Signaling beyond Punching Holes: Modulation of Cellular Responses by Vibrio cholerae Cytolysin

Transmembrane oligomeric form ofVibrio choleraecytolysin triggers TLR2/TLR6–dependent proinflammatory responses in monocytes and macrophages

(2015) Barkha Khilwani et al.   BIOCHEMICAL JOURNAL

Revisiting the membrane interaction mechanism of a membrane-damaging β-barrel pore-forming toxinVibrio choleraecytolysin

(2015) Anand Kumar Rai et al.   MOLECULAR MICROBIOLOGY

Trapping ofVibrio choleraeCytolysin in the Membrane-bound Monomeric State Blocks Membrane Insertion and Functional Pore Formation by the Toxin

(2014) Anand Kumar Rai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-pore oligomer formation by Vibrio cholerae cytolysin: Insights from a truncated variant lacking the pore-forming pre-stem loop

(2013) Karan Paul et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Pore-Forming Toxins in Bacterial Infectious Diseases

(2013) F. C. O. Los et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation

(2013) Peter Keyel et al.   Toxins

Pathogenic Pore-Forming Proteins: Function and Host Response

(2012) Mirko Bischofberger et al.   Cell Host & Microbe

Single point mutation inVibrio choleraecytolysin compromises the membrane pore-formation mechanism of the toxin

(2012) Karan Paul et al.   FEBS Journal

Functional Mapping of the Lectin Activity Site on the β-Prism Domain ofVibrio choleraeCytolysin

(2012) Anand Kumar Rai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unfolding Distinguishes theVibrio choleraeCytolysin Precursor from the Mature Form of the Toxin

(2011) Karan Paul et al.   BIOCHEMISTRY

Hemolysin Induces Toll-like Receptor (TLR)-independent Apoptosis and Multiple TLR-associated Parallel Activation of Macrophages

(2011) Deep Chandan Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serratia marcescens Is Able to Survive and Proliferate in Autophagic-Like Vacuoles inside Non-Phagocytic Cells

(2011) Griselda V. Fedrigo et al.   PLoS One

Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins

(2011) S. De et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF- B Signaling

(2010) C. Toma et al.   JOURNAL OF IMMUNOLOGY

Pro-autophagic signal induction by bacterial pore-forming toxins

(2010) Nicole Kloft et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Role of MAPK p38 in the cellular responses to pore-forming toxins

(2010) Helena Porta et al.   PEPTIDES

Vibrio cholerae Hemolysin Is Required for Lethality, Developmental Delay, and Intestinal Vacuolation in Caenorhabditis elegans

(2010) Hediye Nese Cinar et al.   PLoS One

Pore-forming toxins activate MAPK p38 by causing loss of cellular potassium

(2009) Nicole Kloft et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Three-dimensional structure of the detergent-solubilized Vibrio cholerae cytolysin (VCC) heptamer by electron cryomicroscopy

(2009) Yongning He et al.   JOURNAL OF STRUCTURAL BIOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Vibrio cholerae Cytolysin Causes an Inflammatory Response in Human Intestinal Epithelial Cells That Is Modulated by the PrtV Protease

(2009) Gangwei Ou et al.   PLoS One

Hypoxia and the Hypoxic Response Pathway Protect against Pore-Forming Toxins in C. elegans

(2009) Audrey Bellier et al.   PLoS Pathogens

Programmed Cellular Necrosis Mediated by the Pore-Forming α-Toxin from Clostridium septicum

(2009) Catherine L. Kennedy et al.   PLoS Pathogens

The Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine production

(2008) Diletta Arcidiacono et al.   CELLULAR MICROBIOLOGY

Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis

(2008) Vincent Idone et al.   JOURNAL OF CELL BIOLOGY

Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo

(2008) Larry J. Bischof et al.   PLoS Pathogens

Vibrio cholerae cytolysin is essential for high enterotoxicity and apoptosis induction produced by a cholera toxin gene-negative V. cholerae non-O1, non-O139 strain

(2007) Hector Alex Saka et al.   MICROBIAL PATHOGENESIS

Vibrio cholerae hemolysin is apoptogenic to peritoneal B-1a cells but its oligomer shepherd the cells for IgA response

(2007) Gayatri Mukherjee et al.   MOLECULAR IMMUNOLOGY