Article
Urology & Nephrology
Seok Hui Kang, Bo Yeon Kim, Eun Jung Son, Gui Ok Kim, Jun Young Do
Summary: This study compared the effect of two uric acid-lowering drugs (allopurinol and febuxostat) on patient survival in hemodialysis patients. The results showed that patient survival during the use of uric acid-lowering drugs was similar to that of patients not receiving the drugs.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Marios Marcou, Matthias Galiano, Anja Tzschoppe, Katja Sauerstein, Sven Wach, Helge Taubert, Bernd Wullich, Karin Hirsch-Koch, Hendrik Apel
Summary: Recognizing risk factors is crucial for decision-making in pediatric kidney transplantation. A retrospective study identified small body surface area (<1 m(2)) as a favorable prognostic factor for long-term graft survival, while adolescents over the age of 12 had poorer outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Transplantation
Seung Hwan Song, Hoon Young Choi, Ha Yan Kim, Chung Mo Nam, Hyeon Joo Jeong, Myoung Soo Kim, Soon I. I. Kim, Yu Seun Kim, Kyu Ha Huh, Beom Seok Kim
Summary: The study investigated the effects of bisphosphonates on long-term graft outcomes after kidney transplantation and found that bisphosphonate therapy may improve long-term graft survival in kidney transplant recipients, particularly for those with osteopenia or osteoporosis. The use of bisphosphonates was associated with higher death-censored graft survival and significantly reduced risk of graft failure in the study cohort.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Immunology
Raphael Porret, Raphael P. H. Meier, Josip Mikulic, Manuel Pascual, Vincent Aubert, Thomas Harr, Dela Golshayan, Yannick D. D. Muller, Swiss Transplant Cohort Study
Summary: The study found that atopy is associated with better long-term patient and graft survival after kidney transplantation, independently of age and living donor donation. However, it does not affect the occurrence of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Siawosh K. Eskandari, Mariana Gaya da Costa, Bernardo Faria, Vojtech Petr, Jamil R. Azzi, Stefan P. Berger, Marc A. J. Seelen, Jeffrey Damman, Felix Poppelaars
Summary: Genetic research suggests that targeting interleukin 6 (IL-6) in kidney transplantation can improve graft survival. A genetic risk score (GRS) based on IL6 and IL10 variants can also predict the risk of graft loss, surpassing current clinical markers.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Yohan Park, Hanbi Lee, Sang Hun Eum, Hyung Duk Kim, Eun Jeong Ko, Chul Woo Yang, Byung Ha Chung
Summary: This study revealed that intrapatient variability (IPV) of tacrolimus (TAC) trough levels post-kidney transplantation significantly impacts allograft outcomes, emphasizing the importance of maintaining low TAC-IPV even with high mean TAC levels for improving transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Agnieszka Furmanczyk-Zawiska, Barbara Bullo-Piontecka, Michal Komorniczak, Alicja Debska-Slizien, Hanna Augustyniak-Bartosik, Magdalena Durlik
Summary: Antiphospholipid syndrome (APS) is a devastating autoimmune disease that can lead to allograft thrombosis or other extra-renal manifestations in renal transplant recipients. The impact of APS on renal allograft function and survival is still unknown, especially in recipients without APS nephropathy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Samarra Badrouchi, Abdulaziz Ahmed, Mohamed Mongi Bacha, Ezzedine Abderrahim, Taieb Ben Abdallah
Summary: This study proposes a machine learning framework to predict graft survival after five years of kidney transplantation and determines the most influential parameters. The XGBoost algorithm was found to be the best model with high AUC and sensitivity. The framework can serve as a decision support system for Nephrologists to provide safer treatment recommendations and achieve positive kidney transplant outcomes.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Article
Immunology
Bartlomiej J. Witczak, Soren E. Pischke, Anna Reisaeter, Karsten Midtvedt, Judith K. Ludviksen, Kristian Heldal, Trond Jenssen, Anders Hartmann, Anders Asberg, Tom E. Mollnes
Summary: Early complement activation, assessed by plasma TCC levels, is associated with impaired long-term patient and graft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Zhen Guo, Mei-Hua Bao, Yun-Xia Fan, Yan Zhang, Hai-Yan Liu, Xiao-Long Zhou, Ben Wu, Qing-Qing Lu, Bin-Sheng He, Xu-Ying Nan, Jiao-Yang Lu
Summary: The genetic polymorphisms of linc00312 may serve as potential biomarkers for NPC carcinogenesis and prognosis, as they can influence the expression and secondary structure of linc00312, thus affecting the sensitivity and survival of NPC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Isaac Rodriguez-Rovira, Angela Lopez-Sainz, Maria Encarnacion Palomo-Buitrago, Belen Perez, Francesc Jimenez-Altayo, Victoria Campuzano, Gustavo Egea
Summary: Redox stress is involved in the pathogenesis of aortic aneurysm in Marfan syndrome. Allopurinol, a xanthine oxidoreductase inhibitor, acts as an antioxidant without changing uric acid levels and can block aortopathy in a MFS mouse model. This study aimed to evaluate the impact of hyperuricaemia on aortopathy pathogenesis in MFS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yingdong Han, Yu Cao, Xinxin Han, Hong Di, Yue Yin, Juan Wu, Yun Zhang, Xuejun Zeng
Summary: This study evaluated the relationship among hyperuricemia, gout, heart failure (HF), and all-cause mortality. The results showed that patients with hyperuricemia or gout were more likely to have HF, and those with HF and hyperuricemia or gout were more likely to experience all-cause mortality in the long-term follow-up.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jesus Venegas-Ramirez, Karla Esmeralda Barrios-Mora, Eder Fernando Rios-Bracamontes, Jose Guzman-Esquivel, Martha Irazema Cardenas-Rojas, Efren Murillo-Zamora
Summary: This study assessed the survival experience of long-term peritoneal dialysis (PD) patients in Mexico and found that older age at PD initiation and the use of continuous ambulatory peritoneal dialysis were associated with an increased risk of mortality. This highlights the need to optimize treatment strategies to enhance long-term prognosis for patients with end-stage kidney disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Lashodya V. Dissanayake, Adrian Zietara, Vladislav Levchenko, Denisha R. Spires, Mariana Burgos Angulo, Ashraf El-Meanawy, Aron M. Geurts, Melinda R. Dwinell, Oleg Palygin, Alexander Staruschenko
Summary: The dysregulation of uric acid homeostasis is detrimental to cardiovascular and kidney health. This study established a rat model with the genetic ablation of the Xdh gene and found that the absence of Xdh leads to the accumulation of uric acid metabolites in the kidney, resulting in severe kidney injury and functional decline.
Article
Immunology
Wanvisa Udomsinprasert, Nuttakant Nontawong, Wacharapol Saengsiwaritt, Bhakbhoom Panthan, Poramate Jiaranai, Nartthawee Thongchompoo, Siwalee Santon, Chakkaphan Runcharoen, Insee Sensorn, Jiraphun Jittikoon, Usa Chaikledkaew, Wasun Chantratita
Summary: This study aimed to determine possible associations between single nucleotide polymorphisms (SNPs) in 37 candidate genetic variants and clinical consequences of COVID-19, especially long-term symptoms (Long COVID). Genotyping of selected polymorphisms was performed and 9 SNPs were significantly associated with an increased risk of developing Long COVID, while 1 SNP was significantly associated with a reduced risk of Long COVID.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Hematology
Noriaki Kawano, Shinya Kimura, Masatomo Miura, Taro Tochigi, Takashi Nakaike, Kiyoshi Yamashita, Koichi Mashiba, Ikuo Kikuchi, Naoto Takahashi
Summary: Serial evaluation of the pharmacokinetics of ponatinib may provide meaningful information about its safety and efficacy.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yumiko Akamine, Nobuhiro Fujiyama, Hideaki Kagaya, Mitsuru Saito, Hiroshi Miura, Yukihiro Terada, Tsutomu Takahashi, Shigeru Satoh, Masatomo Miura
Summary: The study reveals that maternal tacrolimus concentrations directly affect the fetus and neonate, with minimal transfer through breast milk detected in the neonate 3 weeks after birth.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Kazuma Fujita, Satoru Motoyama, Yusuke Sato, Akiyuki Wakita, Yushi Nagaki, Yoshihiro Minamiya, Masatomo Miura
Summary: The study found that the ABCC2 -24C>T polymorphism is significantly associated with grade 3-4 hematological toxicity after platinum plus 5-FU therapy, along with radiation therapy and baseline white blood cell count.
Article
Oncology
Natsuki Fukuda, Yumiko Akamine, Maiko Abumiya, Saori Takahashi, Tomoko Yoshioka, Yoshihiro Kameoka, Naoto Takahashi, Masatomo Miura
Summary: In this study, we evaluated the plasma exposure and response relationships of nilotinib in patients with newly diagnosed CML. The results showed that the nilotinib C-trough values were significantly higher in patients with MMR at 3 months compared to those without MMR. The threshold value of nilotinib C-trough at 3 months for predicting MMR achievement was 619 ng/mL with the best sensitivity (71.4%) and specificity (77.8%). Patients with a nilotinib C-trough above 619 ng/mL had a shorter time to achieve DMR and higher rates of DMR by 2 years.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Oncology
Honami Sato, Takahiro Kobayashi, Nanako Fujita, Takaya Yamashita, Akihiro Kitadate, Tomoko Yoshioka, Miho Nara, Yoshihiro Kameoka, Masatomo Miura, Naoto Takahashi
Summary: The PK parameters of administering crushed venetoclax through a PEG tube were similar to those of orally administered venetoclax, suggesting it could be an alternative route for patients who have difficulty with oral administration. The clinical course was safe with no unexpected adverse events during the administration of crushed venetoclax tablets in combination with azacitidine.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hironobu Yagishita, Hideaki Kagaya, Mitsuru Saito, Kazuyuki Numakura, Ryohei Yamamoto, Ryuichiro Sagehashi, Tomonori Habuchi, Shigeru Satoh, Masatomo Miura
Summary: The study evaluated the effects of NR1I2 and ABCB1 genetic polymorphisms on everolimus pharmacokinetics in Japanese renal transplant patients. The results showed significant correlations between different genotypes, gender, age, and liver function with the dose-adjusted AUC(0-12) of everolimus. Therefore, age and liver function should be considered when evaluating dose reductions for everolimus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hayato Yokota, Kazuhiro Sato, Sho Sakamoto, Yuji Okuda, Natsuki Fukuda, Mariko Asano, Masahide Takeda, Katsutoshi Nakayama, Masatomo Miura
Summary: This study investigated the effects of polymorphisms in CYP3A4, CYP3A5, ABCB1, ABCG2, and ABCC2 on the area under the concentration-time curve (AUC) of osimertinib in patients with non-small cell lung cancer. The results showed significant correlations between osimertinib AUC and age, serum albumin, and serum creatinine. Differences in osimertinib AUC were observed among different treatment groups. There were no significant differences in osimertinib AUC based on genotypes or the presence of side effects. Serum albumin was identified as an independent factor predicting osimertinib AUC.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Biochemical Research Methods
Natsuki Fukuda, Takahiro Kobayashi, Honami Sato, Yumiko Akamine, Naoto Takahashi, Masatomo Miura
Summary: A simple and sensitive HPLC method was developed for measuring venetoclax concentrations in plasma samples. The method showed good separation of venetoclax and the internal standard, with no interference from the biological matrix. Only a small amount of plasma was required to reach a low limit of quantification. The method was successfully applied to determine venetoclax concentrations in plasma of leukemia patients and can be used to assess drug interactions between venetoclax and CYP3A4 inhibitors.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Oncology
Satoru Motoyama, Miki Hosaka, Takashi Kamei, Masaki Ueno, Masayuki Watanabe, Yu Ohkura, Shinji Mine, Shunsuke Tanabe, Takahiro Toyokawa, Akiyuki Wakita, Katsunori Nishikawa, Itasu Ninomiya, Kazuma Fujita, Mie Kanda, Mitsuharu Hirai, Manami Hoshi, Shih-Wei Chiu, Munenori Takata, Takuhiro Yamaguchi, Masatomo Miura
Summary: The utility of a CRP genetic polymorphism test kit for determining the risk of lymph node metastasis in esophageal squamous cell carcinoma patients was tested in this study. The results showed that this test kit is not an effective indicator for determining the risk of lymph node metastasis.
ANTICANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yayoi Fukushi, Yumiko Akamine, Maiko Abumiya, Nagi Tozawa, Takaya Yamashita, Miho Nara, Yoshihiro Kameoka, Naoto Takahashi, Masatomo Miura
Summary: The effects of ABCB1 and ABCG2 polymorphisms on the pharmacokinetics of ponatinib were investigated. Subjects with specific ABCB1 variant genotypes exhibited significantly higher ratios of cerebrospinal fluid (CSF) to plasma concentration of ponatinib compared to others. These findings suggest that ABCB1 polymorphisms modulate the brain distribution of ponatinib through the regulation of P-glycoprotein at the blood-brain and blood-CSF barriers.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yoshiko Takahashi, Shintaro Narita, Masaki Shiota, Masatomo Miura, Hideaki Kagaya, Soki Kashima, Ryohei Yamamoto, Taketoshi Nara, Mingguo Huang, Kazuyuki Numakura, Mitsuru Saito, Masatoshi Eto, Tomonori Habuchi
Summary: This study assessed the impact of plasma trough concentrations and polymorphisms on adverse events in patients with metastatic prostate cancer who received abiraterone acetate. The results showed that high plasma trough concentrations were associated with the presence of adverse events and treatment failure.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yumiko Akamine, Miyuki Matsushita, Satoru Morikawa, Masatomo Miura
Summary: This study compared the results of analyzing MPA plasma concentrations using the LM1010 method and the previously described HPLC method, showing a high correlation between the two methods. The LM1010 method had a short analysis time and was suitable for fresh plasma samples.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2023)
Meeting Abstract
Urology & Nephrology
Yoshiko Takahashi, Shintaro Narita, Masaki Shiota, Soki Kashima, Ryohei Yamamoto, Atsushi Koizumi, Kazuyuki Numakura, Mitsuru Saito, Masatoshi Eto, Masatomo Miura, Tomonori Habuchi
JOURNAL OF UROLOGY
(2022)
Meeting Abstract
Oncology
T. Nakagawa, T. Fukuhara, K. Imai, R. Igusa, H. Yokota, K. Watanabe, A. Suzuki, M. Morita, A. Inoue, M. Miura, Y. Minamiya, M. Maemondo
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Maiko Abumiya, Yumiko Akamine, Shiori Sato, Saori Takahashi, Tomoko Yoshioka, Yoshihiro Kameoka, Naoto Takahashi, Masatomo Miura
Summary: This study investigated the relationship among nilotinib plasma trough concentration, LDL cholesterol, and PCSK9 plasma concentration in patients with chronic myeloid leukaemia. Results showed that LDL cholesterol concentrations increased significantly after nilotinib treatment, with higher PCSK9 concentrations at 3 months post-treatment. Patients with a higher change rate in PCSK9 had a significantly higher change rate in LDL cholesterol, suggesting that nilotinib may lead to hypercholesterolaemia by increasing PCSK9 concentrations.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)