Article
Immunology
Lorenza Pugni, Carlo Pietrasanta, Andrea Ronchi, Giovanna Lunghi, Laura Pellegrinelli, Fabio Mosca, Giulia Campanini, Fausto Baldanti
Summary: HHV-6 can integrate its genome in human chromosomes and be inherited by the next generation. Diagnosing inherited chromosomally integrated HHV-6 in neonates is crucial to avoid misdiagnosis and unnecessary treatment.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Microbiology
Liliana Gabrielli, Alice Balboni, Eva Caterina Borgatti, Giulio Virgili, Evangelia Petrisli, Alessia Cantiani, Matteo Pavoni, Federico Baiesi Pillastrini, Simona Venturoli, Giulia Piccirilli, Tiziana Lazzarotto
Summary: This study aimed to determine the prevalence of inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) in hospitalized patients and investigate the clinical features of individuals carrying this integration. HHV-6 PCR on hair follicles was used to confirm iciHHV-6 status when the blood viral load was more than 5 Log(10) copies/mL. The results showed that the prevalence of iciHHV-6 in our population was 2.6% (53/2019).
Article
Immunology
Laura Berneking, Anna Both, Claudia Langebrake, Martin Aepfelbacher, Marc Luetgehetmann, Nicolaus Kroeger, Maximilian Christopeit
Summary: This study retrospectively analyzed the epidemiology of HHV-6 infections and their impact on outcome in 689 adult allo-HSCT recipients. The results showed that about 10.5% of patients with HHV-6 blood viral loads had ciHHV-6. Screening of the donor for ciHHV-6 before antiviral therapy initiation is recommended.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Amr Aswad, Giulia Aimola, Darren Wight, Pavitra Roychoudhury, Cosima Zimmermann, Joshua Hill, Dirk Lassner, Hong Xie, Meei-Li Huang, Nicholas F. Parrish, Heinz-Peter Schultheiss, Cristina Venturini, Susanne Lager, Gordon C. S. Smith, D. Stephen Charnock-Jones, Judith Breuer, Alexander L. Greninger, Benedikt B. Kaufer
Summary: This study used advanced sequencing technology and mining of public human genome datasets to comprehensively understand the evolution of HHV-6, revealing that heritable integration of HHV-6 has existed since human migrations out of Africa. The research also showed that circulating and integrated HHV-6A and HHV-6B have distinct evolutionary histories and characteristics.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Biology
Michael L. Wood, Colin D. Veal, Rita Neumann, Nicolas M. Suarez, Jenna Nichols, Andrei J. Parker, Diana Martin, Simon P. R. Romaine, Veryan Codd, Nilesh J. Samani, Adriaan A. Voors, Maciej Tomaszewski, Louis Flamand, Andrew J. Davison, Nicola J. Royle
Summary: Human herpesviruses 6A and 6B can transition between telomere-integrated and free virus forms, with mainly maternal transmission of acquired virus observed in families. Some healthy adults have shown telomere integration of acqHHV-6B in saliva, indicating latency. The excision of viral genome from telomeres in iciHHV-6B carriers is high and tissue-specific, with potential reactivation from circular extrachromosomal forms.
Review
Immunology
Guy Handley
Summary: Human herpesvirus 6 (HHV-6) frequently reactivates after allogeneic stem cell transplantation, leading to transplant-related complications. Various strategies have been explored to reduce these risks, but no clear benefit for preemptive or prophylactic intervention has been demonstrated. The role of HHV-6 monitoring and preemptive/prophylactic therapy in stem cell transplantation is controversial.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Huanyu Wang, Cristina Tomatis-Souverbielle, Kathy Everhart, Sophonie J. Oyeniran, Amy L. Leber
Summary: Interpretation of human herpesvirus type 6 (HHV6) detection in the cerebrospinal fluid (CSF) of children can be complex. Our study aimed to determine the prevalence of HHV6, including inherited chromosomally integrated HHV6 (iciHHV6), in CSF and compare the clinical and laboratory characteristics of patients with and without iciHHV6. We found that the prevalence of HHV6 in CSF was 2.4%, while iciHHV6 prevalence was 0.85%. Patients with iciHHV6 were younger and less likely to have fever. They also had higher viral loads in CSF and whole blood. Most patients with iciHHV6 had incidental detection of HHV6 without presenting symptoms. This suggests that molecular detection of HHV6 in CSF may indicate iciHHV6, particularly in infants evaluated for sepsis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Virology
May Moheb Eldin Raouf, Nancy Mohammed Ouf, Manal Abdel Sattar Elsorady, Faika Mahmoud Ghoneim
Summary: The study aimed to detect HHV-6 reactivation among HSCT recipients and found that it was more common in allo-HSCT recipients. Clinical manifestations such as fever, engraftment delay, and bone marrow suppression were observed in patients with HHV-6 DNAemia.
Article
Virology
Darren J. Wight, Giulia Aimola, Georg Beythien, Louis Flamand, Benedikt B. Kaufer
Summary: Human herpesvirus 6A and 6B can integrate into host telomeres, which has significant implications for virus morphology. Researchers have developed a new method to measure telomere length and found diverse telomere lengths after virus integration.
Article
Biochemistry & Molecular Biology
Sandra Skuja, Simons Svirskis, Modra Murovska
Summary: The study evaluated the infection of HHV-6 and -7 in the brain, finding higher expression of HHV-7 in the temporal gray matter of patients with unspecified encephalopathy. Additionally, HHV-6 predominantly infected oligodendrocytes, while HHV-7 was detected in both astrocytes and oligodendrocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Guy Handley, Fareed Khawaja, Divya S. Kondapi, Hun J. Lee, Gregory P. Kaufman, Sattva S. Neelapu, Luis E. Fayad, Sudhakar Tummala, Linda Chi, Paolo Strati, Victor E. Mulanovich
Summary: This article presents a fatal case of HHV-6 myelitis following CD19-targeted chimeric antigen receptor T-cell therapy. The patient initially developed cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, which progressed to neuromuscular respiratory failure and death. Treatment with foscarnet and immunomodulating agents was ineffective in halting disease progression.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
James Milburn, Kwana Lechiile, Keatlaretse Siamisang, Christopher G. Williams, Leah Owen, Ezekiel Gwakuba, Tichaona Machiya, Tshepo Leeme, Hannah E. Barton, Ronan Doyle, Mark W. Tenforde, Madisa Mine, David M. Goldfarb, Margaret Mokomane, Joseph N. Jarvis
Summary: The prevalence and clinical relevance of human herpesvirus-6 (HHV-6) in cerebrospinal fluid (CSF) using multiplex polymerase chain reaction (PCR) testing in high human immunodeficiency virus (HIV)-prevalence African settings are still unknown. This study describes the clinical and laboratory characteristics of 13 patients with HHV-6 CSF PCR positivity in Botswana.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Virology
Ahmed Elsanhoury, Uwe Kuehl, Bruno Stautner, Oliver Klein, Alexander Krannich, Daniel Morris, Monika Willner, Ewa Jankowska, Karin Klingel, Sophie Van Linthout, Carsten Tschoepe
Summary: This study investigated the clinical course and effectiveness of steroid-based intervention in patients with HHV6-positive lymphocytic myocarditis. It found that low levels of HHV6 DNA were frequently detected in the myocardium, and patients with low levels of HHV6 DNA showed spontaneous clinical improvement. In selected symptomatic patients with cardiac HHV6 DNA, steroid-based therapy was found to be effective and safe.
Article
Virology
Katia Lino, Lilian S. Alves, Jessica Raposo, Thalia Medeiros, Cintia F. Souza, Andrea A. da Silva, Vanessa S. de Paula, Jorge R. Almeida
Summary: This real-world pilot study aimed to understand the frequency and clinical impact of HHV-6 coinfection in moderate to critically ill patients hospitalized due to COVID-19. Despite the high frequency of HHV-6 coinfection in SARS-CoV-2 positive cases, it did not impact general mortality. More extensive prospective studies are suggested to further elucidate the influence of HHV-6 reactivation in COVID-19 cases, focusing on specific clinical outcomes and viral reactivation mechanisms.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Endocrinology & Metabolism
Therese Weider, Angelo Genoni, Francesco Broccolo, Trond H. Paulsen, Knut Dahl-Jorgensen, Antonio Toniolo, Sara Salehi Hammerstad
Summary: This study found a high prevalence of common viruses in thyroid tissue, with enteroviruses, human herpesvirus 6, and parvovirus B19 being the most common. The significance of these detected viruses as causal agents, possible cofactors, or bystanders remains to be determined.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Deok-Bog Moon, Sung-Gyu Lee, Yong-Kyu Chung, Woo-Hyoung Kang, Ki-Hun Kim, Gi-Won Song, Dong-Hwan Jung, Tae-Yong Ha, Chul-Soo Ahn, Gil-Chun Park, Shin Hwang, Young-In Yoon, Hwui-Dong Cho, Sang-Hyun Kang, Jin-Uk Choi, I-Jy Jeong, Byeong-Gon Na, Min-Jae Kim, Sang-Hoon Kim, Kyu-Bo Sung, Gi-Young Ko, Dong-Il Kwon, Sung-Koo Lee, Dong-Wook Oh, Gyu-Sam Hwang, Jun-Gol Song, In-Gu Jun, Young-Jin Moon, Sang-Oh Lee, Sung-Han Kim, Jin-Won Huh
Summary: This study reports on the methodology and innovative techniques used in liver transplants at Asan Medical Center, showing a steady increase in living-donor liver transplants since 2011, while deceased-donor liver transplants remained constant. Effective management of complications during surgery was crucial for successful patient outcomes.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Surgery
Ye Eun Shim, Sung Shin, Youngmin Ko, Dong Hyun Kim, Seong Jun Lim, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Sung-Han Kim, Sang-Oh Lee, Duck Jong Han
Summary: After pancreas transplantation, laboratory biomarkers to differentiate between infectious and non-infectious fever remain elusive. This study found that serum procalcitonin levels at the peak of fever could significantly differentiate between the two types of fever, with a high sensitivity and specificity for procalcitonin compared to CRP.
CLINICAL TRANSPLANTATION
(2021)
Article
Virology
Sang Hyun Ra, Min Jae Kim, Min-Chul Kim, Se Yoon Park, Seong Yeon Park, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Keun Hwa Lee, Sung-Han Kim, Sun-Ho Kee
Summary: In patients with SFTS, SFTSV-specific IgG was detected at days 5-9 after symptom onset and increased during the course of the disease. The titer of SFTSV-specific IgM peaked around 2-3 weeks from symptom onset. The use of IFA or ELISA for IgM testing may not be sensitive enough for early diagnosis of SFTS.
Article
Critical Care Medicine
Ji Hyun Yun, Sang-Bum Hong, Sung-Ho Jung, Pil Je Kang, Heungsup Sung, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang-Soo Kim, Yong Pil Chong
Summary: The incidence of BSI during ECMO decreased significantly over time mainly due to a decrease in gram-positive cocci BSI. Patients with gram-negative rods BSI experienced higher and earlier mortality, with older age and gram-negative rods BSI identified as independent risk factors for 14-day mortality.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Eunmi Yang, Eunsil Kim, Hyemin Chung, Yun Woo Lee, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim
Summary: In a longitudinal study, changes in clinical and microbiological characteristics of MRSA bacteremia, specifically sequence type (ST) 72, were evaluated over an 11-year period. While the overall relative risk of MRSA bacteremia decreased annually, the relative risk of ST72 MRSA increased annually. The study also found a decrease in vancomycin minimum inhibitory concentration (MIC) and a significant decrease in erythromycin resistance rate among ST72 MRSA strains.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Seongman Bae, Ye-Jee Kim, Min-Ju Kim, Jwa Hoon Kim, Sung-Cheol Yun, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Yang Soo Kim, Sang-Oh Lee
Summary: This study evaluated the risk of tuberculosis in cancer patients exposed to immune checkpoint inhibitors (ICIs) in South Korea using National Health Insurance claims data. While the incidence of TB was eightfold higher in cancer patients exposed to ICIs compared to the general population, the risk of developing TB did not significantly differ between cancer patients exposed to ICIs and those who were not exposed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Yun Woo Lee, Seongman Bae, Eunmi Yang, Hyemin Chung, Eunsil Kim, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim
Summary: In Korea, the community-associated MRSA strain ST72-SCCmecIV has been found to cause a higher prevalence of osteoarticular infections in hospital-acquired cases, with patients being younger and less likely to have a history of recent surgery, antibiotic treatment, nasal MRSA colonization, and central venous catheter placement compared to the hospital-associated strain ST5-SCCmecII. Overall, there were no significant differences in mortality rates between the two groups.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yun Woo Lee, So Yun Lim, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Yang Soo Kim, Sang-Ho Choi
Summary: This study evaluated the clinical characteristics and outcomes of Enterococcus raffinosus bacteremia in adults. The study found that E. raffinosus bacteremia mainly originated from biliary tract infection, had high resistance rates to penicillin and ampicillin, but had a low bacteremia-related mortality rate.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Haein Kim, Hyeonji Seo, Hyemin Chung, Sunghee Park, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Yong Pil Chong
Summary: The value of follow-up blood culture (FUBC) in the management of Gram-negative bacteremia (GNB) is controversial. This study evaluated bedside risk predictors and found that hemodialysis, fever on the day of FUBCs, intravascular device, no use of in vitro active antibiotic within 24 h, non-fermenting bacteria, and multidrug resistance were independent risk factors for positive FUBCs in GNB. The yield of FUBCs increased as the number of bedside risk predictors increased, and positive FUBCs were significantly associated with 30-day mortality.
Article
Infectious Diseases
Moonsuk Bae, Yunseo Jeong, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jiwon Jung
Summary: The study found that in patients with uncomplicated Pseudomonas aeruginosa bloodstream infection, there was no significant difference in recurrence rates or 30-day mortality between short-course and prolonged-course antimicrobial therapy. Prolonged therapy did not significantly reduce the risk of P. aeruginosa infection recurrence within 180 days compared to short-course therapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Kyung Hwa Jung, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Summary: The study identified hematologic malignancy and ulcerative colitis as independent risk factors for the relapse of gastrointestinal cytomegalovirus disease. Approximately 10% of the participants experienced disease relapse after antiviral treatment. Prolonged antiviral treatment may not be helpful in preventing relapse of GI CMV disease.
Article
Virology
Hyemin Chung, Eunsil Kim, Bomin Kwon, Yeong-Geon Cho, Seongman Bae, Jiwon Jung, Min-Jae Kim, Yong-Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang-Soo Kim
Summary: This study investigated the kinetics of Gn-specific antibodies in patients with severe fever with thrombocytopenia syndrome (SFTS). The results showed that the peak of anti-Gn-specific IgM occurred later than that of anti-NP-specific IgM, and anti-Gn-specific IgG lasted for at least 3 years.
Article
Immunology
Hyeonji Seo, Jeong-Young Lee, Seung Hee Ryu, Sun Hee Kwak, Eun Ok Kim, Seongman Bae, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Heungsup Sung, Mi-Na Kim, Yang Soo Kim, Jiwon Jung
Summary: The study suggests that patients with negative CPE culture had lower rates of infection and transmission compared to those with positive CPE culture. The Xpert Carba-R assay is clinically useful not only for rapid identification of CPE but also for predicting the risks of infection and transmission when performed along with culture.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Hyeonji Seo, Haein Kim, Seongman Bae, Seonghee Park, Hyemin Chung, Heung-Sup Sung, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Ki Young Son, Yong Pil Chong
Summary: This study found no significant differences in clinical deterioration between patients treated with fluvoxamine and placebo among adult patients with symptomatic COVID-19 admitted to the CTC. Factors such as age, fever, and pneumonia may be independent risk factors for clinical deterioration.
INFECTION AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Seong-Ho Choi, Jeongsoo Lee, Jiwon Jung, Eun Sil Kim, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim
Summary: This study investigated the temporal changes in Staphylococcus aureus genotypes causing bacteremia in South Korea over the last decade. Hospital clones ST5 and ST239 have been replaced by community genotype ST72. The decrease in CVC-related and persistent SAB was associated with this genotype shift, while mortality and recurrence rates remained stable. Further research is needed to understand the reasons behind the ST72 epidemic and predict the potential epidemic of ST8 strains, including USA300.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)