Article
Immunology
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: The study revealed the significant role of IL-33/ST2 signaling in cardiac allograft vasculopathy, with opposite effects observed when either allografts or recipients had ST2 deficiency. The differential impact on immune cell infiltration by ST2 deficiency suggests a potential for different outcomes in post-heart transplant intervention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Wen Lin, Chien-Sung Tsai, Chun-Yao Huang, Yi-Ting Tsai, Chun-Ming Shih, Shing-Jong Lin, Chi-Yuan Li, Cheng-Yen Lin, Shih-Ying Sung, Feng-Yen Lin
Summary: This study explores the feasibility of far-infrared therapy in preventing vasculopathy induced by orthotopic allograft transplantation (OAT). The results show that far-infrared therapy can effectively inhibit smooth muscle cell proliferation and reduce inflammation, leading to decreased severity of vasculopathy in OAT recipients.
Article
Medicine, Research & Experimental
Jan Novak, Tana Machackova, Jan Krejci, Julie Bienertova-Vasku, Ondrej Slaby
Summary: Congestive heart failure affects about 23 million people worldwide, and cardiac allograft transplantation is one of the last options for patients with terminal refractory heart failure. The prognosis of patients after heart transplantation is influenced by rejection and allograft vasculopathy, with monitoring requiring invasive and uncomfortable procedures. MiRNAs play a potential role in the pathophysiology of rejection and may be used in clinical practice for diagnosis and prediction of rejection occurrence.
Review
Cardiac & Cardiovascular Systems
Jordan S. Pober, Sharon Chih, Jon Kobashigawa, Joren C. Madsen, George Tellides
Summary: This article discusses the incidence and diagnosis, the nature of the vascular remodelling, immune and non-immune contributions to pathogenesis, current therapies, and future areas of research in cardiac allograft vasculopathy (CAV).
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Sharon Chih, Aun Yeong Chong, Vladimir Dzavik, Derek Y. Y. So, Natasha Aleksova, George A. Wells, Jordan Bernick, Christopher B. Overgaard, Ellamae Stadnick, Lisa M. Mielniczuk, Rob S. B. Beanlands, Heather J. Ross
Summary: This study aimed to determine predictors of early coronary artery disease (CAD) after heart transplantation. Heart transplant recipients were evaluated for one year for coronary anatomic-physiologic changes and the related predictors. The study found that fibrotic plaque on optical coherence tomography and index of microcirculatory resistance could predict CAD progression early posttransplant.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen, Peter Verhamme, Zhen-Yu Zhang
Summary: This study identified and validated a urinary proteomic signature for the surveillance of cardiac allograft vasculopathy (CAV). The proteins in the signature may offer insights into CAV pathological processes and warrant further investigation into personalized treatment targets.
Review
Biochemistry & Molecular Biology
Guillaume Coutance, Eva Desire, Jean-Paul Duong Van Huyen
Summary: Despite advances in immunosuppression, allograft rejection remains a significant complication after heart transplantation. The current invasive diagnostic method has limitations, thus innovative strategies are needed to improve the accuracy of diagnosis.
Article
Surgery
Oscar A. Mendiz, Paul Gamboa, Maria F. Renedo, Gustavo A. Lev, Liliana E. Favaloro, Alejandro M. Bertolotti
Summary: Cardiac allograft vasculopathy (CAV) is a fibro-proliferative disease affecting coronary arteries post-heart transplantation. Despite often being clinically silent, IVUS is a reliable and safe technique for detecting angiographically silent CAV in heart transplant patients, with potential long-term clinical impact. Further large multicenter studies are needed to validate these findings.
CLINICAL TRANSPLANTATION
(2021)
Article
Materials Science, Multidisciplinary
Cheng Deng, Chenyuan Wang, Wenpei Fu, Lujuan Wu, Qiaofeng Jin, Li Zhang, Wen Zhang, Wei Li, Mingxing Xie
Summary: This study evaluated the efficacy of a FK506-loaded microneedle (FK506 MN) in treating acute rejection in heart transplantation. The results showed that FK506 MN could successfully alleviate acute rejection and prolong allograft survival. In addition, it also reduced T cell and macrophage infiltration as well as the secretion of certain cytokines.
MATERIALS & DESIGN
(2023)
Article
Medicine, Research & Experimental
Zhang Chen, Heng Xu, Yuan Li, Xi Zhang, Jikai Cui, Yanqiang Zou, Jizhang Yu, Jie Wu, Jiahong Xia
Summary: This study investigated the immune cell dynamics and local intercellular communication of acute cardiac allograft rejection using single-cell RNA sequencing. The results revealed the functional characteristics and differentiation trajectory of various alloreactive cell subpopulations, and suggested that the CXCR3 pathway may serve as a potential therapeutic target for transplant rejection.
Article
Cardiac & Cardiovascular Systems
Carmela Napolitano, Giorgia Grutter, Paola Francalanci, Antonio Amodeo, Aurelio Secinaro
Summary: Heart transplant recipients undergo postoperative screening to exclude complications. Cardiac magnetic resonance imaging is a non-invasive tool for monitoring graft health. We describe a case of a female heart transplant recipient with worsening clinical condition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Brian A. Bergmark, Thomas A. Zelniker, Miae Kim, Mandeep R. Mehra, Garrick C. Stewart, Deborah S. Page, Erica L. Woodcome, Michael M. Givertz
Summary: Early aspirin use after orthotopic heart transplantation was associated with lower rates of cardiac allograft vasculopathy, particularly in patients with episodes of allograft rejection.
CLINICAL TRANSPLANTATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefan Roest, Ricardo P. J. Budde, Jasper J. Brugts, Jan von der Thusen, Theo van Walsum, Yannick J. H. J. Taverne, Felix Zijlstra, Daniel Bos, Olivier C. Manintveld
Summary: This study found that the volume of epicardial fat (EFV) is associated with the development of cardiac allograft vasculopathy (CAV) in heart transplant patients, and the recipient sex has a greater influence on EFV than the donor sex.
EUROPEAN RADIOLOGY
(2023)
Article
Geriatrics & Gerontology
Liang Tan, Yanan Xu, Gongbin Lan, Hongxia Wang, Zhanfeng Liang, Zhaoqi Zhang, Qianchuan Tian, Yangxiao Hou, Yong Zhao, Xubiao Xie
Summary: This study found that deficiency of TSC1 in T cells accelerates acute allograft rejection. TSC1 deficiency leads to increased accumulation of CD8(+) T cells in the allografts and enhances their responsiveness to alloantigens. TSC1-deficient recipients may be more resistant to mTOR inhibitor-mediated immunosuppression during organ transplantation.
Article
Health Care Sciences & Services
Silvia Lozano-Edo, Esther Rosello-Lleti, Ignacio Sanchez-Lazaro, Estefania Tarazon, Manuel Portoles, Maryem Ezzitouny, Raquel Lopez-Vilella, Miguel Angel Arnau, Luis Almenar, Luis Martinez-Dolz
Summary: This study found that serum RANGAP1 levels can serve as a non-invasive biomarker for predicting the risk of ACR during the first year after heart transplantation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Eshan U. Patel, Allison R. Kirkpatrick, Mary Kate Grabowski, Godfrey Kigozi, Ronald H. Gray, Jessica L. Prodger, Andrew D. Redd, Fred Nalugoda, David Serwadda, Maria J. Wawer, Thomas C. Quinn, Aaron A. R. Tobian
CLINICAL INFECTIOUS DISEASES
(2017)
Article
Immunology
Cindy M. Liu, Jessica L. Prodger, Aaron A. R. Tobian, David Serwadda, Ronald M. Galiwango, Fred Nalugoda, Nehemiah Kighoma, Joshua Mwinike, Margaret Anyokorit, Lance B. Price, Maria J. Wawer, Godfrey Kigozi, Ronald H. Gray
JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Microbiology
Jessica L. Prodger, Ronald H. Gray, Brett Shannon, Kamnoosh Shahabi, Xiangrong Kong, Kate Grabowski, Godfrey Kigozi, Fred Nalugoda, David Serwadda, Maria J. Wawer, Steven J. Reynolds, Cindy M. Liu, Aaron A. R. Tobian, Rupert Kaul
Article
Immunology
Martha C. Nason, Eshan U. Patel, Allison R. Kirkpatrick, Jessica L. Prodger, Kamnoosh Shahabi, Aaron A. R. Tobian, Sara Gianella, Sarah Kalibbala, Paschal Ssebbowa, Rupert Kaul, Ronald H. Gray, Thomas C. Quinn, David Serwadda, Steven J. Reynolds, Andrew D. Redd
OPEN FORUM INFECTIOUS DISEASES
(2016)
Article
Microbiology
Cindy M. Liu, Jessica L. Prodger, Aaron A. R. Tobian, Alison G. Abraham, Godfrey Kigozi, Bruce A. Hungate, Maliha Aziz, Fred Nalugoda, Sanjeev Sariya, David Serwadda, Rupert Kaul, Ronald H. Gray, Lance B. Price
Review
Infectious Diseases
Jessica L. Prodger, Rupert Kaul
AIDS RESEARCH AND THERAPY
(2017)
Article
Virology
Art F. Y. Poon, Jessica L. Prodger, Briana A. Lynch, Jun Lai, Steven J. Reynolds, Jingo Kasule, Adam A. Capoferri, Susanna L. Lamers, Christopher W. Rodriguez, Daniel Bruno, Stephen F. Porcella, Craig Martens, Thomas C. Quinn, Andrew D. Redd
Article
Immunology
Ronald Moses Galiwango, Sergey Yegorov, Vineet Joag, Jessica Prodger, Kamnoosh Shahabi, Sanja Huibner, Enoch Muyanja, Brian Roy Kabuubi, Annmarie Namuniina, Annet Nalutaaya, Aloysius Ssemaganda, Fredrick Lutwama, Paul Kato Kitandwe, Annet Nanvubya, Juliet Mpendo, Bernard Bagaya, Noah Kiwanuka, Rupert Kaul
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2019)
Article
Immunology
Cindy M. Liu, Zoe R. Packman, Alison G. Abraham, David M. Serwadda, Fred Nalugoda, Maliha Aziz, Jessica L. Prodger, Rupert Kaul, Sarah Kalibbala, Ronald H. Gray, Lance B. Price, Thomas C. Quinn, Aaron A. R. Tobian, Steven J. Reynolds
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Multidisciplinary Sciences
Godfrey Kigozi, Cindy M. Liu, Daniel Park, Zoe R. Packman, Ronald H. Gray, Rupert Kaul, Aaron A. R. Tobian, Alison G. Abraham, Joseph Ssekasanvu, Joseph Kagaayi, Jessica L. Prodger
Article
Medicine, Research & Experimental
Jessica L. Prodger, Adam A. Capoferri, Katherine Yu, Jun Lai, Steven J. Reynolds, Jingo Kasule, Taddeo Kityamuweesi, Paul Buule, David Serwadda, Kyungyoon J. Kwon, Katherine Schlusser, Craig Martens, Eileen Scully, Yun-Hee Choi, Andrew D. Redd, Thomas C. Quinn
Article
Virology
Roux-Cil Ferreira, Jessica L. Prodger, Andrew D. Redd, Art F. Y. Poon
Summary: The long-term persistence of a population of cells carrying transcriptionally silent integrated viral DNA remains the primary barrier to developing an effective cure for people living with HIV-1. The contribution of ongoing cell division via proliferation to the latent HIV-1 reservoir is supported by the observation that proviral sequences sampled from the reservoir are often identical. However, clonality is not adequate for characterizing the dynamics and proviral composition of the reservoir due to the complexity of how infected cells are 'labeled' by proviral sequences and variation in cell birth and death rates among lineages and over time.
Review
Virology
Rupert Kaul, Cindy M. Liu, Daniel E. Park, Ronald M. Galiwango, Aaron A. R. Tobian, Jessica L. Prodger
Summary: Most HIV transmission occurs through vaginal-penile sex. The local microbiome plays a critical role in shaping the immune environment at the site of HIV exposure. However, the microbial drivers of inflammation and immune quiescence vary between the vagina and penis. Different taxa are associated with increased HIV risk and optimal microbiota at these tissue sites.
Article
Health Policy & Services
Edward Nelson Kankaka, Joseph Ssekasanvu, Jessica Prodger, Dorean Nabukalu, Hadijja Nakawooya, Anthony Ndyanabo, Godfrey Kigozi, Ronald Gray
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2018)
Article
Immunology
Jessica L. Prodger, Jun Lai, Steven J. Reynolds, Jeanne C. Keruly, Richard D. Moore, Jingo Kasule, Taddeo Kityamuweesi, Paul Buule, David Serwadda, Martha Nason, Adam A. Capoferri, Stephen F. Porcella, Robert F. Siliciano, Andrew D. Redd, Janet D. Siliciano, Thomas C. Quinn
CLINICAL INFECTIOUS DISEASES
(2017)