Cutting, dicing, healing and sealing: the molecular surgery of tRNA

Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function

(2014) Ender Karaca et al.   CELL

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

The mammalian tRNA ligase complex mediates splicing ofXBP1mRNA and controls antibody secretion in plasma cells

(2014) Jennifer Jurkin et al.   EMBO JOURNAL

The RtcB RNA ligase is an essential component of the metazoan unfolded protein response

(2014) S. G. Kosmaczewski et al.   EMBO REPORTS

Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1

(2014) J. Wu et al.   GENES & DEVELOPMENT

RTCB-1 Mediates Neuroprotection via XBP-1 mRNA Splicing in the Unfolded Protein Response Pathway

(2014) A. Ray et al.   JOURNAL OF NEUROSCIENCE

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB

(2014) Yanyan Lu et al.   MOLECULAR CELL

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

(2014) Johannes Popow et al.   NATURE

A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation

(2014) Kevin K. Desai et al.   NUCLEIC ACIDS RESEARCH

hCLE/C14orf166 Associates with DDX1-HSPC117-FAM98B in a Novel Transcription-Dependent Shuttling RNA-Transporting Complex

(2014) Alicia Pérez-González et al.   PLoS One

CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders

(2014) Stefan Weitzer et al.   Wiley Interdisciplinary Reviews-RNA

Welcome to the new tRNA world!

(2014) Akio Kanai   Frontiers in Genetics

Handling tRNA introns, archaeal way and eukaryotic way

(2014) Tohru Yoshihisa   Frontiers in Genetics

Unusual Noncanonical Intron Editing Is Important for tRNA Splicing in Trypanosoma brucei

(2013) Mary Anne T. Rubio et al.   MOLECULAR CELL

CLP1 links tRNA metabolism to progressive motor-neuron loss

(2013) Toshikatsu Hanada et al.   NATURE

Diversity and roles of (t)RNA ligases

(2012) Johannes Popow et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Beyond tRNA cleavage: novel essential function for yeast tRNA splicing endonuclease unrelated to tRNA processing

(2012) N. Dhungel et al.   GENES & DEVELOPMENT

Novel Mechanism of RNA Repair by RtcB via Sequential 2′,3′-Cyclic Phosphodiesterase and 3′-Phosphate/5′-Hydroxyl Ligation Reactions

(2011) Naoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RtcB, a Novel RNA Ligase, Can Catalyze tRNA Splicing andHAC1mRNA Splicingin Vivo

(2011) Naoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RtcB Is the RNA Ligase Component of anEscherichia coliRNA Repair Operon

(2011) Naoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel three-unit tRNA splicing endonuclease found in ultrasmall Archaea possesses broad substrate specificity

(2011) Kosuke Fujishima et al.   NUCLEIC ACIDS RESEARCH

The intron of tRNA-TrpCCA is dispensable for growth and translation of Saccharomyces cerevisiae

(2011) S. Mori et al.   RNA

HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex

(2011) J. Popow et al.   SCIENCE

Biogenesis of spliceosomal small nuclear ribonucleoproteins

(2011) Utz Fischer et al.   Wiley Interdisciplinary Reviews-RNA

The tertiary structure of group II introns: implications for biological function and evolution

(2010) Anna Marie Pyle   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Branchiostoma floridae has separate healing and sealing enzymes for 5'-phosphate RNA ligation

(2010) M. Englert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-splicing endonuclease structure and function

(2008) K. Calvin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia

(2008) Birgit S Budde et al.   NATURE GENETICS

GtRNAdb: a database of transfer RNA genes detected in genomic sequence

(2008) P. P. Chan et al.   NUCLEIC ACIDS RESEARCH

Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo

(2008) A. Ramirez et al.   RNA