Review
Biochemistry & Molecular Biology
Sahng G. Kim
Summary: Despite the recent surge in studies on dental pulp regeneration using tissue engineering strategies, the translation of these findings into therapeutic applications remains a challenge. This scoping review systematically reviewed the efficacy of mesenchymal stem cell transplantation for dental pulp regeneration, showing potential for vascularized pulp-like tissue regeneration and successful regeneration of vital tissue in clinical trials. More high-quality studies are needed to further evaluate the safety and efficacy of stem cell transplantation for dental pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Jiaxi Liu, Jinfang Gao, Zixie Liang, Chong Gao, Qing Niu, Fengping Wu, Liyun Zhang
Summary: This review discusses the characteristics of MSCs, their interaction with the microenvironment, and the importance of the microenvironment in maintaining cell function and disease progression.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Michael Thoene, Ewa Bejer-Olenska, Joanna Wojtkiewicz
Summary: Articular cartilage has low regenerative ability and requires therapy for significant joint injuries. This article reviews the causes of osteoarthritis and its treatment using traditional methods and the latest stem cell technology. The use and potential risks of mesenchymal stem cells for tissue regeneration and implantation are discussed, along with applications in treating osteoarthritis in humans after using canine animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Xiaofeng Wang, Fanyuan Yu, Ling Ye
Summary: Recent studies have shown that MSCs play a vital role in bone regeneration, including osteogenic differentiation and providing seed cells. However, factors like drug intake and body senescence can affect MSCs' functions in bone regeneration. Epigenetic regulation has received attention for its heritable nature and involvement in bone metabolism disorders. This review focuses on the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs and its role in bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Lin-Hong Wang, Si-Zhe Gao, Xiao-Lei Bai, Zheng-Lin Chen, Fan Yang
Summary: Stem cell research has grown exponentially in recent years. Dental tissues contain mesenchymal stem cells, which have multipotency and are ideal for tissue redevelopment. Studying dental stem cells can provide new materials and methods for clinical tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic
Summary: MSCs are multipotent stem cells that can enhance tissue repair and regeneration by regulating immune cell function, promoting new blood vessel formation, and modulating phenotype and function of immune cells. This review article summarizes the current knowledge about the molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Kangkang Zha, Xu Li, Zhen Yang, Guangzhao Tian, Zhiqiang Sun, Xiang Sui, Yongjing Dai, Shuyun Liu, Quanyi Guo
Summary: Articular cartilage is difficult to repair due to its avascular nature, but mesenchymal stem cells (MSCs) show promise in cartilage regeneration. However, the heterogeneous nature of MSCs can lead to unstable therapeutic effects. Understanding MSC heterogeneity and utilizing different types of MSCs for cartilage regeneration can improve treatment efficiency.
NPJ REGENERATIVE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Insun Song, Jongseop Rim, Jaemin Lee, Inseok Jang, Bosung Jung, Kisoo Kim, Soonchul Lee
Summary: This review examines the biological advantages of human fetal MSCs (hfMSCs) in healing diseases and regeneration, as well as the research evidence for their engraftment and immunomodulation. The potential therapeutic feasibilities of hfMSCs for musculoskeletal disorders are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Lin Zhao, Junli Zhao, Zhenhe Tuo, Guangtie Ren
Summary: Tissue engineered periosteum (TEP) and TEP combined with deproteinized bone (DPB) scaffold can effectively restore large size long bone defects, providing an alternative approach for resolving pathological bone defects in clinical settings.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Review
Cell Biology
Candice Bohaud, Rafael Contreras-Lopez, Jholy de la Cruz, Claudia Terraza-Aguirre, Mingxing Wei, Farida Djouad, Christian Jorgensen
Summary: Osteoarthritis is a multifaceted degenerative and inflammatory joint disorder, with current therapies often only providing short-term benefits without complete structural and functional reconstitution. Identifying novel therapeutic targets and strategies is crucial to achieve long-term clinical benefits for OA patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Veronika Smolinska, Michaela Debreova, Martina Culenova, Maria Csobonyeiova, Andrey Svec, Lubos Danisovic
Summary: Healing of articular cartilage defects is challenging and traditional reparative approaches are limited. Mesenchymal stromal cells have been extensively studied and proven to have therapeutic effects on articular cartilage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Sylwia Dabrowska, Anna Andrzejewska, Miroslaw Janowski, Barbara Lukomska
Summary: Mesenchymal stem cells (MSCs) possess supportive, differentiating, and immunoregulatory functions, while the extracellular vesicles (EVs) they produce can serve as a potential cellular therapy tool.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Asma Sepahdar, Abolfazl Nazbar, Saeed Bahadorikhalili, Ghassem Rezaei, Mohammad Ali Shokrgozar, Mohammad Mehdi Dehghan, Hamid Akbari Javar, Shahin Bonakdar
Summary: This paper presents a novel composite scaffold for the regeneration of cartilage tissue. The scaffold is made of a combination of a hydrogel and a controlled release drug delivery system. The release of kartogenin, a chondrogenic-inducing drug, from the scaffold is successfully controlled. The scaffold also demonstrates a porous structure and shows good performance in inducing chondrogenic differentiation of stem cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xudong Yao, Yuanzhu Ma, Wenyan Zhou, Youguo Liao, Zongsheng Jiang, Junxin Lin, Qiulin He, Hongwei Wu, Wei Wei, Xiaozhao Wang, Mikael Bjorklund, Hongwei Ouyang
Summary: The study showed that transfer of exogenous mitochondria can enhance the survival and engraftment of adipose-derived mesenchymal stem cells, as well as increasing their energy levels and ATP production. The process of mitochondrial transfer was captured using high-content live-cell imaging. This transfer also led to changes in secretome profiles and induced mRNA expression linked to DNA replication and cell division in ADSCs. The enhanced bioenergetics from mitochondrial transfer may be responsible for promoting proliferation, migration, and differentiation of ADSCs.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Cell & Tissue Engineering
Liangrui Chen, Shasha Zhu, Shujuan Guo, Weidong Tian
Summary: Periodontitis is a common oral disease that causes damage to both hard and soft tissues of the periodontium, leading to tooth mobility and loss. Mesenchymal stem cells (MSCs) have emerged as a promising therapy for periodontitis due to their unique characteristics. Accumulating evidence suggests that the regenerative effects of MSCs are mainly mediated through paracrine signaling, including the release of extracellular vesicles (EVs) that contain bioactive substances. These MSC-EVs play a crucial role in regulating the biological functions of periodontal tissue cells, immune cells, and the local microenvironment, promoting tissue regeneration and repair. As a cell-free therapy, MSC-EVs offer advantages in terms of stability, immune rejection, and ethical concerns, making them potentially valuable for clinical applications in periodontal regeneration.
STEM CELL RESEARCH & THERAPY
(2023)