Article
Infectious Diseases
Chun-Hai Gao, Yan-An Zhang, Mao-Shui Wang
Summary: The performance of interferon-gamma release assays (IGRAs) was evaluated in patients with Mycobacterium kansasii infection. The positivity rates of IGRAs in patients with M. kansasii isolates were relatively low. More efforts are required to improve the performance of IGRAs in diagnosing M. kansasii infection.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Multidisciplinary Sciences
Tao Luo, Peng Xu, Yangyi Zhang, Jessica L. Porter, Marwan Ghanem, Qingyun Liu, Yuan Jiang, Jing Li, Qing Miao, Bijie Hu, Benjamin P. Howden, Janet A. M. Fyfe, Maria Globan, Wencong He, Ping He, Yiting Wang, Houming Liu, Howard E. Takiff, Yanlin Zhao, Xinchun Chen, Qichao Pan, Marcel A. Behr, Timothy P. Stinear, Qian Gao
Summary: A population genomics analysis of Mycobacterium kansasii reveals municipal water as a main source of infection and shows that nearly 80% of infections are due to closely-related strains, forming a main cluster that originated in the 1900s. Bioinformatic analyses suggest that certain genes may have contributed to the pathogen's success and adaptation to the human host.
NATURE COMMUNICATIONS
(2021)
Article
Infectious Diseases
Lara Munoz-Munoz, Jose A. Ainsa, Santiago Ramon-Garcia
Summary: This study evaluated the in vitro activity of various beta-lactam antibiotics against Mycobacterium kansasii (Mkn), a tuberculosis-like lung infection. Penicillins plus clavulanate and first- and third-generation cephalosporins were found to be the most active beta-lactams against Mkn. Combinatorial time-kill assays also showed favorable interactions of amoxicillin-clavulanate and cefadroxil with the standard Mkn treatment, making them potential alternative options for Mkn therapy.
Article
Microbiology
Florian Tagini, Trestan Pillonel, Claire Bertelli, Katia Jaton, Gilbert Greub
Summary: The study evaluated the genetic determinants leading to pathogenicity in members of the Mycobacterium kansasii complex. It found that Mycobacterium kansasii is the most frequent and most pathogenic species, while the other species are mostly colonizers. Genomic analysis showed that M. kansasii is the only species exhibiting a large genomic island encoding for 17 type-VII secretion system-associated proteins, while other species lack genes associated with the pathogenicity of M. tuberculosis.
Article
Oncology
Alberto Testori, Gianluca Perroni, Camilla De Carlo, Alessandro Crepaldi, Marco Alloisio, Ugo Cioffi
Summary: Primary lung signet-ring cell carcinomas are rare and often diagnosed at an advanced stage with poor prognosis. Surgical therapy combined with chemoradiotherapy is the standard care for these patients.
Article
Infectious Diseases
Shashikant Srivastava, Jotam G. Pasipanodya, Scott K. Heysell, Gunavanthi D. Boorgula, Tawanda Gumbo, Pamela J. McShane, Julie Philley
Summary: The study aimed to determine and compare the efficacy of drugs for the treatment of Mycobacterium kansasii pulmonary disease. The results showed that certain drugs had lower minimum inhibitory concentrations and exhibited stronger bactericidal activity in time-kill studies, which could potentially contribute to the development of a safer, more effective, and shorter-duration treatment regimen.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Microbiology
Vinicius O. Mussi, Thatiana L. B. Simao, Fabricio M. Almeida, Edson Machado, Luciana D. de Carvalho, Sanderson D. Calixto, Guilherme A. M. Sales, Eulogio C. Q. Carvalho, Sidra E. G. Vasconcellos, Marcos Catanho, Philip N. Suffys, Elena B. Lasunskaia
Summary: Among non-tuberculous mycobacteria, Mycobacterium kansasii is one of the most pathogenic, capable of causing lung disease indistinguishable from tuberculosis in susceptible adults. C57BL/6 mice intratracheally infected with highly virulent M. kansasii strains developed chronic infection and necrotic lung pathology. The presence of highly pathogenic strains in Brazil showed genomic similarities with strains isolated in the United States and Europe, suggesting global spread of a few pathogenic clones within M. kansasii population.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Xiaoling Yu, Wenqian Jiang
Summary: Non-tuberculous mycobacteria are conditional pathogens that can cause various diseases, with pulmonary infections being the most common, involving species like Mycobacterium avium and Mycobacterium abscessus. Researchers have developed a novel molecular-based method to identify Mycobacterium species, which could potentially enhance the accuracy and speed of diagnosis for these infections in the future.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Makoto Hasegawa, Yuji Ito, Yasuhiro Osugi, Masahiro Hashimoto, Nanako Hashimoto, Kunio Yano
Summary: This article presents a case of extrapulmonary pneumocystosis in an HIV-positive patient. The diagnosis was confirmed through a core-needle biopsy, and the patient was treated with trimethoprimsulfamethoxazole and pentamidine, followed by initiation of antiretroviral treatment. The patient's clinical condition improved after treatment.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Changlin Gong, Xiaojing Song, Xiaoxia Li, Lianfeng Lu, Taisheng Li
Summary: Viral activation and CD4+ T cell loss were observed in a treatment-naive HIV-positive patient after receiving inactivated COVID-19 vaccine, suggesting that the vaccine should only be given to HIV-positive individuals receiving antiretroviral therapy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Florentina Dumitrescu, Catalina-Gabriela Pisoschi, Vlad Padureanu, Andreea Cristina Stoian, Livia Dragonu, Lucian Giubelan
Summary: A 31-year-old HIV-infected patient was hospitalized for dyspnea, cough with mucopurulent sputum, and asthenia in July 2021. He was diagnosed with Serratia liquefaciens pneumonia and acute respiratory failure. Despite initial unfavorable outcomes, initiation of antituberculosis therapy led to significant improvement and discharge.
Review
Urology & Nephrology
Zunaid Barday, Kathryn Manning, Robert Freercks, Laurie Bertels, Nicola Wearne, Elmi Muller
Summary: Managing the interaction between ART and CNI immunosuppression in HIV-positive kidney transplant recipients is challenging. This study retrospectively analyzed ART regimen switches in 53 patients and found that PI-based regimen may be associated with increased rejection rates.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Infectious Diseases
An-Yu Cheng, Chih-Hung Lee
Summary: This case report describes a successful treatment of cutaneous Mycobacterium farcinogenes-senegalense group infection in an immunocompetent patient with medication and surgical excision.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Lu Guo, Sha Lv, Jing Zeng, Jiayu Yang, Baihui Shan, Fuqiu Li
Summary: This case report highlights a misdiagnosis of cutaneous Mycobacterium chelonae infection as sporotrichosis in a patient with Sjogren's syndrome. The patient initially received antifungal therapy based on a misinterpreted histopathological examination, but after treatment failure, correct diagnosis was made and proper antibiotic and corticosteroid treatment led to successful outcomes.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Pharmacology & Pharmacy
Ye Xiong, Qing Cao, Yongzheng Guo, Xiang Liu, Xueling Zhu, Bohao Dai, Biao Zhu
Summary: Savolitinib, a small-molecule inhibitor of MET factor, was approved for the treatment of NSCLC in China. However, a rare case of shock occurred in an HIV-1-positive patient with NSCLC after receiving Savolitinib. The patient developed a mild rash in the first 2 weeks and experienced three hospitalizations due to fever and circulatory shock in the following month.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Georges Ambaraghassi, Claire Beliveau, Annie-Claude Labbe, Christian Lavallee
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2019)
Article
Microbiology
Georges Ambaraghassi, Philippe J. Dufresne, Simon F. Dufresne, Emilie Vallieres, Jose F. Munoz, Christina A. Cuomo, Elizabeth L. Berkow, Shawn R. Lockhart, Linh Luong
JOURNAL OF CLINICAL MICROBIOLOGY
(2019)