Review
Surgery
Dieter Broering, Mark L. Sturdevant, Ahmed Zidan
Summary: Living donation is a crucial resource for organ transplantation, and advancements in minimally invasive surgical techniques are improving safety and outcomes for living donors. The introduction of robotic platforms with advanced instruments is allowing for better emulation of open surgeries in a closed abdomen, potentially leading to wider adoption of minimally invasive donor surgeries.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Marjolein Leemkuil, Franka Messner, Stan Benjamens, Felix J. Krendl, Henri G. D. Leuvenink, Christian Margreiter, Robert A. Pol
Summary: This study retrospectively analyzed 317 pancreas transplants and found that pancreas donor extraction time was not associated with graft survival, but had a significant impact on postoperative complications occurrence.
Article
Surgery
Carli J. Lehr, Melissa A. Skeans, Erika D. Lease, Maryam Valapour
Summary: The US lung transplant policy changed on November 24, 2017, expanding the geographic organ distribution to a 250-nautical-mile radius. This change resulted in increased travel distance and time for organ procurement, leading to higher travel costs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Marluce da Cunha Mantovani, Ilana Gabanyi, Carlos Andres Pantanali, Vinicius Rocha Santos, Maria Lucia Cardillo Correa-Giannella, Mari Cleide Sogayar
Summary: Background: Type 1 diabetes mellitus (T1D) is a condition caused by autoimmune destruction of pancreatic beta cells. Transplantation of isolated pancreatic islets from donors is a potential treatment for T1D, but the limited availability of suitable pancreas donors is a major challenge. Methods: A retrospective study was conducted to analyze the profile of brain-dead human pancreas donors and the reasons for organ refusal. Results: The main reasons for refusal were hyperglycemia, technical issues, age, positive serology, and hyperamylasemia. Conclusions: This study provides insights to improve the availability of suitable pancreas donors and enhance the outcome of islet isolation and transplantation.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Surgery
Kristen L. King, S. Ali Husain, Adler Perotte, Joel T. Adler, Jesse D. Schold, Sumit Mohan
Summary: Deceased donor kidney allocation allows exceptions in special circumstances, but these exceptions are often concentrated in a few outlier centers. The kidneys involved in the exceptions are usually transplanted to larger centers with higher acceptance rates.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Syed A. Husain, Kristen L. King, David C. Cron, Nikole A. Neidlinger, Han Ng, Sumit Mohan, Joel T. Adler
Summary: This study investigated the impact of local market competition and/or organ availability on kidney procurement and utilization. The results showed that lower competition was associated with higher export, while market monopoly was weakly associated with lower discard. Higher organ availability was associated with both export and discard.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Hwai-Ding Lam, Alexander F. Schaapherder, Ian P. J. Alwayn, Willemijn N. Nijboer, Maarten E. Tushuizen, Aline C. Hemke, Andrzej Baranski, Stephanie L. Van der Pas
Summary: The value of the unadjusted CUSUM graph in analyzing liver surgical injury and discard rates in organ procurement in the Netherlands was investigated. The results showed that the unadjusted CUSUM chart is a simple and effective tool for monitoring organ procurement quality. Both national and local CUSUM charts can reflect the impact on organ procurement injury, and separate CUSUM charts are needed for injury and discard analysis.
CLINICAL TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Mary Froehlich, Naoru Koizumi, Rosy M. M. James, Ana Gayle Weatherly Christian, Ankur Choubey, Sunil Patel, Jorge Ortiz, Eric J. J. Siskind
Summary: This study found that the absence of vasopressor use or the use of dopamine increases the risk of pancreas transplant graft failure and recipient mortality. In contrast, the use of phenylephrine and norepinephrine reduces the risk of mortality. These findings suggest the importance of careful selection and use of vasopressors in pancreas transplantation procedures.
Article
Biochemistry & Molecular Biology
Wayne J. Hawthorne, Sussan Davies, Hee-chang Mun, Yi Vee Chew, Lindy Williams, Patricia Anderson, Natasha Rogers, Philip J. O'Connell
Summary: This study compared the isolation and transplant outcomes of donor pancreata according to the distance from the islet isolation facility. The results showed that the distance of donors did not significantly impact the isolation and transplant outcomes.
Article
Surgery
B. L. Kasiske, K. L. Lentine, Y. Ahn, M. A. Skeans, T. Eberhard, C. Folken, J. Wainright, L. Larkin, C. Nystedt
Summary: Living donor transplantation is an important source of organs, but there has been little growth in the number of living donor transplants in the past decade. To better understand the barriers and risks associated with living donation, a national registry has been established.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Xingxing S. Cheng, Philip J. Held, Avi Dor, Jennifer L. Bragg-Gresham, Jane C. Tan, John D. Scandling, Glenn M. Chertow, John P. Roberts
Summary: Expanding donor acceptability criteria to include nonstandard donors could be a potential solution to the organ shortage issue. Despite higher costs per organ, kidney transplantation from nonstandard donors remained cost-effective based on contemporary US data, with economies of scale observed in high OPO volume leading to lower costs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Nishma Valikodath, Nicole Lambert, Alison Butler, Daniel J. Lebovitz, Gretchen Chapman, Meng Xu, James C. Slaughter, Jonathan N. Menachem, Justin Godown
Summary: This study aimed to report the trends in deceased organ donation in the United States and assess the regional differences in OPO performance after accounting for the different mechanisms of donor consent. The results showed that organ donor registration among adult eligible deaths in the U.S. increased over time, while next-of-kin authorization rates declined. There was significant variability across OPOs in the consent of potentially persuadable donors, indicating the need for targeted initiatives to improve deceased organ donation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Surgery
Kyung-Suk Suh, Suk Kyun Hong, Sola Lee, Su Young Hong, Sanggyun Suh, Eui Soo Han, Seong-Mi Yang, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee
Summary: Minimally invasive living donor liver transplantation with pure laparoscopic techniques, including explant hepatectomy and graft implantation through a suprapubic incision, was performed successfully in a patient with liver cirrhosis and carcinoma. The procedure, conducted by an experienced surgical team, resulted in a smooth recovery and short hospital stay. Larger studies are needed to validate the safety and feasibility of this approach.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Jeong-Moo Lee
Summary: This study analyzed the use of living-donor liver transplantation in South Korea to overcome a shortage of deceased donors. The results showed that policy factors such as independent organ-procurement organization (IOPO) activities and the establishment of regional trauma centers had an impact on the recruitment and donation of deceased donors. The study found that cerebrovascular events and head trauma were the most common causes of donor death. The locations where deceased donors were identified changed based on these policies, highlighting the need for communication with regional trauma center staff to recruit more donors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ethics
Anthony P. Smith
Summary: The Dead Donor Rule is intended to protect the public and patients, but it remains controversial. This article argues for abandoning the rule by using Joel Feinberg's account of harm to show that death does not harm permanently unconscious patients, especially when they have consented to organ donation. Therefore, causing the death of these patients is not morally wrong, undermining the main argument for the Dead Donor Rule.
JOURNAL OF MEDICAL ETHICS
(2023)
Article
Transplantation
Erik Nilsson, Peter Stenvinkel, Sai Liu, Margaret R. Stedman, Glenn M. Chertow, Juergen Floege
Summary: Lower free testosterone and higher SHBG in serum are associated with higher risk of death or cardiovascular event in men undergoing chronic hemodialysis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Bernadette J. Prentice, Kathryn J. Potter, Adele Coriati, Valerie Boudreau, Leah Rusnell, Tamizan Kherani, A. Peter, Shihab Hameed, Remi Rabasa-Lhoret
Summary: Cystic Fibrosis-Related Diabetes (CFRD) is a distinct type of diabetes that combines features of both type 1 and type 2 diabetes. However, its characteristic acute pulmonary complications and catabolic metabolism pose challenges to traditional definitions and treatments for diabetes. Patients with CF undergo annual screening from the age of 10, which is hindered by limited accuracy and reproducibility. As the lifespan of CF patients increases, over 50% are expected to develop CFRD, including a significant proportion of adolescents. Evidence-based practice in CFRD is currently limited due to small and short-term studies, but recent advancements in CFTR modulator medications may change our understanding. This review discusses the challenges in diagnosing and managing CFRD, highlighting knowledge gaps, screening methods, research priorities, and providing guidance for screening, diagnosis, and treatment.
PAEDIATRIC RESPIRATORY REVIEWS
(2023)
Article
Immunology
Kevin Verhoeff, Braulio A. Marfil-Garza, Khaled Dajani, David L. Bigam, Blaire Anderson, Tatsuya Kin, Anna Lam, Doug O'Gorman, Peter A. Senior, A. M. James Shapiro
Summary: This study analyzed patients undergoing islet transplantation and found that C-peptide levels are correlated with blood glucose control and insulin independence. The study determined threshold values for insulin independence and hypoglycemic freedom based on C-peptide levels, as well as BETA-2 scores, providing reference values for evaluating pancreatic or stem cell therapies.
Article
Endocrinology & Metabolism
Jeremy Gilbert, Phil McFarlane, James Kim, Susie Jin, Peter Senior, Jeremy Gilbert, Harpreet S. Bajaj, Susie Jin, James Kim, Harpreet S. Bajaj, Jeremy Gilbert, Robyn Houlden, James Kim, Barbara MacDonald, Dylan MacKay, Kerry Mansell, Doreen Rabi, Diana Sherifali, Peter Senior
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Nutrition & Dietetics
Kelly Picard, Melanie Griffiths, Peter A. Senior, Diana R. Mager, Caroline Richard
Summary: The frequency and impact of phosphate additives in the United States Branded Foods Product Database are unknown. This study found that products with phosphate additives had higher phosphorus content compared to those without additives.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Kelly Picard, Melanie Griffiths, Janelle Dusterhoft, Shonagh Colebrook-Fonseca, Peter A. Senior, Diana R. Mager, Caroline Richard
Summary: This study aimed to investigate the impact of plant protein intake on serum potassium and phosphate levels in patients with chronic kidney disease. The results showed that increased proportion of plant protein intake was not associated with higher levels of serum potassium or phosphate, but was related to higher fiber intake and diet quality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Colin M. Dayan, Beatriz Lecumberri, Ilaria Muller, Sashiananthan Ganesananthan, Samuel F. Hunter, Krzysztof W. Selmaj, Hans-Peter Hartung, Eva K. Havrdova, Christopher C. LaGanke, Tjalf Ziemssen, Bart Van Wijmeersch, Sven G. Meuth, David H. Margolin, Elizabeth M. Poole, Darren P. Baker, Peter A. Senior
Summary: This study aimed to describe the endocrine and multiple sclerosis outcomes over 6 years for alemtuzumab-treated relapsing multiple sclerosis patients. The results showed that the common adverse event of this treatment was autoimmune thyroid events, but it did not affect the disease course.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Endocrinology & Metabolism
Mikael Chetboun, Elodie Drumez, Cassandra Ballou, Mehdi Maanaoui, Elizabeth Payne, Franca Barton, Julie Kerr-Conte, Marie-Christine Vantyghem, Lorenzo Piemonti, Michael R. Rickels, Julien Labreuche, Francois Pattou
Summary: This global multicentre study shows a linear and independent association between primary graft function (PGF) and 5-year clinical outcomes of islet transplantation. The study reveals that PGF is closely related to the success rate of islet transplantation, graft exhaustion, inadequate glucose control, and the need for exogenous insulin therapy. It emphasizes the importance of PGF in long-term outcomes of islet transplantation.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Hannah Craven, Helen Erlandsson, Dagmara Mcguinness, David H. Mcguinness, Denise Mafra, Umer Zeeshan Ijaz, Peter Bergman, Paul G. Shiels, Peter Stenvinkel
Summary: This study investigated the bacterial DNA signatures in the circulation of CKD patients and those receiving KTx treatment. The results suggest that dysbiosis increases as CKD progresses, accompanied by an increase in trimethylamine (TMA) producing pathobionts Pseudomonas and Bacillus. Surprisingly, KTx patients displayed a significantly different microbiota compared to CKD5 patients, with further increase in TMA producing Bacillus and loss of salutogenic Lactobacilli. Two genera (Veillonella and Saccharimonidales) showed significant differences in abundance following KTx, reflecting a reciprocal relationship between TMA producers and utilisers.
Article
Endocrinology & Metabolism
Kathryn J. Potter, Florence Racine, Anne Bonhoure, Valerie Boudreau, Noemie Belanger, Adele Coriati, Azadeh Shohoudi, Annick Lavoie, Peter A. Senior, Genevieve Mailhot, Remi Rabasa-Lhoret
Summary: The study aimed to identify specific thresholds of glycated hemoglobin A1c associated with the risk of cystic fibrosis-related diabetes (CFRD) progression and changes in body mass index and forced expiratory volume. The results showed that an A1C above 6% may be associated with a high risk of developing CFRD and a lower probability of weight gain in both adults and children with CF.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Vichy Liyanage, Olesya Barrett, Deliwe Ngwezi, Anamaria Savu, Peter Senior, Roseanne O. Yeung, Sonia Butalia, Padma Kaul
Summary: This study aims to provide real-world evidence on the uptake of and outcomes associated with the modified GDM screening approach offered during the COVID-19 pandemic compared with the standard screening approach.
Review
Endocrinology & Metabolism
Alfonso Galderisi, Alice L. J. Carr, Mariangela Martino, Peter Taylor, Peter Senior, Colin Dayan
Summary: Clinically symptomatic type 1 diabetes is preceded by a pre-symptomatic phase, during which there is a progressive loss of functional beta cell mass and potential changes in glucose profile. Identifying metabolic tests to track beta cell function is crucial for understanding disease progression and treatment effectiveness.
Meeting Abstract
Immunology
Michael Rickels, Thomas L. Eggerman, Levent Bayman, Julie C. Qidwai, Joseph R. Naji, Huong-Lan Nguyen, Rodolfo Alejandro, Melena D. Bellin, Peter A. Senior, Lawrence G. Hunsicker
Meeting Abstract
Immunology
Braulio Marfil-Garza, Alice L. J. Carr, Meiying Zhuang, Anna Lam, Khaled Dajani, Blaire Anderson, Doug O'Gorman, Tatsuya Kin, David Bigam, James Shapiro, Peter A. Senior
Meeting Abstract
Immunology
Doug O'Gorman, Tatsuya Kin, Shawn Rosichuk, Wendy Zhai, Jennifer Moriarty, Kyle Park, Advaita Ganguly, Peter A. Senior, James A. M. Shapiro