Article
Endocrinology & Metabolism
Roland Chapurlat, Melanie A. Legrand
Summary: Bisphosphonates have shown potential in reducing bone pain and improving bone strength in patients with FD, particularly through intravenous administration. Oral bisphosphonates, however, have limited efficacy in this indication and should not be used as a primary treatment option.
Article
Endocrinology & Metabolism
Rachel Chava Rosenblum, Orit Twito, Liat Barzilay-Yoseph, Erez Ramaty, Noa Klein, Pnina Rotman-Pikielny
Summary: This study evaluated the efficacy and safety of pamidronate for moderate-to-severe parathyroid hormone-related hypercalcemia (PTHRH) and found that pamidronate is effective and safe for treating PTHRH, with close laboratory monitoring of calcium and phosphorus metabolism recommended. Larger prospective studies are needed to further establish the role of pamidronate and other potent bisphosphonates in moderate-to-severe PTHRH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Health Care Sciences & Services
Yang Wang, Zuolei Tang, Rongqin Meng, Liang He
Summary: Incardronate sodium showed comparable efficacy to pamidronate disodium in treating bone metastasis pain, while having fewer adverse reactions. The systematic review and meta-analysis included a total of 510 patients from seven articles, indicating the potential benefit of using incardronate as a treatment option for bone metastasis pain.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Review
Dentistry, Oral Surgery & Medicine
K. C. Kumar, Bishwa Prakash Bhattarai, Shilu Shrestha, Bijaya Shrestha, Manash Shrestha
Summary: Locally delivered bisphosphonates have a positive effect on alveolar bone regeneration in patients with periodontitis and can reduce marginal bone loss after dental implant placement.
JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE
(2021)
Review
Endocrinology & Metabolism
Y. Wu, F. Wang, Z. Zhang
Summary: Bisphosphonates are safe and beneficial for maintaining bone mineral density in patients with spinal cord injury, reducing the risk of bone loss.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Clinical Neurology
Zijian Ma, Mingling Ma, Yilang He, Hao Sun, Bin Yang, Hui Dong, Yongxiang Wang
Summary: In this meta-analysis of 7 randomized controlled trials, bisphosphonates were found to effectively alleviate bone loss in patients with acute spinal cord injury, particularly in the lumbar spine, femoral neck, and total hip. Early application of bisphosphonates is recommended.
WORLD NEUROSURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kirsten W. Slagter, Henny J. A. Meijer, Diederik F. M. Hentenaar, Arjan Vissink, Gerry M. Raghoebar
Summary: After 5 years of follow-up, there was no significant difference in marginal bone level changes, buccal bone thickness, clinical outcomes, esthetic ratings, and patient-reported satisfaction between immediate implant placement with bone defects >= 5 mm and delayed implant placement after ridge preservation in the esthetic zone.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Endocrinology & Metabolism
Mark A. Jara, Jeena Varghese, Mimi I. Hu
Summary: Bone metastatic disease can cause serious adverse events. Bone-directed therapies are available to prevent bone-related adverse events, but they can have side effects related to dosage and treatment duration. These side effects range from common and mild symptoms like fever, myalgias, and arthralgias, to less common but more severe side effects like medication-related osteonecrosis of the jaw and atypical femoral fractures. Familiarity with the literature on adverse events associated with bone-directed therapies is important for clinicians.
Article
Biochemistry & Molecular Biology
Lilian Rauch, Ruediger Hein, Tilo Biedermann, Kilian Eyerich, Felix Lauffer
Summary: Bisphosphonates show beneficial effects in a subgroup of patients with calcinosis cutis. Most patients have positive subjective evaluations, with improvement seen in approximately half of the cases. A careful risk-benefit evaluation is necessary before treatment initiation due to potential severe side effects.
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, Research & Experimental
Ahmad Oryan, Sonia Sahvieh
Summary: Osteoporosis mainly affects older individuals and postmenopausal women, with bisphosphonates (BPs) being the most effective medication for treatment. The use of zoledronate (Zol) within the BPs family shows promising results in improving bone density and preventing fractures, making it a potential treatment option for osteoporosis.
Review
Pharmacology & Pharmacy
Jiangbi Li, Yang Sun, Zhuo Chen, Xiaoping Xie, Feng Gu, Songqi Bi, Tiecheng Yu
Summary: This review examined the effects of bisphosphonates on bone density, fractures, and bone markers in osteopenic older women. The study found that bisphosphonates had significant positive effects on bone density and bone markers, as well as reducing the risk of fractures. However, further research is needed to determine their safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Sujung Park, Kyemyung Park, Jae Geun Lee, Tae Yang Choi, Sungtaik Heo, Bon-Nyeo Koo, Dongwoo Chae
Summary: This study developed machine learning models and a scoring system to predict massive hemorrhage in liver transplantation. Factors such as disease etiology, aPTT, and operation duration were found to be important predictors.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, Jad G. Sfeir, Japneet Kaur, Elizabeth J. Atkinson, James R. Edwards, Graham G. Russell, Robert J. Pignolo, James L. Kirkland, Tamar Tchkonia, Laura J. Niedernhofer, David G. Monroe, Nathan K. Lebrasseur, Joshua N. Farr, Paul D. Robbins, Sudeep Khosla
Summary: In addition to reducing fracture risk, zoledronic acid has been found to extend lifespan and healthspan in animals. The study suggests that the non-skeletal actions of zoledronic acid could be due to its ability to kill senescent cells and inhibit the secretion of harmful substances from these cells. These findings highlight the potential of zoledronic acid in anti-aging therapy.
Article
Surgery
Maria J. Citores, Sofia Perez-Pulgar, Ana Duca, Gonzalo Crespo, Sara de la Fuente, Carlos Vilches, Miquel Navasa, Valentin Cuervas-Mons
CLINICAL TRANSPLANTATION
(2016)
Article
Gastroenterology & Hepatology
Fernando Aguero, Alejandro Forner, Christian Manzardo, Andres Valdivieso, Marino Blanes, Rafael Barcena, Antoni Rafecas, Lluis Castells, Manuel Abradelo, Julian Torre-Cisneros, Luisa Gonzalez-Dieguez, Magdalena Salcedo, Trinidad Serrano, Miguel Jimenez-Perez, Jose Ignacio Herrero, Mikel Gastaca, Victoria Aguilera, Juan Fabregat, Santos del Campo, Itxarone Bilbao, Carlos Jimenez Romero, Asuncion Moreno, Antoni Rimola, Jose M. Miro
Article
Gastroenterology & Hepatology
Angela Puente, Joaquin Cabezas, Maria Jesus Lopez Arias, Jose Ignacio Fortea, Maria Teresa Arias, Angel Estebanez, Fernando Casafont, Emilio Fabrega, Javier Crespo
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2017)
Article
Gastroenterology & Hepatology
Fernando Aguero, Alejandro Forner, Andres Valdivieso, Marino Blanes, Rafael Barcena, Christian Manzardo, Antoni Rafecas, Lluis Castells, Manuel Abradelo, Pilar Barrera-Baena, Luisa Gonzalez-Dieguez, Magdalena Salcedo, Trinidad Serrano, Miguel Jimenez-Perez, Jose Ignacio Herrero, Mikel Gastaca, Victoria Aguilera, Juan Fabregat, Santos del Campo, Itxarone Bilbao, Carlos Jimenez Romero, Asuncion Moreno, Antoni Rimola, Jose M. Miro
LIVER TRANSPLANTATION
(2017)
Article
Oncology
Alberto Lue, Maria Trinidad Serrano, Francisco Javier Bustamante, Mercedes Inarrairaegui, Juan Ignacio Arenas, Milagros Testillano, Sara Lorente, Cristina Gil, Manuel de la Torre, Alexandra Gomez, Bruno Sangro
Article
Pharmacology & Pharmacy
Pilar Jimenez, Eduardo Chueca, Maira Arruebo, Mark Strunk, Estela Solanas, Trinidad Serrano, Maria A. Garcia-Gonzalez, Angel Lanas
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Surgery
Christian Manzardo, Maria C. Londono, Lluis Castells, Milagros Testillano, Jose Luis Montero, Judit Penafiel, Marta Subirana, Ana Moreno, Victoria Aguilera, Maria Luisa Gonzalez-Dieguez, Jorge Calvo-Pulido, Xavier Xiol, Magdalena Salcedo, Valentin Cuervas-Mons, Jose Manuel Sousa, Francisco Suarez, Trinidad Serrano, Jose Ignacio Herrero, Miguel Jimenez, Jose R. Fernandez, Carlos Gimenez, Santos del Campo, Juan I. Esteban-Mur, Gonzalo Crespo, Asuncion Moreno, Gloria de la Rosa, Antoni Rimola, Jose M. Miro
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Article
Gastroenterology & Hepatology
Jose Ignacio Fortea, Angela Puente, Iranzu Ezcurra, Antonio Cuadrado, Maria Teresa Arias-Loste, Joaquin Cabezas, Susana Llerena, Paula Iruzubieta, Carlos Rodriguez-Lope, Patricia Huelin, Fernando Casafont, Emilio Fabrega, Javier Crespo
DIGESTIVE AND LIVER DISEASE
(2019)
Article
Gastroenterology & Hepatology
Juan Jose Araiz-Burdio, Maria Trinidad Serrano-Aullo, Agustin Garcia-Gil, Ana Pascual-Bielsa, Alberto Lue, Sara Lorente-Perez, Beatriz Villanueva-Anadon, Miguel Angel Suarez-Pinilla
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2018)
Article
Gastroenterology & Hepatology
Jose Ignacio Herrero, Valentin Cuervas-Mons, Miguel Angel Gomez-Bravo, Joan Fabregat, Alejandra Otero, Itxarone Bilbao, Maria Magdalena Salcedo, Maria Luisa Gonzalez-Dieguez, Jose Ramon Fernandez, Maria Trinidad Serrano, Miguel Jimenez, Juan Miguel Rodrigo, Isidoro Narvaez, Gloria Sanchez
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2018)
Review
Cell Biology
Natalia Sanchez-Romero, Pilar Sainz-Arnal, Iris Pla-Palacin, Pablo Royo Dachary, Helen Almeida, Cristina Pastor, Daniela Rubio Soto, Milagros Chico Rodriguez, Emma Olmedo Arbizu, Lourdes Bengochea Martinez, Trinidad Serrano-Aullo, Pedro M. Baptista
Article
Immunology
Alberto Lue, Elena Martinez, Mercedes Navarro, Viviana Laredo, Sara Lorente, Juan Jose Araiz, Francisco Agustin Garcia-Gil, Maria Trinidad Serrano
Article
Gastroenterology & Hepatology
Marc Puigvehi, Maria-Carlota Londono, Xavier Torras, Sara Lorente, Mercedes Vergara, Rosa Maria Morillas, Helena Masnou, Trinidad Serrano, Mireia Miquel, Adolfo Gallego, Sabela Lens, Jose Antonio Carrion
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Environmental Sciences
Rocio Aznar-Gimeno, Luis M. Esteban, Gorka Labata-Lezaun, Rafael del-Hoyo-Alonso, David Abadia-Gallego, J. Ramon Pano-Pardo, M. Jose Esquillor-Rodrigo, Angel Lanas, M. Trinidad Serrano
Summary: This study developed a predictive model using data from 3623 COVID-19 patients to estimate the risk of ICU admission or mortality and aid clinicians in decision-making. Various techniques and machine learning algorithms were explored, with XGBoost algorithm performing the best. The model was externally validated, achieving good discrimination and calibration, with a user-friendly web application also created to assist in rapid decision-making in clinical practice.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Surgery
Diego Aguiar, Diego Martinez-Urbistondo, Alberto Baroja-Mazo, Manuel de la Mata, Manuel Rodriguez-Peralvarez, Angel Rubin, Lorena Puchades, Trinidad Serrano, Jessica Montero, Antonio Cuadrado, Fernando Casafont, Magdalena Salcedo, Diego Rincon, Jose A. Pons, Jose I. Herrero
ANNALS OF TRANSPLANTATION
(2017)