Article
Transplantation
Hanne Skou Jorgensen, Geert Behets, Bert Bammens, Kathleen Claes, Bjorn Meijers, Maarten Naesens, Ben Sprangers, Dirk R. J. Kuypers, Patrick D'Haese, Pieter Evenepoel
Summary: Overall, the majority of kidney transplant recipients exhibit normal bone turnover at 1-year post-transplant, while a significant subset show low bone turnover and high bone turnover is rare. Interventions targeting vitamin D deficiency and hypophosphatemia may help improve bone health after transplantation.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Hanne Skou Jorgensen, Geert Behets, Liesbeth Viaene, Bert Bammens, Kathleen Claes, Bjorn Meijers, Maarten Naesens, Ben Sprangers, Dirk Kuypers, Patrick C. D'Haese, Pieter Evenepoel
Summary: This study investigated the diagnostic performance of static histomorphometry for the evaluation of bone turnover in renal osteodystrophy, finding it to be a viable alternative in the absence of tetracycline labels. The results showed very good diagnostic performance for high turnover, with a combination of static parameters resulting in high predictive values, and reasonably good performance for low turnover as well.
Article
Urology & Nephrology
Hanne Skou Jorgensen, Geert Behets, Bert Bammens, Kathleen Claes, Bjorn Meijers, Maarten Naesens, Ben Sprangers, Dirk R. J. Kuypers, Etienne Cavalier, Patrick Dhaese, Pieter Evenepoel
Summary: This study aimed to characterize the evolution of bone disease in the first year after kidney transplantation. The results showed that changes in bone turnover, mineralization, and volume were related to steroid exposure and ongoing disturbances of mineral metabolism. Optimal control of mineral metabolism may be crucial for improving bone quality in kidney transplant recipients.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Thomas Levin Andersen, Pia Rosgaard Jensen, Tanja Tvistholm Sikjaer, Lars Rejnmark, Charlotte Ejersted, Jean-Marie Delaisse
Summary: Proper bone remodeling relies not only on the actions of osteoclasts and osteoblasts, but also on the delivery of osteoblast lineage cells to the remodeling site. A CD271-positive/PDGF beta-R-positive cell layer surrounding the bone marrow provides osteoblastogenic potential on all bone surfaces, including both quiescent and remodeling sites. This cell layer, known as the canopy, plays a critical role in initiating bone remodeling by activating early markers of osteoblastogenesis and supporting cell delivery to the bone surface.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Fnu Deepika, Siresha Bathina, Reina Armamento-Villareal
Summary: The burden of obesity and osteoporosis is increasing and becoming a major public health concern. Recent evidence has identified novel adipokines that play a role in bone metabolism. Obesity, characterized by adipose tissue inflammation, negatively impacts bone health. Adipokines secreted from white adipose tissue and bone marrow adipose tissue have effects on osteoblasts and osteoclasts. Understanding the complex interplay between fat cells and bone is crucial in the context of osteoporosis. This review summarizes recent advances in the understanding of adipokines' role in bone metabolism.
Review
Biology
Alessandra Pecorelli, Valeria Cordone, Maria Lucia Schiavone, Carla Caffarelli, Carlo Cervellati, Gaetana Cerbone, Stefano Gonnelli, Joussef Hayek, Giuseppe Valacchi
Summary: Rett syndrome is a monogenic neurodevelopmental disorder caused by mutations in the MECP2 gene. Patients exhibit a broad spectrum of symptoms, with orthopedic complications being a common non-neurological manifestation, including scoliosis and osteopenia/osteoporosis. Further research is needed to understand the molecular mechanisms underlying these bone problems and develop new therapeutic approaches.
Article
Biochemistry & Molecular Biology
Kalpana Patel, S. V. V. S. Ravi Mangu, Shinde Vijay Sukhdeo, Kunal Sharan
Summary: This study investigates the effects of sesamol on bone metabolism. It found that sesamol can promote bone formation but can also lead to bone deterioration in ovariectomized rats. These findings highlight the potential negative impact of sesamol in postmenopausal women.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Immunology
Camilo G. Sotomayor, Stan Benjamens, Antonio W. Gomes-Neto, Robert A. Pol, Dion Groothof, Charlotte A. te Velde-Keyzer, Guillermo Chong, Andor W. J. M. Glaudemans, Stefan P. Berger, Stephan J. L. Bakker, Riemer H. J. A. Slart
Summary: CKD-MBD and vascular calcification are common in kidney transplant recipients. This study found a high prevalence of BMD disorders in KTR, with an independent inverse association between BMD and AAC suggesting the existence of a bone-vascular axis post transplantation.
Review
Medicine, General & Internal
Luca Dalle Carbonare, Maria Teresa Valenti, Sandro Giannini, Maurizio Gallieni, Francesca Stefani, Roberto Ciresa, Cristina Politi, Maria Fusaro
Summary: Bone biopsy for histomorphometric analysis provides quantitative information on bone remodeling and structure, particularly useful in diagnosing bone diseases such as renal osteodystrophy. Despite being the gold standard, its limited use is attributed to lack of expertise, cost, invasiveness, and pain associated with the procedure. Implementing sedation, standardizing analyses, and utilizing new tools can optimize the approach and utility of bone biopsy in managing CKD patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Francesca Miglietta, Luca Iamartino, Gaia Palmini, Francesca Giusti, Francesca Marini, Teresa Iantomasi, Maria Luisa Brandi
Summary: Hematopoietic stem cell transplantation (HSCT) is an effective therapy for various hematopoietic diseases. While the mortality rate has decreased, late HSCT-related complications have emerged, particularly affecting the endocrine system and mineral metabolism. This review focuses on the impact of HSCT on calcium homeostasis, including osteoporosis and renal dysfunctions, and discusses possible secondary implications on parathyroid glands and calcium homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Makoto Tsujita, Yohei Doi, Yoshitsugu Obi, Takayuki Hamano, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Norihiko Goto, Yoshitaka Isaka, Asami Takeda, Shunji Narumi, Yoshihiko Watarai
Summary: The study found that cholecalciferol significantly reduced PTH levels and attenuated LS BMD loss after kidney transplantation, especially showing a more pronounced effect in patients with low bone mass.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Frank C. Ko, Margaret M. Kobelski, Wanlin Zhang, Gina M. Grenga, Janaina S. Martins, Marie B. Demay
Summary: Phosphate restriction leads to decreased bone formation and increased bone marrow adipose tissue by affecting cellular signaling pathways and gene expression.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sumin Lee, Jae-Hyun Kim, Minsun Kim, Sooyeon Hong, Hoyeon Park, Eom Ji Kim, Eun-Young Kim, Chungho Lee, Youngjoo Sohn, Hyuk Sang Jung, Jose Luis Perez-Castrillon
Summary: This study investigated the potential of a natural compound called daucosterol (DC) as a treatment for osteoporosis. The results showed that DC effectively inhibited osteoclast differentiation, promoted osteoblast activity, and prevented bone density loss caused by LPS. These findings suggest that DC may be a new therapeutic alternative for osteoporosis patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Berenice Gitomer, Renata Pereira, Isidro B. Salusky, Jason W. Stoneback, Tamara Isakova, Xuan Cai, Lorien S. Dalrymple, Norma Ofsthun, Zhiying You, Harmut H. Malluche, Franklin Maddux, Diana George, Vicente Torres, Arlene Chapman, Theodore I. Steinman, Myles Wolf, Michel Chonchol
Summary: Patients with ADPKD have lower alkaline phosphatase levels, higher circulating intact fibroblast growth factor 23, and decreased bone formation rate. However, ADPKD is not associated with higher rates of bone fracture in ESKD.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Ana Gabriela J. T. Melo, Gessica Sabrine B. Barbosa, Daniela Del P. V. R. Cortes, Rayra G. Ribeiro, Luiza K. Araujo, Benedito J. Pereira, Hugo Abensur, Rosa M. A. Moyses, Rosilene M. Elias
Summary: The study compared the prognosis of patients returning to PD after failed kidney transplant with those starting PD for other reasons, finding no significant differences in technique survival, peritonitis-free survival, and residual diuresis between the two groups, suggesting that PD is a viable dialysis option after kidney transplant failure.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, Research & Experimental
Wander Barros do Carmo, Barbara Bruna Abreu Castro, Luisa Cardoso Manso, Priscylla Aparecida Vieira do Carmo, Clovis Antonio Rodrigues, Melani Ribeiro Custodio, Vanda Jorgetti, Helady Sanders-Pinheiro
Summary: The study found that the chitosan-iron III chelator was effective in reducing phosphorus excretion without iron accumulation, paving the way for potential use of this class of chelators in clinical settings in the future.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Urology & Nephrology
Tiago Emanuel M. Costa, Julia C. Lauar, Mariana L. R. Innecchi, Venceslau A. Coelho, Rosa M. A. Moyses, Rosilene M. Elias
Summary: This study found an association between hyperuricemia and secondary hyperparathyroidism in patients with CKD, suggesting that hyperuricemia may contribute to the development of SHPT.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Urology & Nephrology
Eduardo J. Duque, Rosilene M. Elias, Rosa M. A. Moyses
Summary: Phosphate balance is crucial in the treatment of chronic kidney disease (CKD), with current therapy focusing on dietary restrictions, phosphate binders, and optimal removal by dialysis. Future studies may confirm the benefits of phosphate control in CKD patients.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2022)
Article
Nutrition & Dietetics
Renata G. Rodrigues, Maria Aparecida Dalboni, Marilia de A. Correia, Luciene M. dos Reis, Rosa M. A. Moyses, Rosilene M. Elias
Summary: This study evaluated whether reduced calf circumference (CC) could predict falls in older patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis. The study found that reduced CC, higher age, and higher body weight were associated with falls. This study suggests that CC measurement is a simple and low-cost tool to predict fall risk in older patients undergoing hemodialysis.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Multidisciplinary Sciences
Lilian Cordeiro, Walther Yoshiharu Ishikawa, Maria Claudia C. Andreoli, Maria Eugenia F. Canziani, Luiza Karla R. P. Araujo, Benedito J. Pereira, Hugo Abensur, Rosa M. A. Moyses, Rosilene M. Elias
Summary: This study aimed to investigate the impact of icodextrin solution compared to glucose solution on left ventricular hypertrophy in peritoneal dialysis patients. The results showed that icodextrin solution was not able to improve left ventricular mass. Further large-scale randomized trials with longer follow-up periods may be needed to observe changes in left ventricular mass in this patient population.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Kalyanna S. Bezerra de Carvalho, Julia C. Lauar, Luciano F. Drager, Rosa M. A. Moyses, Rosilene M. Elias
Summary: There is a discrepancy between self-reported and objectively measured sleep duration in CKD patients. Objective measurements are recommended for accurate assessment of sleep duration in CKD patients.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Biographical-Item
Endocrinology & Metabolism
Vanda Jorgetti, Sampaio-Barros Pd, Shinjo Sk, Eloisa Bonfa
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Maria Clara Teixeira Piraciaba, Lilian Cordeiro, Erica Adelina Guimaraes, Hugo Abensur, Benedito Jorge Pereira, Vanda Jorgetti, Rosa Maria Affonso Moyses, Rosilene Motta Elias
Summary: Reducing the dialysate calcium concentration (D[Ca]) in peritoneal dialysis patients is a safe and beneficial option to prevent a rise in parathyroid hormone (PTH) levels.
Article
Urology & Nephrology
Cinthia E. M. Carbonara, Noemi A. V. Roza, Luciene M. dos Reis, Aluizio B. Carvalho, Vanda Jorgetti, Rodrigo Bueno de Oliveira
Summary: The Brazilian Registry of Bone Biopsy (REBRABO) is a national multicenter cohort that provides clinical information on renal osteodystrophy (ROD). This subanalysis described the profile of ROD, including the most frequent diagnoses and associated findings. The results showed a high proportion of patients with osteoporosis, vascular calcification, and clinical symptoms.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Medicine, Research & Experimental
Marta Martinez-Calle, Guillaume Courbon, Bridget Hunt-Tobey, Connor Francis, Jadeah Spindler, Xueyan Wang, Luciene M. dos Reis, Carolina S. W. Martins, Isidro B. Salusky, Hartmut Malluche, Thomas L. Nickolas, Rosa M. A. Moyses, Valentin David, Aline Martin
Summary: Renal osteodystrophy (ROD) is a bone metabolism disorder that affects patients with chronic kidney disease (CKD) and is associated with negative clinical outcomes. The study found that hepatocyte nuclear factor 4α (HNF4α), expressed mostly in the liver, is also expressed in bone and its reduced expression is observed in ROD patients and mice. Deletion of Hnf4α in osteoblasts led to impaired osteogenesis. Multi-omics analyses showed that the main isoform of HNF4α regulating osteogenesis, cell metabolism, and cell death is HNF4α2. Osteoblast-specific overexpression of HNF4α2 prevented bone loss in CKD mice.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Urology & Nephrology
Paula M. R. Pina, Luis Carlos Arcon, Roberto Zatz, Rosa M. A. Moyses, Rosilene M. Elias
Summary: Although factors related to CKD progression have been extensively studied, little is known about renal function decline specifically in older individuals. This study found that older patients with CKD exhibit slower progression of the disease, even after adjusting for multiple factors. These findings have important implications for the management and planning of dialysis in older CKD patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Maria Beatriz C. N. Pessoa, Ruth Miyuki Santo, Aline A. de Deus, Eduardo J. Duque, Shirley F. Crispilho, Vanda Jorgetti, Maria Aparecida Dalboni, Carlos Eduardo Rochitte, Rosa M. A. Moyses, Rosilene M. Elias
Summary: This cross-sectional study aimed to investigate the relationship between corneal and conjunctival calcification (CCC) and coronary artery calcification in patients with chronic kidney disease. The study found that CCC was frequent in this population but did not correlate with coronary artery calcification. Hyperphosphatemia appeared to contribute to CCC.
Article
Nutrition & Dietetics
Luana Cristina A. de Silva, Marilia A. de Correia, Renata Daniel Gouveia, Mayara S. Souza, Carlos P. Isaac Jr, Fernando Parrillo, Rosa M. A. Moyses, Maria Aparecida Dalboni, Rosilene M. Elias
Summary: Malnutrition is common in older patients with end-stage renal disease, and nutritional supplementation can mitigate the loss of the SMM index and improve survival rate. However, the effects on sarcopenia were not significant in this study.
CLINICAL NUTRITION ESPEN
(2023)