Article
Medicine, General & Internal
Malgorzata Kielar, Paulina Dumnicka, Agnieszka Gala-Bladzinska, Alina Bedkowska-Prokop, Ewa Ignacak, Barbara Maziarz, Piotr Ceranowicz, Beata Kusnierz-Cabala
Summary: This study aimed to evaluate urinary NGAL as a predictor of changes in kidney transplant function, finding that high urinary NGAL levels may indicate graft dysfunction or urinary tract infections in clinically stable kidney transplant recipients beyond the first year post-transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yi-Chinn Weng, Yu-Ting Huang, I-Chen Chiang, Pei-Ju Tsai, Yu-Wen Su, Wen-Hai Chou
Summary: The study found that LCN2 has neurotoxic effects on engrafted neurons during neural transplantation and can also modulate neuroinflammatory responses. Inhibition of LCN2 may be useful in reducing rejection after neural transplantation.
Article
Medical Laboratory Technology
Zhimin Huang, Lin Wu, Ming Zeng, Buyun Wu, Xueqiang Xu, Huijuan Mao, Yanggang Yuan, Changying Xing
Summary: This study aimed to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) in differentiating acute kidney injury (AKI) from chronic kidney disease (CKD). The results showed that urinary NGAL (uNGAL) levels were significantly higher in the AKI group compared to the CKD group, while serum NGAL (sNGAL) levels were not significantly different. Furthermore, the u/s NGAL ratio and fractional excretion of NGAL (Fe NGAL) were able to effectively distinguish AKI from CKD. Further confirmatory studies are still necessary.
CLINICA CHIMICA ACTA
(2022)
Article
Gastroenterology & Hepatology
Masato Nakai, Kenichi Morikawa, Takashi Sasaki, Risako Kohya, Sonoe Yoshida, Shunichi Hosoda, Akinori Kubo, Yoshimasa Tokuchi, Takashi Kitagataya, Ren Yamada, Masatsugu Ohara, Takuya Sho, Goki Suda, Koji Ogawa, Naoya Sakamoto
Summary: This study investigated the usefulness of urinary neutrophil gelatinase-associated lipocalin (uNGAL) in predicting the short- and long-term effects of tolvaptan (TVP) and the incidence of acute kidney injury (AKI) post-TVP administration. The results showed that uNGAL can be a useful predictor of the short- and long-term efficacy of TVP and can be used to predict the occurrence of AKI after TVP administration.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Urology & Nephrology
Anthony Batte, Sahit Menon, John M. Ssenkusu, Sarah Kiguli, Robert Kalyesubula, Joseph Lubega, Zachary Berrens, Edrisa Ibrahim Mutebi, Rodney Ogwang, Robert O. Opoka, Chandy C. John, Andrea L. Conroy
Summary: This study investigated the diagnosis of acute kidney injury in low- and middle-income countries. By measuring urine NGAL levels using a dipstick test, it was found that children with sickle cell anemia were at a higher risk of acute kidney injury, and urine NGAL levels may be associated with mortality.
KIDNEY INTERNATIONAL
(2022)
Article
Medical Laboratory Technology
Ahram Yi, Chang-Hoon Lee, Yeo-Min Yun, Hanah Kim, Hee-Won Moon, Mina Hur
Summary: The study suggests that PNGAL may be a useful biomarker for predicting AKI in high-risk patients, however UNGAL may be more effective in predicting AKI in patients with CKD.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
Ze-Liang Qiu, Bi-Qing Yan, Rui Zhao, Dong-Wei Xu, Kan Shen, Xing-Qi Deng, Shi-Qi Lu
Summary: This study aimed to assess the early predictive values of hepcidin, NGAL, and their combination for secondary AKI in patients with sepsis. Results indicated that higher serum hepcidin and urine NGAL levels at admission were independent predictors of AKI development in critically septic patients. Serum hepcidin and urine NGAL were comparable predictive indicators of AKI occurrence, with their combination showing improved accuracy in prediction.
CLINICA CHIMICA ACTA
(2021)
Article
Gastroenterology & Hepatology
Roshan George, Ujjwal Sonika, Bhawna Mahajan, Ashok Sharma, Ashok Dalal, Sanjeev Sachdeva, Ajay Kumar
Summary: This study compared the diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin (UNGAL) and renal resistive index (RRI) in predicting the type of acute kidney injury (AKI) in decompensated cirrhosis (DC) patients. The results showed that UNGAL has an excellent diagnostic accuracy in predicting ATN-AKI.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Medicine, Research & Experimental
Hong Zhou, Juan Cui, You Lu, Jing Sun, Jianzhou Liu
Summary: This study assessed the diagnostic value of NGAL in early diagnosis of AKI among patients with suspected sepsis through a meta-analysis. The results showed that urine NGAL outperformed serum and plasma NGAL in diagnosing AKI. However, further research is needed to clarify the controversial issue regarding the utility of serum and plasma NGAL.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Amaal E. Abdulle, Martin F. Bourgonje, Lyanne M. Kieneker, Sacha la Bastide-van Gemert, Sanne J. Gordijn, Clara Hidden, Tom Nilsen, Ron T. Gansevoort, Douwe J. Mulder, Robin P. F. Dullaart, Martin H. de Borst, Stephan J. L. Bakker, Harry van Goor
Summary: Circulating levels of NGAL are associated with acute kidney injury, severity and progression of CKD. This study investigated NGAL as a potential biomarker for new-onset CKD and found that higher plasma NGAL concentrations are associated with an increased risk of developing CKD in the general population, mainly driven by renal function decline.
Article
Urology & Nephrology
Stuart L. Goldstein, Kelli A. Krallman, Cassie Kirby, Jean-Philippe Roy, Michaela Collins, Kaylee Fox, Alexandra Schmerge, Sarah Wilder, Bradley Gerhardt, Ranjit Chima, Rajit K. Basu, Lakhmir Chawla, Lin Fei
Summary: Acute kidney injury is common among children and young adults admitted to the pediatric intensive care unit, and severe acute kidney injury is associated with mortality. The integration of renal angina index and urine NGAL improves the prediction of severe acute kidney injury.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Critical Care Medicine
Heng-Chih Pan, Shao-Yu Yang, Terry Ting-Yu Chiou, Chih-Chung Shiao, Che-Hsiung Wu, Chun-Te Huang, Tsai-Jung Wang, Jui-Yi Chen, Hung-Wei Liao, Sheng-Yin Chen, Tao-Min Huang, Ya-Fei Yang, Hugo You-Hsien Lin, Ming-Jen Chan, Chiao-Yin Sun, Yih-Ting Chen, Yung-Chang Chen, Vin-Cent Wu
Summary: This study compared the predictive performance of different biomarkers for acute kidney injury (AKI). The biomarkers containing NGAL showed the best predictive accuracy for the occurrence of AKI, especially in medically treated patients. However, the predictive performance of urinary NGAL was limited in surgical patients, and urinary NGAL/creatinine seemed to be the most accurate biomarkers in these patients. All of the biomarkers had similar predictive performance in critically ill patients.
Article
Agriculture, Dairy & Animal Science
Barbara Bruno, Roberta Troia, Francesco Dondi, Cristiana Maurella, Paola Gianella, Ilaria Lippi, Alberto Tarducci, Antonio Borrelli
Summary: This study evaluated the effects of constant rate infusion of HES 130/0.4 on renal biomarkers in dogs. The results indicated that in hypoalbuminemic dogs, the dose and rate of HES infusion did not lead to significant changes in the investigated biomarkers of kidney injury. Further prospective studies are needed to assess the renal safety profile of low-molecular-weight HES administration in more severely affected dogs.
Article
Medicine, General & Internal
Izabela Duda, Lukasz Krzych
Summary: The study demonstrated that plasma NGAL, combined with indices of critical illness, is a useful biomarker for predicting mortality in heterogeneous population of ICU patients. pNGAL on D3 was found to be the most suitable for predicting in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Marcos Antonio Marton Filho, Rodrigo Leal Alves, Paulo do Nascimento Junior, Gabriel dos Santos Tarquinio, Paulo Ferreira Mega, Norma Sueli Pinheiro Modolo
Summary: In laparoscopic cholecystectomy, increased intra-abdominal pressure leads to elevation of NGAL and cystatin C levels intraoperatively, while the use of low-pressure pneumoperitoneum does not alter the course of these biomarkers.