Article
Surgery
Hillary J. Braun, Ana Marie Torres, Finesse Louie, Sandy Weinberg, Sang-Mo Kang, Nancy L. Ascher, John P. Roberts
Summary: Living donor liver transplantation (LDLT) is more common in Asia than in North America, where living donor kidney transplantation, including paired exchanges for ABO-incompatible pairs, is prevalent. The first liver paired exchange (LPE) in the United States, completed over two consecutive days, was initiated by a non-directed donor and benefited an ABO-incompatible pair. This innovative approach demonstrates the feasibility of LPE in centers with experience in LDLT, offering new possibilities for transplantation in cases of ABO incompatibility.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Basri Satilmis, Sami Akbulut, Tevfik Tolga Sahin, Yasin Dalda, Adem Tuncer, Zeynep Kucukakcali, Zeki Ogut, Sezai Yilmaz
Summary: This study evaluated the course of liver regeneration after living donor hepatectomy using routine and regeneration-related biomarkers. The results showed that regenerative markers increased in a sustained fashion following the surgery, especially in right-lobe grafts, indicating progenitor-associated liver regeneration.
Article
Surgery
Babak J. Orandi, Rhiannon D. Reed, Haiyan Qu, Grace Owens, Sydney Brooks, A. Cozette Killian, Vineeta Kumar, Saulat S. Sheikh, Robert M. Cannon, Douglas J. Anderson, Cora E. Lewis, Jayme E. Locke
Summary: This study surveyed living kidney donors to understand their perspectives on follow-up laboratory testing. The completion of 6-month testing was strongly associated with the completion of 12-month testing. Donors who did not prioritize testing and forgot to get labs drawn until reminded were more likely to complete the testing.
CLINICAL TRANSPLANTATION
(2022)
Article
Immunology
Hillary J. Braun, Joshua D. Grab, Jennifer L. Dodge, Shareef M. Syed, Garrett R. Roll, Marisa P. Schwab, Iris H. Liu, Alexa C. Glencer, Chris E. Freise, John P. Roberts, Nancy L. Ascher
Summary: The study found that approximately 10% of patients who underwent living donor liver transplantation required retransplantation. Patients who received retransplantation had significantly lower survival rates compared to those who only underwent primary transplantation.
Article
Medicine, General & Internal
Seoung Hoon Kim, Jang Ho Park, Byoung Ho An
Summary: This study introduces how to perform LDLT with minimal manpower and evaluates the outcomes in adult patients. It shows that under the supervision of a single expert surgeon, a team of minimal manpower can successfully perform all the main surgical procedures without compromising the results.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Surgery
Dieter Broering, Mark L. Sturdevant, Ahmed Zidan
Summary: Living donation is a crucial resource for organ transplantation, and advancements in minimally invasive surgical techniques are improving safety and outcomes for living donors. The introduction of robotic platforms with advanced instruments is allowing for better emulation of open surgeries in a closed abdomen, potentially leading to wider adoption of minimally invasive donor surgeries.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim M. Olthoff, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Tiffany CL. Wong, Chung-Mau Lo, Kiyoshi Hasegawa, Deniz Balci, Mark Cattral, Gonzalo Sapisochin, Nazia Selzner, Long Bin Jeng, Dieter Broering, Jae-Won Joh, Chao-Long Chen, Kyung-Suh Suk, Mohamed Rela, Pierre-Alain Clavien
Summary: This study aims to establish benchmark values for adult-to-adult living-donor liver transplantation (LDLT). By analyzing data from 15 high-volume centers, it was found that benchmark LDLT can reduce waitlist mortality, with Asian centers outperforming others and non-benchmark low-volume centers displaying inferior outcomes.
Article
Gastroenterology & Hepatology
Ehab E. Abdel-Khalek, Mohamed Abdel-Wahab, Mohamed H. Elgazzar, Mahmoud A. Khattab, Abdel-Hady El-Gilany, Hesham M. Elgouhari, Ahmed Shehta
Summary: This study examined the long-term health consequences of living liver donation and found that living liver donors had lower scores in physical functioning, role limitations, energy/fatigue, and bodily pain compared to non-donors. However, donors whose recipients received a liver transplant had higher scores on health-related quality of life measures.
LIVER TRANSPLANTATION
(2022)
Article
Pediatrics
Takehisa Ueno, Koki Takase, Chiyoshi Toyama, Koichi Deguchi, Kazunori Masahata, Motonari Nomura, Miho Watanabe, Masafumi Kamiyama, Yuko Tazuke, Kazuhiko Bessho, Hiroomi Okuyama
Summary: This study examined the relationship between serum autotaxin levels and histological findings in pediatric patients who underwent living donor liver transplant (LDLT) for biliary atresia (BA). The results showed that serum autotaxin levels were associated with the degree of fibrosis after transplantation, and were higher in patients with portal vein complications.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Gastroenterology & Hepatology
Tomoharu Yoshizumi, Shinji Itoh, Mototsugu Shimokawa, Shoichi Inokuchi, Noboru Harada, Kazuki Takeishi, Yohei Mano, Shohei Yoshiya, Takeshi Kurihara, Yoshihiro Nagao, Toru Ikegami, Yuji Soejima, Masaki Mori
Summary: The study demonstrates that simultaneous splenectomy after living donor liver transplantation can prevent small-for-size graft syndrome and improve graft survival rates. It is recommended to perform simultaneous splenectomy for patients with predicted small grafts, portal hypertension, or high portal pressure.
JOURNAL OF HEPATOLOGY
(2021)
Article
Surgery
Kwang-Woong Lee, YoungRok Choi, Suk Kyun Hong, Sola Lee, Su Young Hong, Sanggyun Suh, Eui Soo Han, Nam-Joon Yi, Kyung-Suk Suh
Summary: This study suggests that laparoscopic explant hepatectomy followed by robot-assisted engraftment is feasible in selected recipients only.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Kyung-Suk Suh, Suk Kyun Hong, Sola Lee, Su Young Hong, Sanggyun Suh, Eui Soo Han, Seong-Mi Yang, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee
Summary: Minimally invasive living donor liver transplantation with pure laparoscopic techniques, including explant hepatectomy and graft implantation through a suprapubic incision, was performed successfully in a patient with liver cirrhosis and carcinoma. The procedure, conducted by an experienced surgical team, resulted in a smooth recovery and short hospital stay. Larger studies are needed to validate the safety and feasibility of this approach.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Arianna Barbetta, Mayada Aljehani, Michelle Kim, Christine Tien, Aaron Ahearn, Hannah Schilperoort, Linda Sher, Juliet Emamaullee
Summary: A systematic review comparing adult living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) found that LDLT is associated with improved patient survival, reduced waiting time, and lower MELD score, despite an increased risk of biliary complications. Hepatic artery thrombosis rates did not differ between the two types of transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Matthias Schaier, Christian Morath, Lei Wang, Christian Kleist, Gerhard Opelz, Thuong Hien Tran, Sabine Scherer, Lien Pham, Naruemol Ekpoom, Caner Suesal, Gerald Ponath, Florian Kaelble, Claudius Speer, Louise Benning, Christian Nusshag, Christoph F. Mahler, Luiza Pego da Silva, Claudia Sommerer, Angela Hueckelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Ruediger Waldherr, Paul Schnitzler, Uta Merle, Vedat Schwenger, Markus Krautter, Stephan Kemmner, Michael Fischereder, Manfred Stangl, Ingeborg A. Hauser, Anna-Isabelle Kaelsch, Bernhard K. Kraemer, Georg A. Boehmig, Carsten Mueller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Summary: Administration of modified immune cells (MIC) before kidney transplantation led to improved clinical outcomes, including stable kidney graft function, absence of donor-specific human leukocyte antigen antibodies (DSA) or acute rejections, and reduced opportunistic infections compared to standard immunosuppressive therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Madhukar S. Patel, Zubaida Mohamed, Anand Ghanekar, Gonzalo Sapisochin, Ian McGilvray, Blayne A. Sayed, Trevor Reichman, Markus Selzner, Jed A. Gross, Zita Galvin, Mamatha Bhat, Les Lilly, Mark Cattral, Nazia Selzner
Summary: Paired organ exchange, such as liver paired exchange, offers a solution for living donor-recipient ABO incompatibilities. The success of this method relies on careful planning and coordination of multiple simultaneous operations. By initiating a chain of donations, the donor pool can be expanded, benefiting incompatible living liver donor-recipient pairs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)