Article
Gastroenterology & Hepatology
Xuefeng Luo, Tong Xiang, Junchao Wu, Xiaoze Wang, Yongjun Zhu, Xiaotan Xi, Yuling Yan, Jinlin Yang, Juan Carlos Garcia-Pagan, Li Yang
Summary: This study compared the efficacy and safety of endoscopic cyanoacrylate injection and balloon-occluded retrograde transvenous obliteration (BRTO) to prevent rebleeding in patients with cirrhosis and gastric varices. The results showed that BRTO was more effective in preventing rebleeding from gastric varices, with similar impacts on complications and mortality.
Article
Medicine, Research & Experimental
Wen Zhao, Ningning Xue, Po Cui, Lingdi Liu, Yiqi Wang, Xiaoxiao Zhang, Yuhui Tang, Huijuan Du, Yuemin Nan
Summary: This study found that plasma YAP1 levels were significantly elevated in cirrhotic patients with esophageal varices, making it a potential noninvasive biomarker for predicting EV and HRV. Logistic regression analysis showed that YAP1 is an independent predictor for these conditions, with specific cut-off values providing high diagnostic performance.
BIOMARKERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Bogdan Dumitru Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Luis Ibanez, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nouria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Helene Larrue, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Remy Schwarzer, Christian Jansen, Marie-Angele Robic, Irene Conejo, Javier Martinez Gonzalez, Maria Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Georgina Casanovas, Jaume Bosch, Juan-Carlos Garcia-Pagan, Dominique Thabut
Summary: pTIPS is more effective in improving survival compared to endoscopic treatment for high-risk patients with cirrhosis and variceal bleeding. HE at admission does not affect the efficacy of pTIPS.
Article
Medicine, General & Internal
Bozhidar Hristov, Vladimir Andonov, Daniel Doykov, Katya Doykova, Siyana Valova, Emiliya Nacheva-Georgieva, Petar Uchikov, Gancho Kostov, Mladen Doykov, Eduard Tilkian
Summary: Portal hypertension (PH) and esophageal varices (EVs) are common complications of liver cirrhosis. This study aimed to investigate whether liver stiffness measured by 2D-SWE can predict the presence and severity of EVs in cirrhotic patients. The results showed that 2D-SWE can be used as a non-invasive method for assessing high-grade esophageal varices, while upper endoscopy remains the method of choice for other grades.
Article
Gastroenterology & Hepatology
Jose Ricardo Borem Lopes, Alexandre Rodrigues Ferreira, Priscila Menezes Ferri Liu, Thais Costa Nascentes Queiroz, Eleonora Druve Tavares Fagundes, Julio Rocha Pimenta, Jose Andrade Franco Neto, Simone Diniz Carvalho, Maria Eduarda Marques Borges, Lucas Garcia de Figueiredo Colin
Summary: This study evaluated non-invasive predictive factors of varices with a high risk of bleeding in pediatric cirrhotic patients. The risk score and aspartate aminotransferase-to-platelet ratio index were found to be predictive of high-risk varices, with good sensitivity to identify these patients.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cheng Yan, Xinjun Han, Xiaohong Liang, Jidong Jia, Youqing Xu, Liqin Zhao
Summary: The study indicates that splenic hemodynamic parameters measured using low-dose perfusion CT can be used to noninvasively evaluate the severity of esophageal varices in cirrhotic patients. Patients with EV showed higher PS, V-S, and BV-S, while lower BV and BF compared to the control group.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Medicine, General & Internal
Sarah-Louise Gillespie, Norma C. McAvoy, Diana E. Yung, Alexander Robertson, John N. Plevris, Peter C. Hayes
Summary: Endoscopic thrombin injection is effective and safe for treating gastric varices and other portal-hypertension-related bleeding, including esophageal varices, ulcers secondary to endoscopic band ligation, and ectopic varices. Although there is a relatively high rate of rebleeding, overall mortality does not significantly differ between patient groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuling Yan, Xian Xing, Xiaoze Wang, Li Yang
Summary: Using liver stiffness measured by two-dimensional shear wave elastography and platelet count can help rule out high-risk varices in patients with compensated advanced chronic liver disease. Applying the new criteria of LS < 16 kPa and PLT > 100 x 10(9)/L may potentially spare more endoscopy screenings with a miss rate of less than 5% for high-risk varices.
EUROPEAN RADIOLOGY
(2022)
Article
Medical Laboratory Technology
Huan Liu, Peng Chen, Bei Jiang, Fei Li, Tao Han
Summary: The study found that platelet parameters and related scoring systems can effectively predict the presence of esophageal varices and para-esophageal veins in patients with liver cirrhosis, and have good predictive value.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yue Liu, Hao-yan Tan, Xiao-guang Zhang, Yan-hua Zhen, Fan Gao, Xue-feng Lu
Summary: Liver stiffness and spleen stiffness measured by point shear wave elastography and 2D shear wave elastography have good accuracy in predicting high-risk esophageal varices.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yudai Koya, Michihiko Shibata, Tatsuyuki Watanabe, Shinsuke Kumei, Koichiro Miyagawa, Shinji Oe, Yuichi Honma, Keiichiro Kume, Ichiro Yoshikawa, Masaru Harada
Summary: Esophageal variceal bleeding is associated with gastroesophageal flap valve, and abnormal GEFV is an independent risk factor for esophageal variceal bleeding and appearance of RC sign.
DIGESTIVE ENDOSCOPY
(2021)
Article
Medicine, General & Internal
Yifei Huang, Wenhui Zhang, Huiling Xiang, Yanna Liu, Lili Yuan, Liyao Zhang, Shengjuan Hu, Dongli Xia, Jia Li, Min Gao, Xing Wang, Xingsi Qi, Lijun Peng, Ying Song, Xiqiao Zhou, Jing Zeng, Xiaoyan Tan, Mingming Deng, Haiming Fang, Shenglin Qi, Song He, Yongfeng He, Bin Ye, Wei Wu, Tong Dang, Jiangbo Shao, Wei Wei, Jianping Hu, Xin Yong, Chaohui He, Jinlun Bao, Yuening Zhang, Guo Zhang, Rui Ji, Yang Bo, Wei Yan, Hongjiang Li, Yanling Wang, Mengmeng Li, Fengmei Wang, Jia Lian, Chang'en Liu, Ping Cao, Zhenbei Liu, Aimin Liu, Lili Zhao, Shuang Li, Yunhai Wu, Ye Gu, Yan Wang, Yanfei Fang, Pan Jiang, Bin Wu, Chuan Liu, Xiaolong Qi
Summary: This study compared the outcomes of emergency endoscopic injection sclerotherapy (EIS) and endoscopic variceal ligation (EVL) in cirrhotic patients with acute esophageal variceal bleeding (EVB). The results showed that both EIS and EVL were efficient strategies for the treatment of acute EVB, with EIS being a cost-effective option.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Veeral Ajmera, Beom Kyung Kim, Kun Yang, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Natalie E. Quach, Xin Tu, Xinlian Zhang, Mazen Noureddin, Alina M. Allen, Rohit Loomba
Summary: Liver stiffness assessed by magnetic resonance elastography (MRE) is associated with liver-related events, and the combination of MRE and Fibrosis-4 has excellent negative predictive value for hepatic decompensation.
Article
Gastroenterology & Hepatology
Jordan S. Sack, Michael Li, Stephen D. Zucker
Summary: Among cirrhotic patients, esophageal varices did not increase the risk of overt gastrointestinal bleeding following transesophageal echocardiography (TEE). The likelihood of a hemoglobin decline by at least 2 g/dL or blood transfusion within 48 hours after TEE was not significantly higher in patients with esophageal varices after adjusting for confounders. The timing of upper endoscopy relative to TEE did not impact the risk of secondary outcomes, suggesting routine preprocedural endoscopy may have limited utility.
HEPATOLOGY COMMUNICATIONS
(2021)
Review
Gastroenterology & Hepatology
Liwei Jing, Qiumeng Zhang, Ziwei Chang, Hui Liu, Xuan Shi, Xingyu Li, Jing Wang, Yanbo Mo, Xiujing Zhang, Lizhuan Ma, Zhiting Li, Chao Zhang
Summary: This study evaluated the effectiveness of non-surgical secondary prophylaxis interventions for esophageal varices rebleeding in cirrhotic patients. The results showed that TIPS was more effective in reducing the incidence of rebleeding, rebleeding-related mortality, and overall mortality in cirrhotic patients compared to other interventions.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Surgery
Sae Hee Ko, Robert Hye, David A. Frankel
ANNALS OF VASCULAR SURGERY
(2015)
Article
Surgery
Robert J. Hye, Ariane Mackey, Michael D. Hill, Jenifer H. Voeks, David J. Cohen, Kaijun Wang, MeeLee Tom, Thomas G. Brott
JOURNAL OF VASCULAR SURGERY
(2015)
Article
Surgery
Robert J. Hye, Tazo S. Inui, Faith F. Anthony, Mary-Lou Kiley, Robert W. Chang, Thomas F. Rehring, Nicolas A. Nelken, Bradley B. Hill
JOURNAL OF VASCULAR SURGERY
(2015)
Article
Surgery
Marshall J. Orloff, Robert J. Hye, Henry O. Wheeler, Jon I. Isenberg, Kevin S. Haynes, Florin Vaida, Barbara Girard, Karen J. Orloff
Article
Surgery
Marshall J. Orloff, Jon I. Isenberg, Henry O. Wheeler, Kevin S. Haynes, Horacio Jinich-Brook, Roderick Rapier, Florin Vaida, Robert J. Hye, Susan L. Orloff
AMERICAN JOURNAL OF SURGERY
(2012)
Article
Surgery
Marshall J. Orloff, Jon I. Isenberg, Henry O. Wheeler, Kevin S. Haynes, Horacio Jinich-Brook, Roderick Rapier, Florin Vaida, Robert J. Hye, Susan L. Orloff
AMERICAN JOURNAL OF SURGERY
(2012)
Article
Gastroenterology & Hepatology
Marshall J. Orloff, Jon I. Isenberg, Henry O. Wheeler, Kevin S. Haynes, Horacio Jinich-Brook, Roderick Rapier, Florin Vaida, Robert J. Hye
JOURNAL OF GASTROINTESTINAL SURGERY
(2010)
Article
Gastroenterology & Hepatology
Marshall J. Orloff, Jon I. Isenberg, Henry O. Wheeler, Kevin S. Haynes, Horacio Jinich-Brook, Roderick Rapier, Florin Vaida, Robert J. Hye
JOURNAL OF GASTROINTESTINAL SURGERY
(2011)
Article
Gastroenterology & Hepatology
Marshall J. Orloff, Florin Vaida, Kevin S. Haynes, Robert J. Hye, Jon I. Isenberg, Horacio Jinich-Brook
JOURNAL OF GASTROINTESTINAL SURGERY
(2012)
Article
Surgery
Marshall J. Orloff, Jon I. Isenberg, Henry O. Wheeler, Kevin S. Haynes, Horacio Jinich-Brook, Roderick Rapier, Florin Vaida, Robert J. Hye, Susan L. Orloff
JOURNAL OF SURGICAL RESEARCH
(2012)
Article
Surgery
Marshall J. Orloff, Florin Vaida, Jon I. Isenberg, Henry O. Wheeler, Kevin S. Haynes, Horacio Jinich-Brook, Roderick Rapier, Robert J. Hye, Susan L. Orloff
JOURNAL OF SURGICAL RESEARCH
(2012)
Article
Surgery
Karen Woo, Patrick R. Cook, Joy Garg, Robert J. Hye, Timothy G. Canty
JOURNAL OF VASCULAR SURGERY
(2010)
Article
Surgery
Robert J. Hye, Andrea E. Smith, Gary H. Wong, Southida S. Vansomphone, Ronald D. Scott, Michael H. Kanter
JOURNAL OF VASCULAR SURGERY
(2014)
Article
Surgery
Robert J. Hye, Eric K. Peden, Timothy P. O'Connor, Barry J. Browne, Bradley S. Dixon, Andres S. Schanzer, Stephen C. Jensik, Laura M. Dember, Michael R. Jaff, Steven K. Burke
JOURNAL OF VASCULAR SURGERY
(2014)
Article
Clinical Neurology
Karen Woo, Joy Garg, Robert J. Hye, Ralph B. Dilley