Article
Multidisciplinary Sciences
Fotios Sampaziotis, Daniele Muraro, Olivia C. Tysoe, Stephen Sawiak, Timothy E. Beach, Edmund M. Godfrey, Sara S. Upponi, Teresa Brevini, Brandon T. Wesley, Jose Garcia-Bernardo, Krishnaa Mahbubani, Giovanni Canu, Richard Gieseck, Natalie L. Berntsen, Victoria L. Mulcahy, Keziah Crick, Corrina Fear, Sharayne Robinson, Lisa Swift, Laure Gambardella, Johannes Bargehr, Daniel Ortmann, Stephanie E. Brown, Anna Osnato, Michael P. Murphy, Gareth Corbett, William T. H. Gelson, George F. Mells, Peter Humphreys, Susan E. Davies, Irum Amin, Paul Gibbs, Sanjay Sinha, Sarah A. Teichmann, Andrew J. Butler, Teik Choon See, Espen Melum, Christopher J. E. Watson, Kourosh Saeb-Parsy, Ludovic Vallier
Summary: The study demonstrates the potential of cholangiocyte organoids to repair human biliary epithelium, despite the loss of transcriptional diversity during organoid culture, they remain plastic and have regenerative capabilities.
Article
Gastroenterology & Hepatology
Lukas Hartl, Katharina Haslinger, Martin Angerer, Georg Semmler, Mathias Schneeweiss-Gleixner, Mathias Jachs, Benedikt Simbrunner, David Josef Maria Bauer, Ernst Eigenbauer, Robert Strassl, Monika Breuer, Oliver Kimberger, Daniel Laxar, Katharina Lampichler, Emina Halilbasic, Albert Friedrich Staettermayer, Ahmed Ba-Ssalamah, Mattias Mandorfer, Bernhard Scheiner, Thomas Reiberger, Michael Trauner
Summary: This study found that approximately 20% of patients with chronic liver disease (CLD) develop progressive cholestasis after COVID-19 infection. Patients with NAFLD/NASH and metabolic risk factors are at higher risk of developing cholestatic liver failure and/or secondary sclerosing cholangitis (SSC) after COVID-19.
Article
Immunology
Dhiraj Agrawal, Sanjiv Saigal, Shekhar Singh Jadaun, Shweta A. Singh, Shaleen Agrawal, Subhash Gupta
Summary: Paired exchange liver transplantation is an evolving strategy to overcome ABO blood group incompatibility and other barriers in living donor liver transplantation. This study analyzed the experience with liver paired exchange program over the past 9 years and found that with careful attention to ethical and logistical issues, the program can expand the living donor liver pool and facilitate a greater number of living donor liver transplantations. The study involved simultaneous performance of 4 major operations, which posed a challenging task for the transplant team. However, donor survival rate was 100% and baseline clinical parameters and postoperative complications were comparable between different groups.
Article
Surgery
Nicholas Gilbo, Desley Neil, Rebecca Brais, Steffen Fieuws, Letizia Lo Faro, Peter Friend, Rutger Ploeg, Diethard Monbaliu
Summary: This study investigated the impact of preservation type on histological bile duct injury score (BDIS) in liver NMP. The results showed that BDIS increased over time, and the BDIS estimate was higher in NMP than in SCS, but did not increase the risk of ischemic cholangiopathy.
TRANSPLANT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Mark Ly, Ngee-Soon Lau, Catriona Mckenzie, James G. Kench, Doruk Seyfi, Avik Majumdar, Ken Liu, Geoffrey Mccaughan, Michael Crawford, Carlo Pulitano
Summary: Histological assessment of bile duct injury is limited in predicting post-transplant biliary strictures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jeffrey R. Ord, Madison K. Krischak, Jigesh A. Shah, Andrew S. Barbas
Summary: This case report presents the first case of a Duct of Luschka biliary leak seen after DCD liver transplant. The patient underwent surgical re-exploration due to bilious output from a surgical drain, where a Duct of Luschka was found and oversewn. Besides immunosuppression-related neutropenia, the patient recovered uneventfully postoperatively.
AMERICAN JOURNAL OF CASE REPORTS
(2021)
Article
Surgery
Davide Citterio, Marta Vaiani, Carlo Sposito, Roberta Elisa Rossi, Maria Flores, Carlo Battiston, Vincenzo Mazzaferro
Summary: This study shows that gadoxetic acid disodium-enhanced magnetic resonance cholangiography is highly accurate in detecting and locating postoperative biliary leaks, especially in peripheral locations, reducing the need for invasive cholangiography by 50%. Patients with peripheral leaks can avoid invasive procedures and have shorter hospital stays when managed conservatively.
Article
Cell Biology
Ho Taek Oh, Woong Heo, Gi Don Yoo, Kyung Min Kim, Jun-Ha Hwang, Eun Sook Hwang, Jesang Ko, Young-Gyu Ko, Jeong-Ho Hong
Summary: This study found that knockout of ductal TAZ in mice and TAZ in cholangiocyte organoids led to decreased liver fibrosis and decreased expression levels of fibrosis inducers. CD133 stabilized TAZ via Src activation, promoting fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Surgery
Mario Vilatoba, Mariana Chavez-Villa, Rodrigo Figueroa-Mendez, Ismael Dominguez-Rosado, Rodrigo Cruz-Martinez, Rafael P. Leal-Villalpando, Ignacio Garcia-Juarez, Miguel A. Mercado
Summary: By analyzing the outcomes of patients undergoing liver transplantation (LT) due to bile duct injury (BDI), it was found that although the postoperative mortality is high, LT remains the only possibility of a cure and has acceptable long-term outcomes. Early referral to a tertiary care center is crucial for avoiding long-term complications of BDI. Post-cholecystectomy BDI accounted for 3.4% of all LT in our center.
Article
Multidisciplinary Sciences
Simona Hankeova, Jakub Salplachta, Noemi Van Hul, Michaela Kavkova, Afshan Iqbal, Tomas Zikmund, Jozef Kaiser, Emma R. Andersson
Summary: The technique described in the study, double resin casting micro-computed tomography (DUCT), involves injecting two different resins into the portal vein and bile duct, followed by tissue fixation, to visualize the three-dimensional structure of the liver. DUCT can be applied to postnatal and adult mouse liver and other tubular networks.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Surgery
James A. Richards, Rohit Gaurav, Sara S. Upponi, Lisa Swift, Corrina Fear, Gwilym J. Webb, Michael E. D. Allison, Christopher J. E. Watson, Andrew J. Butler
Summary: The liver is crucial for life, and without a transplant from a donor, patients with liver failure will die. Unfortunately, limited availability of liver organs results in some patients dying while waiting. This article presents a novel technique that enables resuscitation and testing of potential donor livers, increasing the chances for safe transplantation.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Eleftherios Gialamas, Michela Assalino, Laure Elkrief, Fani Apostolidou-Kiouti, Arthur Piveteau, Graziano Oldani, Philippe Compagnon, Thierry Berney
Summary: This study found no significant difference in the prevalence of biliary and arterial complications between patients with and without MAL during orthotopic liver transplantation (OLT). The treatment of MAL did not have a significant impact on the overall outcome and development of complications in patients.
CLINICAL TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Wen-Lung Su, Fang-Jung Yu, Jian-Wei Huang, Ming-Chen Shih, Wen-Hung Hsu, Hsiang-Yao Shih, Yu-Ling Huang, Ling-An Chen, Po-Hsuan Wu, Chia-Jen Wu, Chiao-Yun Chen, Kung-Kai Kuo, King-Teh Lee, Wen-Tsan Chang
Summary: This study aimed to describe the experience and outcomes of using percutaneous transhepatic biliary drainage (PTBD) in patients with biliary complications after liver transplantation (LT). The study found that salvage PTBD had limited effectiveness in patients without dilated intrahepatic bile ducts (IHBDs) within 1 month after LT.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Immunology
Marjolein J. M. ten Dam, Geert W. J. Frederix, Renske M. T. ten Ham, Luc J. W. van der Laan, Kerstin Schneeberger
Summary: Due to a shortage of suitable donor livers, alternative treatments for end-stage liver disease need to be explored. Recent advances in organoid technology show potential for cell therapy and tissue engineering approaches as a solution.
Article
Medicine, General & Internal
Alessandra Cristaudi, Ignazio Tarantino, Andreas Scheiwiller, Andrea Wiencierz, Pietro Majno-Hurst, Bruno M. Schmied, Juerg Metzger, Mark Hartel, Michael Kremer, Giulia Manzini
Summary: The study proposes a multicentric randomized controlled trial to compare the effectiveness of the white test in reducing postoperative bile leakage.
Article
Immunology
Shanice A. Karangwa, Jelle Adelmeijer, Johannes G. M. Burgerhof, Ton Lisman, Vincent E. de Meijer, Ruben H. de Kleine, Koen M. E. M. Reyntjens, Aad P. van den Berg, Robert J. Porte, Marieke T. de Boer
Summary: This study found that controlled DCD liver transplantation does not result in higher intraoperative blood loss or more transfusion requirements compared with DBD liver transplantation. The results of the study also showed that there was no evidence for increased hyperfibrinolysis upon reperfusion in DCD liver grafts compared with DBD liver grafts.
Article
Hematology
Johannes Thaler, Ton Lisman, Peter Quehenberger, Lena Hell, Philipp Schwabl, Bernhard Scheiner, Theresa Bucsics, Rienk Nieuwland, Cihan AY, Michael Trauner, Ingrid Pabinger, Thomas Reiberger, Mattias Mandorfer
Summary: This study investigated the coagulation system in ascites of patients with cirrhosis and found that ascitic fluid was procoagulant with high extracellular vesicle-associated tissue factor activity. Fibrinolytic enzymes were activated in ascitic fluid, potentially re-entering the systemic circulation and inducing systemic fibrinolysis. Plasma D-dimer levels were independently linked to ascites severity in a separate cohort of patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Surgery
Tamar A. J. van den Berg, Ton Lisman, Frank J. M. F. Dor, Cyril Moers, Robert C. Minnee, Stephan J. L. Bakker, Robert A. Pol
Summary: This survey investigates the different thromboprophylactic strategies used in kidney transplantation in Europe, finding a high variation and inconsistency across centers. Further research is needed to develop better guidelines.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Ellen G. Driever, Fien A. von Meijenfeldt, Jelle Adelmeijer, Robbert J. de Haas, Marius C. van den Heuvel, Chandrasekaran Nagasami, John W. Weisel, Constantino Fondevila, Robert J. Porte, Anabel Blasi, Nigel Heaton, Stephen Gregory, Pauline Kane, William Bernal, Yoh Zen, Ton Lisman
Summary: The study found that portal vein thrombosis in cirrhotic patients is mainly composed of intimal fibrosis, with fibrin-rich thrombus present in only one-third of cases. Clinical characteristics showed no significant association with the presence of fibrin-rich thrombi.
Letter
Gastroenterology & Hepatology
Ellen G. Driever, William Bernal, Ton Lisman
Article
Gastroenterology & Hepatology
Fien A. von Meijenfeldt, R. Todd Stravitz, Jingwen Zhang, Jelle Adelmeijer, Yoh Zen, Valerie Durkalski, William M. Lee, Ton Lisman
Summary: The study found evidence of NET formation in patients with acute liver failure (ALF), and elevated levels of MPO-DNA complexes were associated with poor outcomes, indicating that NET formation may contribute to disease progression.
Letter
Gastroenterology & Hepatology
Fien A. von Meijenfeldt, R. Todd Stravitz, William M. Lee, Ton Lisman
Letter
Gastroenterology & Hepatology
Fanny Turon, Ton Lisman, Juan Carlos-Garcia-Pagan
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Aglaia Zellos, Dominique Debray, Giuseppe Indolfi, Piotr Czubkowski, Marianne Samyn, Nedim Hadzic, Girish Gupte, Bjorn Fischler, Francoise Smets, Stephan Clement de Clety, Ryszard Grenda, Yael Mozer, Sara Mancell, Jorg Jahnel, Georg Auzinger, Austen Worth, Ton Lisman, Christian Staufner, Ulrich Baumann, Anil Dhawan, Estelle Alonso, Robert H. Squires, Henkjan J. Verkade
Summary: This report summarizes the latest research and developments in the field of acute liver failure in infants and children, with a focus on early recognition, curative therapies, intensive care management, imaging techniques, and treatment paradigms.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Aglaia Zellos, Dominique Debray, Giuseppe Indolfi, Piotr Czubkowski, Marianne Samyn, Nedim Hadzic, Girish Gupte, Bjorn Fischler, Francoise Smets, Stephan Clement de Clety, Ryszard Grenda, Yael Mozer, Sara Mancell, Jorg Jahnel, Georg Auzinger, Austen Worth, Ton Lisman, Christian Staufner, Ulrich Baumann, Anil Dhawan, Estelle Alonso, Robert H. Squires, Henkjan J. Verkade
Summary: This article summarizes a conference organized by the Hepatology Committee of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition on pediatric liver disease, specifically focusing on Acute Liver Failure (ALF). The aim was to update physicians on developments in medical therapy, indications for liver transplantation, and future areas of research. The article provides an overview of the topics discussed during the conference and highlights key learning points.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Letter
Hematology
Fien A. von Meijenfeldt, Sebastian Havervall, Jelle Adelmeijer, Charlotte Thalin, Ton Lisman
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Ellen G. Driever, Ton Lisman
Summary: Patients with liver diseases experience imbalances in their hemostasis, which can be further destabilized by disease complications. Systemic inflammation in these patients leads to alterations in the hemostatic system, potentially causing local ischemia, liver disease progression, and multiorgan failure. Anti-inflammatory treatment may prove beneficial in preventing thrombotic or bleeding complications and halting liver disease progression.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Hematology
Andreas Tiede, Barbara Zieger, Ton Lisman
Summary: This article provides an overview of acquired bleeding disorders, including acquired hemophilia A, acquired von Willebrand syndrome, and liver function disorders. It discusses the pathophysiology, diagnostic tests, and treatment strategies for these conditions.
Review
Hematology
Bente P. van den Boom, Ton Lisman
Summary: Patients with liver disease often experience complex changes in their blood coagulation system, including decreased platelet count and altered levels of coagulation-related proteins. Conventional coagulation tests do not accurately reflect procoagulant changes, but novel tests can better reflect the overall hemostatic changes. Despite a rebalanced hemostatic status, liver disease patients have a more fragile hemostatic system and are at risk for both bleeding and thrombosis. Many hemostatic complications in liver disease are not directly related to hemostatic failure, highlighting the importance of identifying the underlying cause for appropriate treatment.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ton Lisman, Stephen H. Caldwell, Nicolas M. Intagliata
Summary: Patients with cirrhosis experience complex changes in their haemostatic system, but it remains balanced overall. New understanding of clinical management for patients with cirrhosis has emerged, although there is a lack of solid evidence from well-designed clinical studies. The paper outlines recent advances in bleeding and thrombotic complications in patients with cirrhosis.
JOURNAL OF HEPATOLOGY
(2022)
