Article
Microbiology
Peng Song, Yu-Chun Cai, Mu-Xin Chen, Shao-Hong Chen, Jia-Xu Chen
Summary: This study found that B. microti infection can lead to changes in erythrocyte structure, hemolytic anemia, and splenomegaly. After infection, phosphatidylserine (PS) exposure and reactive oxygen species (ROS) levels in erythrocytes increased, and severe splenomegaly and anemia were observed. Furthermore, the parasitemia level was higher in the splenectomized group, indicating that the spleen plays a critical protective role in controlling infection and preventing anemia.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Physiology
Alaa El-Din H. Sayed, Zainab Eid, Usama M. Mahmoud, Jae-Seong Lee, Imam A. A. Mekkawy
Summary: This study investigated the toxic effects of 4-non-ylphenol (4-NP) exposure on juvenile African catfish. The results showed dose-dependent damage and improvements in reproductive toxicity during the recovery period.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Toxicology
Zhangde Chen, Bingwei Yang, Ziyi Yan, Erqun Song, Yang Song
Summary: Silica nanoparticles (SiO2 NPs) have potential hazards to human health, but their hemolytic properties vary under different coatings. The results emphasize the influence of surface modification on the toxicity of environmental nanoparticles.
TOXICOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Mohammad A. Alfhili, Ahmed M. Basudan, Jawaher Alsughayyir
Summary: The study demonstrates that Wogonin (WGN) can prevent red blood cell death induced by various factors leading to anemia, including calcium overload, hyperosmotic shock, oxidative stress, and metabolic exhaustion.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Physical
Van Ngo, Hui Li, Alexander D. MacKerell Jr, Toby W. Allen, Benoit Roux, Sergei Noskov
Summary: The study demonstrates that considering induced electronic polarization effects can more accurately evaluate the transport dynamics of ions in narrow channels. Additionally, induced polarization has a direct impact on free-energy barriers and ion permeation rates. Therefore, this is of significant importance for revising proposed mechanisms of ion permeation in various ion channels.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2021)
Article
Immunology
Coralie Boulet, Taylah L. Gaynor, Teresa G. Carvalho
Summary: Research has shown that different culture conditions can affect the results of eryptosis experiments and the growth of malaria parasites; three compounds, while not affecting cell viability, interfere with parasite development through a mechanism yet to be elucidated.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Thilo Bartolmaes, Axel Pruss, Beate Mayer
Summary: This study investigated different types of hemolysis in autoimmune hemolytic anemia (AIHA) and found that in addition to the routine C3d-DAT test, indirect tests should be used to determine the proportion of extravascular, intravascular, and eryptotic hemolysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Grazia Maria Virzi, Sabrina Milan Manani, Davide Marturano, Anna Clementi, Silvia Lerco, Ilaria Tantillo, Anna Giuliani, Giovanni Giorgio Battaglia, Claudio Ronco, Monica Zanella
Summary: This study investigated the connection between eryptosis and inflammatory damage in PD patients with PD-related peritonitis. The results showed that eryptosis was significantly higher in PD patients with peritonitis and had positive correlations with CRP, IL-1 beta, and IL-6. In vitro exposure to higher concentrations of cytokines also resulted in increased eryptosis. These findings suggest that upregulated inflammatory markers and immune system dysregulation may contribute to systemic eryptosis during PD-related peritonitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Physiology
Toru Maruyama, Michinari Hieda, Shiro Mawatari, Takehiko Fujino
Summary: Erythrocytes are vulnerable to oxidative injury, leading to impaired filterability and systemic microcirculation. This is particularly evident in diseases such as diabetes, hypertension, and sickle cell disease. Oxidative inflammation and excessive reactive oxygen species are the main causes of these pathophysiological conditions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sumiah A. Alghareeb, Jawaher Alsughayyir, Mohammad A. Alfhili
Summary: This study found that α-MG has hemolytic and eryptotic activities, which are mediated through Ca2+ signaling, Rac1 GTPase activity, and oxidative injury. Furthermore, α-MG accelerates cellular aging and selectively targets platelets and monocytes.
Article
Multidisciplinary Sciences
Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M. Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Summary: Liver disease is a leading cause of premature death, with oxidative stress in the liver being a key driver. The compound dimethyl fumarate (DMF) has been shown to activate antioxidant responses and protect against liver damage. This study demonstrated that DMF could reduce liver damage and cell senescence by inhibiting Nf-κB and TGF-β signaling pathways.
Article
Biochemistry & Molecular Biology
Romain Carin, Gabriel Deglicourt, Hamdi Rezigue, Marie Martin, Christophe Nougier, Camille Boisson, Yesim Dargaud, Philippe Joly, Celine Renoux, Philippe Connes, Emeric Stauffer, Elie Nader
Summary: Acute hypoxia does not exacerbate the changes in red blood cell (RBC) properties and coagulation induced by exercise, according to a crossover study comparing the effects of acute hypoxia vs. normoxia on blood rheology, RBC senescence, and coagulation during exercise.
Article
Cell Biology
Xia Pan, Daniela Giustarini, Florian Lang, Ranieri Rossi, Thomas Wieder, Martin Koeberle, Mehrdad Ghashghaeinia
Summary: In this study, we found that desipramine, a representative of tricyclic antidepressants, promotes recovery of depressed patients by inhibiting the reuptake of serotonin and norepinephrine. Additionally, desipramine enhances programmed erythrocyte death through calcium ion regulation.
Article
Microbiology
Alejandro Lopez-Prieto, Lorena Rodriguez-Lopez, Myriam Rincon-Fontan, Jose Manuel Cruz, Ana Belen Moldes
Summary: A Bacillus strain in corn steep liquor (CSL) was found to produce biosurfactants, but the specific species responsible for production is still unidentified. The Bacillus strain isolated from CSL was identified as Aneurinibacillus aneurinilyticus and found to produce both cell-bound and extracellular biosurfactants, composed of a mixture of lipopeptides and amino acids. The biosurfactant extracts were characterized using electrospray ionization mass spectrometry.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Environmental Sciences
Sharon Daniel, Itai Kloog, Pam Factor-Litvak, Amalia Levy, Eitan Lunenfeld, Marianthi-Anna Kioumourtzoglou
Summary: Exposure to PM2.5 between the 7th and the 14st gestational weeks was significantly associated with preeclampsia among Jewish women, while no such association was observed for Bedouin women. Cumulative exposure to PM2.5 during the first 25th gestational weeks was also significantly linked to preeclampsia among Jewish women.
ENVIRONMENT INTERNATIONAL
(2021)