Article
Multidisciplinary Sciences
Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O'Connell, Alastair D. G. Lawson
Summary: TNF can be inhibited by small molecules that stabilize the TNF trimer in an asymmetric conformation. The authors also developed a monoclonal antibody that selectively binds this inactive form of TNF, enabling both target engagement assessment and structural characterization of TNF binding to TNF receptor 1.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Valentina Palmerini, Silvia Monzani, Quentin Laurichesse, Rihab Loudhaief, Sara Mari, Valentina Cecatiello, Vincent Olieric, Sebastiano Pasqualato, Julien Colombani, Ditte S. Andersen, Marina Mapelli
Summary: The Drosophila tumour necrosis factor (TNF) system consists of a single ligand, Eiger (Egr), and two receptors. The crystallographic structure of Egr in complex with the extracellular domain of the receptor Grindelwald suggests that distinct affinities of TNF ligand for its receptors mediate non-redundant functions.
NATURE COMMUNICATIONS
(2021)
Review
Gastroenterology & Hepatology
Roberta Figueiroa Souza, Marcos Antonio Ferreira Caetano, Henrique Inhauser Riceti Magalhaes, Patricia Castelucci
Summary: Ulcerative colitis (UC) and Crohn's disease (CD) are types of Inflammatory Bowel Diseases (IBD) characterized by bowel necrosis and the involvement of enteric neurons and glial cells. The main inflammatory mediator is tumor necrosis factor-alpha (TNF-alpha), which is also associated with the production of other cytokines like interleukins (IL). TNF-alpha acts through two receptors, TNFR1 and TNFR2, which have been detected in IBD and their expression correlates with disease activity. Biologic agents targeting TNF-alpha have revolutionized IBD treatment by inducing and maintaining disease remission in a majority of patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Olga Zbodakova, Karel Chalupsky, Lenka Sarnova, Petr Kasparek, Marketa Jirouskova, Martin Gregor, Radislav Sedlacek
Summary: ADAM10 and ADAM17 play concurrent roles in liver regeneration and fibrosis, affecting growth receptor signaling and TNF RI release. Their pathological roles are context-dependent, with antagonistic effects observed in some models but not others.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ping Li, Yang Yang, Xinyu Yang, Yifei Wang, Chon-Kit Chou, Mengmeng Jiang, Jingbin Zheng, Fengyang Chen, Xin Chen
Summary: The study found that TNF receptor type II (TNFR2) is expressed in a wide range of tumor cells. Knocking out TNFR2 in mouse colon cancer cells MC38 and CT26 using CRISPR/Cas9 technology inhibited in vitro proliferation and colony formation of cancer cells through inhibition of AKT phosphorylation and promotion of autophagy-induced cell death. In addition, TNFR2 deficiency significantly impaired the in vivo growth of MC38 or CT26 tumors in mice, accompanied by a decrease in soluble TNFR2 levels in the circulation and an increase in the number of tumor-infiltrating IFN gamma+ CD8 cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xiao-Han Tang, Marta Melis, Karen Mai, Lorraine J. Gudas, Steven E. Trasino
Summary: This study demonstrated the potential anti-ALD properties of fenretinide in a mouse model of chronic ethanol exposure, showing its ability to modulate intestinal permeability, reduce endotoxemia, and decrease inflammation, suggesting further investigation as a potential anti-ALD drug.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Hao Yang, Heng Li, Fen Yang, Ze Tao, Qiuxiao Shi, Tianshan She, Yanru Feng, Zhao Li, Jie Chen, Yi Zhong, Tao Su, Wengjuan Zeng, Yong Zhang, Shisheng Wang, Lan Li, Tingting Long, Dan Long, Jingqiu Cheng, Hong Zhu, Xiaofeng Lu
Summary: Increasing the valency of death receptor agonist by promoting higher-order receptor clustering is an efficient way to induce tumor cell apoptosis. However, currently available strategies to improve the clustering ability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) often result in large proteins with poor tumor penetration. In this study, we demonstrate that covalent protein ligation using small molecular superglues can assemble higher-order TRAIL variants, leading to significantly increased apoptosis induction in vitro and in vivo.
Article
Oncology
Yangyang Wang, Wei Zhang, Hongbin Ge, Xu Han, Jiangchao Wu, Xuqi Sun, Ke Sun, Wanyue Cao, Chao Huang, Jingsong Li, Qi Zhang, Tingbo Liang
Summary: Tumor micronecrosis is a histopathological feature that predicts poor prognosis in patients with hepatocellular carcinoma (HCC). This study aimed to evaluate the role of tumor micronecrosis in liver transplantation for HCC. The findings suggest that HCC patients with tumor micronecrosis have worse prognosis and tumor micronecrosis can help predict recurrence-free survival after liver transplantation.
Review
Medicine, Research & Experimental
Farid Ghorbaninezhad, Patrizia Leone, Hajar Alemohammad, Basira Najafzadeh, Niloufar Nourbakhsh, Marcella Prete, Eleonora Malerba, Hossein Saeedi, Neda Tabrizi, Vito Racanelli, Behzad Baradaran
Summary: This study reviews the dual role of tumor necrosis factor-alpha (TNF-alpha) in systemic lupus erythematosus (SLE), as well as the efficacy and safety of anti-TNF-alpha therapies in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Wen-juan Jiang, Chuan-ting Xu, Chang-lin Du, Jia-hui Dong, Song-bing Xu, Bing-feng Hu, Rui Feng, Dan-dan Zang, Xiao-ming Meng, Cheng Huang, Jun Li, Tao-tao Ma
Summary: This study revealed a novel cell communication mechanism between tubular epithelial cells and macrophages in diabetic nephropathy. The communication is mediated by extracellular vesicles enriched with LRG1 and TRAIL, leading to worsened kidney damage and activation of inflammation.
Article
Medicine, General & Internal
Nader Abraham, Min Zhang, Paul Cray, Qimeng Gao, Kannan P. Samy, Ryan Neill, Greta Cywinska, JonCarlo Migaly, Riley Kahan, Arya Pontula, Samantha E. Halpern, Caroline Rush, Jude Penaflor, Samuel J. Kesseli, Madison Krischak, Mingqing Song, Matthew G. Hartwig, Justin J. Pollara, Andrew S. Barbas
Summary: Based on a rat model, this study shows that during SNMP, the biliary compartment is more sensitive in detecting graft injury compared to the perfusate compartment. Additionally, using acRTMP provides better graft preservation in DCD liver transplantation compared to SCS.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Hojjat Alizadeh Zeinabad, Eva Szegezdi
Summary: TRAIL, as a promising anticancer drug with low toxicity, has not been successfully translated into a therapeutic molecule due to its short in vivo half-life and tumor cells' resistance. Nanotechnology shows potential to overcome these limitations and offers better solutions.
Article
Fisheries
Yaojia Zhou, Ping Ouyang, Yu Tao, Lizi Yin, Kaiyu Wang, Yi Geng, Weiming Lai, Defang Chen, Hongrui Guo, Jing Fang, Zhengli Chen, Li Tang, Xiaoli Huang
Summary: This study revealed the regulatory role of CyHV-3 vTNFRs in host immune response and cell apoptosis, indicating that vTNFRs participate in virus invasion by up-regulating the expression levels of certain immune-related factors and inducing cell apoptosis.
AQUACULTURE REPORTS
(2021)
Article
Neurosciences
Peipei Guan, Di Zhu, Pu Wang
Summary: This study demonstrates that meloxicam inhibits neuronal apoptosis by deactivating TNFRSF25, leading to the improvement of memory loss in Alzheimer's disease mice.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biology
Brett D. Anderson, Erek D. Nelson, DongJin Joo, Bruce P. Amiot, Aleksandr A. Katane, Alyssa Mendenhall, Benjamin G. Steiner, Aron R. Stumbras, Victoria L. Nelson, R. Noelle Palumbo, Thomas W. Gilbert, Dominique S. Davidow, Jeffrey J. Ross, Scott L. Nyberg
Summary: Organ bioengineering provides a promising solution to the shortage of donor organs. Anderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver scaffold that had been previously reendothelialized, a significant advancement in generating transplantable livers of a clinically relevant size for humans.
COMMUNICATIONS BIOLOGY
(2021)
