Article
Multidisciplinary Sciences
Jesus Paez-Mayorga, Jocelyn Nikita Campa-Carranza, Simone Capuani, Nathanael Hernandez, Hsuan-Chen Liu, Corrine Ying Xuan Chua, Fernanda Paola Pons-Faudoa, Gulsah Malgir, Bella Alvarez, Jean A. Niles, Lissenya B. Argueta, Kathryn A. Shelton, Sarah Kezar, Pramod N. Nehete, Dora M. Berman, Melissa A. Willman, Xian C. Li, Camillo Ricordi, Joan E. Nichols, A. Osama Gaber, Norma S. Kenyon, Alessandro Grattoni
Summary: By using the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) device, pancreatic islet transplantation for type 1 diabetes can achieve long-term reversal without the need for systemic immunosuppression, making it a promising approach for effective treatment.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Qi Zhang, Carmen Gonelle-Gispert, Yanjiao Li, Zhen Geng, Sandrine Gerber-Lemaire, Yi Wang, Leo Buhler
Summary: Islet transplantation is a promising approach for treating type 1 diabetes, but there are challenges of immune response and long-term use of immunosuppression. Encapsulation of islets in semi-permeable biomaterials allows long-term graft survival while preventing immune response. Researchers have developed various strategies, including encapsulating porcine islets and co-encapsulation with other cells or ingredients, to improve the functionality of transplanted islets. Hydrogels, both natural and synthetic, have been widely used for cell encapsulation and therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Kevin Verhoeff, Braulio A. Marfil-Garza, Zofia Czarnecka, Nerea Cuesta-Gomez, Ila Tewari Jasra, Nidheesh Dadheech, Peter A. Senior, A. M. James Shapiro
Summary: Historically, only patients with certain types of diabetes have been considered for islet transplantation. However, with the development of stem cell-derived transplantation and the reclassification of diabetes subtypes, it may soon be justifiable to consider a broader patient population for this procedure. This review evaluates the potential of islet transplantation for different diabetes subtypes and explores unique transplant features that need to be taken into account.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Engineering, Biomedical
M. Birgul Akolpoglu, Yasemin Inceoglu, Ugur Bozuyuk, Ana Rita Sousa, Mariana B. Oliveira, Joao F. Mano, Seda Kizilel
Summary: The focus of current research is on overcoming challenges such as islet donor shortage, engraftment, prolonged islet availability, and post-transplant vascularization through the design of 3D cell clusters that can accurately secrete insulin and have superior features. These engineered heterocellular islet organoids aim to address the current obstacles in islet transplantation protocols and have the potential to improve clinical outcomes.
Article
Medicine, General & Internal
Roi Anteby, Aaron Lucander, Piotr J. Bachul, Jordan Pyda, Damian Grybowski, Lindsay Basto, Gabriela S. Generette, Laurencia Perea, Karolina Golab, Ling-jia Wang, Martin Tibudan, Celeste Thomas, John Fung, Piotr Witkowski
Summary: This study evaluated the prognostic utility of monitoring islet autoantibodies in diabetic patients after islet transplantation. It was found that GAD antibody levels could potentially serve as a predictive marker for outcomes post-transplant, while IA-2A and ZnT8A were undetectable in all patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell & Tissue Engineering
Nathaniel J. Hogrebe, Matthew Ishahak, Jeffrey R. Millman
Summary: The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs) has great potential for diabetes treatment. To be widely adopted, highly functional and well-characterized stem cell-derived islets (SC-is-lets) need to be manufactured at scale. This review discusses recent advances in generating and characterizing SC-is-lets, as well as strategies to ensure graft viability and safety after transplantation.
Review
Food Science & Technology
Yang Liu, Qianwen Wang, Kangze Wu, Zhouyi Sun, Zhe Tang, Xian Li, Bo Zhang
Summary: The incidence of diabetes mellitus is increasing every year, causing a global burden. Existing treatments have limitations, and new approaches are needed. Anthocyanins have positive effects on diabetes, reducing the risk and improving metabolism and antioxidant activity. They also improve the damage and function of pancreatic islets after transplantation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Eiji Kawasaki
Summary: Anti-islet autoantibodies are crucial markers for immune-mediated type 1 diabetes (T1D) and slowly progressive T1D (SPIDDM) or latent autoimmune diabetes in adults (LADA). They are used for diagnosis, pathological analysis, and prediction of T1D. Different autoantibodies serve different purposes, such as reflecting insulitis or pancreatic & beta-cell destruction. Combinatorial analysis of these autoantibodies helps diagnose immune-mediated T1D, while a lack of autoantibodies is associated with fulminant T1D. Evaluating the epitopes and subclasses of these autoantibodies aids in distinguishing diabetes-associated from non-diabetes-associated autoantibodies and predicting future insulin deficiency. New advancements in autoantibody assays can improve the accuracy of diagnosis and prediction of autoimmune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Thomas Pomposelli, Christian Schuetz, Ping Wang, Kazuhiko Yamada
Summary: Islet cell transplantation as a pre-vascularized composite islet-kidney graft has shown promise in providing long term durable blood glucose control, but is limited by the long term immunosuppression requirements. Strategies aimed at inducing host tolerance to the allogeneic and xenogeneic islet-kidney grafts could potentially avoid long-term immunosuppression and provide a near-limitless organ supply. This could lead to a durable and long-term cure for diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Multidisciplinary Sciences
Anneliese J. S. Flatt, Carla J. Greenbaum, James A. M. Shaw, Michael R. Rickels
Summary: Type 1 diabetes is characterized by loss and dysfunction of pancreatic islet beta cells, leading to insulin deficiency and hyperglycemia. Assessment of beta cell secretory capacity can detect the loss of beta cells during a presymptomatic phase of autoimmune attack. Islet transplantation can restore physiologic reserve capacity for insulin secretion.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Medicine, Research & Experimental
Butian Wei, Xin Zhang, Jiwei Qian, Zhe Tang, Bo Zhang
Summary: Nrf2 is an important intracellular regulator of antioxidant stress, regulating not only antioxidant function but also insulin secretion, proliferation, and differentiation of beta cells, ER stress, and mitochondrial function. Pharmacological activation of Nrf2 has been shown to protect islet cells during different stages of transplantation in experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Endocrinology & Metabolism
Braulio A. Marfil-Garza, Joshua Hefler, Mario Bermudez De Leon, Rena Pawlick, Nidheesh Dadheech, A. M. James Shapiro
Summary: Regulatory T cells (Tregs) are important in the pathophysiology and treatment of autoimmune diseases like type 1 diabetes (T1D) and have shown potential in transplantation as well. Modulating the quantity and function of Tregs can increase self-tolerance and provide a potential cure for diseases. Islet transplantation serves as a critical approach to study the interplay between autoimmunity and transplantation immunity, offering a potential cure for T1D.
Article
Multidisciplinary Sciences
Paola S. Apaolaza, Diana Balcacean, Jose Zapardiel-Gonzalo, Grace Nelson, Nataliya Lenchik, Pouria Akhbari, Ivan Gerling, Sarah J. Richardson, Teresa Rodriguez-Calvo
Summary: The study reveals the presence of IFN response markers in the islets of T1D patients, which may lead to inflammation and impair beta cell function. Therapeutic interventions targeting the elimination of persistent infections and reduction of inflammation are crucial for individuals with T1D.
Review
Pharmacology & Pharmacy
Abiramy Jeyagaran, Chuan-en Lu, Aline Zbinden, Andreas L. Birkenfeld, Sara Y. Brucker, Shannon L. Layland
Summary: The development of new therapeutic approaches to treat type 1 diabetes mellitus relies on understanding the biology of insulin-secreting p-cells and the mechanisms responsible for their autoimmune destruction. This review discusses the current state of p-cell differentiation and the possibilities for enhancing insulin-secreting cell/islet transplantation from a translational perspective.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Surgery
James F. Markmann, Michael R. Rickels, Thomas L. Eggerman, Nancy D. Bridges, David E. Lafontant, Julie Qidwai, Eric Foster, William R. Clarke, Malek Kamoun, Rodolfo Alejandro, Melena D. Bellin, Kathryn Chaloner, Christine W. Czarniecki, Julia S. Goldstein, Bernhard J. Hering, Lawrence G. Hunsicker, Dixon B. Kaufman, Olle Korsgren, Christian P. Larsen, Xunrong Luo, Ali Naji, Jose Oberholzer, Andrew M. Posselt, Camillo Ricordi, Peter A. Senior, A. M. James Shapiro, Peter G. Stock, Nicole A. Turgeon
Summary: Allogeneic islet transplant is a safe and effective treatment option for patients with T1D, improving metabolic control and quality of life.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Mathie Tenenbaum, Valerie Plaisance, Raphael Boutry, Valerie Pawlowski, Cecile Jacovetti, Clara Sanchez-Parra, Helene Ezanno, Julien Bourry, Nicole Beeler, Gianni Pasquetti, Valery Gmyr, Stephane Dalle, Julie Kerr-Conte, Francois Pattou, Syu-ichi Hirai, Romano Regazzi, Amelie Bonnefond, Philippe Froguel, Amar Abderrahmani
Summary: The study revealed that activation of Jnk3 signaling by Dlk could be a key mechanism for adapting islet beta-cell mass during postnatal development and weight gain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Jimmy Vandel, Julie Dubois-Chevalier, Celine Gheeraert, Bruno Derudas, Violetta Raverdy, Dorothee Thuillier, Luc Gaal, Sven Francque, Francois Pattou, Bart Staels, Jerome Eeckhoute, Philippe Lefebvre
Summary: This study explored transcriptomic profiles of livers from a cohort of 910 obese patients, identifying differentially expressed genes in NASH patients based on sex using bootstrapping and random forest approaches. The findings highlighted the sexually dimorphic nature of NASH and its link with fibrosis, emphasizing the importance of integrating sex as a major determinant of liver responses to NASH progression and drug responses.
Article
Endocrinology & Metabolism
Betty Salgues, Carole Guerin, Vincent Amodru, Francois Pattou, Laurent Brunaud, Jean-Christophe Lifante, Eric Mirallie, Nicolas Sahakian, Frederic Castinetti, Anderson Loundou, Karine Baumstarck, Frederic Sebag, David Taieb
Summary: [F-18]FDG PET/CT improves the characterization of adrenal tumors, with the Tumour SUVmax:Liver SUVmax ratio showing good diagnostic performance for malignancy. A predictive model based on tumor size and uptake ratio provides an additional approach for assessing malignancy risk.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Pierre Bauvin, Claire Delacote, Guillaume Lassailly, Line Carolle Ntandja Wandji, Viviane Gnemmi, Flavien Dautrecque, Alexandre Louvet, Robert Caiazzo, Violeta Raverdy, Emmanuelle Leteurtre, Francois Pattou, Sylvie Deuffic-Burban, Philippe Mathurin
Summary: This study developed a predictive tool based on a Markov model to help identify the risk of NAFLD patients, predict disease progression and adapt treatment strategies. The model takes into account factors such as sex, BMI, diabetes, etc., and provides decision support for healthcare professionals.
LIVER INTERNATIONAL
(2021)
Letter
Surgery
Chirag S. Desai, Kristen R. Szempruch, Jennifer S. Vonderau, Mikael Chetboun, Francois Pattou, Toby Coates, Diedert Luc De Paep, Wayne J. Hawthorne, Khalid M. Khan, Eelco J. P. de Koning, Bashoo Naziruddin, Andrew Posselt, Beth A. Schrope, Martin Wijkstrom, Piotr Witkowski, A. M. James Shapiro
TRANSPLANT INTERNATIONAL
(2021)
Article
Surgery
Richard Welbourn, Marianne Hollyman, Robin Kinsman, John Dixon, Ricardo Cohen, John Morton, Amir Ghaferi, Kelvin Higa, Johan Ottosson, Francois Pattou, Salman Al-Sabah, Merhan Anvari, Jacques Himpens, Ronald Liem, Villy Vage, Peter Walton, Wendy Brown, Lilian Kow
Summary: International comparative practice of bariatric-metabolic surgeries for T2DM patients is not well understood. Older men with higher rates of BMI <35 kg/m2 have an increased likelihood of having T2DM and undergoing food rerouting operations.
Article
Surgery
Adrian Mancini, Vincent Vangelder, Robert Caiazzo, Camille Marciniak, Naima Oukhouya Daoud, Neil Patel, Francois Pattou, Gregory Baud
Summary: Robotic-assisted RYFJ surgery is a new and emerging technology for the treatment of chronic fistulas. This case presentation demonstrates the successful management of a chronic gastro-colic fistula using a robotic approach.
Article
Surgery
Nicolas Santucci, Sebastien Gaujoux, Christine Binquet, Cynthia Reichling, Jean-Christophe Lifante, Bruno Carnaille, Francois Pattou, Eric Mirallie, Olivier Facy, Muriel Mathonnet, Pierre Goudet
Summary: Pancreatoduodenectomy in MEN1 patients can control hormone secretions (gastrin, glucagon, VIP) and remove large NETs. PD was found to control gastrin secretions in about 60% of cases.
WORLD JOURNAL OF SURGERY
(2021)
Review
Veterinary Sciences
Julien Thevenet, Valery Gmyr, Nathalie Delalleau, Francois Pattou, Julie Kerr-Conte
Summary: Diabetes cell therapy by human islet transplantation can restore endogenous insulin secretion and normal glycaemic control in patients, and the use of animal models in research has become more accurate with advancements in technology.
LABORATORY ANIMALS
(2021)
Letter
Otorhinolaryngology
Maxime Gerard, Antoine Hamy, Jean-Christophe Lifante, Francois Pattou, Niki Christou, Claire Blanchard, Eric Mirallie
Summary: This nonrandomized clinical trial compared the incidence of postoperative morbidity after total thyroidectomy between adult patients with preoperative hyperthyroidism and those without, aimed to explore the differences between the two groups.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Article
Oncology
Segolene Hescot, Matthieu Faron, Manal Kordahi, Christine Do Cao, Annabelle Naman, Livia Lamartina, Julien Hadoux, Sophie Leboulleux, Francois Pattou, Sebastien Aubert, Jean-Yves Scoazec, Abir Al Ghuzlan, Eric Baudin
Summary: The aim of this study was to identify and prioritize potential prognostic parameters in metastatic ACC. The study found P53 and PDxK to be independent prognostic markers of metastatic adrenocortical carcinoma, highlighting the importance of adjusting biomarkers to validated prognostic factors.
Correction
Endocrinology & Metabolism
Claire Douillard, Arnaud Jannin, Marie-Christine Vantyghem
ANNALES D ENDOCRINOLOGIE
(2022)
Article
Oncology
Gregory Baud, Arnaud Jannin, Camille Marciniak, Benjamin Chevalier, Christine Do Cao, Emmanuelle Leteurtre, Amandine Beron, Georges Lion, Samuel Boury, Sebastien Aubert, Brigitte Bouchindhomme, Marie-Christine Vantyghem, Robert Caiazzo, Francois Pattou
Summary: This study aimed to analyze the risk factors of post-thyroidectomy complications and assess the morbidity of lymph node dissection, particularly in the central neck compartment. The results showed that lymph node dissection in the central and lateral compartments increased the risk of hypoparathyroidism and recurrent laryngeal nerve injuries.
Article
Nutrition & Dietetics
Marion Courtalin, Helene Verkindt, Naima Oukhouya Daoud, Nassima Ramdane, Bernard Cortet, Francois Pattou, Julien Paccou
Summary: The study aimed to evaluate the implementation of the ECTS 2022 recommendations for preventing and treating osteoporosis after bariatric surgery. A retrospective cohort study was conducted on postmenopausal women and men aged 50 and older who had undergone or were undergoing bariatric surgery. Osteoporosis medication was indicated if certain criteria were met, and a fifth of the population surveyed was found to be eligible.
Article
Psychology, Clinical
Clemence Willem, Jean-Louis Nandrino, Karyn Doba, Meline Roussel, Claire Triquet, Helene Verkindt, Francois Pattou, Marie-Charlotte Gandolphe
Summary: The study found that good interoceptive awareness can increase the risk of emotional eating in obese patients if not supported by good interoceptive reliance. Interoceptive reliance should be a primary target for psychotherapeutic interventions in obesity.
JOURNAL OF HEALTH PSYCHOLOGY
(2021)