Article
Medicine, General & Internal
Jeong-Moo Lee
Summary: This study analyzed the use of living-donor liver transplantation in South Korea to overcome a shortage of deceased donors. The results showed that policy factors such as independent organ-procurement organization (IOPO) activities and the establishment of regional trauma centers had an impact on the recruitment and donation of deceased donors. The study found that cerebrovascular events and head trauma were the most common causes of donor death. The locations where deceased donors were identified changed based on these policies, highlighting the need for communication with regional trauma center staff to recruit more donors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Matthew P. Robertson, Jacob Lavee
Summary: This study conducts a forensic review of Chinese-language transplant publications and finds evidence suggesting that Chinese physicians have participated in executions by organ removal, implying a violation of the dead donor rule.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Ethics
Anthony P. Smith
Summary: The Dead Donor Rule is intended to protect the public and patients, but it remains controversial. This article argues for abandoning the rule by using Joel Feinberg's account of harm to show that death does not harm permanently unconscious patients, especially when they have consented to organ donation. Therefore, causing the death of these patients is not morally wrong, undermining the main argument for the Dead Donor Rule.
JOURNAL OF MEDICAL ETHICS
(2023)
Article
Surgery
Syed A. Husain, Kristen L. King, David C. Cron, Nikole A. Neidlinger, Han Ng, Sumit Mohan, Joel T. Adler
Summary: This study investigated the impact of local market competition and/or organ availability on kidney procurement and utilization. The results showed that lower competition was associated with higher export, while market monopoly was weakly associated with lower discard. Higher organ availability was associated with both export and discard.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Surgery
Dieter Broering, Mark L. Sturdevant, Ahmed Zidan
Summary: Living donation is a crucial resource for organ transplantation, and advancements in minimally invasive surgical techniques are improving safety and outcomes for living donors. The introduction of robotic platforms with advanced instruments is allowing for better emulation of open surgeries in a closed abdomen, potentially leading to wider adoption of minimally invasive donor surgeries.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Kristen L. King, S. Ali Husain, Adler Perotte, Joel T. Adler, Jesse D. Schold, Sumit Mohan
Summary: Deceased donor kidney allocation allows exceptions in special circumstances, but these exceptions are often concentrated in a few outlier centers. The kidneys involved in the exceptions are usually transplanted to larger centers with higher acceptance rates.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Naissa Abdoul, Camille Legeai, Christelle Cantrelle, Olaf Mercier, Anne Olland, Pierre Mordant, Pascal Alexandre Thomas, Jacques Jougon, Adrien Tissot, Jean-Michel Maury, Edouard Sage, Richard Dorent
Summary: Donors whose lungs were transplanted after EVLP had similar profiles to those whose lungs were declined, but were quite different from donors with lungs transplanted without EVLP. Predictors for graft nonuse included age ≥ 50 years, smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, abnormal chest imaging, and purulent secretions. EVLP was found to increase the utilization of lungs from donors with a smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, and abnormal chest imaging.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Verner Eerola, Ville Sallinen, Marko Lempinen, Ilkka Helantera
Summary: A longer procurement interval is associated with improved long-term outcomes in pancreas transplantation, as it is correlated with increased death-censored graft survival and decreased acute rejections. This study analyzed the association between procurement interval and pancreas graft outcomes using multivariable models. The results showed that a longer procurement interval is beneficial for pancreas transplantation.
TRANSPLANT INTERNATIONAL
(2023)
Review
Cardiac & Cardiovascular Systems
Amit Bery, Gary Marklin, Akinobu Itoh, Daniel Kreisel, Tsuyoshi Takahashi, Bryan F. Meyers, Ruben Nava, Benjamin D. Kozower, Hailey Shepherd, G. Alexander Patterson, Varun Puri
Summary: This review discusses advances in donor management models, focusing on the specialized donor care facility model. Strategies such as lung protective ventilation, recruitment of atelectatic lung, and hormone therapy can improve lung utilization rates. Stroke volume-based resuscitation is associated with improved heart utilization rates.
ANNALS OF THORACIC SURGERY
(2022)
Article
Surgery
Carli J. Lehr, Melissa A. Skeans, Erika D. Lease, Maryam Valapour
Summary: The US lung transplant policy changed on November 24, 2017, expanding the geographic organ distribution to a 250-nautical-mile radius. This change resulted in increased travel distance and time for organ procurement, leading to higher travel costs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Damiano Patrono, Davide Cussa, Veronica Sciannameo, Elena Montanari, Rebecca Panconesi, Paola Berchialla, Mirella Lepore, Alessandro Gambella, Giorgia Rizza, Giorgia Catalano, Stefano Mirabella, Francesco Tandoi, Francesco Lupo, Roberto Balagna, Mauro Salizzoni, Renato Romagnoli
Summary: Dual hypothermic oxygenated machine perfusion (D-HOPE) improves preservation and outcomes in liver transplantation, especially when utilizing donors after neurological determination of death (DBD). D-HOPE reduces early graft failure, complications, and improves survival for both patients and grafts, including elderly donors.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
B. L. Kasiske, K. L. Lentine, Y. Ahn, M. A. Skeans, T. Eberhard, C. Folken, J. Wainright, L. Larkin, C. Nystedt
Summary: Living donor transplantation is an important source of organs, but there has been little growth in the number of living donor transplants in the past decade. To better understand the barriers and risks associated with living donation, a national registry has been established.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Katia Bravo-Jaimes, Kelly Axsom, Jonathan Menachem, David Danford, Shelby Kutty, Ari Cedars
Summary: A study using SRTR data compared waitlist outcomes and posttransplant mortality in ACHD patients listed for heart transplantation from two eras. The new UNOS donor heart allocation system improved waitlist time and decreased the proportion of ACHD patients not transplanted within the first 300 days after listing, without changing early posttransplant outcomes significantly or altering the gap in outcomes compared to non-ACHD patients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Xingxing S. Cheng, Philip J. Held, Avi Dor, Jennifer L. Bragg-Gresham, Jane C. Tan, John D. Scandling, Glenn M. Chertow, John P. Roberts
Summary: Expanding donor acceptability criteria to include nonstandard donors could be a potential solution to the organ shortage issue. Despite higher costs per organ, kidney transplantation from nonstandard donors remained cost-effective based on contemporary US data, with economies of scale observed in high OPO volume leading to lower costs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Hwai-Ding Lam, Alexander F. Schaapherder, Ian P. J. Alwayn, Willemijn N. Nijboer, Maarten E. Tushuizen, Aline C. Hemke, Andrzej Baranski, Stephanie L. Van der Pas
Summary: The value of the unadjusted CUSUM graph in analyzing liver surgical injury and discard rates in organ procurement in the Netherlands was investigated. The results showed that the unadjusted CUSUM chart is a simple and effective tool for monitoring organ procurement quality. Both national and local CUSUM charts can reflect the impact on organ procurement injury, and separate CUSUM charts are needed for injury and discard analysis.
CLINICAL TRANSPLANTATION
(2023)