Journal
TRANSPLANT INFECTIOUS DISEASE
Volume 13, Issue 3, Pages 303-308Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1399-3062.2010.00592.x
Keywords
cryptococcosis; immune reconstitution inflammatory syndrome; meningitis; kidney transplantation; corticosteroid; immunosuppression
Categories
Ask authors/readers for more resources
Immune reconstitution inflammatory syndrome (IRIS) is a rare entity that has been described recently in solid organ transplant (SOT) recipients. IRIS is characterized by an exuberant and dysregulated immune response following treatment of opportunistic infections. We describe here the case of a kidney transplant recipient who developed cryptococcal meningitis that was efficiently treated with antifungal therapy and decreased immunosuppression regimen. Eight months later, a paradoxical worsening of neurological symptoms and neuroradiological findings led to the diagnosis of IRIS. A short course of high-dose steroid therapy allowed complete resolution of neurological symptoms. This report highlights the challenge for physicians to distinguish IRIS from a relapsing cryptococcal infection. Clinical improvement of cryptococcosis-associated IRIS by anti-inflammatory drugs needs to be confirmed among SOT recipients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available