Article
Virology
Weixu Zhang, Hefeng Xu, Shuxuan Guan, Chengmin Wang, Guoying Dong
Summary: This study analyzed the available NA protein sequences of H1N1 influenza viruses worldwide and found that 3.76% of H1N1 viruses currently harbor oseltamivir resistance, with the most common mutation being H274Y. Oseltamivir resistance is mainly found in humans, swine, and avian, and the resistance level peaked in 2007-2008 and quickly decreased in 2009. The study highlights the importance of globally monitoring oseltamivir resistance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Omid Rashidi, Afagh Moattari, Neda Pirbonyeh, Amir Emami, Mohammad Rahim Kadivar, Nahid Tavakoli Movaghar, Fahimeh Edalat
Summary: The study aimed to determine the genetic mutation of the neuraminidase gene in influenza A (H1N1) viruses in southwest Iran. The emergence of oseltamivir resistance was identified, highlighting the importance of conducting similar evaluations in different geographical regions and planning treatment strategies for influenza.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Teena Mohan, Ha T. Nguyen, Krista Kniss, Vasiliy P. Mishin, Angiezel A. Merced-Morales, Jennifer Laplante, Kirsten St George, Patricia Blevins, Anton Chesnokov, Juan A. De la Cruz, Rebecca Kondor, David E. Wentworth, Larisa Gubareva
Summary: Four cases of oseltamivir-resistant influenza A(H1N1) pdm09 virus infection were detected among inhabitants of a border detention center in Texas, USA. The hemagglutinin of these viruses belongs to subclade 6B.1A5A-156K, which may enable viral escape from preexisting immunity, highlighting the importance of monitoring both drug resistance and antigenic drift of circulating viruses.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Sebastian Wurster, Jezreel Pantaleon Garcia, Nathaniel D. Albert, Ying Jiang, Keerthi Bhoda, Vikram V. Kulkarni, Yongxing Wang, Thomas J. Walsh, Scott Evans, Dimitrios P. Kontoyiannis
Summary: We established a novel corticosteroid-immunosuppressed murine model of influenza-associated pulmonary aspergillosis (IAPA), highlighting the detrimental effect of corticosteroid therapy on the outcomes of IAPA and providing a preclinical platform to study its pathogenesis and therapy.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Smriti Krishna, Anup Jayaram, Ujwal Shetty, Prasad Varamballi, Chiranjay Mukhopadhyay, Anitha Jagadesh
Summary: Influenza viruses can mutate, leading to respiratory ailments. The H275Y mutation in the neuraminidase gene reduces the effectiveness of oseltamivir, a commonly used drug for treating Influenza A and B virus infection. This study aimed to estimate the prevalence of the H275Y mutation among hospitalized patients from 2014 to 2021. The results showed a low prevalence of oseltamivir resistance and raised concerns about the effectiveness of the recommended probes for detecting the mutation in recent years.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Hong-Dou Chen, Xu Wang, Shu-Le Yu, Yue-Hui Ding, Meng-Lei Wang, Jin-Na Wang
Summary: This study evaluated the efficacy of peramivir and oseltamivir in the treatment of severe influenza A with primary viral pneumonia, showing that peramivir is no less effective than oseltamivir. Patients treated with peramivir had significantly shorter remission times of fever symptoms than those treated with oseltamivir, providing guidance for clinical medication.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yan Lv, Guodong Yu, Xiaoli Zhang, Jueqing Gu, Chanyuan Ye, Jiangshan Lian, Xiaoqing Lu, Yingfeng Lu, Yida Yang
Summary: This study aimed to investigate the differences between elderly patients hospitalized with COVID-19 or influenza A H1N1 virus infections. Results showed that the clinical manifestations of patients with COVID-19 are more concealed than those of patients with influenza, with fewer symptoms of sputum production, fatigue, and shortness of breath.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Chemistry, Medicinal
Saad Alqarni, Laura Cooper, Jazmin Galvan Achi, Ryan Bott, Veeresh Kumar Sali, Andrew Brown, Bernard D. Santarsiero, Aleksej Krunic, Balaji Manicassamy, Norton P. Peet, Pin Zhang, Gregory R. J. Thatcher, Irina N. Gaisina, Lijun Rong, Terry W. Moore
Summary: This study identifies a novel imidazo[1,2-a]dpyrimidine scaffold for targeting group 2 IAV entry. By exploring different regions of the lead compound, researchers have developed a series of small molecules with nanomolar activity against oseltamivir-sensitive and -resistant forms of group 2 IAVs. These small molecules target HA, blocking viral entry.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Saad Alqarni, Laura Cooper, Jazmin Galvan Achi, Ryan Bott, Veeresh Kumar Sali, Andrew Brown, Bernard D. Santarsiero, Aleksej Krunic, Balaji Manicassamy, Norton P. Peet, Pin Zhang, Gregory R. J. Thatcher, Irina N. Gaisina, Lijun Rong, Terry W. Moore
Summary: The study presents a novel drug scaffold and a series of small molecules that have nanomolar activity against both oseltamivir-sensitive and -resistant forms of group 2 IAVs, targeting hemagglutinin (HA) involved in viral entry.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Blanca Valenzuela-Mendez, Francisco Valenzuela-Sanchez, Juan Francisco Rodriguez-Gutierrez, Rafael Bohollo-de-Austria, Angel Estella, Pilar Martinez-Garcia, Maria Angela Gonzalez-Garcia, Grant Waterer, Jordi Rello
Summary: This study found that early dysregulation of host immune response in influenza pneumonia is associated with increased mortality. Immunoparalysis was identified as a major driver of death. Personalized approaches of adjunctive therapy should consider early specific host response dysregulations.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Darling Melany de C. Madrid, Weihong Gu, Bianca L. Artiaga, Guan Yang, Julia Loeb, Ian K. Hawkins, William L. Castleman, John A. Lednicky, Jurgen A. Richt, John P. Driver
Summary: Influenza virus infections are a major respiratory disease in humans, and the primary antiviral medication used, NAIs, are not always effective. The emergence of NAI-resistant virus strains and the risk of severe side effects are concerns. This study compared the efficacy of oseltamivir with the iNKT cell superagonist, alpha-GalCer, and found that alpha-GalCer had no impact on virus replication or transmission.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Georgios Angelidakis, Fareed Khawaja, Victor E. Mulanovich, Natalie Dailey-Garnes, Ella Ariza-Heredia, Roy F. Chemaly
Summary: This study reports on two hematopoietic cell transplant recipients with severe influenza infections who were treated with a combination of baloxavir and oseltamivir. The study discusses possible reasons for their different responses.
MICROBES AND INFECTION
(2022)
Article
Virology
Murat Karatas, Erhan Tatar, Cenk Simsek, Ali Murat Yildirim, Alpay Ari, Baha Zengel, Adam Uslu
Summary: This study examined the clinical outcomes of kidney transplant recipients with COVID-19 pneumonia treated with a broad-spectrum anti-inflammatory protocol. Treatment in organ transplant centers with experience yielded better results, with significant improvement in respiratory parameters and lower mortality rates.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Surgery
Zitta Barrella Harboe, Daniel Modin, Finn Gustafsson, Michael Perch, Gunnar Gislason, Soren Schwartz Sorensen, Allan Rasmussen, Tor Biering-Sorensen, Susanne Dam Nielsen
Summary: Vaccination against influenza can reduce the risk of all-cause pneumonia admission and all-cause mortality in solid organ transplant recipients. However, there is no significant effect on influenza-related admission and ICU admission. Despite the benefits, the uptake of influenza vaccination among these recipients is low, highlighting the need for prioritizing annual vaccination.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Chemistry, Multidisciplinary
Anna Egorova, Martina Richter, Maria Khrenova, Elisabeth Dietrich, Andrey Tsedilin, Elena Kazakova, Alexander Lepioshkin, Birgit Jahn, Vladimir Chernyshev, Michaela Schmidtke, Vadim Makarov
Summary: Influenza infections are often worsened by bacterial infections such as Streptococcus pneumoniae. We discovered a new compound that may be useful in the development of small molecules against influenza. This compound inhibits both viral and bacterial neuraminidases, making it a promising candidate for treating influenza pneumonia complicated by bacterial infections.