Article
Microbiology
Ryuta Uraki, Masaki Imai, Mutsumi Ito, Hiroaki Shime, Mizuyu Odanaka, Moe Okuda, Yoshihiro Kawaoka, Sayuri Yamazaki
Summary: This study showed that transient Treg-cell depletion without adjuvants in mice induced protective antigen-specific immunity to SARS-CoV-2, including the production of antibodies and cellular immune responses. The manipulation of Treg cells could activate antigen-presenting DCs, offering an innovative approach to vaccine design for SARS-CoV-2 and emerging variants.
Article
Immunology
Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen
Summary: There is evidence that topical administration of TET nanoemulsion can stimulate the expansion of Tregs through the TNF-TNFR2 pathway and inhibit the development of psoriasis-like disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Hyunju Oh, Jingyao Zhao, Yenkel Grinberg-Bleyer, Thomas S. Postler, Pingzhang Wang, Sung-Gyoo Park, Raul Rabadan, Matthew S. Hayden, Sankar Ghosh
Summary: This study demonstrates the essential role of PDK1 in both T cell activation and Treg cell suppressive activity, with PDK1 regulating Treg cell gene expression and suppressor function primarily through the NF-κB pathway.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Daniel S. Shin, Sneha Ratnapriya, Creel Ng Cashin, Lucy F. Kuhn, Rod A. Rahimi, Robert M. Anthony, James J. Moon
Summary: Self-antigen-specific T cells are regulated through tolerance mechanisms, but tissue injury can disrupt this regulation and trigger autoimmunity. Using mouse models of lung injury, we found that acute injury leads to the expansion of CD4+ regulatory T cells (Tregs) that specifically recognize self-antigen. Conventional CD4+ T cells with the same self-antigen specificity remained unresponsive even after Treg ablation. Therefore, the self-antigen-specific CD4+ T cell repertoire plays a regulatory role in limiting tissue damage and autoimmunity during acute injury.
Article
Oncology
Huanhe Ni, Huanling Zhang, Lin Li, He Huang, Hui Guo, Lin Zhang, Chunwei Li, Jing-Xiao Xu, Cai-Ping Nie, Kui Li, Xiaoshi Zhang, Xiaojun Xia, Jiang Li
Summary: In this study, it was found that increased STING and CCL22 levels, as well as higher levels of FOXP3(+) cells and lower levels of CD8(+) cells in tumor tissues of cervical cancer, predicted poor survival. Activation of STING signaling in cooperation with T cell receptor and other signals promoted iTreg differentiation in both human and murine CD4(+) naive T cells. Additionally, tumor-derived exosomes were found to activate STING signaling in tumor-infiltrated T cells, leading to iTreg expansion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Article
Multidisciplinary Sciences
Pawan K. Gupta, Jennifer B. Allocco, Jane M. Fraipont, Michelle L. McKeague, Peter Wang, Michael S. Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li, Jorge Andrade, Jose R. Conejo-Garcia, Anita S. Chong, Maria-Luisa Alegre
Summary: This study investigates the susceptibility of Tconvs to Treg suppression during tolerance induction in transplantation. The findings suggest that transplantation tolerance is associated with an increased sensitivity of alloreactive Tconvs to Treg suppression, which is regulated by the expression of the transcription factor Satb1. Targeting Satb1 could potentially be a strategy to improve transplant outcomes by modulating Treg-sparing immunosuppressive therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Yifei Wang, Jingbin Zheng, Md Sahidul Islam, Yang Yang, Yuanjia Hu, Xin Chen
Summary: Tregs play a crucial role in COVID-19, influencing disease severity and immunopathology mechanisms. They may help regulate immune responses in the early stages and alleviate organ damage in the later stages.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Rulin Zhuang, Qingshu Meng, Xiaoxue Ma, Shanshan Shi, Shiyu Gong, Jing Liu, Mimi Li, Wenchao Gu, Dan Li, Xumin Zhang, Zhulin Wang, Xinyu Ge, Jiayou Tang, Fang Lin, Xiaoting Liang, Liang Zheng, Zhongmin Liu, Xiaohui Zhou
Summary: Research suggests that FoxP3(+)CD73(+) Tregs play a crucial role in inflammation resolution and cardiac healing post-myocardial infarction. CD73 deficiency in Tregs affects tissue tropism and immunosuppressive function.
Article
Biochemistry & Molecular Biology
Engku Nur Syafirah Engku Abd Rahman, Ahmad Adebayo Irekeola, Rafidah Hanim Shueb, Norhafiza Mat Lazim, Rohimah Mohamud, Xin Chen, Liyana Ghazali, Nik Mohd Syahrul Hafizzi Awang, Ali Haron, Yean Yean Chan
Summary: This study explored the expression of TNFR2 by regulatory T cells in nasopharyngeal carcinoma patients and found that these cells exhibited higher proliferation, migration, and survival capacity. Additionally, they expressed higher levels of cytokines associated with disease progression and poor prognosis.
Article
Multidisciplinary Sciences
Roman Istomine, Tho-Alfakar Al-Aubodah, Fernando Alvarez, Jacob A. Smith, Carston Wagner, Ciriaco A. Piccirillo
Summary: CD4(+) T cells are crucial for adaptive immunity, and their differentiation into specific subsets is regulated by transcriptional programs. However, recent research has revealed that mRNA translation plays a significant role in determining the abundance of proteins and has identified eIF4E as a central transcript involved in this process. By studying mice lacking eIF4E-binding proteins (BP-/-), researchers found that altered eIF4E activity led to enhanced Th1 responses and differentiation, increased TCR activation, and elevated glycolytic activity in effector T cells. These findings highlight the potential therapeutic target of the eIF4EBP-eIF4E axis for controlling abnormal T cell responses.
Article
Oncology
Tianzhen He, Yibo Chen, De Yang, Md Sahidul Islam, Chon-Kit Chou, Jiarui Liu, Denise L. Faustman, Joost J. Oppenheim, Xin Chen
Summary: This study found that an anti-mouse TNFR2 antibody TY101 can inhibit the proliferative expansion of Tregs and promote their death. In a mouse tumor model, TY101 antibody treatment effectively inhibited tumor growth and triggered potent antitumor immune responses.
Article
Multidisciplinary Sciences
Kazuyuki Kasahara, Naoto Sasaki, Hilman Zulkifli Amin, Toru Tanaka, Sayo Horibe, Tomoya Yamashita, Ken-Ichi Hirata, Yoshiyuki Rikitake
Summary: This study demonstrates that Foxp3(+) Tregs can suppress pro-inflammatory CD4(+) T cell immune responses to control the development of atherosclerosis under hypercholesterolemia.
