Review
Pharmacology & Pharmacy
Letian Yang, Bo Wang, Liang Ma, Ping Fu
Summary: Hyperuricemia is a common disorder that can lead to kidney disease. Traditional Chinese medicine has been proven effective in reducing uric acid levels and protecting kidney function, making it a widely used treatment for chronic kidney disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Kaiqing Li, Yanchun Ma, Xue Xia, Huili Huang, Jianing Li, Xiaoxin Wang, Yang Gao, Shuxiang Zhang, Tong Fu, Ying Tong
Summary: Hyperuricemia nephropathy, also known as gouty nephropathy, refers to renal damage induced by hyperuricemia caused by excessive production of serum uric acid or low excretion of uric acid. The persistence of symptoms will lead to changes in renal tubular phenotype and accelerate the progress of renal fibrosis. The existence and progressive aggravation of symptoms will bring a heavy burden to patients, their families and society, affect their quality of life and reduce their well-being.
Article
Biochemistry & Molecular Biology
Yuki Shinzato, Ryo Zamami, Nanako Oshiro, Takuto Nakamura, Akio Ishida, Yusuke Ohya, Kentaro Kohagura
Summary: The combined effects of smoking and hyperuricemia on renal arteriolosclerosis in patients with IgA nephropathy are not well understood. This study investigated the association between smoking (current or former) and renal arteriolar hyalinosis and wall thickening in 87 patients with IgA nephropathy. The results showed that the group with both smoking and hyperuricemia had the highest indices for hyalinosis and wall thickening.
Article
Urology & Nephrology
Daorina Bao, Nan Lv, Xiufang Duan, Xu Zhang, Jinwei Wang, Suxia Wang, Yu Wang, Ming-hui Zhao
Summary: In this study, it was found that hyperechoic crystal deposits can be detected in the kidney medulla of patients with chronic kidney disease (CKD) by ultrasonography. The presence of these deposits is associated with hyperuricemia and ischemic nephropathy.
JOURNAL OF NEPHROLOGY
(2023)
Review
Endocrinology & Metabolism
Yongsheng Mei, Bingzi Dong, Zhuang Geng, Lili Xu
Summary: The article discusses the synthesis and metabolism of uric acid, the etiology of hyperuricemia, the relationship between hyperuricemia and kidney disease, and the treatment of gout and gouty nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
Summary: Elevated serum urate concentration is a risk factor for kidney disease development. Through studies on UOX-KO rats, it was found that hyperuricemia-induced autophagy and NLRP3-dependent inflammation play crucial roles in renal damage. Inhibiting autophagy and inflammation may serve as potential therapeutic strategies for uric acid nephropathy.
DISEASE MODELS & MECHANISMS
(2021)
Article
Biochemistry & Molecular Biology
Hailong Li, Hui Zhang, Fei Yan, Yuwei He, Aichang Ji, Zhen Liu, Maichao Li, Xiaopeng Ji, Changgui Li
Summary: Hyperuricemia (HUA) is closely linked to kidney damage and diseases, but the underlying mechanisms of HUA-induced kidney diseases are still unknown. In this study, a HUA mouse model was created by knocking out the urate oxidase (Uox) gene, and the kidney and plasma metabolic profiles were examined. The results revealed disturbances in purine metabolism, amino acid biosynthesis, tryptophan metabolism, and neuroactive ligand-receptor interaction in the Uox-Ko mice. Betaine and biotin were identified as potential plasma metabolic biomarkers for predicting urate nephropathy (UN).
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Transplantation
Yeshwanter Radhakrishnan, Ladan Zand, Sanjeev Sethi, Fernando C. Fervenza
Summary: Membranous nephropathy (MN) is a disease characterized by the deposition of immune complexes leading to thickening of glomerular basement membranes. The understanding of MN has evolved, with the identification of specific autoantibodies against novel podocyte antigens and the unraveling of intricate pathogenic pathways. Rituximab, an anti-CD20 monoclonal antibody, is favored as the initial therapy for MN, but some patients may be resistant to it, requiring alternative agents for treatment.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Agriculture, Multidisciplinary
Xiaofei Zhou, Bowei Zhang, Xiuli Zhao, Yongxi Lin, Yuan Zhuang, Jingting Guo, Shuo Wang
Summary: Chlorogenic acid (CGA) shows potential as a substance for preventing hyperuricemia nephropathy (HN) by reducing uric acid levels, relieving oxidative stress and inflammation, and alleviating kidney fibrosis. It regulates the cascade response of the microbiota-TMAO-PI3K/AKT/mTOR signaling pathway, thereby delaying kidney fibrosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Medicine, General & Internal
Guang Ma, Min Li, Wei Teng, Zhaohui He, Xiaojv Zhai, Zhenhua Xia
Summary: This study aimed to assess the efficacy of febuxostat combined with hydration for the prevention of contrast-induced nephropathy (CIN) in coronary heart disease patients undergoing percutaneous coronary intervention (PCI). The results showed that febuxostat combined with hydration can reduce the incidence of CIN and improve renal function.
Article
Urology & Nephrology
Yin-Hong Geng, Zhe Zhang, Jun-Jun Zhang, Bo Huang, Zui-Shuang Guo, Xu-Tong Wang, Lin-Qi Zhang, Song-Xia Quan, Rui-Min Hu, Chun-Dong Song, Feng-Yang Duan, Ya-Fei Liu
Summary: A novel nomogram model was constructed to predict the risk of hyperuricemia incidence in IgA nephropathy (IgAN). The model included 8 independent risk factors and exhibited moderate prediction ability. It may be useful in predicting the risk of hyperuricemia in IgAN.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Bolong Fang, Yamin Yu, Xiaowei Dong, Lin Qi, Yan Wang, Fang Dai, Lan Wei, Yajie Kang
Summary: This study investigated the relationship between serum uric acid levels and glomerular ischemic lesions in patients with immunoglobulin A nephropathy (IgAN) and the associated risk factors. The results showed that elevated serum uric acid levels were independently associated with the occurrence of glomerular ischemic disease. Lowering serum uric acid levels may delay the progression of IgAN.
Article
Multidisciplinary Sciences
Dongming Chen, Chenlei Jiang, Hong Lu
Summary: In this study, the therapeutic potential of total flavonoids of Phellinus igniarius (TFPI) in uric acid nephropathy was evaluated. The results showed that TFPI can effectively reduce serum uric acid and creatinine levels, inhibit xanthine oxidase activity, and promote the expression of ABCG2 by targeting TLR4 receptor and NLRP3 inflammasome.
Article
Veterinary Sciences
Masaki Watanabe, Koki Hiura, Hayato Sasaki, Tadashi Okamura, Nobuya Sasaki
Summary: Animal models are useful for studying podocytopathy and chronic kidney diseases. ADR-induced nephropathy in rodents is a common model for podocytopathy. A new strain of mutant B6 mice with ADR nephropathy was developed and found to progress to CKD. Comparisons with BALB/c mice revealed genetic background differences related to inflammatory mediators and further analysis is needed.
EXPERIMENTAL ANIMALS
(2023)
Article
Multidisciplinary Sciences
Jan Dvorak, Michal Koucky, Eva Jancova, Marek Myslivecek, Vladimir Tesar, Antonin Parizek
Summary: Pregnancy complicated by CKD is associated with impaired glomerular filtration rate and proteinuria, leading to negative maternal and fetal outcomes. Higher serum creatinine levels and proteinuria predispose to shorter gestation period and lower birth weight of the neonate, emphasizing the need for pre-pregnancy evaluation and regular monitoring during pregnancy.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Zahide Cavdar, Mehmet Asi Oktan, Cemre Ural, Meryem Calisir, Ayse Kocak, Cihan Heybeli, Serkan Yildiz, Aylin Arici, Hulya Ellidokuz, Ali Celik, Osman Yilmaz, Sulen Sarioglu, Caner Cavdar
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Urology & Nephrology
Mehtat Unlu, Serkan Yildiz, Hulya Ellidokuz, Sulen Sarioglu
Article
Oncology
Cihan Heybeli, Kubra Canaslan, Mehmet Asi Oktan, Serkan Yildiz, Hayri Ustun Arda, Caner Cavdar, Ali Celik, Necati Gokmen, Bilgin Comert
Summary: Nephrotoxicity is common following colistin administration, and this study found that glucocorticoid exposure is associated with a decreased risk of AKI in critically-ill patients receiving colistin therapy. Factors such as age, other drug use were associated with AKI development, while APACHE-II score and serum albumin level were related to mortality risk.
JOURNAL OF CHEMOTHERAPY
(2021)
Review
Pathology
M. Hasan Toper, Sulen Sarioglu
Summary: Salivary gland neoplasms are a rare and heterogeneous group of tumors with diverse molecular characteristics. Recent advancements in molecular pathology have provided insights into the genetic aberrations and potential diagnostic, prognostic, and predictive biomarkers in these tumors.
ADVANCES IN ANATOMIC PATHOLOGY
(2021)
Article
Urology & Nephrology
Meral Torun Bayram, Cihan Heybeli, Gizem Yildiz, Alper Soylu, Ali Celik, Sulen Sarioglu, Salih Kavukcu
Summary: The study compared the clinical, pathological, and long-term renal outcomes of children with HSPN and IgAN, finding little difference between the two in our population. HSPN patients had higher proteinuria at the onset of nephritis, likely associated with inflammation due to systemic vasculitis, but both groups showed good long-term renal outcomes.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hande Melike Bulbul, Ogun Bulbul, Sulen Sarioglu, Ozhan Ozdogan, Ersoy Dogan, Nuri Karabay
Summary: This study found significant correlations between DWI, DCE-MRI, and PET/CT parameters, providing effective evaluation of tumor cellularity, vascular permeability, and glucose metabolism. MTV may play a key role in predicting T4 tumors.
MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
(2021)
Letter
Rheumatology
B. Karakaya, S. Gulle, D. Gurel, S. Sarioglu, S. Ozkal, M. Birlik, F. Onen, M. O. Tarhan
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2022)
Article
Health Care Sciences & Services
Ender Berat Ellidokuz, Tolga Sever, Gizem Calibasi Kocal, Aras Emre Canda, Sulen Sarioglu, Hasan Kurter, Ilhan Oztop, Yesim Tuncok, Yasemin Basbinar
Summary: This study investigated the cellular biology and physiology of colon cancer tissues in in vitro. The results showed that isolating cells from larger and non-necrotic tumor tissues resulted in better growth patterns for 3D cultures. Size and presence of necrotic areas were found to be important factors affecting the viability of cancer cells.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hakki Celik, Funda Barlik, Selman Sokmen, Cem Terzi, Aras Emre Canda, Ozgul Sagol, Sulen Sarioglu, Mehtat Unlu, ilknur Bilkay Gorken, Zuemre Arican Alicikus, Ilhan Oztop
Summary: This study aims to investigate the diagnostic performance of MRI in predicting the pathologic stage of LARC after neoadjuvant CRT and the role of MRI in selecting patients with ypCR. The results showed moderate accuracy and sensitivity in predicting ypT and N stages, mainly due to underestimating tumor stage and overestimating nodal status. Furthermore, high specificity and NPV but low sensitivity were observed in predicting the complete response.
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Transplantation
Cihan Heybeli, Serkan Yildiz, Mehmet Asi Oktan, Zekai Serhan Derici, Mehtat Unlu, Caner Cavdar, Aykut Sifil, Ali Celik, Sulen Sarioglu, Taner Camsari
Summary: This study compared the graft and patient survival rates and complications following kidney transplant in amyloidosis patients and patients with kidney disease due to other causes. The results showed that amyloidosis patients had lower patient survival rates, but similar graft failure and acute rejection rates compared to patients with other diseases.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Review
Pathology
Cihan Heybeli, Berna Demir Yuksel, Mehtat Unlu, Mehmet Asi Oktan, Hayri Ustun Arda, Ozcan Uzun, Filiz Yildirim, Serkan Yildiz, Caner Cavdar, Aykut Sifil, Ali Celik, Sulen Sarioglu
Summary: This study investigated the distribution of causes and renal survival of granulomatous interstitial nephritis in a tertiary care hospital in Western Turkey. The majority of cases were caused by vasculitis, and renal outcomes were unfavorable despite treatment. The study suggests the need for multicenter studies to determine the etiology and outcome of granulomatous interstitial nephritis at different geographic locations.
TURKISH JOURNAL OF PATHOLOGY
(2022)
Article
Geriatrics & Gerontology
Cihan Heybeli, Pinar Soysal, Mehmet Asi Oktan, Lee Smith, Ali Celik, Rumeyza Kazancioglu
Summary: Excessive daytime sleepiness (EDS) is associated with malnutrition in older patients with chronic kidney disease (CKD), highlighting the importance of evaluating EDS and nutritional status together in clinical practice. Future studies are needed to determine the direction of the association between malnutrition and EDS and to evaluate if dietary intervention can improve EDS.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Gercek Can, Sulen Sarioglu, Merih BIrlIk, Gokce Kenar, Ozgul Soysal, Dilek Solmaz, Vedat Gerdan, Fatos Onen, Nurullah Akkoc, Servet Akar
Summary: This study investigated the prevalence of sicca symptoms and secondary Sjogren's syndrome (SjS) in patients with systemic sclerosis (SSc), as well as evaluated the expression of alpha-smooth muscle actin (alpha-SMA) in minor salivary gland (MSG) specimens. Results showed that sicca symptoms were common among SSc patients, with nearly one-third fulfilling the criteria for SjS, particularly in the limited subtype. Older age and positive anti-SS-A antibodies were identified as predictors for SjS, and glandular fibrosis was significant but alpha-SMA staining was rare in patients with SSc.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Mehtat Unlu, Evren Uzun, Goksel Bengi, Ozgul Sagol, Sulen Sarioglu
TURKISH JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Urology & Nephrology
Mehmet Asi Oktan, Cihan Heybeli, Hayri Ustun Arda, Serkan Yildiz, Mehtat Unlu, Caner Cavdar, Aykut Sifil, Ali Celikl, Sulen Sarioglu, Taner Camsari
TURKISH JOURNAL OF NEPHROLOGY
(2020)