Article
Immunology
Elisabet Van Loon, Baptiste Lamarthee, Thomas Barba, Sandra Claes, Maarten Coemans, Henriette de Loor, Marie-Paule Emonds, Priyanka Koshy, Dirk Kuypers, Paul Proost, Aleksandar Senev, Ben Sprangers, Claire Tinel, Olivier Thaunat, Amaryllis H. Van Craenenbroeck, Dominique Schols, Maarten Naesens
Summary: Through multiplex assay, we found that kidney transplant patients with donor-specific anti-human leukocyte antigen antibodies and histological rejection have increased levels of pro-inflammatory cytokines in blood. Even in patients without histological rejection, elevated pro-inflammatory cytokine levels can be observed. These findings challenge the concept of histology as the gold standard for identifying ongoing allo-immune activation after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Solaf Al-Awadhi, Marc Raynaud, Kevin Louis, Antoine Bouquegneau, Jean-Luc Taupin, Olivier Aubert, Alexandre Loupy, Carmen Lefaucheur
Summary: In this systematic review, meta-analysis, and critical appraisal, the impact of complement-activating anti-HLA DSAs on solid organ transplant outcomes was investigated. The study found that complement-activating anti-HLA DSAs were associated with an increased risk of allograft loss and rejection. These findings demonstrate the significant deleterious impact and independent prognostic value of circulating complement-activating anti-HLA DSAs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Brian D. Cone, Jennifer Q. Zhang, Rebecca A. Sosa, Fiorella Calabrese, Elaine F. Reed, Gregory A. Fishbein
Summary: This study revealed a positive correlation between de novo DSA and p-S6RP expression in pneumocytes and macrophages using IHC. p-S6RP was found to be relatively sensitive, specific, and had superior inter-rater reliability compared to C4d.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Immunology
Nicholas G. Larkins, Lloyd D'Orsogna, Anne Taverniti, Ankit Sharma, Aron Chakera, Doris Chan, Anoushka Krishnan, Germaine Wong, Wai H. Lim
Summary: High resolution HLA typing is crucial for eplet compatibility and specificity of DSA. NGS and LD typing show high concordance but significant differences. Inaccurate DSA assignment from LD typing may inappropriately exclude candidates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Justin C. Quon, Kelli Kaneta, Nicholas Fotiadis, Jondavid Menteer, Rachel M. Lestz, Molly Weisert, Lee Ann Baxter-Lowe
Summary: This study investigated the prevalence and potential impact of unrepresented HLA proteins in different ethnic populations, and found a higher number of unrepresented HLA alleles in non-European populations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rebeca Bailen, Jose Luis Vicario, Laura Solan, Irene Sanchez-Vadillo, Pilar Herrera, Maria Calbacho, Raquel Alenda, Jose Luis Lopez-Lorenzo, Karem Humala, Anabelle Chinea, Jose Sanchez-Pina, Antonio Balas, Miguel Angel Moreno, Javier Arzuaga, Virginia Pradillo, Nieves Dorado, Gillen Oarbeascoa, Javier Anguita, Jose Luis Diez-Martin, Mi Kwon
Summary: This study reports the experience of using desensitization treatments for patients with DSAs undergoing haplo-HSCT. The results show that utilizing desensitization strategies guided by DSAs intensity kinetics can effectively decrease DSA intensity and improve engraftment rates.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pediatrics
Ryoichi Goto, Yasutomo Fukasaku, Yoshikazu Ganchiku, Norio Kawamura, Masaaki Watanabe, Takuji Ota, Kanako C. Hatanaka, Tomomi Suzuki, Tsuyoshi Shimamura, Akinobu Taketomi
Summary: This study aimed to identify the risks of post-transplant anti-HLA donor specific antibody (DSA) for graft fibrosis progression in pediatric living donor liver transplantation (LDLT). The results showed that pediatric cases with a high DSA-MFI and specific risk factors should undergo histological examination to determine the appropriate treatment for post-transplant DSA.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Michal Gniewkiewicz, Katarzyna Czerwinska, Katarzyna Zielniok, Magdalena Durlik
Summary: This study investigated the association between circulating DSAs and their characteristics with renal allograft long-term outcomes. The detection of DSAs at the time of biopsy and their C1q-binding capacity were found to be independent predictors of inferior renal allograft function and graft failure in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Covadonga Lopez del Moral, Kaiyin Wu, Marcel Naik, Bilgin Osmanodja, Aylin Akifova, Nils Lachmann, Diana Stauch, Sabine Hergovits, Mira Choi, Friederike Bachmann, Fabian Halleck, Eva Schrezenmeier, Danilo Schmidt, Klemens Budde
Summary: This study provides a comprehensive analysis of the natural course of dnDSA after kidney transplantation, demonstrates the impact of MFI evolution on graft outcomes, and identifies a subgroup of patients with a stable disappearance of dnDSA associated with better allograft survival.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Jasmin Mucha, Ara Cho, Anna Marianne Weijler, Moritz Muckenhuber, Amun Georg Hofmann, Markus Wahrmann, Andreas Heinzel, Birgit Linhart, Pia Gattinger, Rudolf Valenta, Gabriela Berlakovich, Andreas Zuckermann, Peter Jaksch, Rainer Oberbauer, Thomas Wekerle
Summary: This study aims to determine the frequency of pre-existing and de novo anti-HLA IgE antibodies in solid organ transplant recipients. The study found that anti-HLA IgE antibodies occur at low frequency in kidney, liver, heart, and lung transplant recipients and are associated with sensitization at the IgG level.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Tomoyasu Jo, Yasuyuki Arai, Kazuo Hatanaka, Hiroyuki Ishii, Akiko Ono, Nobuki Matsuyama, Jumpei Mori, Yangsook Koh, Fumihiro Azuma, Takafumi Kimura
Summary: This study examined the impact of anti-HLA antibodies against HLA-DP and -DQ on cord-blood transplantation outcomes. The presence of DSAs against HLA-DP and -DQ was associated with lower engraftment rates, longer engraftment time, increased risk of bacterial infection, and reduced survival after transplantation.
Review
Immunology
Scott M. Krummey, Alison J. Gareau
Summary: Advances in hematopoietic stem cell transplant have led to changes in donor selection approach, including the use of haploidentical donors or permissive HLA mismatches. However, this may increase the risk of donor-specific HLA antibodies, which can limit engraftment. Desensitization treatments can effectively reduce HLA antibodies and improve transplant outcomes. The consideration and management of HLA antibodies in donor selection are increasingly important in HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Aleksandar Senev, Evelyne Lerut, Maarten Coemans, Jasper Callemeyn, Hannah Charlotte Copley, Frans Claas, Priyanka Koshy, Vasilis Kosmoliaptsis, Dirk Kuypers, Ben Sprangers, Amaryllis Van Craenenbroeck, Elisabet Van Loon, Vicky Van Sandt, Marie-Paule Emonds, Maarten Naesens
Summary: The histology of antibody-mediated rejection after kidney transplantation can be observed in the absence of detectable donor-specific anti-HLA antibodies, and the degree of HLA mismatch is associated with the development of this phenotype.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Cell Biology
Hugo Bakis, Charlene Bouthemy, Jean-Benoit Corcuff, Cindy Lauro, Gwendaline Guidicelli, Marine Cargou, Claire Guibet, Benjamin Taton, Pierre Merville, Lionel Couzi, Karine Moreau, Jonathan Visentin
Summary: This study evaluated the association between 25-hydroxyvitamin D levels and rejection reactions, antibody-mediated rejection, and graft survival in kidney transplant recipients. They found that patients with sufficient 25(OH)D levels had fewer clinical rejection reactions and longer occurrence-free survival of donor-specific antibodies. Additionally, sufficient 25(OH)D levels were associated with longer graft survival in the first three years post-transplant.
Article
Biochemistry & Molecular Biology
Pascal Pedini, Lucas Hubert, Federico Carlini, Jean Baptiste Baudey, Audrey Tous, Francois Jordier, Agnes Basire, Claude Bagnis, Martine Reynaud-Gaubert, Benjamin Coiffard, Jacques Chiaroni, Monique Silvy, Christophe Picard
Summary: Lung transplantation is often complicated by acute and/or chronic rejection leading to graft-function loss. In addition to the HLA donor-specific antibodies (HLA-DSA), a few autoantibodies are correlated with the occurrence of these complications. Recently, antibodies directed against non-classical HLA molecules, HLA-G, -E, and -F have been detected in autoimmune diseases, like systemic lupus erythematosus. Non-classical HLA molecules are crucial in the immunological acceptance of the lung graft, and some of their isoforms, like HLA-G*01:04 and -G*01:06, are associated with a negative clinical outcome. The aim of this study is to determine the frequency of detection of HLA-G antibodies in lung transplant recipients (LTRs) and their impact on the occurrence of clinical complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
C. Picard, M. Boisseau, S. De Miranda, A. Hamid, D. Grenet, F. Parquin, E. Sage, M. Stern, A. Roux
REVUE DES MALADIES RESPIRATOIRES
(2015)
Letter
Critical Care Medicine
Magali Colombat, Sonia Holifanjaniaina, Francois Guillonneau, Herve Mal, Sandrine Hirschi, Martine Reynaud-Gaubert, Marc Stern
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2013)
Letter
Pathology
Magali Colombat, Sonia Holifanjaniaina, Sandrine Hirschi, Herve Mal, Marc Stern
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2014)
Article
Immunology
Antoine Roux, Gisele Mourin, Solene Fastenackels, Jorge R. Almeida, Maria Candela Iglesias, Anders Boyd, Emma Gostick, Martin Larsen, David A. Price, Karim Sacre, Daniel C. Douek, Brigitte Autran, Clement Picard, Sandra de Miranda, Delphine Sauce, Marc Stern, Victor Appay
CLINICAL IMMUNOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Delphine Mitilian, Edouard Sage, Philippe Puyo, Pierre Bonnette, Francois Parquin, Marc Stern, Marc Fischler, Alain Chapelier
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2014)
Article
Immunology
Maxime Samson, Xavier Puechal, Herve Devilliers, Camillo Ribi, Pascal Cohen, Marc Stern, Christian Pagnoux, Luc Mouthon, Loic Guillevin
JOURNAL OF AUTOIMMUNITY
(2013)
Article
Cardiac & Cardiovascular Systems
Marion Lafarge, Pierre Mordant, Gabriel Thabut, Laurent Brouchet, Pierre-Emmanuel Falcoz, Alain Haloun, Francoise Le Pimpec-Barthes, Jean-Michel Maury, Martine Reynaud-Gaubert, Christelle Saint-Raymond, Edouard Sage, Marc Stern, Pascal Thomas, Yves Castier, Richard Dorent, Herve Mal
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2013)
Article
Immunology
Antoine Roux, Gisele Mourin, Martin Larsen, Solene Fastenackels, Alejandra Urrutia, Guy Gorochov, Brigitte Autran, Catherine Donner, Daniel Sidi, Joyce Sibony-Prat, Arnaud Marchant, Marc Stern, Delphine Sauce, Victor Appay
JOURNAL OF IMMUNOLOGY
(2013)
Article
Multidisciplinary Sciences
Sylvia Sanquer, Catherine Amrein, Dominique Grenet, Romain Guillemain, Bruno Philippe, Veronique Boussaud, Laurence Herry, Celine Lena, Alphonsine Diouf, Michelle Paunet, Eliane M. Billaud, Francoise Loriaux, Jean-Philippe Jais, Robert Barouki, Marc Stern
Editorial Material
Respiratory System
M. Colombat, M. Stern
REVUE DES MALADIES RESPIRATOIRES
(2013)
Article
Immunology
O. Launay, P. Y. Boelle, A. Krivine, D. Grenet, V. Boussaud, N. Remus, H. Corvol, F. Chedevergne, D. Hubert, I. Sermet-Gaudelus
Article
Cardiac & Cardiovascular Systems
Gregoire Trebbia, Edourd Sage, Morgan Le Guen, Antoine Roux, Alexis Soummer, Philippe Puyo, Francois Parquin, Marc Stern, Tai Pham, Samir G. Sakka, Charles Cerf
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Article
Hematology
Mylene Camus, Sandrine Hirschi, Gregoire Prevot, Marie-Pierre Chenard, Herve Mal, Marc Stern, Martine Reynaud-Gaubert, Julia Gilhodes, Odile Burlet-Schiltz, Pierre Brousset, Magali Colombat
Article
Pediatrics
D. Grenet, A-S Bonnel, C. Dautricourt, S. De Miranda, P. Foucaud, M. Stern
ARCHIVES DE PEDIATRIE
(2012)