Article
Radiology, Nuclear Medicine & Medical Imaging
Daopeng Yang, Bowen Zhuang, Yan Wang, Gang Huang, Ming Xu, Manxia Lin, Wei Wang, Guangliang Huang, Changxi Wang, Xiaoyan Xie, Xiaohua Xie
Summary: High-frequency ultrasound characteristics are valuable for diagnosing BK polyomavirus-associated nephropathy (BKPyVAN) and distinguishing it from transplant rejection in kidney transplant recipients.
Article
Multidisciplinary Sciences
James McCaffrey, Vijesh J. Bhute, Mohan Shenoy
Summary: In pediatric kidney transplant recipients, BK virus infection is typically associated with younger age at transplantation, CMV-negative recipient serostatus, and higher levels of immunosuppression. Close monitoring of BK viremia and timely clinical intervention can lead to similar long-term outcomes for BKN patients compared to controls.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Whitney A. Perry, Jessica K. Paulus, Lori Lyn Price, David R. Snydman, Jennifer K. Chow
Summary: The study showed that low absolute lymphocyte count (ALC) at 1 month post-heart transplant is significantly associated with an increased risk of infectious outcomes or death in the following 11 months. This simple and accessible laboratory measure can serve as a useful clinical indicator for overall infection risk in heart transplant recipients.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Genetics & Heredity
Margherita Borriello, Diego Ingrosso, Alessandra Fortunata Perna, Angela Lombardi, Paolo Maggi, Lucia Altucci, Michele Caraglia
Summary: Poliomavirus BK virus (BKV) is a highly infective virus that can cause asymptomatic infections. In renal transplanted recipients, BKV can lead to severe complications. Current treatments and prophylaxis options are limited, but increasing surveillance and early diagnosis show promise in improving outcomes.
Article
Biochemistry & Molecular Biology
Yu Jin, Yi Zhou, Wenfeng Deng, Yuchen Wang, Richard J. Lee, Yanna Liu, Nahel Elias, Yangcheng Hu, Min-Hua Luo, Rumin Liu, Bowen Guan, Jian Geng, Jian Xu, Junfeng Ma, Jiapeng Zhou, Na Liu, Michael L. Blute, Robert B. Colvin, Chin-Lee Wu, Yun Miao
Summary: Chronic BK polyomavirus (BKPyV) infection is considered a potential oncogenic factor for urothelial carcinoma (UC) in renal transplant recipients. Integration sites between human and BKPyV genomes were enriched with microhomologies, and viral insertional integration led to fusion sequences of 75 human genes, with 15 genes showing statistical association with UC based on expression analysis. These findings suggest a potential mechanism of viral-driven carcinogenesis in BKPyV-related UC.
Article
Surgery
Laura N. Walti, Catrina Mugglin, Daniel Sidler, Matteo Mombelli, Oriol Manuel, Hans H. Hirsch, Nina Khanna, Nicolas Mueller, Christoph Berger, Katia Boggian, Christian Garzoni, Dionysios Neofytos, Christian van Delden, Cedric Hirzel
Summary: Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of solid organ transplantation (SOT), mostly associated with Epstein-Barr virus (EBV) infection. The role of antiviral prophylaxis or rituximab therapy in preventing PTLD in SOT recipients is controversial. However, receiving rituximab as induction treatment was associated with a significantly longer PTLD-free survival time in patients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Daniel Q. Huang, Andrew Tran, Ming-Lun Yeh, Satoshi Yasuda, Pei-Chien Tsai, Chung-Feng Huang, Chia Yen Dai, Eiichi Ogawa, Masatoshi Ishigami, Takanori Ito, Ritsuzo Kozuka, Masaru Enomoto, Takanori Suzuki, Yoko Yoshimaru, Carmen M. Preda, Raluca I. Marin, Irina Sandra, Sally Tran, Sabrina X. Z. Quek, Htet Htet Toe Wai Khine, Norio Itokawa, Masanori Atsukawa, Haruki Uojima, Tsunamasa Watanabe, Hirokazu Takahashi, Kaori Inoue, Mayumi Maeda, Joseph K. Hoang, Lindsey Trinh, Scott Barnett, Ramsey Cheung, Seng Gee Lim, Huy N. Trinh, Wan-Long Chuang, Yasuhito Tanaka, Hidenori Toyoda, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study aimed to evaluate the association between antiviral therapy and the risk of hepatocellular carcinoma (HCC) in patients with indeterminate-phase chronic hepatitis B (CHB). The analysis of 855 treatment-naive CHB patients showed that antiviral therapy reduced the risk of developing HCC.
Article
Cell Biology
Marie N. Sorin, Antonio Di Maio, Lisete M. Silva, Domenic Ebert, Clement P. Delannoy, Ngoc-Khan Nguyen, Yann Guerardel, Wengang Chai, Franck Halary, Karine Renaudin-Autain, Yan Liu, Celine Bressollette-Bodin, Thilo Stehle, Dorian McIlroy
Summary: This study characterizes the impact of naturally occurring VP1 mutations on ganglioside binding, VP1 protein structure, and virus tropism in BK polyomavirus (BKPyV). Mutants E73Q, E73A, and A72V-E73Q-E82Q (VQQ) retain sialic acid-dependent infectious entry and bind to a-series gangliosides, including GD1a. However, E73A and VQQ mutants lose the ability to infect ganglioside-complemented cells, and this correlates with a BC2 loop shift in their crystal structures. The K69N mutation in the K69N-E82Q variant inhibits sialic acid binding but retains significant infectivity in 293TT cells, suggesting the existence of an unknown sialic acid-independent entry receptor for BKPyV.
Article
Multidisciplinary Sciences
Olga Mineeva-Sangwo, Elisabet Van Loon, Graciela Andrei, Dirk Kuypers, Maarten Naesens, Robert Snoeck
Summary: BK polyomavirus (BKPyV) is a latent human DNA virus in renal tissue that can reactivate and cause polyomavirus-associated nephropathy (PVAN), particularly in kidney transplant recipients. There are currently no specific antivirals for BKPyV, so reducing immunosuppression is the main treatment approach. Mutations in the major capsid protein VP1 of BKPyV can accumulate over time and lead to neutralization escape in kidney transplant recipients. A study found mutations throughout the entire BKPyV genome, including VP1, and these changes should be considered in future approaches for treating BKPyV infection in kidney transplant recipients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Linh Tran, Roger Feldman, Thomas Riley, Jeah Jung
Summary: The study found a positive association between Project ECHO and the use of DAA treatment in patients with HCV infection, especially in areas with limited specialist physicians. This suggests that Project ECHO may help improve access to DAA treatment by enhancing the capacity of primary care physicians in treating HCV infection, particularly in underserved areas.
Article
Biochemistry & Molecular Biology
Xusheng Chen, Zhenyu Ou, Lei Wang, Zhenting Zhang, Xiaodong Fan, Huanhuan Liu, Wenping Wang, Yanrui Zhang, Jun Zhu, Xiayuan Liang, Feng Lou, Shanbo Cao, Ye Yao, Huina Wang, Xin Yao
Summary: The study analyzed the TMB in Chinese UC patients using the Acornmed 808 panel, revealing associations between TMB, CNV, and DDR gene status, suggesting TMB as a potential biomarker for stratification of UC patients. The findings indicated that patients with high TMB may have unique carcinogenic mechanisms.
MOLECULAR CARCINOGENESIS
(2022)
Article
Immunology
Raphael P. H. Meier, Yannick D. Mueller, Pierre-Yves Dietrich, Jean-Christophe Tille, Sergey Nikolaev, Ambra Sartori, Intidhar Labidi-Galy, Thomas Ernandez, Amandeep Kaur, Hans H. Hirsch, Thomas A. McKee, Christian Toso, Jean Villard, Thierry Berney
Summary: The investigation revealed an oncogenic role of BKPyV in collecting duct carcinoma in renal allografts. Immunosuppression withdrawal and IL-2 therapy led to efficient antitumor cellular mediated rejection, possibly through host-versus-graft, host-versus-tumor, and anti-BKPyV responses. The patient showed no evidence of disease at 6-year follow-up, with persistently elevated anti-BK virus IgG titers and a specific anti-BKPyV T cell response.
Article
Microbiology
Elias Myrvoll Lorentzen, Stian Henriksen, Christine Hanssen Rinaldo
Summary: Most humans have a lifelong BK Polyomavirus (BKPyV) infection in their urinary tract, which can cause kidney damage in kidney transplant recipients. The virus primarily enters the cells through the apical membrane and is released from the apical compartment. The virus can also be transmitted to uninfected cells through shed decoy-like cells. In kidney transplant recipients, the replication of BKPyV in the allograft can lead to allograft damage and failure.
Article
Surgery
Emma Cannon, Chara Ntala, Nicola Joss, Maeve Rahilly, Wendy Metcalfe, Marie O'Donnell, Paul J. Phelan
Summary: Kidney transplant recipients have an increased risk of developing urothelial carcinoma, and BK polyoma virus infection may play a role in this. A study found that kidney transplant recipients with a history of BKV infection developed rare micropapillary tumors, supporting the pathogenicity of BK virus in the development of these tumors.
CLINICAL TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Wen-Qiang He, Guan Nan Guo, Chenxi Li
Summary: The study demonstrates that the hepatitis B vaccine has been highly effective in preventing HBV infection since its inclusion in the infant immunization schedule in the US in 1991. For participants who received three or more doses of the vaccine, it also showed a reduction in all-cause mortality and cancer-related mortality.
Article
Pathology
Ruth J. Pepper, Hsu-Han Wang, Gayathri K. Rajakaruna, Eugenia Papakrivopoulou, Thomas Vogl, Charles D. Pusey, H. Terence Cook, Alan D. Salama
AMERICAN JOURNAL OF PATHOLOGY
(2015)
Article
Multidisciplinary Sciences
Sally Hamour, Poh-Yi Gan, Ruth Pepper, Fernanda Florez Barros, Hsu-Han Wang, Kim O'Sullivan, Yoichiro Iwakura, Terence Cook, Charles Pusey, Stephen Holdsworth, Alan Salama
Article
Immunology
C. -Y. Hsieh, C. -H. Chien, K. -L. Liu, H. -H. Wang, K. -J. Lin, Y. -J. Chiang
TRANSPLANTATION PROCEEDINGS
(2017)
Article
Surgery
Hsu-Han Wang, Chi-Jeng Hsieh, Kuo-Jen Lin, Sheng-Hsien Chu, Cheng-Keng Chuang, Hsiao-Wen Chen, Min-Li Hsieh, Ta-Min Wang, Yu Chen, Kuan-Lin Liu, Hsin-Chien Huang, Yu-Chao Hsu, Yang-Jen Chiang
ASIAN JOURNAL OF SURGERY
(2011)
Meeting Abstract
Immunology
Ping Chin Lai, Hsu Han Wang, Tai Di Chen, Ling Yin Chiu
Article
Immunology
C. -H. Chien, H. -H Wang, Y. -J. Chiang, S. -H. Chu, H. -E. Liu, K. -L. Liu
TRANSPLANTATION PROCEEDINGS
(2010)
Article
Immunology
C. -H. Chien, H. -H. Wang, Y. -J. Chiang, S. -H. Chu, H. -E. Liu, K. -L. Liu
TRANSPLANTATION PROCEEDINGS
(2010)
Article
Immunology
Y. -J. Chiang, P. -S. Yang, H. -H. Wang, K. -J. Lin, K. -L. Liu, S. -H. Chu, C. -Y. Hsieh
TRANSPLANTATION PROCEEDINGS
(2012)
Article
Immunology
H. -H. Wang, K. -J. Lin, K. -L. Liu, S. -H. Chu, C. -Y. Hsieh, Y. -J. Chiang
TRANSPLANTATION PROCEEDINGS
(2012)
Article
Immunology
H. -H. Wang, K. -J. Lin, S. -H. Chu, Y. -J. Chiang, K. -L. Liu, C. -Y. Hsieh
TRANSPLANTATION PROCEEDINGS
(2014)
Article
Immunology
K. -L. Liu, C. -H. Chien, C. -Y. Hsieh, X. -Y. Huang, H. -H. Wang, K. -J. Lin, Y. -J. Chiang
TRANSPLANTATION PROCEEDINGS
(2018)
Article
Urology & Nephrology
Ta-Min Wang, Hsiao-Wen Chen, Yang-Jen Chiang, Sheng-Hsien Chu, Kuan-Lin Liu, Hsu-Han Wang
UROLOGIA INTERNATIONALIS
(2010)
Meeting Abstract
Surgery
Hsu-Han Wang, Yang-Jen Chiang, Kuan-Lin Liu, Kuo-Jen Lin, Sheng-Hsien Chu
TRANSPLANT INTERNATIONAL
(2011)
Meeting Abstract
Immunology
R. J. Pepper, R. Tarzi, Hsu-Han Wang, C. D. Pusey, H. T. Cook, A. D. Salama
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2011)
Meeting Abstract
Surgery
Yang-jen Chiang, Hsu-han Wang, Kuan-lin Liu, Wei-chan Lee, Sheng-hsien Chu
AMERICAN JOURNAL OF TRANSPLANTATION
(2009)