Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 14, Issue 6, Pages E161-E165Publisher
WILEY
DOI: 10.1111/tid.12017
Keywords
Clostridium difficile infection; fecal microbiota therapy; fecal transplant
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We present a case of severe Clostridium difficile infection (CDI) in a non-neutropenic allogeneic hematopoietic stem cell transplant recipient who was treated successfully with fecal microbiota therapy after standard pharmacologic therapy had failed. Following naso-jejunal instillation of donor stool, the patient's symptoms resolved within 48 h. Bowel resection was averted. This is the first case in the literature, to our knowledge, to describe fecal microbiota therapy in a profoundly immunocompromised host with severe CDI. We propose that fecal microbiota therapy be considered as a therapeutic option in immunosuppressed patients with refractory severe CDI.
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