Article
Biochemistry & Molecular Biology
Xilin Shen, Bingbing Wu, Wei Jiang, Yu Li, Yuping Zhang, Kun Zhao, Nanfang Nie, Lin Gong, Yixiao Liu, Xiaohui Zou, Jian Liu, Jingfen Jin, HongWei Ouyang
Summary: This study quantitatively measured the aging blood transcriptome and identified age-related genes. It revealed the characteristics of linear and non-linear dimensions of aging and evaluated the rejuvenation effect of molecules using an aging clock.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Immunology
Surendra Gulla, Madhava C. Reddy, Vajra C. Reddy, Sriram Chitta, Manjula Bhanoori, Dakshayani Lomada
Summary: Thymic involution, characterized by decreased T-cell development and impaired immune function, increases susceptibility to infectious diseases, autoimmune disorders, and cancers. Understanding the molecular mechanisms behind thymic involution is crucial for identifying treatment targets and developing strategies to mitigate associated complications.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Review
Cell Biology
Bohan Zhang, Alexandre Trapp, Csaba Kerepesi, Vadim N. Gladyshev
Summary: There are interventions proposed to reverse aging rather than just slow it down, but the criteria for achieving rejuvenation are still controversial. A key prerequisite for a rejuvenation intervention is a significant reduction in biological age, which can be assessed by biomarkers such as epigenetic clocks.
Review
Cell Biology
Siamak Tabibzadeh
Summary: Pluripotency and senescence represent two extremes of cell life, but they are closely linked and can be generated together in different contexts. Senescence can promote the generation of pluripotency, while pluripotency can induce senescence. Precise control of senescence is necessary to harness the full benefits of pluripotency during tissue regeneration or rejuvenation.
AGEING RESEARCH REVIEWS
(2022)
Review
Cell Biology
Patrick T. Paine, Ada Nguyen, Alejandro Ocampo
Summary: Partial cellular reprogramming is a biological process that can modify cell age and has the potential to improve or restore various age-related traits. While it offers therapeutic benefits, there are also limitations and areas for future development in this field.
Article
Construction & Building Technology
Haisen Chen, Jun Xie, Shaopeng Wu, Chao Yang, Bo Gao, Dong Yang, Junlin Chen
Summary: The selective absorption of bitumen by BOF has been studied previously, but research on the selective absorption of bitumen by BOF at different aging stages is still lacking. This study aims to explore the selective absorption behavior of BOF towards bitumen components at different aging and rejuvenation stages, as well as the road performance of the bituminous mixtures at different stages. The results show that BOF and natural aggregates both exhibit selective absorption of bitumen, with BOF showing a more significant effect. The selective absorption of bitumen by aggregates exhibits a time-dependent effect, with the strongest selective absorption seen at the short-term aging stage. The ability of adhesion for bitumen decreases with aging, which is the key factor affecting the performance of bituminous mixtures.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Geriatrics & Gerontology
Yan-Ying Wang, Le Chang, Gao-Hong Zhu, Gong-Hua Li, Qing-Peng Kong, Long-Bao Lv, Qiang Wang, Chuan Tian, Ye Li, Xiang-Qing Zhu, Xing-Hua Pan
Summary: Stem cell therapy is considered an ideal method to prevent or reverse thymus aging, as it can increase thymus volume, promote tissue regeneration, reduce fibrosis, and improve protein expression. Transcriptomic analysis also shows that stem cell therapy has a positive impact on aging-related genes.
REJUVENATION RESEARCH
(2022)
Article
Cell Biology
Kyusik Ahn, Seung-Jae Lee, Inhee Mook-Jung
Summary: This article assesses the current state of knowledge on brain aging, with a focus on the roles of white matter and microglia, and suggests potential approaches for rejuvenating the aged brain.
AGEING RESEARCH REVIEWS
(2022)
Article
Construction & Building Technology
Meng Guo, Meichen Liang, Anand Sreeram, Amit Bhasin, Daisong Luo
Summary: This study investigated the rejuvenation effect of reclaimed asphalt pavement binder and the impact of modification processes on asphalt binders. Results showed that the addition of rejuvenators reduced the complex modulus of asphalt binders, but further research is needed to fully understand the rejuvenation mechanisms.
INTERNATIONAL JOURNAL OF PAVEMENT ENGINEERING
(2022)
Article
Construction & Building Technology
Jianmin Ma, Yue Deng, Daquan Sun, Simon A. M. Hesp
Summary: The use of rejuvenators can help restore the performance of aged asphalt, but as time goes on, the performance of the rejuvenated mixture decreases significantly.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Review
Engineering, Biomedical
Robert S. Rosen, Martin L. Yarmush
Summary: The process of aging poses risks to health and functionality and has been the subject of investigation for potential therapeutics. However, identifying impactful treatments has been challenging due to limited experimental validation and study design. This review explores the biological mechanisms of aging, discusses promising therapeutic strategies, and proposes a unified approach for evaluating and vetting current and future treatments.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
(2023)
Article
Cell & Tissue Engineering
Yusheng Cai, Si Wang, Jing Qu, Juan Carlos Izpisua Belmonte, Guang-Hui Liu
Summary: Stem cell therapies offer promising approaches for treating various diseases by addressing stem cell exhaustion and dysfunction. Recent advances in understanding the mechanisms of stem cell regeneration and rejuvenation strategies utilizing intrinsic and extrinsic factors may pave the way for interventions to delay aging and treat age-associated diseases.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Yanhan Hou, Shasha Li, Hongyan Zhu, Mengxue Qiao, Xiaowen Sun, Guorong Li
Summary: This study systematically investigated the development and degeneration of the thymus and kidney in Nothobranchius guentheri fish and the effects of resveratrol on aging. The results showed that the thymus and kidney underwent distinct developmental changes at different stages of fish growth, and degeneration of the thymus and kidney occurred with age. Feeding resveratrol ameliorated the aging-related changes in the kidney and thymus and reduced inflammation. This study provides important insights into the development of immune organs and the anti-aging effects of resveratrol in short-lived fish.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Fangjin Li, Yuhong Wang, Miomir Miljkovic, Kin Ming Chan
Summary: This study revealed the fundamental changes of colloidal particles in asphalt binder during aging and rejuvenation, and connected the changes in particle morphology to the relaxation spectrum of the binder. By using commonly used engineering tests with a dynamic shear rheometer, practitioners can analyze the nanoscale effects of aging and rejuvenation in asphalt binder, aiding in material selection and design.
MATERIALS & DESIGN
(2022)
Article
Multidisciplinary Sciences
Hongli Jiao, Ming-Song Lee, Athillesh Sivapatham, Ellen M. Leiferman, Wan-Ju Li
Summary: This study successfully derived iPSCs from different breeds of miniature pigs and found that YMS fibroblasts showed higher reprogramming efficiency. The study also demonstrated the differentiation potential of YMS iPSC lines with a normal pig karyotype and identified the regulation of BAF60A expression by STAT3 signaling as a determinant of pig iPSC generation efficiency.
SCIENTIFIC REPORTS
(2022)