Article
Immunology
Su Woong Jung, Won-Hee Cho, Jung-Woo Seo, Yang-Gyun Kim, Ju-Young Moon, Jin Sug Kim, Chan-Duck Kim, Byung Ha Chung, Jae Berm Park, Yeong Hoon Kim, Sang-Ho Lee
Summary: Urine exosomal bkv-miR-B1-5p is associated with BK virus nephropathy and may serve as a predictive marker during the early posttransplant period.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Hyunjoo Bae, Seungwon Jung, Byung Ha Chung, Chul Woo Yang, Eun-Jee Oh
Summary: Pretransplant BK serostatus and BK-specific CMI can predict posttransplant BK infection in kidney transplant recipients, and timely interventions based on high-risk patients could improve outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Hatice Yazisiz, Vedat Uygun, Dilek Colak, Derya Mutlu, Volkan Hazar, Dilara Ogunc, Gozde Ongut, Funda Tayfun Kupesiz
Summary: The study revealed a high detection rate of BKV DNA in urine and plasma samples of pediatric patients undergoing HSCT, with some patients showing symptoms of BKV-related HC. Monitoring BKV DNA viral load in urine and plasma is valuable for understanding the development of BKV-related HC in high-risk pediatric HSCT patients.
PEDIATRIC TRANSPLANTATION
(2021)
Article
Immunology
Julie Ho, Stefan Schaub, Annette M. Jackson, Robert Balshaw, Robert Carroll, Sylvia Cun, Sacha A. De Serres, Daniel Fantus, Joelle Handschin, Gideon Hoenger, Anthony M. Jevnikar, Marc Kleiser, Jar-How Lee, Yan Li, Peter Nickerson, Rui Pei, Denise Pochinco, Remi Shih, Michael Trinh, Jason Wang, Julie Nguyen, Stuart Knechtle
Summary: This study demonstrates that urine CXCL10 Luminex immunoassay is robust, reproducible, and accurate, indicating its potential for clinical use in HLA laboratories for posttransplant surveillance.
Article
Transplantation
Jacopo Burrello, Silvia Monticone, Alessio Burrello, Sara Bolis, Carlotta Pia Cristalli, Giorgia Comai, Valeria Corradetti, Cristina Grange, Giuseppe Orlando, Massimiliano Bonafe, Gaetano La Manna, Lucio Barile, Benedetta Bussolati
Summary: This study explored the use of extracellular vesicle (EV) surface antigens as potential predictors of kidney transplant outcome. It found that endothelial cells and platelet markers in serum EVs were higher in patients with persistent kidney dysfunction, while mesenchymal progenitor cell markers in urine EVs increased in patients with renal recovery. These markers correlated with kidney function indicators and were able to predict patient outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Virology
Sara Querido, Andre Weigert, Iola Pinto, Ana Luisa Papoila, Maria Ana Pessanha, Perpetua Gomes, Teresa Adragao, Paulo Paixao
Summary: This study evaluated the relationship between BK polyomavirus (BKV) or JC polyomavirus (JCV) infection and long-term clinical outcomes in kidney transplant patients, finding that there was no association between viral infection and death or graft failure. However, higher urinary viral loads may indicate over immunosuppression.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Christian Savard, Olivier Ariel, Richard Fredrickson, Leyi Wang, Andre Broes
Summary: Kobuviruses infect the gastrointestinal tract of different animals and have been found in faecal samples from diarrhoeic cattle in many countries, including Canada. A study in Quebec detected BKV in diarrhoeic calves, which was more common than other known enteric calf pathogens. Further genomic characterization and surveillance are needed to monitor BKV in cattle worldwide.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Urology & Nephrology
Elisabetta Bussalino, Luigina Marsano, Angelica Parodi, Rodolfo Russo, Fabio Massarino, Maura Ravera, Gabriele Gaggero, Iris Fontana, Giacomo Garibotto, Gianluigi Zaza, Giovanni Stallone, Ernesto Paoletti
Summary: Switching kidney transplant recipients with BKVN from standard treatment to Everolimus therapy effectively improved renal function, reduced virus replication, and enhanced transplant survival rate.
JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Piotr K. Krajewski, Kinga Tyczynska, Klaudia Bardowska, Piotr Olczyk, Danuta Nowicka-Suszko, Dariusz Janczak, Hanna Augustyniak-Bartosik, Magdalena Krajewska, Jacek C. Szepietowski
Summary: The aim of this study was to assess the differences in concentration of IL-31 among itchy renal transplant recipients (RTR). The results demonstrate a significantly increased IL-31 serum concentration in itchy RTR compared to non-itchy RTR and the healthy control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Xu-Tao Chen, Jiang Qiu, Zi-Xuan Wu, Hui Zhang, Tong Chen, Shi-Cong Yang, Guo-Dong Zhao, Yu He, Xue Shen, Jin-Quan Luo, Yang Huang, Chang-Xi Wang, Li-Zhong Chen, Cheng-Lin Wu, Gang Huang
Summary: Both plasma and urine donor-derived cell-free DNA (dd-cfDNA) are sensitive markers for renal allograft injuries. The interpretation of a specific disease by dd-cfDNA should be combined with other clinical indicators.
CLINICAL CHEMISTRY
(2022)
Article
Microbiology
Tobias Peitz, Birte Mohlendick, Ute Eisenberger, Winfried Siffert, Falko Markus Heinemann, Andreas Kribben, Justa Friebus-Kardash
Summary: The GNAS gene polymorphism c.393C>T is associated with a lower risk of BK viremia and BKV-associated nephropathy in renal allograft recipients.
Article
Biochemistry & Molecular Biology
Baptiste Demey, Marine Bentz, Veronique Descamps, Virginie Morel, Catherine Francois, Sandrine Castelain, Francois Helle, Etienne Brochot
Summary: This study investigates the stability and distribution of bkv-miR-B1-5p, a potential biomarker for active BK polyomavirus replication. The study found that bkv-miR-B1-5p is stable in samples from humans and in vitro experiments. It is mainly bound to proteins, particularly Ago2, rather than associated with exosomes. The level of bkv-miR-B1-5p can predict viral infectivity, making it a potential specific biomarker for active BKPyV replication after kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Julien Gras, Arnaud Le Flecher, Axelle Dupont, Jerome Verine, Ali Amara, Constance Delaugerre, Jean Michel Molina, Marie Noelle Peraldi
Summary: This study aims to identify factors associated with biopsy-proven BK virus associated nephropathy (BKVN) diagnosis. The study found that lymphopenia below 500/mm(3) and corticosteroid maintenance therapy are significantly associated with biopsy-proven BKVN diagnosis.
BMC INFECTIOUS DISEASES
(2023)
Article
Hematology
Malgorzata Salamonowicz-Bodzioch, Jowita Fraczkiewicz, Krzysztof Czyzewski, Olga Zajac-Spychala, Ewa Gorczynska, Anna Panasiuk, Marek Ussowicz, Krzysztof Kalwak, Zofia Szmit, Grazyna Wrobel, Bernarda Kazanowska, Alicja Chybicka, Bogna Ukielska-Hoffmann, Danuta Wendycz-Domalewska, Mariusz Wysocki, Magdalena Dziedzic, Jacek Wachowiak, Agnieszka Zaucha-Prazmo, Jerzy Kowalczyk, Jolanta Gozdzik, Jan Styczynski
Summary: BK virus is a common cause of hemorrhagic cystitis in children undergoing hematopoietic cell transplantation. Various factors such as age, type of transplantation, conditioning regimen, and presence of acute graft-versus-host disease are associated with the development of BKV-HC in these patients. The study aimed to evaluate the incidence, clinical course, and risk factors for BKV-HC in children undergoing HCT.
ANNALS OF HEMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Lihua Liu, Aosong Duan, Qiaoyan Guo, Guangdong Sun, Wenpeng Cui, Xuehong Lu, Hongyu Yu, Ping Luo
Summary: The study found that the levels of miR-33a-5p in the serum, urine, and kidney tissues of IgA nephropathy (IgAN) patients were significantly lower compared to healthy individuals. Furthermore, the levels of miR-33a-5p decreased with the severity of renal injury and the progression of renal failure in IgAN patients. This suggests that miR-33a-5p detected in the serum and urine could serve as a non-invasive biomarker to reflect the progression of renal injury and renal failure in IgAN patients.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Geriatrics & Gerontology
Tazio Maleitzke, Petra Reinke, Alison N. Agres, Sonia A. Alves, Levent Akyuz, Florian N. Fleckenstein, Anna Bichmann, Racheli Ofir, Carsten Perka, Georg N. Duda, Tobias Winkler
Summary: In this case report, we demonstrate a successful treatment of a chronic quadriceps tendon rupture (QTR) using a synergistic surgical and biological reconstructive approach. The addition of PLX-PAD cells as a local treatment option may be considered in specific cases of chronic QTRs that are not suitable for traditional surgical procedures and have a high risk of treatment failure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Immunology
Krystallenia Paniskaki, Moritz Anft, Constantin J. Thieme, Sarah Skrzypczyk, Margarethe Justine Konik, Sebastian Dolff, Timm H. Westhoff, Mikalai Nienen, Anna Stittrich, Ulrik Stervbo, Oliver Witzke, Guido Heine, Toralf Roch, Nina Babel
Summary: The study found that cross-reactive memory B and T cells against SARS-CoV-2 exist in kidney transplant recipients, suggesting a primed adaptive immunity. The impact on the disease course may depend on the concomitant use of immunosuppressive drugs.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Multidisciplinary Sciences
Sebastian Bertram, Arturo Blazquez-Navarro, Maximilian Seidel, Bodo Hoelzer, Felix S. Seibert, Adrian Doevelaar, Benjamin Rohn, Panagiota Zgoura, Alexandra Witte-Lack, Sarah Skrzypczyk, David Scholten, Klaus Kisters, Nina Babel, Timm H. Westhoff
Summary: A study found that 99.9% of healthcare workers in three German hospitals developed an antibody response after receiving the BNT162b2 vaccine. The antibody concentration after vaccination was significantly higher than after infection with SARS-CoV-2. Individuals with submaximal or lacking humoral response had comparable cellular immune responses to those with maximal antibody titers, and immunosuppression was identified as a significant risk factor for impaired immune response.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Daniela Toma, Sebastian Bertram, Diana Racovitan, Maximilian Seidel, Adrian Doevelaar, Felix S. Seibert, Benjamin Rohn, Nina Babel, Dominic Muehlberger, Nikolaus Buechner, Simon Wang, Timm H. Westhoff
Summary: Treatment with dopaminergic medication for restless legs syndrome with periodic limb movements in sleep (PLMS) improves sleep quality and decreases systolic blood pressure.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Felix S. Seibert, Arturo Blazquez-Navarro, Bodo Hoelzer, Adrian A. N. Doevelaar, Christian Nusshag, Uta Merle, Christian Morath, Panagiota Zgoura, Rita Dittmer, Sonja Schneppenheim, Jochen Wilhelm, Nina Babel, Ulrich Budde, Timm H. Westhoff
Summary: Ubiquitous microthromboses in the pulmonary vasculature play a crucial role in the pathogenesis of COVID-19 associated acute respiratory distress syndrome (ARDS). Plasma exchange (PLEX) therapy can restore the balance between vWf and ADAMTS13, reduce inflammation, and improve ventilation parameters.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Frederic Bauer, Janine Lindtke, Felix Seibert, Benjamin Rohn, Adrian Doevelaar, Nina Babel, Peter Schlattmann, Sebastian Bertram, Panagiota Zgoura, Timm H. Westhoff
Summary: The study found that high temperatures are associated with fewer hospital admissions for hypertensive episodes. However, acutely changing weather conditions are not associated with a higher risk of hypertensive emergencies.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Lena Peter, Desiree Jacqueline Wendering, Stephan Schlickeiser, Henrike Hoffmann, Rebecca Noster, Dimitrios Laurin Wagner, Ghazaleh Zarrinrad, Sandra Muench, Samira Picht, Sarah Schulenberg, Hanieh Moradian, Mir-Farzin Mashreghi, Oliver Klein, Manfred Gossen, Toralf Roch, Nina Babel, Petra Reinke, Hans-Dieter Volk, Leila Amini, Michael Schmueck-Henneresse
Summary: Solid organ transplant (SOT) recipients with compromised immune response are at high risk of severe COVID-19. This research proposes the adoptive transfer of tacrolimus-resistant SARS-CoV-2-specific T cells to enhance immune response in immunosuppressed patients. Promising results from laboratory analysis support the potential clinical validation of this approach in transplantation. The combinatory use of tacrolimus and tacrolimus-resistant T cells is suggested to prevent immunopathology and facilitate viral clearance in severe COVID-19 cases.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Clinical Neurology
Frauke Stascheit, Annette Aigner, Philipp Mergenthaler, Benjamin Hotter, Sarah Hoffmann, Sophie Lehnerer, Christian Meisel, Andreas Meisel
Summary: This study aimed to evaluate the association between Nfl and neuromuscular destruction and disease severity in MG patients. Serum samples from MG patients and controls were analyzed and compared. The results showed that sNfl levels were higher in MG patients compared to controls, but were not consistently associated with disease severity. Thus, sNfl is not a suitable biomarker for monitoring individual disease progression in MG patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Dirk Reinhold, Vadim Farztdinov, Yan Yan, Christian Meisel, Henrik Sadlowski, Joachim Kuehn, Frank H. Perschel, Matthias Endres, Emrah Duezel, Stefan Vielhaber, Karina Guttek, Alexander Goihl, Morten Veno, Bianca Teegen, Winfried Stoecker, Paula Stubbemann, Florian Kurth, Leif E. Sander, Markus Ralser, Carolin Otto, Simon Streit, Sven Jarius, Klemens Ruprecht, Helena Radbruch, Jorgen Kjems, Michael Muelleder, Frank Heppner, Peter Koertvelyessy
Summary: Patients with COVID-19 may experience various neurological symptoms, but the role of the central nervous system (CNS) in COVID-19 is still unclear. The inflammatory response in the cerebrospinal fluid (CSF) of COVID-19 patients was studied, and it was found that there were attenuated inflammatory changes compared to patients with herpes simplex virus encephalitis (HSVE). The inflammatory mediators in the CSF of COVID-19 patients were likely derived from the systemic circulation rather than produced within the CNS. Further investigation is needed to understand the relevance of blood-derived mediators of inflammation in the CSF for neurological COVID-19 and post-COVID-19 symptoms.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Thomas Meyer, Peggy Schumann, Patrick Weydt, Susanne Petri, Yasemin Koc, Susanne Spittel, Sarah Bernsen, Rene Guenther, Jochen H. Weishaupt, Marie Dreger, Felix Kolzarek, Dagmar Kettemann, Jenny Norden, Matthias Boentert, Maximilian Vidovic, Christian Meisel, Christoph Muench, Andre Maier, Peter Koertvelyessy
Summary: This study assessed the changes in neurofilament light chain (NfL) levels in patients with amyotrophic lateral sclerosis (ALS) caused by superoxide dismutase 1 (SOD1) gene mutations (SOD1-ALS) during treatment with tofersen. The results showed a decrease in NfL levels in all patients treated with tofersen, suggesting its potential disease-modifying activity.
Article
Allergy
Olga Staudacher, Jeanette Klein, Stephanie Thee, Jan Ullrich, Volker Wahn, Nadine Unterwalder, Uwe Koelsch, Erwin Lankes, Anna Stittrich, Cinzia Dedieu, Sarah Dinges, Mirjam Voeller, Catharina Schuetz, Johannes Schulte, Kaan Boztug, Christian Meisel, Joern-Sven Kuehl, Renate Krueger, Oliver Blankenstein, Horst von Bernuth
Summary: TREC screening at birth may not be able to identify certain CIDs that develop with age, highlighting the importance of early recognition and treatment for CID patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Letter
Urology & Nephrology
Arturo Blazquez-Navarro, Lisa Mittmann, Constantin Joachim Thieme, Moritz Anft, Krystallenia Paniskaki, Adrian Doevelaar, Felix Sebastian Seibert, Bodo Hoelzer, Margarete Justine Konik, Marc Moritz Berger, Thorsten Brenner, Clemens Tempfer, Carsten Watzl, Toni Luise Meister, Stephanie Pfaender, Eike Steinmann, Sebastian Dolff, Ulf Dittmer, Oliver Witzke, Ulrik Stervbo, Toralf Roch, Michal Or-Guil, Timm Henning Westhoff, Nina Babel
JOURNAL OF NEPHROLOGY
(2023)
Article
Surgery
Panagiota Zgoura, Adrian Doevelaar, Benjamin Rohn, Felix S. Seibert, Maximilian Seidel, Falko Markus Heinemann, Nina Pillokeit, Richard Viebahn, Nina Babel, Timm H. Westhoff
Summary: Keeping a kidney graft in situ after returning to dialysis does not lead to an increase in microinflammation. Although more than 50% of patients develop DSA after an allograft nephrectomy, the outcome of a renal re-transplantation seems to be unaffected.
ANNALS OF TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Philipp Georg, Rosario Astaburuaga-Garcia, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J. Lippert, Tomislav Kostevc, Christiane Gaebel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemuend, Matthias Barone, Pinkus Tober-Lau, Elisa T. Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Muelleder, Simran Kaur Aulakh, Sonja Djudjaj, Roman D. Buelow, Henrik E. Mei, Axel R. Schulz, Andreas Thiel, Stefan Hippenstiel, Antoine-Emmanuel Saliba, Roland Eils, Irina Lehmann, Marcus A. Mall, Sebastian Stricker, Jobst Roehmel, Victor M. Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer, Saskia von Stillfried, Peter Boor, Munevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Mueller-Redetzky, Jacob Nattermann, Wolfgang M. Kuebler, Christian Meisel, Markus Ralser, Joachim L. Schultze, Anna C. Aschenbrenner, Charlotte Thibeault, Florian Kurth, Leif E. Sander, Nils Bluethgen, Birgit Sawitzki
Summary: Severe COVID-19 is associated with highly activated CD16(+) T cells that exhibit cytotoxic functions and contribute to endothelial injury. These CD16(+) T cells can degranulate and induce cytotoxicity through immune-complex-mediated mechanisms independent of the T cell receptor, which is not observed in other diseases. The presence of activated CD16(+) T cells and elevated levels of complement proteins upstream of C3a are associated with a fatal outcome of COVID-19, indicating the pathological role of enhanced cytotoxicity and complement activation in the disease.
Article
Rheumatology
S. Horn, K. Minden, F. Speth, T. Schwarz, F. Dressler, N. Groesch, J-P Haas, C. Hinze, G. Horneff, A. Hospach, T. Kallinich, J. Klotsche, K. Koestner, C. Meisel, M. Niewerth, P. T. Oommen, C. Schuetz, F. Weller-Heinemann, N. Unterwalder, C. Sengler
Summary: The study aimed to describe a cohort of German patients with juvenile dermatomyositis (JDM) and evaluate their clinical manifestations and prognosis based on a specific myositis-specific autoantibody (MSA). The results showed that JDM patients in Germany exhibited a wide range of clinical manifestations, which could be grouped using MSAs, and this classification helped to predict disease course and prognosis.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)