sainan Zhang, Qingqing Hu, Zuhong Li, Fen Zhang, Qian Li, Lanjuan Li
Summary: This study demonstrated that MenSC transplantation was effective in treating cholestatic liver injury in mice, improving survival rates and decreasing liver enzyme levels. MenSCs may exert therapeutic effects by regulating beta-catenin expression and repairing liver damage caused by cholestasis.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Giovanni Schepici, Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury (SCI) is a devastating condition that causes permanent motor and sensory deficits. Researchers have been studying potential therapeutic strategies to mitigate the neuro-inflammatory response following injury. Recent studies have shown that exosomes-derived MSCs (MSC-EXOs) have promising effects as an innovative therapy for SCI patients.
Article
Medicine, Research & Experimental
Tung-Sheng Chen, Yi-An Lai, Yun-Ju Lai, Chiang-Ting Chien
Summary: Stem cells pre-incubated with green tea theanine showed enhanced cell capabilities and better therapeutic effects on rats with liver injury, indicating the potential of theanine in stem cell therapy for liver diseases. Increased paracrine VEGF secretion from theanine pre-incubated stem cells plays a crucial role in liver regeneration, suggesting the need for future clinical studies to further verify these experimental findings.
Article
Neurosciences
Kiyoharu Shimizu, Takafumi Mitsuhara, Yuyo Maeda, Masashi Kuwabara, Masahiro Hosogai, Masaaki Takeda, Louis Yuge, Nobutaka Horie
Summary: This study compared the gene expression characteristics of rcMSCs and rbMSCs and investigated their therapeutic effects in a rat model of cervical SCI. The results showed that intravenous administration of rcMSCs contributed to functional recovery and lesion reduction. rcMSCs may induce an anti-inflammatory environment in SCI.
NEUROSCIENCE LETTERS
(2023)
Article
Critical Care Medicine
Meng Deng, Jing He, Changfu Hao, Yonghua Guo, Huifang Si, Xuedan Deng, Chengpeng Zhang, Shiyu Li, Sanqiao Yao, Wenjie Ren, Wu Yao
Summary: This study investigates the effect of bone marrow mesenchymal stem cells (BMSCs) and exosomes derived from BMSCs (BMSCs-Exo) on blast lung injuries (BLIs) caused by gas explosion in rats. The findings demonstrate that BMSCs and BMSCs-Exo significantly reduce oxidative stress and inflammatory infiltration in the lungs. Additionally, they regulate apoptosis, autophagy, and pyroptosis, suggesting their potential in attenuating BLI.
Article
Dentistry, Oral Surgery & Medicine
Yong Zhang, Jiayao Chen, Haijun Fu, Shuhong Kuang, Feng He, Min Zhang, Zongshan Shen, Wei Qin, Zhengmei Lin, Shuheng Huang
Summary: Our study demonstrated that exosomes derived from mesenchymal stem cells (MSCs) cultured in a 3D system (3D-exos) have enhanced anti-inflammatory effects in periodontitis compared to those from a traditional 2D culture system (2D-exos). This improvement is mediated by the increased expression of miR-1246 in 3D-exos, which suppresses Nfat5 expression and restores the Th17 cell/Treg balance in inflamed periodontal tissues. Furthermore, local injection of 3D-exos also attenuated experimental colitis by rebalancing immune responses.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yelei Cen, Guohua Lou, Jinjin Qi, Minwei Li, Min Zheng, Yanning Liu
Summary: This study aimed to investigate the beneficial effects and potential therapeutic mechanisms of adipose-derived mesenchymal stem cell (AMSC) therapy on acetaminophen-induced liver injury (AILI). The results showed that AMSC therapy effectively ameliorated AILI by inhibiting the JNK-ATM mitochondrial retrograde pathway, improving APAP-induced mitochondrial dysfunction and liver injury.
Article
Toxicology
David S. Umbaugh, Rupal P. Soder, Nga T. Nguyen, Olamide Adelusi, Dakota R. Robarts, Ben Woolbright, Luqi Duan, Sunil Abhyankar, Buddhadeb Dawn, Udayan Apte, Hartmut Jaeschke, Anup Ramachandran
Summary: This study evaluated the effects of clinical grade human Wharton's Jelly mesenchymal stem cells (WJMSCs) on APAP-induced liver injury in a mouse model. The results showed that WJMSCs treatment reduced liver damage caused by APAP and promoted liver recovery, with better effects compared to human dermal fibroblasts (HDFs).
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qianqian Zhu, Shengluan Tang, Yanwen Zhu, Di Chen, Jialyu Huang, Jiaying Lin
Summary: The study demonstrated that CTF1-modified BMSCs-exo could enhance neovascularization and improve endometrial receptivity through promoting endothelial cell proliferation, migration, and tube formation, leading to tissue regeneration, neovascularization, and localized tissue fibrosis suppression in a rat model with endometrial thinning. The upregulation of the JAK/PI3K/mTOR/STAT3 signaling pathways may be responsible for the proangiogenic effects of CTF1 in endometrial regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Anatomy & Morphology
Ejaz Rasool Dar, Mudasir Bashir Gugjoo, Fajar Farooq, Tahir Nazir, Showkat Ahmad Shah, Syed Mudasir Ahmad, Riaz Ahmad Shah, Raja Aijaz Ahmad, Shahid Hussian Dar, Dil Mohammad Makhdoomi
Summary: Peripheral nerve injury is a common clinical condition that often leads to permanent impairment in about 50% of cases. This study compared the regenerative potential of bone marrow-derived (BM) and adipose tissue-derived (AD) mesenchymal stem cells (MSCs) in an acute rabbit sciatic nerve injury model. The results showed that MSCs can improve sciatic nerve healing, but complete regeneration was not achieved at day 90, with BM-MSCs showing a better response than AD-MSCs.
Article
Neurosciences
Zerui Zhuang, Mingfa Liu, Jianming Luo, Xiaolei Zhang, Zhuozhi Dai, Bingna Zhang, Huan Chen, Jiajian Xue, Mingliang He, Haixiong Xu, Anmin Liu
Summary: BMSCs-Exos alleviate glutamate excitotoxicity post-TBI by upregulating GLT-1 level and downregulating p-p38 MAPK level in astrocytes, reducing glutamate levels and attenuating neuronal apoptosis. They demonstrate significant neuroprotective effects in experimental and animal models, reducing cortical lesion volume and improving cognitive function after TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Biochemistry & Molecular Biology
Mariangela Pampalone, Giampiero Vitale, Salvatore Gruttadauria, Giandomenico Amico, Gioacchin Iannolo, Bruno Douradinha, Alessandra Mularoni, Pier Giulio Conaldi, Giada Pietrosi
Summary: This study demonstrates the potential usefulness of hA-MSCs in treating carbapenem-resistant bacterial infections in ascites, with significant effects on bacterial load and immune factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Giovanni Zito, Vitale Miceli, Claudia Carcione, Rosalia Busa, Matteo Bulati, Alessia Gallo, Gioacchin Iannolo, Duilio Pagano, Pier Giulio Conaldi
Summary: This study aimed to define an in vitro model to test the effect of primed hAMSCs in reducing immune and hepatic cell damage caused by IRI. The results showed that IFN-gamma pre-treatment and 3D culture significantly reduced inflammation induced by M1-differentiated macrophages, and primed hAMSCs inhibited parenchymal apoptosis at early reperfusion timepoints by blocking the activation of caspase 3/7.
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Amer M. Alanazi, Giuseppe Lanza, Raffaele Ferri, Filippo Caraci, Fabio Galvano, Sabrina Castellano, Giuseppe Grosso
Summary: This study investigated the relationship between the intake of different types of dietary fats and depressive symptoms in Italian individuals living in the Mediterranean area. The results showed a negative association between moderate intake of polyunsaturated fatty acids (PUFA) and depressive symptoms, while moderate intake of saturated fatty acids (SFA) was positively associated with depressive symptoms. Moreover, individuals with lower to moderate intake of short-chain and medium-chain saturated fatty acids had a lower risk of depressive symptoms. These findings highlight the importance of distinguishing between different fat types.
Article
Nutrition & Dietetics
Justyna Godos, Marialaura Bonaccio, Wahidah H. Al-Qahtani, Wolfgang Marx, Melissa M. Lane, Gian Marco Leggio, Giuseppe Grosso
Summary: This study aimed to investigate the relationship between consumption of ultra-processed foods (UPFs) and depressive symptoms in younger Italian adults. The results showed that individuals with higher UPF consumption had a higher likelihood of having depressive symptoms. This association remained significant even after adjusting for potential confounding factors, indicating a potential link between UPF consumption and depressive symptoms in younger Italian individuals.
Article
Biochemistry & Molecular Biology
Agnieszka Micek, Joanna Jurek, Marcin Owczarek, Ida Guerrera, Sebastiano Alfio Torrisi, Sabrina Castellano, Giuseppe Grosso, Ali A. Alshatwi, Justyna Godos
Summary: Emerging evidence suggests that diets rich in plant-based foods and beverages may have positive effects on human health in reducing the risk of chronic diseases. This study investigated the association between polyphenol-rich beverage intake and mental health outcomes among adults in the Mediterranean area. The results showed that moderate intake of coffee and tea was associated with lower perceived stress and depressive symptoms, while regular coffee and moderate/regular red wine drinkers were less likely to have depressive symptoms. However, no significant associations were found for the intake of these beverages and sleep quality.
Review
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Tamara Y. Forbes-Hernandez, Maria D. Navarro-Hortal, Rosa Quirantes-Pine, Giuseppe Grosso, Francesca Giampieri, Vivian Lipari, Cristina Sanchez-Gonzalez, Maurizio Battino, Jose L. Quiles
Summary: Alzheimer's Disease (AD) is a major cause of global dementia cases, affecting around 50 million people worldwide. The leaves of olive trees contain bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT), which have shown medicinal properties in fighting AD. Olive leaf (OL), OLE, and HT can reduce amyloid-beta and neurofibrillary tangles formation, and OL has exhibited high cholinergic inhibitory activity. These compounds may also decrease neuroinflammation and oxidative stress, potentially promoting autophagy and restoring loss of proteostasis in AD models. Therefore, olive phytochemicals hold promise as an adjuvant in AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Felice Giuliante, Francesca Ratti, Elena Panettieri, Vincenzo Mazzaferro, Alfredo Guglielmi, Giuseppe M. Ettorre, Salvatore Gruttadauria, Fabrizio Di Benedetto, Umberto Cillo, Luciano De Carlis, Raffaele Dalla Valle, Alessandro Ferrero, Roberto Santambrogio, Francesco Ardito, Luca Aldrighetti
Summary: The use of minimally invasive liver surgery has greatly reduced surgical risk for hepatocellular carcinoma. This study analyzed the outcomes of minimally invasive liver surgery for small hepatocellular carcinoma tumors less than 3 cm in size.
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Amer M. Alanazi, Giuseppe Lanza, Raffaele Ferri, Filippo Caraci, Giuseppe Grosso, Fabio Galvano, Sabrina Castellano
Summary: The increase in life expectancy has led to a higher prevalence of age-related neurological diseases, such as cognitive impairment, dementia, and Alzheimer's disease. This study aimed to examine the association between specific categories and subcategories of dietary fats and cognitive status in older Italian adults. The results showed that moderate consumption of certain types of saturated fatty acids and monounsaturated fatty acids was associated with a lower risk of cognitive impairment, while moderate intake of linoleic acid was associated with a higher risk of cognitive impairment.
Letter
Surgery
Salvatore Gruttadauria, Duilio Pagano, Fabrizio di Francesco
UPDATES IN SURGERY
(2023)
Article
Nutrition & Dietetics
Roberta De Vito, Maria Parpinel, Michela Carola Speciani, Federica Fiori, Rachele Bianco, Roberto Caporali, Francesca Ingegnoli, Isabella Scotti, Tommaso Schioppo, Tania Ubiali, Maurizio Cutolo, Giuseppe Grosso, Monica Ferraroni, Valeria Edefonti
Summary: Through a recent cross-sectional study in Italy, we found that consuming half a pizza more than once a week had beneficial effects on disease activity in rheumatoid arthritis (RA) patients, with significant reductions in disease severity. Mozzarella cheese and olive oil, among the pizza-related food items, showed particularly beneficial effects in patients with more severe RA. Future cohort studies are needed to confirm these findings.
Review
Nutrition & Dietetics
Maria P. Mogavero, Justyna Godos, Giuseppe Grosso, Filippo Caraci, Raffaele Ferri
Summary: This review focuses on the relationship between sleep-wake regulation and appetite control, emphasizing the inhibitory effect of OREXIN, a neurotransmitter, on REM sleep. It further examines the intricate relationship between OREXIN, REM sleep, and appetite regulation, shedding light on their interconnected nature in both physiological conditions and diseases. Understanding this complex relationship is crucial for unraveling the mechanisms underlying sleep-wake patterns and metabolic control, and for developing novel therapeutic approaches to sleep disorders and metabolic conditions associated with OREXIN dysregulation.
Article
Nutrition & Dietetics
Monica Guglielmetti, Wahidah H. Al-Qahtani, Cinzia Ferraris, Giuseppe Grosso, Simona Fiorini, Eleonora Tavazzi, Giacomo Greco, Alessandro La Malfa, Roberto Bergamaschi, Anna Tagliabue
Summary: Based on the available data, it is suggested that a balanced diet and healthy lifestyle may improve clinical parameters and quality of life for patients with multiple sclerosis (MS). This study aimed to investigate the relationship between dietary adherence to the Mediterranean Diet (MedDiet) and MS severity in Italian patients. The results showed that higher adherence to the MedDiet was associated with a higher probability of having a mild-to-moderate MS.
Article
Medicine, General & Internal
Duilio Pagano, Ester Badami, Giovanni Zito, Pier Giulio Conaldi, Ivan Vella, Barbara Buscemi, Giandomenico Amico, Rosalia Busa, Paola Salis, Sergio Li Petri, Fabrizio di Francesco, Sergio Calamia, Pasquale Bonsignore, Alessandro Tropea, Caterina Accardo, Salvatore Piazza, Salvatore Gruttadauria
Summary: This study aimed to evaluate the impact of the immune system after graft reperfusion during kidney transplantation in adults in order to identify predictive biomarkers. The study found that the percentage of T-lymphocytes in the liver perfusate was significantly associated with delayed functional recovery and secondary infection. However, there was no significant association between the proportions of NK cells and NK-T cells with clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Samuele Laudani, Justyna Godos, Federica Martina Di Domenico, Ignazio Barbagallo, Cinzia Lucia Randazzo, Gian Marco Leggio, Fabio Galvano, Giuseppe Grosso
Summary: Hypertension and cardiovascular disease are major global causes of death, and increased oxidative stress and inflammation are associated with endothelial dysfunction. Anthocyanins, with their antioxidant and cardioprotective effects, have garnered significant interest, but their detection in blood serum is limited due to metabolism by gut microbiota. This review summarizes the main findings from clinical studies on the cardioprotective effects of anthocyanins, as well as the role of gut microbiota in their metabolism, bioavailability, and impact on microbiota composition. Further research is needed to clarify which molecules and doses of anthocyanins offer vascular benefits, while considering the crucial role of the microbiota.
