Article
Surgery
Kaisa Ahopelto, Ville Sallinen, Ilkka Helantera, Akseli Bonsdorff, Juulia Grasberger, Ines Beilmann-Lehtonen, Heikki Makisalo, Arno Nordin, Fernanda Ortiz, Johanna Savikko, Eija Tukiainen, Aki Uutela, Agneta Ekstrand, Marko Lempinen
Summary: This study retrospectively analyzed 166 cases of simultaneous pancreas-kidney transplantation performed at Helsinki University Hospital from March 14, 2010 to March 14, 2020. The results showed that this surgical approach is a safe and effective treatment for patients with type 1 diabetes and kidney failure, with high pancreas graft survival rate and successful kidney transplantation.
CLINICAL TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Delphine Kervella, Benoit Mesnard, Thomas Prudhomme, Sarah Bruneau, Christophe Masset, Diego Cantarovich, Gilles Blancho, Julien Branchereau
Summary: The pancreas is highly vulnerable to ischemia-reperfusion injury, which leads to early graft losses and sterile inflammation. Controlling sterile inflammation is crucial to decrease allograft loss and improve long-term survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Kristina Rydenfelt, Gisle Kjosen, Rune Horneland, Judith Krey Ludviksen, Trond Geir Jenssen, Pal-Dag Line, Tor Inge Tonnessen, Tom Eirik Mollnes, Hakon Haugaa, Soren Erik Pischke
Summary: This study compared the perioperative thromboinflammation between pancreas transplant alone (PTA) and simultaneous pancreaskidney (SPK) recipients, and found that PTA recipients had a more pronounced thromboinflammatory response after surgery. The increased inflammation may contribute to graft thrombosis and graft loss in PTA recipients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Richard Dumbill, James Goetz, Sanjay Sinha, Martin Drage, Christopher J. E. Watson, Shruti Mittal
Summary: The study found that there was no protective benefit of ReY drainage over duodenojejunostomy in terms of early graft loss, but there was an increased risk of return to theater.
Article
Surgery
Je Ho Ryu, Jae Ryong Shim, Tae Beom Lee, Kwangho Yang, Taeun Kim, Seo Rin Kim, Byunghyun Choi
Summary: This study aimed to avoid early technical failure of pancreas transplantation by modifying venous outflow. The results showed that both cadaveric vena cava fence-angioplasty and aortic interposition graft can significantly reduce thrombotic graft failure.
ANNALS OF TRANSPLANTATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. A. Simonis, B. M. de Kok, J. C. Korving, W. H. Kopp, A. G. Baranski, V. A. L. Huurman, M. N. J. M. Wasser, P. J. M. van der Boog, A. E. Braat
Summary: Pancreas allograft thrombosis remains a common cause of early graft failure, and the CPAT grading system can improve documentation. However, the relevance of identifying small Grade 1 thrombosis in clinical practice is questionable, and high-quality CT scans are essential for accurately identifying potential thrombi post-pancreas transplantation.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Surgery
Christophe Masset, Julien Branchereau, Georges Karam, Maryvonne Hourmant, Jacques Dantal, Magali Giral, Claire Garandeau, Aurelie Meurette, Clarisse Kerleau, Delphine Kervella, Simon Ville, Gilles Blancho, Diego Cantarovich
Summary: The study evaluated the clinical interest of C-peptide monitoring after pancreas transplantation, highlighting its value in early identification of graft function failure.
TRANSPLANT INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
P. W. Schreiber, M. Laager, K. Boggian, D. Neofytos, C. van Delden, A. Egli, M. Dickenmann, C. Hirzel, O. Manuel, M. Koller, S. Rossi, B. Schmied, L. Gurke, M. Matter, T. Berney, O. de Rougemont, S. P. Kuster, S. Stampf, N. J. Mueller
Summary: Surgical site infections (SSIs) are common hospital-acquired infections, posing a significant threat to transplant recipients. This study aimed to determine the incidence, risk factors, and impact of SSI on post-transplant outcomes and pancreas transplant recipients. Among 130 transplant recipients, 14% developed SSI within the first 90 days after transplantation, with Enterococcus spp. being the most prevalent pathogen. SSI was independently associated with a longer hospitalization.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Surgery
Akseli Bonsdorff, Ville Sallinen, Juulia Raiha, Agneta Ekstrand, Arno Nordin, Marko Lempinen, Ilkka Helantera
Summary: In conclusion, first-day plasma amylase could be an effective indicator for identifying patients at risk of complications after SPK. Its high AUC value and easy clinical applicability make it a valuable marker for predicting postoperative complications.
CLINICAL TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
William D. Toff, David Hildick-Smith, Jan Kovac, Michael J. Mullen, Olaf Wendler, Anita Mansouri, Ines Rombach, Keith R. Abrams, Simon P. Conroy, Marcus D. Flather, Alastair M. Gray, Philip MacCarthy, Mark J. Monaghan, Bernard Prendergast, Simon Ray, Christopher P. Young, David C. Crossman, John G. F. Cleland, Mark A. de Belder, Peter F. Ludman, Stephen Jones, Cameron G. Densem, Steven Tsui, Manoj Kuduvalli, Joseph D. Mills, Adrian P. Banning, Rana Sayeed, Ragheb Hasan, Douglas G. W. Fraser, Uday Trivedi, Simon W. Davies, Alison Duncan, Nick Curzen, Sunil K. Ohri, Christopher J. Malkin, Pankaj Kaul, Douglas F. Muir, W. Andrew Owens, Neal G. Uren, Renzo Pessotto, Simon Kennon, Wael Awad, Saib S. Khogali, Maciej Matuszewski, Richard J. Edwards, Bandigowdanapalya C. Ramesh, Miles Dalby, Shahzad G. Raja, Giovanni Mariscalco, Clinton Lloyd, Ian D. Cox, Simon R. Redwood, Mark G. Gunning, Paul D. Ridley
Summary: This study aimed to determine whether TAVI was noninferior to surgery in patients at moderately increased operative risk. The results showed that among patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk, TAVI was noninferior to surgery with respect to all-cause mortality at 1 year.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Surgery
Erica Ai Li, Kaveh Farrokhi, Max Y. Y. Zhang, Juliano Offerni, Patrick P. P. Luke, Alp Sener
Summary: This systematic review and meta-analysis aims to evaluate the impact of heparin thromboprophylaxis on pancreas thrombosis, pancreas graft loss, bleeding, and secondary outcomes in SPK, PAK, and PTA. The study found that prophylactic heparinization significantly decreased the risk of pancreas thrombosis and graft loss without increasing bleeding or acute return to the operating room.
TRANSPLANT INTERNATIONAL
(2023)
Article
Surgery
Martin de Santibanes, Victoria Ardiles, Jimmy Walker Uno, Juan Mattera, Eduardo de Santibanes, Juan Pekolj
Summary: Accurate assessment of the extent and severity of PVT is crucial for a comprehensive preoperative evaluation. This information is vital for proper surgical planning, which prepares both the surgeon and the patient for potentially complex procedures during LT. The surgical alternatives presented in this technical report offer promising solutions for treating PVT during LT, making it a viable option for selected patients.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Samrat Ray, Catherine Parmentier, Laura Mazilescu, Masataka Kawamura, Yuki Noguchi, Emmanuel Nogueira, Sujani Ganesh, Bhranavi Arulratnam, Markus Selzner, Trevor Reichman
Summary: Pancreas transplantation has promising results in treating type 1 diabetes mellitus and metabolic syndrome, but the main challenge is the lack of suitable organs for transplantation. The delicate structure of the pancreas makes it more susceptible to injury compared to other organs. Meticulous surgical dissection and tissue handling are crucial for the success of pancreas transplantation. The porcine model can help accurately extrapolate this technique to humans due to the similarity in anatomy.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Urology & Nephrology
Enrique Montagud-Marrahi, Elena Cuadrado-Payan, Evelyn Hermida, Judit Cacho, David Cucchiari, Ignacio Revuelta, Jimena del Risco-Zevallos, Nuria Esforzado, Frederic Cofan, Federic Oppenheimer, Vicens Torregrosa, Joana Ferrer, Antoni J. Amor, Enric Esmatjes, Maria Jose Ramirez-Bajo, Mireia Musquera, Mathew Cooper, Beatriu Bayes, Josep M. Campistol, Fritz Diekmann, Pedro Ventura-Aguiar
Summary: A retrospective analysis of nearly 10,000 simultaneous kidney-pancreas transplant recipients revealed that preemptive transplantation led to improved patient and graft survival rates, particularly for those on dialysis for an extended period.
KIDNEY INTERNATIONAL
(2022)
Article
Surgery
Palmina Petruzzo, Haixia Ye, Claudia Sardu, Olivier Rouviere, Fanny Buron, Jullien Crozon-Clauzel, Xavier Matillon, Jean Kanitakis, Emmanuel Morelon, Lionel Badet
Summary: Pancreatic graft thrombosis (PAT) is a common surgical complication with potential graft loss. The Cambridge Pancreas Allograft Thrombosis (CPAT) grading system provides diagnostic and therapeutic recommendations. This study successfully implemented the CPAT grading system in simultaneous pancreas-kidney (SPK) transplant recipients and found it to be applicable in clinical practice.
TRANSPLANT INTERNATIONAL
(2023)
Article
Immunology
Jared W. Clouse, Chandrashekhar A. Kubal, Jonathan A. Fridell, Richard S. Mangus
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2019)
Article
Surgery
Jared W. Clouse, Chandrashekhar A. Kubal, Jonathan A. Fridell, E. Jordan Pearsall, Richard S. Mangus
CLINICAL TRANSPLANTATION
(2019)
Article
Surgery
Yar L. Yeap, Jonathan A. Fridell, Derrick Wu, Richard S. Mangus, Elizabeth Kroepfl, John Wolfe, John A. Powelson
CLINICAL TRANSPLANTATION
(2019)
Article
Surgery
Jordan Swensson, Santosh Nagaraju, Daniel O'Brien, Mark Tann, Angela Shah, Richard Mangus, John Powelson, Jonathan Fridell
CLINICAL TRANSPLANTATION
(2019)
Article
Pediatrics
Joel R. Schroering, Taylor J. Hathaway, Chandrashekhar A. Kubal, Burcin Ekser, Plamen Mihaylov, Richard S. Mangus
PEDIATRIC TRANSPLANTATION
(2020)
Article
Surgery
Sam M. Atoa, Richard S. Mangus, Ryan C. Graham, Elizabeth A. Kroepfl, John A. Powelson, Jonathan A. Fridell
Summary: This study compared the effects of different inhaled anesthetics on early ischemia-reperfusion injury and clinical outcomes in pancreas allograft recipients. The findings suggest that sevoflurane and desflurane may be associated with lower peak amylase and lipase levels postoperatively in pancreas transplantation, with equivalent short- and long-term clinical outcomes for the three agents.
CLINICAL TRANSPLANTATION
(2021)
Article
Pediatrics
Danielle K. Maue, Richard S. Mangus, Riad Lutfi, Michael J. Hobson, Girish S. Rao, Mara E. Nitu, Samer Abu-Sultaneh
Summary: Advancements in critical care management have improved pediatric liver transplant outcomes, but there is a lack of specific guidelines for immediate post-LT care. A survey of active US centers shows practice variations in staffing, team composition, and anticoagulation for pediatric LT patients. There is marked inconsistency across centers in regards to team composition and immediate post-LT management, highlighting the need for a national consensus on post-LT PICU practices.
PEDIATRIC TRANSPLANTATION
(2021)
Article
Surgery
Daiki Soma, Tejas Nikumbh, Richard S. Mangus, Andrew J. Lutz, John A. Powelson, Jonathan A. Fridell
Summary: Early pancreas allograft failure is often due to vascular thrombosis, which may be salvaged by distal allograft pancreatectomy. This surgery can preserve at least half of the pancreas allograft with functional retention in cases of partial necrosis. Early diagnosis and intervention are crucial for successful salvage of the pancreas allograft in cases of thrombosis.
CLINICAL TRANSPLANTATION
(2021)
Article
Surgery
Chandrashekhar A. Kubal, Plamen Mihaylov, Jonathan Fridell, Arianna Cabrales, Tejas Nikumbh, Lava Timsina, Daiki Soma, Burcin Ekser, Richard Mangus
Summary: In whole liver transplantation, donor-recipient body size mismatch does not have a negative impact on graft survival or other transplant-related parameters, indicating that routine measurement of donor liver size by radiology may help improve organ allocation.
CLINICAL TRANSPLANTATION
(2021)
Article
Surgery
Tommy Ivanics, Rodrigo Vianna, Chandrashekhar A. Kubal, Kishore R. Iyer, George Mazariegos, Cal S. Matsumoto, Richard Mangus, Thiago Beduschi, Marwan Abouljoud, Jonathan A. Fridell, Shunji Nagai
Summary: The update in liver allocation from DSA to AC had varying impacts on waitlist mortality and transplant probability for patients listed for combined liver-intestine transplantation, with lower transplant probability observed in adults but similar outcomes in pediatric patients. Additionally, there was a decrease in the proportion of patients who underwent transplant with exception points post-AC. Efforts should be made to ensure equitable organ allocation in this vulnerable patient population.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Letter
Gastroenterology & Hepatology
Zachary P. Rokop, Joseph Zenisek, Kyle Frick, Richard S. Mangus, Lava Timsina, Elizabeth Kroepfl, Chandrashekhar Kubal
LIVER TRANSPLANTATION
(2023)
Article
Pediatrics
Zachary P. Rokop, Richard S. Mangus, Kyla Tolliver, Jean Molleston, Plamen Mihaylov, Chandrashekhar Kubal
Summary: This study retrospectively analyzed records of liver transplantation in infants younger than 1 year old at Indiana University from 2016 to 2022. The results showed that SLT may have better transplant outcomes compared to WLT in small donors and recipients. Therefore, SLT should be considered as a strategy to reduce waitlist times for infants in the absence of small, deceased donors for WLT.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Transplantation
Joel R. Schroering, Richard S. Mangus, John A. Powelson, Jonathan A. Fridell
TRANSPLANTATION DIRECT
(2018)
Meeting Abstract
Pathology
Natalia Rush, Chandrashekhar Kubal, Richard Mangus, Romil Saxena
Meeting Abstract
Pathology
Natalia Rush, Chandrashekhar Kubal, Richard Mangus, Romil Saxena