Article
Immunology
Anthos Christofides, Xanthi-Lida Katopodi, Carol Cao, Dimitra Karagkouni, Konstantinos Aliazis, Sasitorn Yenyuwadee, Halil-Ibrahim Aksoylar, Rinku Pal, Mohamed A. A. Mahmoud, Laura Strauss, Natalia M. Tijaro-Ovalle, Louis Boon, John Asara, Ioannis S. Vlachos, Nikolaos Patsoukis, Vassiliki A. Boussiotis
Summary: Mice with targeted SHP-2 deletion in myeloid cells showed reduced tumor growth, similar to mice with targeted PD-1 deletion in myeloid cells. SHP-2 and PD-1-SHP-2 signaling suppress myeloid cell differentiation, resulting in suppressed antitumor immunity.
Article
Cell Biology
Li-Ting Wang, Ming-Hong Lin, Kwei-Yan Liu, Shyh-Shin Chiou, Shen-Nien Wang, Chee-Yin Chai, Li-Wen Tseng, Hsin-Ying Clair Chiou, Hsueh-Chun Wang, Kazunari K. Yokoyama, Shih-Hsien Hsu, Shau-Ku Huang
Summary: WLS in DCs plays a critical role as a molecular chaperone in maintaining ER homeostasis, glycoprotein quality control, and calcium dynamics.
Article
Oncology
Qinqin Liu, Mingqiang Hua, Chen Zhang, Ruiqing Wang, Jinting Liu, Xinyu Yang, Fengjiao Han, Ming Hou, Daoxin Ma
Summary: The bone marrow microenvironment in AML patients exhibits immunosuppressive features, and NLRP3-activated BMDCs are found to promote the differentiation of Th1 cells while inhibiting leukemia cell proliferation. This study sheds light on potential immunotherapeutic strategies for AML patients.
Article
Immunology
Shivana M. Lightman, Jennifer L. Peresie, Louise M. Carlson, G. Aaron Holling, Mackenzie M. Honikel, Colin A. Chavel, Michael J. Nemeth, Scott H. Olejniczak, Kelvin P. Lee
Summary: Humoral immunity is crucial for protecting the body against pathogens, and long-term protective immunity relies on the continual production of neutralizing antibodies by long-lived plasma cells (LLPCs). Recent research has shown that the immunosuppressive enzyme IDO1 plays a key role in sustaining antibody responses and LLPC survival.
Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Min Zhao, Jiangyun Wang, Mei Qu, Yao Zhao, Haihua Wang, Yu Ke, Ying Liu, Zi-Ning Lei, Hong-Min Liu, Zhenbo Hu, Liuya Wei, Zhe-Sheng Chen
Summary: AML, characterized by blocked cell differentiation and immature cell accumulation, is commonly treated with ATRA and ATO, which may lead to irreversible resistance and treatment failure. OGP46 shows potential as a compound to overcome differentiation blockage in AML, especially in cases with t(8;21) translocation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Zhen-Tian Cheng, Xiang-Ping Yuan
Summary: This study demonstrated that aloperine can reduce renal fibrosis caused by unilateral ureteral obstruction by inhibiting the TLR4/MyD88 pathway, reducing inflammation and improving renal condition.
PHARMACOGNOSY MAGAZINE
(2021)
Review
Cell Biology
Sarah E. Bondos, A. Keith Dunker, Vladimir N. Uversky
Summary: Signaling pathways allow cells to detect and respond to various chemical and physical stimuli, forming a communication network that regulates cell activities and coordinates cell function. Successful signaling requires proteins that can form active and inactive states and engage in multiple interactions. Intrinsically disordered proteins play a critical role in cell signaling, present in diverse organisms and stages of signaling pathways.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Yukun Mao, Na Ni, Linjuan Huang, Jiaming Fan, Hao Wang, Fang He, Qing Liu, Deyao Shi, Kai Fu, Mikhail Pakvasa, William Wagstaff, Andrew Blake Tucker, Connie Chen, Russell R. Reid, Rex C. Haydon, Sherwin H. Ho, Michael J. Lee, Tong-Chuan He, Jian Yang, Le Shen, Lin Cai, Hue H. Luu
Summary: The study shows that BMP9 can induce osteogenic and adipogenic differentiation of MSCs by upregulating the expression of AGO proteins. Silencing individual AGO expression leads to a decrease in osteogenic marker activity, while silencing all four AGO genes significantly diminishes BMP9-induced differentiation and bone formation of MSCs. AGO proteins and small RNA biogenesis pathway play an essential role in mediating BMP9-induced osteogenic differentiation of MSCs.
Article
Fisheries
Xiuqin Tang, Meijun Yang, Jiaxin Liu, Libing Zheng, Dongdong Xu, Changfeng Chi, Zhenming Lv, Huihui Liu
Summary: A novel isoform of MyD88, NaMyD88, was identified and functionally characterized in Nibea albiflora. This protein shared high identity with known MyD88 and was found to interact with NaTLR9 in the cytoplasm. Expression of NaMyD88 was detected in various tissues and up-regulated after infection, indicating its involvement in the immune response of N.albiflora.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xi Zhang, Aie Chang, Yanqiang Zou, Heng Xu, Jikai Cui, Zhang Chen, Yuan Li, Yifan Du, Jie Wu, Jizhang Yu, Xinling Du
Summary: Aspirin inhibits the maturation of dendritic cells and the production of pro-inflammatory cytokines, attenuating acute cardiac allograft rejection and promoting regulatory T cells, leading to prolonged allograft survival.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Wei Luo, Julia Z. Z. Adamska, Chunfeng Li, Rohit Verma, Qing Liu, Thomas Hagan, Florian Wimmers, Shakti Gupta, Yupeng Feng, Wenxia Jiang, Jiehao Zhou, Erika Valore, Yanli Wang, Meera Trisal, Shankar Subramaniam, Timothy F. Osborne, Bali Pulendran
Summary: Our previous study showed that the sterol regulatory binding protein (SREBP) pathway is associated with humoral immune response. We generated mice with specific deletion of SCAP, an essential regulator of SREBP signaling, in B cells or CD11c(+) antigen-presenting cells (APCs). Deletion of SCAP in CD11c(+) APCs had no impact on immune responses, whereas SREBP signaling in B cells was crucial for antibody responses and the development of immune cells. These studies reveal the regulatory role of sterol metabolism in humoral immunity.
Review
Immunology
Matthew Garis, Lee Ann Garrett-Sinha
Summary: The review discusses the roles of the Notch signaling pathway in B lymphocyte lineage commitment and its function within mature B cells involved in immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Junbin Chen, Yuguo Liu, Huiyu Luo, Guoxun Chen, Zhongdaixi Zheng, Tiannan Wang, Xinge Hu, Yue Zhao, Jiaqi Tang, Chuhong Su, Longying Zha
Summary: Recent studies have shown that chronic inflammation disrupts cholesterol homeostasis and promotes its accumulation in the liver. This study investigated the relationship between the toll-like receptor 4 (TLR4) inflammatory signaling pathway and cholesterol accumulation. The results revealed that the activation of TLR4/MyD88/NF-kappa B pathway increases SREBP-2-mediated cholesterol accumulation in HepG2 cells.
Article
Immunology
Shuang Li, Dawei Zou, Wenhao Chen, Yating Cheng, Gavin W. Britz, Yi-Lan Weng, Zhaoqian Liu
Summary: BATF is a critical transcription factor that drives the effector program of allogeneic CD8(+) T cells and plays an important role in transplant rejection. BATF(-/-) CD8(+) T cells display a dysfunctional phenotype, lack terminal effector cell differentiation, and show impaired effector differentiation at the memory phase.
FRONTIERS IN IMMUNOLOGY
(2022)